Cyclopiazonic acid suppresses the function of Leydig cells in prepubertal male rats by disrupting mitofusin 1-mediated mitochondrial function by Hang Lin, Ming Su, He Zhu, Yang Yu, Jianmin Sang, Yiyan Wang, Qiqi Zhu, Yang Zhu, Xiaoheng Li, Xingwang Li, Ren-Shan Ge, Huitao Li

“…In vitro experiments corroborated these observations, demonstrating that CPA induced mitochondrial fragmentation by downregulating SIRT1, PGC1-α, MFN1, and OPA1, increase reactive oxygen species, and inhibit testosterone synthesis in R2C cells. …”
Get full text

Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis by Ban Li, Yuanzhi Chen, Zhen Yang, Xianglun Sun, Cheng Tian, Jingsi Liu, Lihua Yuan, Kanglin Dai

“…Significant differences in creatinine, international normalized ratio (INR) and L/A were observed between the groups (p < 0.05). The L/A ratio was a substantial predictor of in-hospital mortality, with an odds ratio (OR) of 5.24 (95% CI: 1.51–18.20, p = 0.01). …”
Get full text

Multicentre, multitime, multidimension, prospective follow-up cohort study on patients during the first wave of COVID-19 in China: a study protocol by Ming Zhang, Xuan Niu, Tonghui Liu, Chao Zheng, Huijie Yuan, Yanan Zhu, Huiping Liu, Shan Wu, Zhaoyao Luo, Jia Zhu, Danwei Hou, Tianhua Wei, Zhimin Zhu, Weipeng Huang, Weixian Bai, Xinyi Yu, Wenrui Bao

“…At the first time point, 501 participants (418 patients and 83 HCs) from nine recruiting hospitals have been observed. Ultimately, all of these results will be analysed to explore the short-term and long-term effects of COVID-19.Ethics and dissemination Ethics approval was granted by Ethics Committee of the First Affiliated Hospital of Xi'an Jiaotong University (XJTU1AF2023LSK-013). …”
Get full text

IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…Similar changes were observed in surgically resected neocortex from infantile epileptic spasms syndrome (IESS) patients. …”
Get full text

Delineating urban flooding when incorporating community stormwater knowledge by Madeline Scolio, Peleg Kremer, Virginia Smith, Achira Amur, Bridget Wadzuk, Kate Homet, Eric Devlin, Md Abdullah Al Mehedi, Laura Moore

“…Although there are currently models and frameworks to estimate stormwater runoff and predict urban flooding, there are often minimal observations to validate results due to the quick retreat of floodwaters from affected areas. …”
Get full text

Infiltration of CD8+ cytotoxic T-cells and expression of PD-1 and PD-L1 in ovarian clear cell carcinoma by Mengdi Fu, Huimei Zhou, Jiaxin Yang, Dongyan Cao, Zhen Yuan

“…In adjacent nonneoplastic regions, worse PFS was significantly observed in patients with high CD8+ T-cell expression in both total and stromal cells than those with low expression (p = 0.012 vs p = 0.007). …”
Get full text

Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells by Salam Salloum-Asfar, Rudolf Engelke, Hanaa Mousa, Neha Goswami, I. Richard Thompson, Freshteh Palangi, Kamal Kamal, Muna N. Al-Noubi, Frank Schmidt, Sara A. Abdulla, Mohamed M. Emara

“…We have also unveiled a reduced expression of tubulin that may protect cells against hyperosmolarity stress while inhibiting SG formation without affecting stem cell self-renewal and pluripotency. Our observations may provide a possible cellular mechanism to better understand SG dynamics in pluripotent stem cells.…”
Get full text

Dynamic high resolution US as primary tool in comparison to MRI in evaluation of TMJ disk anterior displacement by Ahmed Y. Ashour, Abdalwhab M.A. Zwiri, Ahmed H. Ali, Ahmed M. Mostafa, Bahaa-Eldin A. Moustafa, Husseini F. EL boraey, Alshimaa Y. Ashour, Elsayed M. Abd El-Hamid

“…However, no significant differences were observed. Compared to MRI, US showed superior diagnostic sensitivity, specificity, and accuracy for TMJ disc displacements. …”
Get full text

Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice by Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang

“…A number of autophagosomes were also observed under electron microscopy. Results. TSS treatment significantly attenuated small intestinal epithelium injury induced by LPS. …”
Get full text

Healthy lifestyle before and during pregnancy to prevent childhood obesity: study protocol for a parallel group randomised trial — the PRE-STORK trial by Tina Vilsbøll, Signe S Torekov, Julie Lyng Forman, Romain Barrès, Andreas Andersen, Filip K Knop, Signe Foghsgaard, Klaus Bønnelykke, Thomas Bergholt, Karoline Kragelund Nielsen, Christina Anne Vinter, Majken Lillholm Pico, Louise Groth Grunnet, Nina Kornerup, Julie Hagstrøm Danielsen, Ronni Eg Sahl, Mette Yun Johansen, Louise Kelstrup, Nida Ghauri, Emilie Grønlund, Lærke Lund

“…With the increasing rates of obesity observed in children, adolescents and adults, there is an urgent need for preventive measures. …”
Get full text

