Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR by Ewa Wunsch, Marta Klak, Urszula Wasik, Malgorzata Milkiewicz, Malgorzata Blatkiewicz, Elzbieta Urasinska, Olivier Barbier, Dariusz Bielicki, Dimitrios P. Bogdanos, Elwyn Elias, Piotr Milkiewicz

“…Increased PXR protein was observed in both PSC and PBC compared to controls and was accompanied by a significant increase of SULT2A1 in PBC but not in PSC. …”
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Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease by Carolinne Thaísa de Oliveira Fernandes Miranda, Victor Hugo Rezende Duarte, Marina Sampaio de Menezes Cruz, Mychelle Kytchia Rodrigues Nunes Duarte, Jéssica Nayara Góes de Araújo, Ayda Maria Quirino Silva dos Santos, Juliana Marinho de Oliveira, Maria Sanali Moura Oliveira Paiva, Adriana Augusto Rezende, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Karla Danielly da Silva Ribeiro, André Ducati Luchessi, Vivian Nogueira Silbiger

“…Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p=0.03). No difference was observed between the mean serum retinol levels among the FI-based groups (n=0.492), and the low frequency of retinol was consistent among the FI groups (n=0.348). …”
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Pentavalent Antimonials Combined with Other Therapeutic Alternatives for the Treatment of Cutaneous and Mucocutaneous Leishmaniasis: A Systematic Review by Taisa Rocha Navasconi Berbert, Tatiane França Perles de Mello, Priscila Wolf Nassif, Camila Alves Mota, Aline Verzignassi Silveira, Giovana Chiqueto Duarte, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verziganassi Silveira

“…Serious adverse effects were not observed in patients treated with drugs combination. …”
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UNCOVER: The Rest-ultraviolet to Near-infrared Multiwavelength Structures and Dust Distributions of Submillimeter-detected Galaxies in A2744 by Sedona H. Price, Katherine A. Suess, Christina C. Williams, Rachel Bezanson, Gourav Khullar, Erica J. Nelson, Bingjie Wang, John R. Weaver, Seiji Fujimoto, Vasily Kokorev, Jenny E. Greene, Gabriel Brammer, Sam E. Cutler, Pratika Dayal, Lukas J. Furtak, Ivo Labbe, Joel Leja, Tim B. Miller, Themiya Nanayakkara, Richard Pan, Katherine E. Whitaker

“…The submillimeter detections and visible dust lanes suggest that centrally concentrated dust is a key driver of the observed color gradients. Further, we find that more concentrated galaxies tend to have lower size ratios (rest-frame NIR to optical); this suggests that the galaxies with the most compact light distributions also have the most concentrated dust. …”
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Strain rebound and inhomogeneity in glass-to-metal seals: Radial vs axial strain evolution by Keqian Gong, Zheng Liu, Zifeng Song, Chao Zhou, Zhangjing Shi, Siyue Nie, Weisong Zhou, He Yan, Zhichun Fan, Yong Zhang

“…Finite element analysis further corroborated these findings, confirming more pronounced variations in axial strain compared to the more uniform behavior observed in radial strain. These results underscore the anisotropic mechanical response of sealing glass within GTM seals, emphasize the value of FBG in situ monitoring for understanding strain evolution, and provide insights into enhancing the reliability of GTM seals across various applications.…”
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Phenotypic Presentation of Children with Joint Hypermobility: Preclinical Signs by Mateus Marino Lamari, Neuseli Marino Lamari, Michael Peres de Medeiros, Gerardo Maria de Araújo Filho, Adriana Barbosa Santos, Matheus Gomes Giacomini, Vitor Roberto Pugliesi Marques, Eny Maria Goloni-Bertollo, Érika Cristina Pavarino

“…BS ≥ 6 is more frequently observed in all positions. The majority of the total sample has BS > 6, with a significant female gender influence. …”
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Comprehensive multispectral and computational study of isoxazolidine derivative ‘ISoXD3’: Synthesis, spectral characteristics, DNA binding, and comparative effects of allyl and pro... by Ibrahim A. Alhagri, Siwar Ghannay, Norah A. Al-Suwailem, Rania Hussien Al-Ashwal, Sadeq M. AlHazmy, Sabri Messaoudi, Kaiss Aouadi

“…A notable Stokes shift of about 129 nm is observed in ethanol, indicating vibrational relaxation. …”
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Genotype-environment interactions on growth and inner shell color variation in Hyriopsis cumingii cultured in different iron-level substrates by Xuefeng Lv, Zhiyan Wang, Quanzhi Bao, Changzhi Li, Tingting Lu, Yuyang Wu, Chuntong Liu, Zhiyi Bai

“…Notably, significant gene-environment interaction effects (G × E) were notably observed for the color exhibited by the inner shell and growth-related traits, especially between Iron 1 and Iron 3, as well as between Iron 3 and Iron 5. …”
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Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid–Liquid Phase Separation and Ferroptosis-Related Genes by Wenchao Chen, Ting Zhu, Xiaofan Pu, Linlin Zhao, Senhao Zhou, Xin Zhong, Suihan Wang, Tianyu Lin

“…Fe2+ content and ROS levels were both significantly increased in the si-NRAS group when compared to those in the si-NC group (P < .01), while opposite results were observed for the protein level of GPX4 and GSH content. …”
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The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study by Tristan Pascart, Elie Dauphin, Chio Yokose, Charlotte Jauffret, Aurore Pacaud, Victor Laurent, Vincent Ducoulombier, Hyon K. Choi, Jean-François Budzik

