Transient response and analytical solution of burst phenomenon in long distance water pipeline by Zhi-Guo Tao, Ling Zhou, Yun-Jie Li, Yuan Huang, Yan-Qing Lu, Yin-Ying Hu, Rui-Ling Feng

“…Specifically, the continuous transition from steady state to transient state and back to steady state in the hydraulic state of the system after a pipe burst event, was observed both in time and space dimensions. The effects of initial pressure and flow rate at steady state, location and size of pipe burst on pressure characteristics were carefully investigated. …”
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Robotic Assistance in Simultaneous Bilateral Medial Unicompartmental Knee Arthroplasty: A Retrospective Cohort Study of 126 Knees Demonstrating Enhanced Radiographic Accuracy and C... by Valentina Rossi, MD, Constant Foissey, MD, Andreas Fontalis, MD, MSc, MRCS, Gabriel Gaggiotti, MD, Stefano Gaggiotti, MD, Elvire Servien, MD, PhD, Sébastien Lustig, MD, PhD

“…No significant differences were observed in complications, length of hospital stay, rehospitalizations, patient-reported outcome measures, or overall clinical outcomes. …”
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HBV and HBsAg strongly reshape the phenotype, function, and metabolism of DCs according to patients’ clinical stage by Lucile Dumolard, Theophile Gerster, Florent Chuffart, Thomas Decaens, Marie-Noelle Hilleret, Sylvie Larrat, Philippe Saas, Evelyne Jouvin-Marche, David Durantel, Patrice N. Marche, Zuzana Macek Jilkova, Caroline Aspord

“…We found that HBV deeply reshaped the DC secretome in response to toll-like receptor ligand. Strikingly, we observed that HBV-exposed DCs secrete high levels of CX3CL1 (fractalkine), a chemokine responsible for attracting antiviral effectors to the site of infection. …”
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Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy by Ya Qiu, Yan Ma, Min Jiang, Sulei Li, Jibin Zhang, Haixu Chen, Mengqi Xu, Shan Gao, Lei Tian, Bo Tao, Yabin Wang, Dong Han, Feng Cao

“…Additionally, double-membrane autophagosomes were observed in LPS-injured hiPSC-CMs treated with 1 μM or 10 μM Mel. …”
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Establishment and internal validation of a model to predict the efficacy of Adalimumab in Crohn’s disease by Fang Wang, He Zhou, Yujie Zhang, Yu Da, Tiantian Zhang, Yanting Shi, Tong Wu, Jie Liang

“…Clinical remission was observed in 55.9% at 12 weeks. Three variables were selected through the least absolute shrinkage and selection operator regression method, including Adalimumab-positive cell count, disease duration, and neutrophil count of Crohn’s disease patients. …”
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Establishment and Validation of a Machine‐Learning Prediction Nomogram Based on Lymphocyte Subtyping for Intra‐Abdominal Candidiasis in Septic Patients by Jiahui Zhang, Wei Cheng, Dongkai Li, Guoyu Zhao, Xianli Lei, Na Cui

“…The calibration curve showed good predictive values and observed values of the nomogram; the Decision Curve Analysis (DCA) results showed that the nomogram had high clinical value. …”
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Microbiota, parasitic infections and their relationship with nutritional status and neurocognitive functioning in children from Ecuador—Proyecto Guagua: research protocol for a cro... by Sandra Victoria Abril-Ulloa, Tannia Valeria Carpio-Arias, Renata Alejandra Alvarado-Barba, Cristina Gabriela Ríos-Romero, Pamela Vinueza-Veloz, Sueny Paloma Lima-dos-Santos, Sueny Paloma Lima-dos-Santos, Igor Eduardo Astudillo-Skliarova, Igor Eduardo Astudillo-Skliarova, Ruth Irene Arias-Gutiérrez, Manuel Pérez-Quintana, Henk-Jan Boele, Henk-Jan Boele, Henk-Jan Boele, María Fernanda Vinueza-Veloz

“…IntroductionThis protocol outlines the Proyecto Guagua, which aims to explore the relationship between the characteristics of the gut microbiota, parasitic infections, nutritional status, and neurocognitive functioning in school-age children in Ecuador.Methods and analysisProyecto Guagua is a cross-sectional observational study funded by the Escuela Superior Politécnica de Chimborazo. …”
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Analysis of 42 Years of Cosmic Ray Measurements by the Neutron Monitor at Lomnický štít Observatory by Imre Kisvárdai, Filip Štempel, Lukáš Randuška, Šimon Mackovjak, Ronald Langer, Igor Strhárský, Ján Kubančák

“…Our investigation is centered on the relationships among the solar radio flux, geomagnetic field activity, and cosmic ray flux, as observed by the Neutron Monitor at the Lomnický štít Observatory in Slovakia. …”
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CRISPR/Cas9-editing of PRNP in Alpine goats by Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux

“…Eight different mutated alleles were observed, including five inducing KO mutations. Three founders carried only genome-edited alleles and were phenotypically indistinguishable from their wild-type counterparts. …”
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Al–Si alloyed uncoated hot stamping steels for enhanced oxidation resistance by Zhaoqi Song, Kaixun Wang, Haitao Zhao, Long Ma, Junheng Gao, Honghui Wu, Yuhe Huang, Chaolei Zhang, Jun Lu, Shuize Wang, Xinping Mao