Prognostic Value of PSMB5 and Correlations with LC3II and Reactive Oxygen Species Levels in the Bone Marrow Mononuclear Cells of Bortezomib-Resistant Multiple Myeloma Patients by Eva Plakoula, Georgios Kalampounias, Spyridon Alexis, Evgenia Verigou, Alexandra Kourakli, Kalliopi Zafeiropoulou, Argiris Symeonidis

“…PSMB5 accumulation was found to diminish after PI treatment (<i>p</i>-value = 0.014), and the same pattern was observed in PPA (<i>p</i>-value < 0.001). Conversely, LC3II protein levels were elevated at both remission and relapse compared to baseline levels (<i>p</i>-value = 0.041). …”
Get full text

Antimicrobial properties of selected microalgae exopolysaccharide-enriched extracts: influence of antimicrobial assays and targeted microorganisms by Marion Pointcheval, Marion Pointcheval, Marion Pointcheval, Anthony Massé, David Floc’hlay, Franck Chanonat, Jacques Estival, Marie-José Durand

“…Using absorbance measurements, growth rate inhibitions of at least 80% were observed on all targeted species for at least one microalgal EPS-enriched extract. …”
Get full text

Effects of Deficit Irrigation on Growth, Yield, and Quality of Pomegranate (<i>Punica granatum</i>) Grown in Semi-Arid Conditions by Islam F. Hassan, Rahaf Ajaj, Ahmed F. Abd El-Khalek, Shamel M. Alam-Eldein, Maybelle S. Gaballah, Habib ur Rehman Athar, Harlene M. Hatterman-Valenti

“…The impact of deficit irrigation on pomegranate growth, yield, and overall fruit quality was observed during this study, which focused on two consecutive years from 2023 to 2024 at a private farm located in El Khatatba, Egypt. …”
Get full text

Comparative Economic Analysis Between Bioenergy and Forage Types of Switchgrass for Sustainable Biofuel Feedstock Production: A Data Envelopment Analysis and Cost–Benefit Analysis... by Muhammad Umer Arshad, David Archer, Daniel Wasonga, Nictor Namoi, Arvid Boe, Rob Mitchell, Emily Heaton, Madhu Khanna, DoKyoung Lee

“…Switchgrass cultivar “Carthage” showed better efficiency score and profitability results in hardiness zone 4b (South Shore, SD) at 56 kg N ha−1. The profit trends observed in current study sites may indicate broader patterns across similar US hardiness zones. …”
Get full text

In-vitro accuracy of the virtual patient model with maxillomandibular relationship at centric occlusion using 3D-printed customized transfer key by Anh Ho-Quynh Nguyen, Nam Cong-Nhat Huynh, Oanh Ngoc-Hoang Nguyen, Nhat Dinh-Minh Nguyen, Hai Hoang Phan, Jong-Eun Kim, Gan Jin, Khanh Hung Nguyen, Hung Trong Hoang

“…Minimal deviations were observed in critical areas, including the tooth and lip position, indicating that the virtual patient model was closely aligned with the CBCT reference. …”
Get full text

Recovery of deformation surface of superelastic and shape memory NiTi alloy by Sneha Samal, Jan Tomáštík, Lukáš Václavek, Mohit Chandra, Jaromír Kopeček, Ivo Stachiv, Petr Šittner

“…In multicycle tests, it was observed a first relative quick functional degradation of the material response, in terms of recovery capability, and a subsequent stabilization that typically occurs. …”
Get full text

Insights of cellular and molecular changes in sugarcane response to oxidative signaling by Lucas Felipe Silva, Kellya F. M. Barreto, Helaine Cristiane Silva, Iara Dantas de Souza, Carlos H. S. G. Meneses, Adriana F. Uchôa, Katia C. Scortecci

“…Lipid peroxidation, observed through TBARs and scanning electron microscopy, highlighted early membrane modifications. …”
Get full text

Spontaneous Lorentz symmetry-breaking constraints in Kalb–Ramond gravity by Ednaldo L. B. Junior, José Tarciso S. S. Junior, Francisco S. N. Lobo, Manuel E. Rodrigues, Diego Rubiera-Garcia, Luís F. Dias da Silva, Henrique A. Vieira

“…Additionally, the shadow radius is determined for two observers, one situated at a finite distance from the KR black hole, and the other located at an infinite distance, to constrain the symmetry-breaking parameter l, with comparisons made to EHT results. …”
Get full text

Cost-Effectiveness of Bariatric Surgery versus Medication Therapy for Obese Patients with Type 2 Diabetes in China: A Markov Analysis by Bin Wan, Nan Fang, Wei Guan, Haixia Ding, Ying Wang, Xin Ge, Hui Liang, Xin Li, Yiyang Zhan

“…The health-care costs in the bariatric surgery group, proportion of patients in each group with remission of diabetes, and state transition probabilities were calculated based on observed resource utilization from the hospital information system (HIS). …”
Get full text

Combined Therapy of Catheter Ablation and Left Atrial Appendage Closure for Patients with Atrial Fibrillation: A Case-Control Study by Bin-Feng Mo, Jian Sun, Peng-Pai Zhang, Wei Li, Mu Chen, Jia-Li Yuan, Yi Yu, Qun-Shan Wang, Yi-Gang Li

“…The feasibility and safety of performing the combined procedure of catheter ablation (CA) and left atrial appendage closure (LAAC) for atrial fibrillation (AF) have been reported by observational studies without controls. The aim of this study was to compare the procedural and long-term outcomes of combined procedures with isolated CA or LAAC. …”
Get full text