Effectiveness of Space Maintainers in Pediatric Patients: A Systematic Review and Meta-Analysis by MDolores Casaña-Ruiz, Juan Ignacio Aura-Tormos, Laura Marques-Martinez, Esther Garcia-Miralles, Marcelino Perez-Bermejo

“…<b>Results:</b> The total number of patients treated in the studies was 479, with four observational studies and seven randomized clinical trials. …”
Get full text

Development of a comprehensive sustainability index for extractive and mining companies: Integrating the Sustainable Development Goals by Marta Fernández-Hernández, Pedro Mora, Marcelo F. Ortega, Juan Pous Cabello

“…The practical application of this index is critical, providing a step-by-step guide for extractive and mining companies to adopt and utilize the sustainability index, aiding in compliance with future regulations.The results of this study show that the system of SDGs, targets, aspects, and metrics is naturally weighted towards social issues. It has also been observed that the SDG system, with respect to the targets, is not balanced. …”
Get full text

Utilization of a Joint Point Regression Model for Predicting Mortality Rates of Common Cancers in Babol City by Pouyan Ebrahimi, Sara Khaleghi, Mohebat Vali, Sahar Delavari, Soraya Khafri, Mohsen Karami, Layla Shojaie, Hossein‐Ali Nikbakht

“…Results Over these 9years, 2417 deaths from the 10 common cancers were recorded. We observed an increase in mortality rates with a slope of 12.05% from 2013 to 2016, and a gentler slope of 3.2% from 2016 to 2021. …”
Get full text

Physicochemical Properties and Bioreactivity of Sub‐10 μm Geogenic Particles: Comparison of Volcanic Ash and Desert Dust by Ines Tomašek, Julia Eychenne, David E. Damby, Adrian J. Hornby, Manolis N. Romanias, Severine Moune, Gaëlle Uzu, Federica Schiavi, Maeva Dole, Emmanuel Gardès, Mickael Laumonier, Clara Gorce, Régine Minet‐Quinard, Julie Durif, Corinne Belville, Ousmane Traoré, Loïc Blanchon, Vincent Sapin

“…We determined particle size, morphology, mineralogy, surface texture and chemistry in sub‐10 μm material to investigate associations between particle physicochemical properties and observed bioreactivity. We assessed cellular responses (cytotoxic and pro‐inflammatory effects) to acute particle exposures (24 hr) in monocultures at the air‐liquid interface using two types of cells of the human airways: BEAS‐2B bronchial epithelial cells and A549 alveolar type II epithelial cells. …”
Get full text

Orally administered live BCG and heat-inactivated Mycobacterium bovis protect bison against experimental bovine tuberculosis by Nirajan Niroula, Priya Ghodasara, Nelson Marreros, Bailey Fuller, Haley Sanderson, Slim Zriba, Stew Walker, Todd K. Shury, Jeffrey M. Chen

“…To this end, we aerosol challenged young bison with different doses of virulent M. bovis and observed disease-associated delayed-type hypersensitivity, gross lung and lymph node pathology and histopathology, as well as M. bovis burden in target organs, thus confirming the establishment of BTB in challenged animals. …”
Get full text

Short- and Mid-term Radiographic Outcomes of Ream-then-broaching Metaphyseal Cones During Revision Total Knee Arthroplasty by Aria Darbandi, MD, Andrew Schaver, MD, Micah MacAskill, MD, Rex Lutz, DO, Amira Scaramella, BS, Christian Sangio, BS, John Shields, MD, Alvin Ong, MD, Matthew Bullock, DO MPT

“…No cases of cone or stem aseptic loosening were observed. The cones scoring system had a significantly strong intraclass correlation between the 3 reviewers (P < .001). …”
Get full text

Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes by Ping Gu, Wei Wang, Yue Yao, Yixin Xu, Liping Wang, Pu Zang, Jian Ma, Cuihua Yang, Junya Liang, Bin Lu, Jiaqing Shao

“…In contrast, no significant difference was observed in plasma chemerin levels between subjects with and without peripheral neuropathy. …”
Get full text

Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons by Yuanlong Song, Zifen Xu, Liangpin Zhang, Linlin Gao

“…Our results revealed several key findings: (1) The expression of Sig-1R was found to be upregulated during the progression of inflammatory pain, with a notable translocation from the cytoplasm to the membrane; (2) Inhibition of peripheral Sig-1R using S1RA resulted in a reduction of CFA-induced allodynia; (3) Activation of Sig-1R through PRE-084 led to a decrease in the fast sodium current in isolated DRG neurons from CFA-treated rats, which was associated with a diminished action potential (AP) peak and maximum depolarizing rate (MDR), as well as an increased rheobase; (4) Furthermore, PRE-084 was observed to enhance the slow component of the sodium current, resulting in hyperpolarization of the threshold potential and an increase in AP firing frequency, alongside an elevation in the mRNA expression of the slow sodium channel Nav1.9 in CFA-treated rats. …”
Get full text

Giant and flexible toroidal circular dichroism from planar chiral metasurface by Shijie Kang, Haitao Li, Jiayu Fan, Jiusi Yu, Boyang Qu, Peng Chen, Xiaoxiao Wu

“…However, as toroidal dipoles are typically represented by solenoidal currents circulating on a three-dimensional (3D) torus, toroidal circular dichroism is usually observed in 3D intricate microstructures. Facing corresponding challenges in fabrication, integration, and application, it is generally difficult to employ toroidal circular dichroism in compact metasurfaces for flexible modulation of chiral interactions between electromagnetic waves and matter. …”
Get full text

Al‐Rich AlGaN Transistors with Regrown p‐AlGaN Gate Layers and Ohmic Contacts by Brianna Klein, Andrew Allerman, Andrew Armstrong, Mary Rosprim, Colin Tyznik, Yinxuan Zhu, Chandan Joishi, Chris Chae, Siddharth Rajan

“…Epitaxial regrowth of AlGaN avoids the use of gate insulators which can suffer from charge trapping effects observed in typical dielectric layers deposited on AlGaN. …”
Get full text

Multivariate Statistical Analysis for the Classification of Sausages Based on Physicochemical Attributes, Using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) a... by Quang Minh Bui, Quang Trung Nguyen, Thanh Thao Nguyen, Ha My Nguyen, Thi Tinh Phung, Viet Anh Le, Ngoc Minh Truong, The Vinh Mac, Tien Dat Nguyen, Le Tuan Anh Hoang, Ha Minh Duc Tran, Van Nhan Le, Minh Duc Nguyen

“…The classification on the spectroscopy profile showed that although more than 90% variation of the dataset was explained on the first two PCs, the difference between several brands was not detected as the distribution of data overlapped with one another. The PCA observation of the elemental composition on PC1 and PC3 has separated the sausage brands into 6 distinctive groups. …”
Get full text

Vertical and spatial differences in ozone formation sensitivities under different ozone pollution levels in eastern Chinese cities by Zhuang Wang, Hao Zhang, Chune Shi, Xianguang Ji, Yizhi Zhu, Congzi Xia, Xiaoyun Sun, Meng Zhang, Xinfeng Lin, Shaowei Yan, Yuan Zhou, Chengzhi Xing, Yujia Chen, Cheng Liu

“…By combining ground–and satellite–based remote sensing with ground station observations, we identified large spatio–temporal differences in the ozone formation sensitivity in eastern Chinese cities under different ozone pollution levels. …”
Get full text

Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines... by Erika Stefàno, Luca Giulio Cossa, Federica De Castro, Erik De Luca, Viviana Vergaro, Giulia My, Gianluca Rovito, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…For the interesting cytotoxic activity observed on YAPC, further biological assays were performed, on this cancer cell line, to evaluate the apoptotic and antimetastatic properties of the considered platinum compounds (1 and 2). …”
Get full text

Some of the applications level of the protection and control of mastitis in dairy cattle farms in turkey with different qualifications by Ali Rişvanlı, Nevzat Saat, Tarık Şafak, Öznur Yılmaz, Burak Fatih Yüksel, Mehmet Akif Kılınç, Halef Doğan, Murat Yüksel, Selim Kul, İbrahim Şeker

