Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…The primary findings from scRNA-seq were further validated by quantitative polymerase chain reaction (qPCR), flow cytometry, and in vivo experiments including selenium supplementation. Results We observed a significant reduction in CD8αα + IELs, accompanied by a marked increase in CD8αβ + IELs in Lpr mice. …”
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Abundant geographical divergence of Clostridioides difficile infection in China: a prospective multicenter cross-sectional study by Lulu Bai, Telong Xu, Wenzhu Zhang, Yajun Jiang, Wenpeng Gu, Wei Zhao, Yang Luan, Yanfeng Xiong, Nianli Zou, Yalin Zhang, Ming Luo, Jinxing Lu, Bike Zhang, Yuan Wu

“…Clindamycin, erythromycin, and moxifloxacin were the top three antibiotics to which resistance was observed, with resistance rates of 81.3%, 63.6%, and 24.0%, respectively. …”
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Complicated caries of permanent teeth in children: status of the problem and modern solution ways by N.S. Proshchenko, H.V. Sorochenko, O.I. Ostapko, O.M. Plyska, Yu.V. Trokhimets

“…The obtained indicators confirm the absence of a downward trend compared to similar data for more than 15 years of observation. Diagnosis, treatment and full rehabilitation of complicated caries of permanent teeth in children is complex, multi-stage and requires the practical experience and patience of a dentist and the usage of the most modern materials and technologies. …”
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Seroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021–2022 by Eilish Hart, John Tulloch, Daniel Bailey, Tim Brooks, Heli Harvala, Peter Simmonds, Roberto Vivancos, Neil French, Amanda Semper

“…Regional and demographic differences in seroprevalence were observed after two-tier testing, but due to the low overall seroprevalence, were not significant upon multivariable analysis. …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…In a multivariate analysis, only MRD >10–3 was associated with a poorer OS (hazard ratio, 2.6; 95% confidence interval, 1.2-5.5; P = .013). We also observed a trend toward a better median OS in patients who underwent hematopoietic stem cell transplantation with MRD <10–3 (not reached vs 26.0 months; P = .06). …”
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Navigating healthcare pathways: Cascade of prevention and care for chronic viral hepatitis in asylum seekers and refugees. A multicenter analysis in Northern Italy by Beatrice Formenti, Roberto Benoni, Jacopo Testa, Giulia Bertoli, Giacomo Stroffolini, Maria Grazia Pizzi, Barbara Menzaghi, Niccolò Ronzoni, Paola Magro, Issa El Hamad, Carla Scolari, Angiola Spinetti, Serena Zaltron, Francesco Castelli, Valentina Marchese, Alberto Matteelli

“…Seven distinct care pathways were identified, where significant differences were observed based on the region of origin and the specific study site, highlighting the impact of local healthcare infrastructure and support systems. …”
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The dynamics of lowland river sections of Danube and Tisza in the Carpathian basin by Imre M. Jánosi, Imre M. Jánosi, István Zsuffa, István Zsuffa, Tibor Bíró, Boglárka O. Lakatos, Boglárka O. Lakatos, András Szöllősi-Nagy, Zsolt Hetesi, Zsolt Hetesi

“…Various possibilities for the explanations of these observations are listed. The empirical histograms for half-daily water level changes can be well-fitted by piecewise-exponential functions containing four or three sections, consistent with the understanding that level changes are deterministic rather than stochastic processes, as is well known in hydrology. …”
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Surgical margins of the oral cavity: is 5 mm really necessary? by James Fowler, Yael Campanile, Andrew Warner, Francisco Laxague, Naif Fnais, Kevin Fung, Adrian Mendez, Danielle MacNeil, John Yoo, David Palma, Anthony Nichols

“…Conclusions Although historical margins for head and neck surgery are 5 mm, similar outcomes were observed for margins greater than 1 mm in our cohort. …”
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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Utilized ARS mouse model to observe survival rates of Usp11−/− (KO) mice post-TBI (Total Body Irradiation). …”
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Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

“…MS2 fragmentation analysis of salivary O-glycans suggests that altered sulfation, fucosylation, sialylation and distribution of core types may all contribute to the observed alteration, directly or indirectly. Additionally, the short disaccharide sialyl-Tn was most abundant in the saliva samples from patients with pSS. …”
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An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model by Michael P. Leviton, Juan C. Lacayo, K. Yeon Choi, Nelmary Hernandez-Alvarado, Andrew Wey, Mark R. Schleiss

