Physically Meaningful Surrogate Data for COPD by Harry J. Davies, Ghena Hammour, Hongjian Xiao, Patrik Bachtiger, Alexander Larionov, Philip L. Molyneaux, Nicholas S. Peters, Danilo P. Mandic

“…The proposed simulator operates on healthy subjects and is able to generate FEV₁/FVC obstruction ratios ranging from greater than 0.8 to less than 0.2, mirroring values that can observed in the full spectrum of real-world COPD. As a final stage of verification, a simple convolutional neural network is trained on surrogate data alone, and is used to accurately detect COPD in real-world patients. …”
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Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma by Changyu Zhu, Heshu Liu, Zhixin Li, Yijun Shi, Jingyang Zhao, Yuping Bai, Qian Chen, Wei Li

“…Concurrently, we assessed the potential therapeutic value of SERPINE1 through drug sensitivity analysis. It was observed that, particularly in human papillomavirus (HPV) negative HNSCC, SERPINE1 exhibited elevated expression levels, correlating with poorer prognosis. …”
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miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells by Yong Li, Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, Xiao-bin Cui, Na Li

“…Although aberrant expression of miR-34a, an essential tumor suppressor miRNA, has been frequently observed in colon cancer (CCa), whether miR-34a can regulate CCa progression by modulating other facets of this malignancy (such as multidrug resistance, MDR) remains unknown. …”
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The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation by Cuizhe Wang, Meixiu Zhang, Jinxiu Wu, Wei Li, Xiaodan Ha, Yajuan Gu, Bo Han, Jianxin Xie, Jun Zhang

“…Thus, our research intended to observe the high FFA effects on TLR9/KLF4 expression and the downstream inflammatory factors, to explore the mechanism of inflammatory response suppressed by TLR9/KLF4. …”
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CT Angiography Assessment of Dorsal Pancreatic Artery and Intrapancreatic Arcade Anatomy: Impact on Whipple Surgery Outcomes by Gorkem Ozdemir, Tolga Olmez, Okan Dilek, Berkay Eyi, Alper Sozutek, Ahmet Seker

“…DPA was visualized in 55.98% (159/284) of patients, while the intrapancreatic arcade was observed in 25% (71/284). The most common origin of the DPA was the splenic artery in 69.2% (n = 110) of patients, followed by the superior mesenteric artery in 17.6% (n = 28). …”
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Association of intratumoral microbiome diversity with hepatocellular carcinoma prognosis by Fengle Jiang, Yuan Dang, Zheting Zhang, Yanan Yan, Yingchao Wang, Yi Chen, Lihong Chen, Jialiang Zhang, Jingfeng Liu, Jianmin Wang

“…Our results indicated that a greater abundance of bacteria could be observed in the neoplastic tissues than in nonneoplastic tissues. …”
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Cigarette and e-cigarette reversely regulated autophagy via distinct level of ROS in vitro by Yao Wang, Jialing Zhong, Zuyi Jin, An Luo, Zehong Wu, Xingtao Jiang, Jianwen Chen, Peiqing Liu, Min Li

“…Furthermore, noteworthy differences in cellular mechanisms were observed between CSC and EAC-Cola in BEAS-2B cells, particularly in terms of ROS level and autophagy regulation. …”
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Clinical and Epidemiological Characteristics of <i>Staphylococcus caprae</i> Infections in Catalonia, Spain by Javier Díez de los Ríos, María Navarro, Judit Serra-Pladevall, Sònia Molinos, Emma Puigoriol, Noemi Párraga-Niño, Glòria Pedemonte-Parramón, Luisa Pedro-Botet, Óscar Mascaró, Esteban Reynaga

“…In this retrospective, observational study, data were compiled from clinical records of all <i>S. caprae</i> infections diagnosed between January 2010 and December 2023. …”
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Weighing temporal fluctuations of drought features in Rwanda through the implementation of the standardized precipitation evapotranspiration index and standardized precipitation in... by Kazora Jonah, Zhu Weijun, Kyaw Oo Than, Temesgen Gebremariam Asfaw, Emmanuel Adu Gyamfi Kedjanyi, Abraham Okrah, Akimana Diane, Mathieu Mbati Mugunga

“…Results reveal substantial spatial and temporal variability in drought patterns, with distinct interdecadal shifts observed. While certain regions experienced increased drought frequency and severity, others exhibited wetter conditions. …”
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Features of the water regime and photosynthesis in hybrid forms of cherry plum under the dry wind season conditions by A. V. Grigoriev, R. A. Pilkevich, L. A. Lukicheva, T. B. Gubanova, V. M. Gorina

“…A relatively increased ability to retain moisture during dehydration was observed in form 12/26 whose leaves gave off moisture more slowly and restored their turgor better. …”
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Enhancing Pan evaporation predictions: Accuracy and uncertainty in hybrid machine learning models by Khabat Khosravi, Aitazaz A. Farooque, Amir Naghibi, Salim Heddam, Ahmad Sharafati, Javad Hatamiafkoueieh, Soroush Abolfathi

