Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. …”
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Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6 by Blaine A. Bates, Kylee E. Bates, Spencer A. Boris, Colin Wessman, David Stone, Justin Bryan, Mary F. Davis, Matthew H. Bailey

“…Summary: Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups of genetic similarity provided by All of Us: African/African American (AFR), Admixed American/Latino (AMR), East Asian (EAS), European (EUR), Middle Eastern (MID), or South Asian (SAS). We observed that germline susceptibility to cancer consistently replicates in EUR-like participants but less so in other participants. …”
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Lyme neuroborreliosis as initial expression of Lyme disease in an elderly patient by Emidio Mata, Bárbara Lage Garcia, André Pereira, Joana Rego, Flávia Santos, Carlos Fernandes, Jorge Cotter

“…Within 24 hours, two well-defined round erythematous lesions were observed on the neck and shoulder. Due to new onset of confusion and lethargy a lumbar puncture was performed, revealing polymorphonuclear pleocytosis, elevated protein levels and normal glucose. …”
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Effects of Tank-Mix Adjuvants on Spray Performance Under Downwash Airflow Fields Using an Indoor Simulated UASS Spraying Platform by Supakorn Wongsuk, Yangfan Li, Zhaoyan Zhu, Mengran Yang, Hao Zhang, Li Zhang, Changling Wang, Xiongkui He

“…The downwash airflow field was observed to increase the vertical droplet velocity, achieving a more uniform spray distribution in the central airflow area. …”
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An Experimental and Numerical Study of Landslides Triggered by Agricultural Irrigation in Northwestern China by Tianfeng Gu, Pingping Sun, Jiading Wang, Herry Lin, Yuanjun Xu, Jiaxu Kong, Bin Sun

“…Based on these results, a three-dimensional numerical model of the slope was established, and the change of seepage field and slope stability before and after irrigation was investigated using simulations and compared with the observed data. The results show that flood irrigation raised the water table, and the increase of soil moisture in the flooded area was more significant than that in the nonirrigated area. …”
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Uncovering the molecular mechanisms of Acer fabri in adjusting to low-temperature stress through integrated physiological and transcriptomic analysis by Gongwei Chen, Dandan Zhang, Fengyuan Chen, Yixiao Zhou, Hongyu Cai, Heng Gu, Yuanzheng Yue, Lianggui Wang, Guohua Liu

“…Furthermore, it was observed that NAC (Af0033429) and MIKC (Af0004917) might have interactions with Af0048792, and MIKC (Af0004917) may additionally interact with Af0026061. …”
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Activation of the periaqueductal gray controls respiratory output through a distributed brain network by Mitchell Prostebby, Jashan Saini, Vivian Biancardi, Vivian Biancardi, Vivian Biancardi, Clayton T. Dickson, Clayton T. Dickson, Clayton T. Dickson, Clayton T. Dickson, Silvia Pagliardini, Silvia Pagliardini, Silvia Pagliardini

“…We then stimulated PAG terminals in those regions to determine whether their activity can account for the observed effects of PAG stimulation.ResultsDirectly stimulating the PAG resulted in prominent changes to all recorded muscle activities and reset the breathing rhythm in either a phase-independent or phase-dependent manner. …”
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Pepper as a phytogenic additive in finishing lambs diets by Suellem Fernanda Pedrosa Zanin, Luiz Juliano Valério Geron, Alexandre Lima de Souza, Fagton de Mattos Negrão, André Gustavo Leão, Anderson de Moura Zanine, Daniele de Jesus Ferreira, Jocilaine Garcia, Nelcino Francisco de Paula, Luciano da Silva Cabral

“…No effects (P > 0.05) were observed for the apparent digestibility of DM, OM, NDF, and ether extract. …”
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Spatial Downscaling of GPM Annual and Monthly Precipitation Using Regression-Based Algorithms in a Mountainous Area by Chesheng Zhan, Jian Han, Shi Hu, Liangmeizi Liu, Yuxuan Dong

“…They were employed to downscale annual and monthly precipitation obtained from the Global Precipitation Measurement (GPM) Mission in Hengduan Mountains, Southwestern China, from 10 km × 10 km to 1 km × 1 km. Ground observations were then used to validate the accuracy of downscaled precipitation. …”
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A Comparative Analysis of the Water Retention Properties of Hydrogels Prepared from Melon and Orange Peels in Soils by Shiwei Fang, Yuan Zhong, Jun Wu, Yufan Xie, Liqun Cai, Minjun Li, Jun Cao, Hejie Zhao, Bo Dong

“…After the MP-gels were applied to the soil, it was observed that the gels enhanced the water retention and holding capacity of the sandy soil. …”
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Efficacy and safety of reduced-port laparoscopic surgery versus conventional laparoscopic surgery for colorectal cancer by Zhi-min Liu, Qi-jun Yao, Fengyun Pei, Fang He, Yandong Zhao, Jun Huang

