Nonlinear effect of body mass index on postoperative survival following isolated heart transplantation by Reid Dale, PhD, Nataliya Bahatyrevich, MD, MS, Matthew Leipzig, BSc, Maria Elizabeth Currie, MD, PhD

“…No inflection point was observed at either of the International Society for Heart and Lung Transplantation recommended cutoffs of BMI = 30 (HR 1.11, confidence interval [CI] 1.07-1.15) or BMI = 35 (HR 1.29, CI 1.24-1.37). …”
Get full text

STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease by Ying Tang, Sanda A. Tan, Atif Iqbal, Jian Li, Sarah C. Glover

“…The accumulation of IFN-γ-producing ILC1s and increased level of proinflammatory cytokines produced by ILCs has been observed in the inflamed terminal ileum of CD patients. …”
Get full text

Biogeographic Insights Into the Late Miocene Diversification of the Giant Deep‐Ocean Amphipod Eurythenes by Carolina E. González, Johanna N. J. Weston, Reinaldo Rivera, Marcelo Oliva, Rubén Escribano, Osvaldo Ulloa

“…A gradual increase in the effective population size of Eurythenes was observed, particularly during the Pliocene (~4 Ma). …”
Get full text

Beyond averages: dissecting urban-rural disparities in skilled antenatal care utilization in Bangladesh - a conway-maxwell-poisson regression analysis by Md. Muddasir Hossain Akib, Farzana Afroz, Bikash Pal

“…Results Significant disparity (p-value < 0.001) has been observed in the mean number of SANC taken by rural (3.17) and urban (4.52) women. …”
Get full text

The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level by Sara Farahi, Sara Hosseini, Hossein Ghanbarian, Seyed Mahmoud Hashemi, Mohammad Salehi, Samaneh Hosseini

“…Significant increase of pluripotency markers, oct4, nanog, sox2, and klf4, was observed in 100 nM TSA-treated samples. 100 nM TSA induced significant upregulation of H2db in generated iPSCs. …”
Get full text

Impact of Sprouting Time of Chickpea on the Physicochemical, Textural, Sensory, and Total Phenolic Characteristics of Falafel Prepared from Sprouted Chickpea Flour by Kimia Goharpour, Fakhreddin Salehi, Amir Daraei Garmakhany

“…The minimum oil uptake was observed in the sample prepared from chickpeas sprouted for two-days (p<0.05). …”
Get full text

To do or not to do? – Endometrial biopsy in younger women with abnormal uterine bleeding by Sandra Lynn Jaya-Bodestyne, Marlene Samantha Goh, Madeline Chan Hiu Gwan, Sonali Prashant Chonkar, Khurshid Merchant, Manisha Mathur

“…Methods: We conducted a retrospective observational study reviewing the records of 464 women aged under 40 years old who underwent endometrial biopsy for AUB. …”
Get full text

A Novel Prognostic Signature Revealed the Interaction of Immune Cells in Tumor Microenvironment Based on Single-Cell RNA Sequencing for Lung Adenocarcinoma by Xing Jin, Zhengyang Hu, Qihai Sui, Mengnan Zhao, Jiaqi Liang, Zhenyu Liao, Yuansheng Zheng, Hao Wang, Yu Shi

“…Patients with higher risk scores had a significantly lower immunotherapy response rate. Conclusion. Our observations implied that immune cells played a pivotal role in TIME and established a 5-gene signature (including IDH2, ADRB2, SFTPC, CCDC69, and CCND2) on the basement of nature killer markers targeted by WGCNA analysis. …”
Get full text

Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease by Prasenjit Das, Sudha Battu, Lalita Mehra, Alka Singh, Muzaffar Ahmad, Ashish Agarwal, Ashish Chauhan, Anam Ahmad, Sreenivas Vishnubhatla, Siddhartha Datta Gupta, Vineet Ahuja, Govind Makharia

“…However, the Ki67 proliferation index, expressions of WNT-activator RSPO1, and position-4 cell marker Bmi1 did not significantly alter in patients’ biopsies as compared to controls (P = 0.001). We also observed depletion of pericrypt stromal fibronectin-1 in patients with CeD compared to controls. …”
Get full text

Effects of the auxin-dependent degradation of the cohesin and condensin complexes on the repair of distant DNA double-strand breaks in mouse embryonic stem cells by A. V. Smirnov, A. S. Ryzhkova, A. M. Yunusova

“…Contrary to expectations, in our setting, Rad21 depletion did not increase deletion/inversion frequencies, not even for the region with an active Ctcf boundary. We actually observed a 12 % decrease in deletions (but not inversions). …”
Get full text

Assessment of long-term changes in subvalvular aortic stenosis in patients following transcatheter aortic valve implantation by Vladlen V. Bazylev, Andrey B. Voevodin, Alexey S. Masyutin

