Fungal Submerged Fermentation of Coffee Silverskin: A Sustainable Source of Natural Meat Additives by Stephany Carolina Terán-Rivera, Gastón Ramón Torrescano-Urrutia, Brisa del Mar Torres-Martínez, Martín Esqueda-Valle, Félix Joel Ibarra-Arias, Armida Sánchez-Escalante, Rey David Vargas-Sánchez

“…Also, an increase in radical cation scavenging activity, reducing power values and antibacterial activity of the extracts obtained with FE, was observed. Regarding pork meat homogenate treated with ME and FE extracts and subjected to oxidation with potassium ferrocyanide, results demonstrated that inclusion of FE-obtained extract led to decreased pH, lipid oxidation, metmyoglobin, and color changes (L*, a*, b*, C*, and h*), and microbial growth. …”
Get full text

Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome by Jan Soukop, Ludmila Kazdová, Martina Hüttl, Hana Malínská, Irena Marková, Olena Oliyarnyk, Denisa Miklánková, Soňa Gurská, Zuzana Rácová, Martin Poruba, Rostislav Večeřa

“…The beneficial effect of combination therapy on the parameters of oxidative stress and lipoperoxidation was also observed, to a lesser extent, in the heart and kidneys. …”
Get full text

Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging by Oliver Lester Saldanha, Jiefu Zhu, Gustav Müller-Franzes, Zunamys I. Carrero, Nicholas R. Payne, Lorena Escudero Sánchez, Paul Christophe Varoutas, Sreenath Kyathanahally, Narmin Ghaffari Laleh, Kevin Pfeiffer, Marta Ligero, Jakob Behner, Kamarul A. Abdullah, Georgios Apostolakos, Chrysafoula Kolofousi, Antri Kleanthous, Michail Kalogeropoulos, Cristina Rossi, Sylwia Nowakowska, Alexandra Athanasiou, Raquel Perez-Lopez, Ritse Mann, Wouter Veldhuis, Julia Camps, Volkmar Schulz, Markus Wenzel, Sergey Morozov, Alexander Ciritsis, Christiane Kuhl, Fiona J. Gilbert, Daniel Truhn, Jakob Nikolas Kather

“…By implementing a real-world SL setup across three international centers, we observe that these collaboratively trained models outperform those trained locally. …”
Get full text

Prognostic value of remnant-like particle cholesterol in ischemic heart failure patients following percutaneous coronary intervention by Xin Huang, Tienan Sun, Biyang Zhang, Meishi Ma, Zheng Chen, Zehao Zhao, Shutong Dong, Yujie Zhou

“…A nonlinear relationship between RLP-C and MACE was observed, indicating that the risk of MACE increased with higher RLP-C levels(Nonlinear p < 0.001). …”
Get full text

Clinical calculator based on clinicopathological characteristics predicts local recurrence and overall survival following radical resection of stage II-III colorectal cancer by Fei Huang, Ran Wei, Shiwen Mei, Tixian Xiao, Wei Zhao, Zhaoxu Zheng, Qian Liu

“…Calibration plots illustrated excellent agreement between the clinical risk calculator predictions and actual observations for 3- and 5-year LRFS and OS. Recurrence risk-stratified analysis showed that low-risk patients were more likely to undergo salvage radical surgery when recurrent disease existed.ConclusionThe clinical calculator can better account for tumor and patient heterogeneity, providing a more individualized outcome prognostication. …”
Get full text

Insight into the role of antioxidant in microbial lignin degradation: Ascorbic acid as a fortifier of lignin-degrading enzymes by Aipeng Li, Weimin Wang, Shuqi Guo, Changzhi Li, Xinying Wang, Qiang Fei

“…This increase in enzyme activity contributed to a higher lignin degradation rate from 17.5% to 35.2%, consistent with observed morphological changes in the lignin structure. …”
Get full text

Optimized Gross Primary Productivity Over the Croplands Within the BEPS Particle Filtering Data Assimilation System (BEPS_PF v1.0) by Xiuli Xing, Mousong Wu, Huajie Zhu, Wenzhuo Duan, Weimin Ju, Xiaorong Wang, Youhua Ran, Yongguang Zhang, Fei Jiang

“…With BEPS_PF DA, the average R2 between GPP and observed data at the hourly scale has been efficiently improved by 0.36 and root mean square error reduced by 0.18 gC m−2 hr−1. …”
Get full text

