<i>Zanthoxylum piperitum</i> Benn. Attenuates Monosodium Urate-Induced Gouty Arthritis: A Network Pharmacology Investigation of Its Anti-Inflammatory Mechanisms by Sung Wook Kim, Soo Hyun Jeong, Jong Uk Kim, Mi Hye Kim, Wonwoong Lee, Cheol-Jung Lee, Tae Han Yook, Gabsik Yang

“…<b>Methods:</b> For anti-inflammatory properties of ZP, Raw264.7 cell stimulated LPS were treated ZP and using RNA-seq with Bone marrow derived macrophage, we observed to change inflammatory gene. Pharmacological networks were conducted to select target gene associated with ZP. …”
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Improved Constraints on the Vertical Profile of CH4 at Jupiter’s Mid- to High Latitudes, Using IRTF-TEXES and SOFIA-EXES Spectroscopy by James A. Sinclair, Thomas K. Greathouse, Rohini S. Giles, Matthew Richter, Maisie Rashman, Curtis de Witt, Julianne Moses, Vincent Hue, Pablo Rodríguez-Ovalle, Thierry Fouchet, Ananyo Bhattacharya, Bilal Benmahi, Glenn S. Orton, Leigh N. Fletcher, Patrick G. J. Irwin

“…The spectra were inverted across a photochemical model grid of varying eddy diffusion coefficient profiles, and the quality of fit of the synthetic spectra to the observed was used to constrain the CH _4 homopause level. …”
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Polydomus karssenii gen. nov. sp. nov. is a dark septate endophyte with a bifunctional lifestyle parasitising eggs of plant parasitic cyst nematodes (Heterodera spp.) by Samad Ashrafi, Jan-Peer Wennrich, Yvonne Becker, Jose G. Maciá-Vicente, Anke Brißke-Rode, Matthias Daub, Torsten Thünen, Abdelfattah A. Dababat, Maria R. Finckh, Marc Stadler, Wolfgang Maier

“…Light microscopic observations on fungus-root interactions in an axenic system revealed the capacity of the same fungal strain to colonise the roots of wheat and produce melanised hyphae and microsclerotia-like structure typical for dark septate endophytes. …”
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Application of new external cooling cycles in technological scheme of helium extraction and natural gas liquefaction by M. Mehrpooya, A. V. Zaitsev, A. O. Lisovtsov

“…Application of the exergic analysis methods to the processes under consideration shows that the greatest value of exergic losses relative to other devices is observed in compressors. A detailed economic analysis has been carried out. …”
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WALLABY Pilot Survey: Star Formation Enhancement and Suppression in Gas-rich Galaxy Pairs by Qifeng Huang, Jing Wang, Xuchen Lin, Se-Heon Oh, Xinkai Chen, B. Catinella, N. Deg, H. Dénes, B. -Q. For, B. S. Koribalski, K. Lee-Waddell, J. Rhee, A. X. Shen, Li Shao, K. Spekkens, L. Staveley-Smith, T. Westmeier, O. I. Wong, A. Bosma

“…When a close companion is present, a pronounced SFR enhancement is found for the most H i -poor high-mass galaxies in our sample. Collecting the observational evidence, we provide a coherent picture of the evolution of galaxy pairs and discuss how the tidal effects and hydrodynamic processes shape the SFR enhancement. …”
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Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

“…Higher cytotoxicity of IR+PDT vs. monotherapies was observed after 72 h. Non-malignant organoids showed no cytotoxic effects. …”
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Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…However, the mutations causing drug resistance have been observed in RdRp and 3CLpro from SARS-CoV-2, which makes it necessary to develop antivirals with novel mechanisms. …”
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The control effect and induced disease resistance mechanism of Bacillus tequilensis on wheat powdery mildew by Qiuyan Bi, Fen Lu, Jie Wu, Xiangyu Liu, Xiuying Han, Jianjiang Zhao

“…Its inhibitory effect was determined via an in vitro method combined with microscopic observation, and the control effect was clarified via pot and field verification. …”
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Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson’s Disease by Megan C. Bakeberg, Alexa Jefferson, Maddeson Riley, Michelle Byrnes, Soumya Ghosh, Frank L. Mastaglia, Malcom K. Horne, Sarah McGregor, Rick Stell, Jade Kenna, Sue Walters, Dana Hince, Ryan S. Anderton

“…A significant positive correlation between homocysteine and MDS-UPDRS III score was identified in males with Parkinson’s disease (rs = 0.319, p<0.001), but not in females, whereas a significant negative correlation between homocysteine levels and total ACE-R score was observed in females with Parkinson’s disease (rs = −0.449, p<0.001), but not in males. …”
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Lateralization study of the basal ganglia, thalamus and supplying arteries in healthy individuals based on structure and connectivity analysis using 7.0T MRI by Hongqin Liang, Yawei Gu, Xiaoqi Yi, Li Kong, Jian Wang, Fajin Lv