“…<p> <b>Results: </b>It has been observed that there are maximum 50-200 cows (n = 96, 56.8% and at most Holstein breeds (n = 97, 57.4%)) in large-scale and 11-20 cows (n = 71, 40.1% and the highest number of Simental breeds (n = 153, 86.4%)) in small scale farms and there are 4 old cows more in these two types of farms. …”
Get full text

Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age by Hea-Ji Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee Soo Ha, Sejung Sohn, Ryota Ebata, Hiromichi Hamada, Hiroyuki Suzuki, Yoichiro Kamatani, Michiaki Kubo, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee

“…Among 26 candidate single nucleotide polymorphisms (SNPs) tested in replication study, only a rare nonsynonymous SNP (rs4365796: c.1106C＞T, p.Thr369Met) in the lymphoid enhancer binding factor 1 (LEF1) gene was very significantly associated with KD in patients younger than 6 months of age (odds ratio [OR], 3.07; pcombined = 1.10 × 10-5), whereas no association of the same SNP was observed in any other age group of KD patients. The same SNP (rs4365796) in the LEF1 gene showed the same direction of risk effect in Japanese KD patients younger than 6 months of age, although the effect was not statistically significant (OR, 1.42; p = 0.397). …”
Get full text

Therapeutic Drug Monitoring of Vancomycin in Hemodialysis Patients in a Hospital in North-East Romania by Aurelia Crețu, Luanda Irina Mititiuc, Iulia-Daniela Lungu, Mihaela Mihaila, Irina Dima, Adrian Covic, Cristina Mihaela Ghiciuc

“…It is important to mention that in 10 (50%) of the patients included in the study, the loading and maintenance doses mentioned in the protocol were respected, but 50% of them had a supratherapeutic AUC. We observed that a supratherapeutic AUC occurred when the loading dose was 1500 mg or 2000 mg, and in one case at 1000 mg with a low BMI. …”
Get full text

Weakened Effective Connectivity Related to Electroacupuncture in Stroke Patients with Prolonged Flaccid Paralysis: An EEG Pilot Study by Yi-Fang Lin, Xin-Hua Liu, Zheng-Yu Cui, Zuo-Ting Song, Fei Zou, Shu-Geng Chen, Xiao-Yang Kang, Bin Ye, Qiang Wang, Jing Tian, Jie Jia

“…The objectives of this study are to explore the disruption of the cortical network in patients in different durations of flaccid stage and observe dynamic network reorganization during and after electroacupuncture. …”
Get full text

Reconstruction of Araucaria araucana cone production reveals warming intensifies regionally synchronized masting by Andrew Hacket‐Pain, Fidel A. Roig, Davide Ascoli, Carlos LeQuesne, Martin Hadad

“…Over the last four decades, direct observations of annual cone production in this species revealed remarkable range‐wide synchrony of masting. …”
Get full text

Heterogeneous long-term changes in larch forest and shrubland cover in the Kolyma lowland are not captured by coarser-scale greening trends by Heather Kropp, Michael M Loranty, Howard Epstein, Gerald V Frost, Adam Koplik, Logan T Berner

“…Changes in shrub and tree cover can be difficult to characterize with limited in-situ observations and moderate/coarse resolution satellite imagery, thereby posing challenges in disentangling changes in vegetation growth from shifts in vegetation composition. …”
Get full text

Cancer Stem Cells from Tumor Cell Lines Activate the DNA Damage Response Pathway after Ionizing Radiation More Efficiently Than Noncancer Stem Cells by Heriberto Abraham Valencia-González, Graciela Ruíz, Elizabeth Ortiz-Sánchez, Alejandro García-Carrancá

“…We found that CSC cultures showed less sensitivity to radiation than conventional tumor cell line cultures. We observed a higher baseline expression of activated response sensor proteins of DNA damage, such as ATM, H2A.X, and PARP1, in untreated CSC cultures. …”
Get full text