Analysis of different therapeutic schemes combining cyclophosphamide and doublestranded DNA preparation for eradication of Krebs-2 primary ascites in mice by E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, A. V. Kozel, O. S. Taranov, V. V. Omigov, E. I. Vereschagin, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…We show that combining CP with cross-linked human and salmon dsDNA results in a synergistic toxicity for ascites-bearing mice, an observation supported by the histopathology analysis of organs and tissues of experimental animals. …”
Get full text

Chikungunya virus infection in the skin: histopathology and cutaneous immunological response by Natália Gedeão Salomão, Natália Gedeão Salomão, Luciana Araújo, Luiz José de Souza, Anna Luiza Young, Carlos Basílio-de-Oliveira, Rodrigo Panno Basílio-de-Oliveira, Jorge José de Carvalho, Priscilla Conrado Guerra Nunes, Juliana Fernandes da Silva Amorim, Douglas Valiati dos Santos Barbosa, Marciano Viana Paes, Kíssila Rabelo, Kíssila Rabelo, Flavia Dos Santos

“…Loss of contact among adjacent keratinocytes, epidermis presenting necrotic cells, and fibroblasts with dilated cisternae in the endoplasmic reticulum and mitochondria with few cristae was observed by transmission electron microscopy. Studies involving skin immunopathogenesis during CHIKV infection are still scarce; therefore, the findings presented here can contribute to a better understanding of the disease immunopathogenesis.…”
Get full text

Dynamic balance control in healthy young women during stair descent: a plantar pressure-based study by Ruiqin Wang, Ruiqin Wang, Jinfeng Cao, Haoran Xu, Panjing Guo, Yumin Li, Yuyi Fan, Yunfei Gui, Leqi Li, Roger Adams, Jia Han, Jia Han, Jia Han, Jie Lyu, Jie Lyu

“…The Center of Pressure (COP), along with its medial-lateral (ML) and anterior-posterior (AP) adjustment velocities, and the VCOP, RCOP-ML, and RCOP-AP were analyzed.ResultWith an increase in the step height, significant enhancements were observed in the VCOP-ML (p &lt; 0.001), VCOP-AP (p &lt; 0.001), RCOP-ML (p &lt; 0.001), and RCOP-AP (p &lt; 0.001) during landing. …”
Get full text

Outlining the Psychological Profile of Persistent Depression in Fibromyalgia Patients Through Personality Assessment Inventory (PAI) by Andrea Doreste, Jesus Pujol, Eva Penelo, Víctor Pérez, Laura Blanco-Hinojo, Gerard Martínez-Vilavella, Helena Pardina-Torner, Fabiola Ojeda, Jordi Monfort, Joan Deus

“…<b>Method:</b> An observational, cross-sectional study was conducted with 66 women (mean age 49.18, SD = 8.09) from Hospital del Mar. …”
Get full text

Vaping – A Beneficial Alternative to Traditional Cigarettes or an Unexplored Danger? by Paulina Błasiak, Aleksandra Ślusarska, Patryk Mikołajec, Barbara Bilecka, Jolanta Mędyk, Małgorzata Wirkijowska, Jakub Wirkijowski, Yauheniya Patarocha, Michał Rogulski, Ruslan Huk

“…Conclusions:  The precise impact of e-cigarette use on health needs further research and long-term observations. Particular concern arises from the unregulated composition of e-liquids, which are gaining popularity among youth, thereby promoting early nicotine addiction and normalizing the use of tobacco products. …”
Get full text

Construction of Recombinant Inbred Lines and Indentification of QTL for Grain Number Traits of Gaozhou Wild Rice by Xing HUO, Yongmei YU, Shuqing QIU, Dilin LIU, Le KONG, Wuge LIU, Feng WANG

“…【Result】A population consisting of 316 recombinant inbred lines was successfully constructed. Phenotypic observations revealed rich genetic diversity within the population and good potential for application in improving the grain number per panicle. …”
Get full text

Impact of Systolic Blood Pressure Trajectories and Variability on Unexplained Early Neurological Deterioration Post‐Endovascular Treatment in Acute Ischemic Stroke Patients by Xuxuan Gao, Qiheng Wu, Yu Ma, Yueran Ren, Jiaying Chen, Xiaofei Lin, Lianghao Ye, Wei Song, Jiajia Zhu, Jia Yin