“…In spite of attenuation, the vaccine was immunogenic, eliciting antibody responses comparable to those observed in natural infection. To assess its protective potential as a vaccine, either recombinant virus or placebo was used to immunize seronegative female guinea pigs. …”
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Verbal fluency and semantic association deficits in children with in birth nonprogressive neuromuscular diseases by Maria Koriakina, Maria Koriakina, Olga E. Agranovich, Ioannis Ntoumanis, Maxim Ulanov, Isak B. Blank, Anna Shestakova, Evgeny Blagovechtchenski

“…Interestingly, MD children with unilateral limb impairment outperformed those with bilateral impairment on semantic association tasks.DiscussionThese results suggest that the cognitive deficits observed in children with motor impairments can be attributed to less engagement with their physical environment, which influences their ability to perceive and manipulate objects differently based on their level of impairment. …”
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A survey of the commercial traits and antioxidant status of goat milk in Mediterranean pastoral farms by Manuel Delgado-Pertiñez, Juan M. Mancilla-Leytón, Eduardo Morales-Jerrett, Sara Muñoz-Vallés, Verónica Cruz, Yolanda Mena

“…Principal changes were observed in the milk composition in different months due to the variation in the lactation stage and differences in feeding regimens. …”
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Polypropylene/myristic acid assisted electrodeposition of eco-friendly micro-engineered copper superhydrophobic coating for enhancing hydrophobicity and anti-corrosion efficiency o... by Himanshu Prasad Mamgain, Krishna Kanta Samanta, Rajeev Gupta, Ranjeet Brajpuriya, Pravat Ranjan Pati, Jitendra Kumar Pandey, Abhijit Bhowmik, Abdulaziz AlHazaa

“…Electrodeposition of copper on aluminium substrate resulted in a distinctive rose flower-like micro-order rough structure, elevating the contact angle from 58° to 140° (highly hydrophobic) when voltage varying up to 10 V, with the highest hydrophobicity observed at 8 V. Subsequent modification with PP/MA (4:1) further increased the contact angle to 148° (superhydrophobic) and reduced the surface energy, enhancing hydrophobicity. …”
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Gastrointestinal Tract Duplications in Children: A Tertiary Referral Center Experience by Meltem CAGLAR OSKAYLI, Furkan ERSOY, Neslihan GULCIN, Ahmet PIRIM, Seyhmus Kerem OZEL, Seyma OZKANLI, Cigdem ULUKAYA DURAKBASA

“…Cystic duplications were observed in 14 (74%) patients and tubular in five (26%). …”
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Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy by Mengyi Liu, Lue Zhang, Quanming Zhang, Nan Zeng, Shuo Li, Shuyue Guo, Yaqin Zhao, Mingxing Tang, Qiong Yang

“…Results: Ear discharge, graft swelling, and poor blood supply were more frequently observed in the HA group. The proportion of patients group that achieved complete epithelialization within 60 days post operation was significantly higher in the CGF/HA group than the HA group. …”
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Influence of ecologically relevant urea fertilizer concentrations on nematodes: A microcosm experiment by Rowena B. Caro-Benavides, Ma. Reina Suzette B. Madamba, Nanette Hope N. Sumaya, Ruben F. Amparado, Jr, Joey Genevieve T. Martinez

“…Secondly, no significant effects on the number of genera and diversity indices were observed with urea, except on the day 15 when nematode abundance was significantly higher at 39.33 mg/kg than at 19.67 mg/kg. …”
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Overview of female healthcare providers’ outlooks on cervical cancer screening: a narrative review by Wubishet Gezimu, Ababo Demeke, Firomsa Bekele, Solomon Seyife Alemu, Lema Fikadu, Addisalem Workie Demsash, Geleta Nenko Dube, Gemeda Wakgari Kitil, Elias Ezo

“…Poor knowledge and screening practices were observed. Moreover, the barriers to cervical cancer screening uptake were described. …”
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Effectiveness and safety of an emergency department-based rapid response system by Fanny Delfanti, Guido Bertolini, Giovanni Nattino, Giulia Acquistapace, Daniela De Palma, Piergiuseppe Ferrari, Sara Martinenghi, Stefano Maiandi, Marco Rossi, Anna Lilia Ruocco, Maria Teresa Spina, Benedetta Chiodi, Stefano Paglia

“…A significant reduction in Intensive Care Unit (ICU) transfers was observed overall (0.26%, p=0.005), but not in mortality (0.10%, p=0.47). …”
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The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues by Xin Xu, Hirokazu Fukui, Ying Ran, Xuan Wang, Yoshihito Inoue, Nobuhiko Ebisudani, Heihachiro Nishimura, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroshi Kiyama, Hiroto Miwa

“…In HCT116 cells, those enhancements were also observed by IL-6 and IL-22 stimulations but not IL-17. …”
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