“…One case of calyceal calculi and one case of ureterolithiasis were observed, wrongly coded as MSU in default post-processing settings for gout but identified as uric acid in the “kidney stone” settings. …”
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Effects of scrap rubber waste on the mechanical performance of mortar made of crushed sand and sediment by Adda Hadj Mostefa, Benamar Balegh, Hamid Sellaf, Mohamed Elamine Dahamni

“…Mortar mixtures were prepared using different sediment-to-crushed sand ratios (10%, 25%, 35%, 50%, and 100%) to observe their influence on physical and mechanical properties. …”
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Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…Additionally, KEGG analysis based on GEO data and high-throughput transcriptome sequencing of cell lines all strongly suggested that CES4A was involved in regulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. It was observed that AKT and phosphorylated AKT were remarkably reduced in CES4A overexpressing NPC cells, indicating that PI3K/AKT signaling pathway is hindered by CES4A. …”
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Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes by Amina Lazrek, Sebastiano Finocchi Ghersi, Adeline Petre, Sarah Houabes, Anne-Agathe Serre, Frederic Gassa, Magali Sandt, Cecile Laude, Camille Roukoz, Salvatore Cozzi

“…The significant biochemical response observed underscores the efficacy of this approach in controlling disease progression. …”
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Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort St... by Xue Liu, Jingjing Jiang, Xiaotian Liu, Zhicheng Luo, Yan Wang, Xiaokang Dong, Dandan Wei, Wenqian Huo, Songcheng Yu, Linlin Li, Shuna Jin, Chongjian Wang, Zhenxing Mao

“…After adjusting for multiple variables, the negative associations of F/E and 11-dexyocortisol with T2DM were observed in females (T3 vs. T1: OR=0.56, 95% CI: 0.39-0.80 for F/E; T3 vs. …”
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Impact of Metabolic States on SARS-CoV-2 Vaccine Responses in Mouse Models of Obesity and Diabetes by Olivia A. Smith, Brent Fujimoto, Teri Ann S. Wong, Albert To, Troy Odo, Aquena Ball, Brien K. Haun, Hiromi Muramatsu, Ying K Tam, Norbert Pardi, Axel T. Lehrer

“…These results suggest that the impaired humoral and cell-mediated responses observed in altered metabolic states may be linked to chronic inflammation associated with obesity and suboptimal glycemic control in diabetes. …”
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Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population by Rocco Capuano, Federica Marchese, Raffaella Sica, Eduardo Capuano, Marzia Manilia, Anna Grazia Iannone, Alessandro D’Ambrosio, Alvino Bisecco, Gioacchino Tedeschi, Antonio Gallo, Vincenzo Capuano

“…Only 13.3% of females and 11.1% of males showed adequate serum concentrations of 25(OH)D (≥30 ng/ml), while 59.3% of females and 55.1% of males showed 25(OH)D deficient levels (<20 ng/ml). We observed an independent association between 25(OH)D concentrations and metabolic syndrome score, LDL cholesterol, HDL cholesterol, and corrected QT (cQT). …”
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An evaluation of financial losses due to lumpy skin disease outbreaks in dairy farms of northern Thailand by Wittawat Modethed, Khwanchai Kreausukon, Tawatchai Singhla, Kittikorn Boonsri, Kidsadagon Pringproa, Nattawooti Sthitmatee, Nattawooti Sthitmatee, Paramintra Vinitchaikul, Supitchaya Srisawang, Roderick Salvador, Simon Gubbins, Georgina Limon, Veerasak Punyapornwithaya, Veerasak Punyapornwithaya

“…In outbreak farms, the average total financial losses was 727.38 USD per farm, significantly higher than the 349.19 USD per farm observed in non-LSD outbreak farms. The primary cause of financial loss in outbreak farms was mortality. …”
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Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study by Luiz Alberto Forgiarini Junior, Luiz Felipe Forgiarini, Arthur de Oliveira Paludo, Rodrigo Mariano, Mikael Marcelo de Moraes, Elaine Aparecida Felix, Cristiano Feijó Andrade

“…After, the animals were evaluated during 180 minutes and, measurements were taken every 30 minutes until the end of the observation period. The animals in the CO group were then ventilated under controlled pressure (Tidal Volume target at 6 mL.kg−1) and 5 cm H2O PEEP. …”
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Assessing the Dark Matter Content of Two Quasar Host Galaxies at z ∼ 6 through Gas Kinematics by Qinyue Fei, John D. Silverman, Seiji Fujimoto, Ran Wang, Luis C. Ho, Manuela Bischetti, Stefano Carniani, Michele Ginolfi, Gareth Jones, Roberto Maiolino, Wiphu Rujopakarn, N. M. Förster Schreiber, Juan M. Espejo Salcedo, L. L. Lee

“…By combining deep observations at both low and high resolution, we recover the diffuse emission, resolve its structure, and measure the rotation curves from the inner region of the galaxy to its outskirts using DysmalPy and ^3D Barolo . …”
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Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice by Tianchan Peng, Jian Xiang, Yun Tian, Xiaogen Tang, Lina Wang, Lijuan Gao, Oscar Junhong Luo, Li’an Huang, Guobing Chen

“…Transmission electron microscopy was used to observe the ultrastructure of mitochondria. Mitochondrial stress assays and JC-1 fluorescent probe were conducted to evaluate mitochondrial function. …”
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