“…A 30-year dataset of monthly meteorological observations (1988–2018) from the Kermanshah synoptic station in Iran served as the basis for this analysis, incorporating variables such as temperature, relative humidity, solar exposure, wind speed, and rainfall. …”
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Discrete Fractional-Order Modeling of Recurrent Childhood Diseases Using the Caputo Difference Operator by Yasir A. Madani, Zeeshan Ali, Mohammed Rabih, Amer Alsulami, Nidal H. E. Eljaneid, Khaled Aldwoah, Blgys Muflh

“…Numerical simulations demonstrate the model’s effectiveness in capturing realistic scenarios, particularly the recurrent patterns observed in some childhood diseases.…”
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Urban green infrastructure index: Assessing supply of regulating and cultural ecosystem services at a megacity scale by Yury Dvornikov, Valentina Grigorieva, Vyacheslav Vasenev, Mikhail Varentsov, Olga Romzaykina, Olga Maximova, Anastasia Konstantinova, Victor Matasov, Ekaterina Kozlova

“…In this study, we have used open-source geospatial data to quantify regulating (air pollution/noise and stormwater runoff regulation, climate mitigation), and cultural (aesthetic values, recreational activities, observation of flora and fauna) ES at three spatial levels within the Moscow megacity (municipal areas (districts), residential areas (quarters), and regular grid). …”
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Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report by Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

“…In vitro testing using patient-derived intestinal organoids was performed in parallel and also demonstrated a significant response to ETI. The deterioration observed following the initiation of ALK inhibitor treatment and subsequent improvement with CFTR modulators suggest that ALK inhibitor therapy may potentially impair CFTR activity. …”
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Otolith annulus validation and population dynamics of dark sleeper Odontobutis potamophila: insights for sustainable fisheries management by Miao Xiang, Miao Xiang, Haoran Liu, Haoran Liu, Haoran Liu, Bo Li, Hongxi Guo, Chuankun Zhu, Man Wang, Man Wang, Jie Wang, Jie Wang, Songguang Xie, Songguang Xie, Lei Zhang, Lei Zhang

“…An isometric growth pattern was observed, with the Logistic growth function providing the best fit for combined sexes. …”
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Spatial Analysis of Building Density and Liquefaction Spread in Izmit Bay and its Surroundings by Arzu Erener, Metin Aşcı, Gül Gülsoy, Aydın Üstün, Muhammed Ali Güvenaltın, Erman Şentürk, Sefa Yalvaç, Fatma Canaslan Çomut, T. Serkan Irmak, Haluk Konak, Pakize Küreç Nehbit, Efdal Kaya, Burak Kotan, Selin Öye

“…In addition, the liquefaction potential observed around the bay and its surroundings is evaluated for 0-3 m, 3-6 m, 6-9 m, 9-12 m from 33-35 m depths. …”
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Peering into the Black Box: Forward Modeling of the Uncertainty Budget of High-resolution Spectroscopy of Exoplanet Atmospheres by Arjun B. Savel, Megan Bedell, Eliza M.-R. Kempton, Peter C. B. Smith, Jacob L. Bean, Lily L. Zhao, Kaze W. K. Wong, Jorge A. Sanchez, Michael R. Line

“…We present an HRCCS observation simulator, scope , ^5 that incorporates spectral contributions from the exoplanet, star, tellurics, and instrument. …”
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Risk Mitigation and Construction Control for Effective Underwater Recovery of an EPB Shield: A Case Study of the First Metro Tunnel in Tel Aviv by Weiqiang Qi, Zhiyong Yang, Yusheng Jiang, Zhiyong Liu, Yinxin Guo, Xing Yang

“…In order to ensure the deformation control of the underground diaphragm wall and the smooth tunneling of the shield, the thrust of the shield excavating the underground diaphragm wall will not be larger than 12 000 kN, and the penetration degree will be limited to 3 mm/r. Qualitative observations and measurements of surface subsidence in the metro tunnel indicate that these risk mitigation techniques are effective and suitable for the underwater recovery of EPB shields in water-rich sand strata.…”
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Trial Characteristics and Appropriateness of Statistical Methods Applied for Design and Analysis of Randomized School-Based Studies Addressing Weight-Related Issues: A Literature R... by Moonseong Heo, Singh R. Nair, Judith Wylie-Rosett, Myles S. Faith, Angelo Pietrobelli, Nancy R. Glassman, Sarah N. Martin, Stephanie Dickinson, David B. Allison

“…We searched PubMed and extracted variables concerning study characteristics, power analysis, ICC use for power analysis, applied statistical models, and the report of the ICC estimated from the observed data. Results. N=263 papers were identified, and N=121 papers were included for evaluation. …”
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Helminth diversity of nutria (Myocastor coypus) across the Morava basin in the Czech Republic by Michal Benovics, Eva Nosková, Anna Klimešová, Lucie Škorpíková, Ema Jaššová, Jakub Drimaj, Jan Slováček, Ondřej Mikulka

“…The highest prevalence was observed for Strongyloides myopotami (78.3%) and Trichuris myocastoris (37.0%), both of which are host-specific nematodes of nutria. …”
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