“…No significant differences in perioperative outcomes, PFS rates and OS rates were observed between the two groups. For certain cases, RPLS was superior to CLS in terms of postoperative recovery.…”
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Higher AVCO2 and Lactate Gradient Combined with SOFA Score as a Mortality Predictor during the 6-Hours of Resuscitation of Septic Shock by Morteza Talebi Doluee, Sahar Azam Ghasemzadeh, Ahmad Bagheri Moghadam, Zahra Abbasishaye, Davood Soroosh, Elnaz Vafadar Moradi

“…In this prospective observational-analytical study patients with septic shock admitted to the ICU were evaluated. …”
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Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy by Paulina Kinga Drobot, Aleksandra Banasik, Karolina Owsińska‐Schmidt, Marcin Wrzosek, Przemysław Podgórski

“…Methods Retrospective, observational study. The MRI and EEG examination results of dogs referred for neurological diagnosis data between 2016 and 2021 were retrospectively analyzed. …”
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Effect of tree size attributes on fruit production and animal-mediated seed dispersal web in Melia azedarach L. (Chinaberry) in north-west Himalaya, India by Sukumaran Arun, Sasidharan Sarath, Khanduri Vinod Prasad, Suraj, Rawat Shweta, Chand Vaisakhy Prem

“…We examined the trees of Melia azedarach to analyse the impact of tree size attributes (diameter, height and crown length) on fruit yield. Furthermore, we observed the seed dispersers to determine their role in fruit removal and dispersal. …”
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Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone Formation by Norfarahin Abdullah Sani, Nur Aqilah Kamaruddin, Ima Nirwana Soelaiman, Kok-Lun Pang, Kok-Yong Chin, Elvy Suhana Mohd Ramli

“…<b>Results</b>: Enhanced matrix mineralization was observed in the cells treated with 0.5 µg/mL PTT, especially on day 18 (<i>p</i> < 0.05). …”
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Agroecological mapping of livestock feed resources for sustain productivity and climate resilience in Benin (West Africa) by Marthe Montcho, Alassan S. Assani, Jean de Dieu Ainamon, André B. Aboh, Pascal A. Olounladé, Brice Sinsin

“…Data were collected through discussions with agropastoralists, structured questionnaires, secondary data and observations. The survey in the eight AEZs of Benin revealed that maize residues are the main crop residues used in livestock feed (53.14%), followed by sorghum residues (8.41%), millet (5.91%), soya (8.1%) and rice (5). …”
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Gender differences in the price elasticity of demand for waterpipe and cigarette smoking in Lebanon, Jordan and Palestine: a volumetric choice experiment by Ramzi G Salloum, Mohammed Jawad, Aya Mostafa, Yousef Khader, Rima Nakkash, Niveen ME Abu-Rmeileh, Ali Chalak, Ruba Abla, Sameera Awawda

“…Gender differences varied across the three countries whereby higher cross-price elasticities were observed for women in Jordan and Palestine. For example, the price elasticity for discount waterpipe was −1.4 and −0.6 for women and men in Jordan, respectively.Conclusions Results on the elasticity of demand for tobacco products and the existence of substitution between tobacco products reveal the higher responsiveness of men and women to changes in tobacco prices. …”
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Assessing the Impact of Traffic Emissions on Fine Particulate Matter and Carbon Monoxide Levels in Hanoi through COVID-19 Social Distancing Periods by Nhung H. Le, Bich-Thuy Ly, Phong K. Thai, Gia-Huy Pham, Ich-Hung Ngo, Van-Nguyet Do, Thuy T. Le, Luan V. Nhu, Ha Dang Son, Yen-Lien T. Nguyen, Duong H. Pham, Tuan V. Vu

“…Hourly PM2.5 and CO concentrations were measured from nine urban and traffic monitoring stations during pre-, soft, hard, and post-social distancing periods. As a result, we observed large reductions in both PM2.5 and CO levels during social distancing periods. …”
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Prospective evaluation of the impact of repeated whole prison testing for hepatitis C by Stuart McPherson, Naw April Phaw, Manoj Valappil, Carolyn Miller, Craig Thompson, Francesca McCullough, Caroline Allsop, Kate McQue, Ryan Jelley, Jenna Kerry, Jodi Aldridge, Tony Jefferson, Colin Lawton, Lee Christensen, Aung Min Thant

“…We aimed to assess the outcomes of HITTs conducted in a prison 4 years apart with ongoing reception testing.Methods A prospective observational evaluation of the impact of HITTs was conducted in January 2020 and February 2024 at Low Newton, a female prison. …”
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The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease... by Farzad Shidfar, Samaneh Sadat Bahrololumi, Saeid Doaei, Assieh Mohammadzadeh, Maryam Gholamalizadeh, Ali Mohammadimanesh

“…A significant decrease in the level of ALT enzymes was observed in the control group at the end of the study (P = 0.004). …”
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