“…In this prospective, observational cohort study, AIS patients who underwent EVT within 24 h of stroke onset were included. …”
Get full text

Benefits of physical exercise through multivariate analysis in sedentary adults and elderly: An analysis of physical fitness, health and anthropometrics by Guilherme da Silva Rodrigues, Andressa Crystine da Silva Sobrinho, Gabriel Peinado Costa, Leonardo Santos Lopes da Silva, João Gabriel Ribeiro de Lima, Leonardo da Silva Gonçalves, Larissa Chacon Finzeto, Carlos Roberto Bueno Júnior

“…Significant gains were observed in the 6MWT and elbow flexion and extension (p < 0.05), indicating improvements in aerobic fitness and strength. …”
Get full text

Stem Cells and Platelet-Rich Plasma Enhance the Healing Process of Tendinitis in Mice by Rosangela Alquieri Fedato, Júlio César Francisco, Gabriel Sliva, Lúcia de Noronha, Márcia Olandoski, Jose Rocha Faria Neto, Priscila Elias Ferreira, Rossana Baggio Simeoni, Eltyeb Abdelwahid, Katherine Athayde Teixeira de Carvalho, Luiz César Guarita-Souza

“…Cell therapy has been studied in several animal models, and encouraging results have been observed with respect to tissue regeneration. This study is aimed at evaluating the functional and histological effects of bone marrow stem cell or platelet-rich plasma implantation compared to eccentric training in the treatment of Achilles tendinopathy in rats. …”
Get full text

Selective Serotonin Reuptake Inhibitors: Antimicrobial Activity Against ESKAPEE Bacteria and Mechanisms of Action by Thiago Hideo Endo, Mariana Homem de Mello Santos, Sara Scandorieiro, Bruna Carolina Gonçalves, Eliana Carolina Vespero, Márcia Regina Eches Perugini, Wander Rogério Pavanelli, Gerson Nakazato, Renata Katsuko Takayama Kobayashi

“…Regarding their mechanisms of action as antibacterials, for the first time, increased membrane permeability was detected, as evidenced by heightened dye absorption, along with the increased presence of total proteins and dsDNA in the extracellular medium of <i>Escherichia coli</i> ATCC2 25922 and <i>Staphylococcus aureus</i> ATCC 25923, and oxidative stress was also detected in bacteria treated with sertraline and paroxetine, with reduced efficiency observed in the presence of antioxidants and higher levels of oxygen-reactive species evidenced by their reaction with 6-carboxy-2′,7′-dichlorodihydrofluorescein diacetate. …”
Get full text

HIV-Envelope–Dependent Cell-Cell Fusion: Quantitative Studies by Leonor Huerta, Nayali López-Balderas, Evelyn Rivera-Toledo, Guadalupe Sandoval, Guillermo Gómez-Icazbalceta, Carlos Villarreal, Edmundo Lamoyi, Carlos Larralde

“…Even in the asymptomatic stage of infection, multinucleated cells have been observed in different organs, indicating that fused cells may be generated and remain viable in the tissues of patients. …”
Get full text

Analysis of the relationship between environmental particulate matter exposure and congenital diseases, as well as the epidemiological trends and burden of impact on newborns by Mulati Julaiti, Dilixiati Wubuli, Tingting Cui, Nadire Nijiati, Pengfei Huang, Bowen Hu

“…However, forecasting models indicated potential future risks, suggesting that the burden of disease in newborns due to particulate matter exposure remains a concern.Conclusion: The study provides evidence of a causal link between environmental particulate and congenital diseases in newborns, highlighting the importance of air pollution reduction for the health of newborns. Despite the observed decline in disease burden, the potential future risks underscore the necessity for continued air quality management and the need for further research to understand the complex interactions between environmental particulate, genetic factors, and fetal development.…”
Get full text

A non-aseptic bioprocess for production and recovery of 2,3-butanediol via conversion of crude glycerol and corn steep liquor at pilot-scale by Dimitris Karayannis, Nikos Angelou, Gabriel Vasilakis, Ioannis Charisteidis, Alexandros Litinas, Seraphim Papanikolaou

“…In all fed-batch fermentations, final BDO and acetoin concentration reached ∼80 g/L, while a plateau was observed at ∼68 g/L of BDO. Finally, the culture was carried out efficiently in the pilot-scale reactor (250 L). …”
Get full text