“…Notably, the scale thickness decreases with increasing Al content, reaching just 3.5 μm at 0.48% Al, which is substantially lower than the 46 μm observed in 22MnB5 steel. However, due to compressive stress in the scale during its growth process, oxide ridges form when the Al content exceeds approximately 0.1%. …”
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A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence by Hennart, Mélanie, Crestani, Chiara, Bridel, Sébastien, Armatys, Nathalie, Brémont, Sylvie, Carmi-Leroy, Annick, Landier, Annie, Passet, Virginie, Fonteneau, Laure, Vaux, Sophie, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain

“…Convergence of toxigenicity with penicillin and erythromycin resistance was observed in 2 isolates from France-2022. Phylogenetic lineages Gravis and Mitis contrasted strikingly in their pathogenicity-associated genes. …”
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Epidemiology of bacterial biofilms on polyps and normal tissues in a screening colonoscopy cohort by Julia L. Drewes, Samara B. Rifkin, Madison McMann, Sara Glass, Emma Spence, Caroline R. Wensel, Abby L. Geis, Courtney Stevens, Joell J. Gills, Hao Wang, Linda M. Hylind, Gerard Mullin, David Kafonek, David Cromwell, Louis La Luna, Francis M. Giardiello, Cynthia L. Sears

“…Here we evaluated potential procedural and demographic risk factors associated with biofilm status using a cross-sectional observational cohort.Methods Histologically normal colonic biopsies from 2,051 individuals undergoing screening colonoscopy were evaluated for biofilm status using fluorescence in situ hybridization with oligonucleotide probes targeting bacterial 16S rRNA. …”
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Otodectes cynotis (Acari: Psoroptidae) infestations in Southern pudus (Pudu puda): In situ and ex situ data of an unexpected host-parasite record by Caroline Wilhelm, Edwin Kniha, Pamela Muñoz, Ángelo Espinoza, Laura Platner, Saskia Dreyer, Lisa Grund, Zoë Tess Lara Lindhorst, Ulrich Gärtner, Julia Walochnik, Anja Taubert, Dominik Fischer, Stephan Hering-Hagenbeck, Carlos Hermosilla, David Ebmer

“…During clinical work, two free-ranging pudus temporarily rehabilitated at the Centro de Rehabilitación de Fauna Silvestre (CEREFAS), Valdivia, Chile, were observed with low to moderate yellowish-brown secretions and encrustations inside the pinna and external auditory canal accompanied by an inflammatory Otitis externa. …”
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Analysis of environmental health risks from exposure to polyethylene terephthalate microplastics in refilled drinking water by S. Kasim, A. Daud, A.B. Birawida, A. Mallongi, A.I. Arundana, A. Rasul, M. Hatta

“…This study aims to analyze environmental health dangers of the exposure to polyethylene terephthalate microplastics in refilled water sources in Tamangapa, Makassar City, Indonesia.METHODS: This research is an observational study with an environmental health risk analysis. …”
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Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

“…A strong positive correlation was observed between serum carbohydrate 19‐9 antigen (CA 19‐9) and tissue carnitines (C12, C18, C18:2) and N8‐acetylspermidine. …”
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Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Dysregulation of this pathway, particularly in the AKT2 isoform, is commonly observed in cancers such as breast, ovarian, and pancreatic cancers, leading to enhanced tumor progression, metastasis, and therapeutic resistance. …”
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The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin—A Randomized, Controlled, Crossover Study by Liva K. Stuhr, Joshua B. Feinberg, Thea Christoffersen, Konstantinos Dimopoulos, Mikkel B. Christensen, David P. Sonne, Troels Riis, Peter S. Plomgaard, Jens P. Goetze, Emil L. Larsen, Kristian Karstoft

“…Similar results were observed for plasma heparin activities. In conclusion, exercise does not affect the overall pharmacokinetics and pharmacodynamics of unfractionated heparin but tends to accelerate absorption and hence effect. …”
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Preparation and Gas-Sensitive Properties of SnO₂@Bi₂O₃ Core-Shell Heterojunction Structure by Jin Liu, Yixin Gao, Yuanyuan Lv, Mengdi Yang, Haoru Guo, Neng Li, Danyang Bai, Anyi Wang

“…Based on the conclusions from XRD and SEM, it can be observed that as the hydrothermal temperature increases, the content of Bi₂O₃ coated on the surface of SnO₂ spheres gradually increases, and the diameter of Bi₂O₃ nanoparticles also increases. …”
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Amniotic fluid microbiota and metabolism with non-syndromic congenital heart defects: a multi-omics analysis by Wenli Xu, Lu Li, Hong Kang, Meixian Wang, Yanqun Liu, Guicun Wang, Ping Yu, Juan Liang, Zhen Liu

“…The differential metabolites were primarily enriched in the steroid hormone biosynthesis, bile secretion and ovarian steroidogenesis, according to KEGG analysis. The observed variations in nine metabolites could attributed to fifty-eight distinct bacterial taxa. …”
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How Does Heavy Precipitation of Varying Durations Respond to Urbanization in China? by Xue Xie, Kairong Lin, Mingzhong Xiao, Xudong Zhou, Gang Zhao, Dai Yamazaki

“…We find that urbanization primarily influences shorter‐duration heavy precipitation, with a more pronounced effect observed in the LTB catchments. Conversely, the influence of urbanization on longer‐duration heavy precipitation appears to be more weakened in the RTB catchments. …”
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