“…The results showed that in the right-handed dominant population, we observed that the total number and length of LSAs in the left hemisphere exceeded those in the right. …”
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Mycotoxicological monitoring. Part 3. Feedstuffs from raw grain processing by G. P. Kononenko, A. A. Burkin, Ye. V. Zotova

“…For the main contaminants, a shift in the medians and 90% percentile towards the lower values of the average and maximum contents was observed, which indicates the possibility of their accumulation beyond the typical range. …”
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Late-time Optical and X-Ray Emission Evolution of the Oxygen-rich SN 1996cr by Daniel Patnaude, Kathryn E. Weil, Robert A. Fesen, Dan Milisavljevic, Ralph P. Kraft

“…Chandra data indicate a slow but steady decline in the overall X-ray luminosity, suggesting that the forward shock has broken through any circumstellar shell or torus, which is inferred from prior deep Chandra ACIS-S/HETG observations. The X-ray properties are consistent with what is expected from a shock breaking out into a lower-density environment. …”
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Polymorphisms in the leptin gene and their role in adolescent obesity and metabolic health by Raden Ayu Tanzila, Irfannuddin Irfannuddin, Yudianita Kesuma, Iche Andriyani Liberty, Miranti Dwi Hartanti, Ni Made Elva Mayasari, Wieke Anggraini, Liza Chairani, Thia Prameswarie, Indri Ramayanti, Wulan Aristi, Delvi Larasari

“…This research was an analytical and observational study. A total of 50 blood samples from adolescents (aged 10-18 years) were analyzed in this study. …”
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The triglyceride–glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with... by Chenyang Li, Zixi Zhang, Xiaoqin Luo, Yichao Xiao, Tao Tu, Chan Liu, Qiming Liu, Cancan Wang, Yongguo Dai, Zeying Zhang, Cheng Zheng, Jiafeng Lin

“…L-shaped relationships were observed between TyG-related indices and mortality. …”
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Characteristics of beta parapapillary atrophy in primary angle-closure suspect by Qing Zhang, Ye Zhang, Xiaohua Pan, Hui Feng, Shuning Li, Zhi Li, Meijuan Zhang, Caixia Li, Fei Xiang, Qianqian Ji

“…Objective To investigate the characteristics of beta parapapillary atrophy (β-PPA) in patients with primary angle-closure suspect (PACS).Methods and analysis In total, 215 and 259 eyes with PACS and non-PACS (NPACS), respectively, were enrolled in this observational, cross-sectional study. Stereoscopic fundus and optical coherence tomography images were used to characterise β-PPA; the former was also used to measure the major β-PPA parameters. …”
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GH inhibits ALV-J replication and restricts cell cycle by activating PI3K/Akt signaling pathway by Junliang Xia, Ling Lin, Rongyang Ju, Chengxun Xu, Guodong Mo, Xiquan Zhang

“…However, the specific role of GH in response to ALV-J remains unclear. In this study, we observed a significant upregulation of GH protein expression in the plasma of ALV infected chickens, and a marked increase in GH mRNA in ALV-J infected cells. …”
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Basic research for ultrasound-guided injection into skeletal muscle lesions in an experimental animal model by KiyomitsuFujimoto, TakashiKanamoto, ShunyaOtani, RyoMiyazaki, KosukeEbina, KenNakata

“…Briefly, CTX was injected into tibialis anterior muscle in rats under ultrasound observation. First, the diagnostic accuracy of abnormal muscle lesions on ultrasound was examined by comparing ultrasound findings and histology. …”
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Dufulin Impacts Plant Defense Against Tomato Yellow Leaf Curl Virus Infecting Tomato by Liping Huang, Yingying Tang, Shuaixin Wang, Jianbin Chen, Jiao Du, Shuo Yan, Deyong Zhang, Xiaobin Shi, Yong Liu, Fan Li

“…Moreover, the treated plants exhibited a higher chlorophyll content than the controls, though no significant differences in the nitrogen levels were observed between the dufulin-treated and water-treated plants. …”
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Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease by Sheng Zhuang, Fu-Yu Wang, Xin Gu, Jia-Jing Wu, Cheng-Jie Mao, Hao Gui, Jing Chen, Chun-Feng Liu

“…No significant changes were observed in the group with sham rTMS. Conclusions. …”
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Lack of Hypoxia Inducible Factor-1α Influences on Macrophages Ability to Deal with Leishmania braziliensis In Vitro and Affects Pathology In Vivo by Rodrigo C.O. Sanches, Leonardo G. Vaz, Fabio V. Marinho, Erika S. Guimarães, Edgar M. Carvalho, Lucas P. Carvalho, Sergio C. Oliveira

“…Evaluating the impact of HIF-1α absence during macrophage infection in vitro, we observed HIF-1α–knockout cells present at high levels of IL-10, reduced production of nitric oxide, and decreased expression of VEGF-A. …”
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