“…MATERIALS AND METHODS: The observational, retrospective, single-center, non-randomized study included 20 patients with diagnosed severe AS, preoperative IVS thickness ≥15 mm, and the preoperative ratio of IVS and left ventricular posterior wall thickness ≥1.3, following TAVI. …”
Get full text

Effects of high-intensity intermittent cross-training on maximal oxygen uptake by Xin Liu, Katsunori Tsuji, Yuzhong Xu, Motoyuki Iemitsu, Izumi Tabata

“…Significant group ​× ​time interactions were observed for both the running and bicycling V˙O2max (p ​< ​0.001 each). …”
Get full text

Characterizing the early relationship between covert narcissism and cognitive empathy in medical students: a cross-sectional study by Adelina Alcorta-Garza, Oscar Vidal-Gutiérrez, Juan F. González-Guerrero, Fernando Alcorta-Núñez, Guillermo A. Porras Garza, Montserrat San-Martín, Roberto C. Delgado Bolton, Luis Vivanco

“…Results In a sample of 283 students (207 females), differences in cognitive empathy and covert narcissism were observed by gender (p < 0.001). Comparison analyses showed that covert narcissism was greater in students enrolled after one semester attending on-line classes than those who were starting their first semester (p = 0.01). …”
Get full text

Clinico-spirometrical correlation of newly detected COPD patients with known tobacco smoking exposure or biomass smoke exposure presenting to a teaching institution in Vadodara, Gu... by Bhavesh Patel, G Mothiganesh, Arti D. Shah, Chirag H. Chakravarti, Parshwa Naik, Princee Patel

“…Materials and Methods: The Department of Respiratory Medicine conducted an observational cross-section study on individuals with recently discovered COPD. …”
Get full text

Remote sensing assessment of dam impact on arid basins in Southern Saudi Arabia: A machine learning and space-for-time approach by Raid Almalki, Mehdi Khaki, Patricia M. Saco, Jose F. Rodriguez

“…In the Reem-Baish basins, the Baish dam caused notable increases in DTW values for NDVI (0.16–0.31), soil salinity (0.15–0.30), groundwater (0.52–1.19), and runoff (0.53–1.33), with the most significant changes observed in groundwater and runoff. Additionally, regression models showed a decrease in predictive accuracy from 2010 to 2020, as evidenced by lower R² values for NDVI (0.82–0.37), soil salinity (0.77–0.38), groundwater (0.98–0.34), and soil moisture (0.96–0.24).…”
Get full text

Evaluation of diastole by echocardiography for detecting early cardiac dysfunction: an outcome study by Tatiana Kuznetsova, Nicholas Cauwenberghs, František Sabovčik, Yukari Kobayashi, Francois Haddad

“…After full adjustment, we did not observe any significant differences in the risk of events between subjects with indeterminate or any grade of LVDDF and subjects with normal diastolic function when classified according to the 2016 recommendation (P ≥ 0.25). …”
Get full text

Using the modified frailty index as a predictor of complications in adults undergoing transforaminal interbody lumbar fusion by Momin M. Mohis, Simon G. Ammanuel, Cuong P. Luu, James A. Stadler

“…Univariate analysis was performed between the 2 cohorts for each collected variable, and multivariable analysis was performed to observe adjusted odds ratios (OR). Results: The frail cohort experienced more unplanned readmission (4.3 vs 6.6 %, p < 0.001). …”
Get full text

BDNF Levels and Cognitive Function in Patients with Type 2 Diabetes Treated with SGLT2 Inhibitors by Betül SÜMBÜL ŞEKERCİ, Şeymanur DEMİRHAN, Esra ÇALIŞICI, Abdüsselam ŞEKERCİ

“…Significant correlations were observed between BDNF levels and the levels of microalbumin, microalbumin/creatinine, estimated glomerular filtration rate (eGFR), lymphocytes, According to linear regression analysis, effect of eGFR levels in predicting BDNF levels was significant. …”
Get full text

Contribution of Glycosaminoglycans to the Microstructural Integrity of Fibrillar and Fiber Crimps in Tendons and Ligaments by Marco Franchi, Viviana De Pasquale, Désirée Martini, Marilisa Quaranta, Maria Macciocca, Alessio Dionisi, Vittoria Ottani

“…Achilles tendons and medial collateral ligaments of the knee from eight female Sprague-Dawley rats (90 days old) incubated in a chondroitinase ABC solution to remove GAGs were observed under a scanning electron microscope (SEM). …”
Get full text

Analysis in Choroidal Thickness in Patients with Graves’ Ophthalmopathy Using Spectral-Domain Optical Coherence Tomography by Nan Yu, Yadi Zhang, Lei Kang, Ying Gao, Junqing Zhang, Yuan Wu

“…The objective of the study is to observe changes in choroidal thickness (CT) in patients with Graves’ ophthalmopathy using spectral-domain optical coherence tomography (SD-OCT). …”
Get full text