Clinical Comparison of QUANTA Flash dsDNA Chemiluminescent Immunoassay with Four Current Assays for the Detection of Anti-dsDNA Autoantibodies by Maria Infantino, Francesca Meacci, Chelsea Bentow, Peter Martis, Maurizio Benucci, Antonella Afeltra, Amelia Rigon, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Mariangela Manfredi, Michael Mahler

“…Significant variations among dsDNA methods were observed. QUANTA Flash dsDNA provides a good combination of sensitivity and specificity for the diagnosis of SLE and good agreement to CLIFT.…”
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Structural and functional changes of Post-Stroke Depression: A multimodal magnetic resonance imaging study by Qiuhong Lu, Shunzu Lu, Xue Wang, Yanlan Huang, Jie Liu, Zhijian Liang

“…No significant differences in the GMV or DTI parameters were observed between the two groups. Furthermore, the ODI of the right superior longitudinal fasciculus and NODDI showed the best classification performance for PSD at their respective comparison level (the areas under the ROC curves (AUC) = 0.917(0.000), 0.933(0.000)). …”
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Subtle genomic differences in Klebsiella pneumoniae sensu stricto isolates indicate host adaptation by Bridget O'Brien, Alla Yushchenko, Jinha Suh, Dongyun Jung, Zhangbin Cai, Ngoc Sang Nguyen, Makeda Semret, Simon Dufour, Séamus Fanning, Jennifer Ronholm

“…No obvious phylogenomic differentiation was observed between isolates from these hosts. However, subtle genetic differences exist between bovine and human KpI which likely reflect environmental adaptation to different host niches, including a higher representation of gene clusters encoding ferric citrate uptake transporters, as well as histidine, arginine, and lactose utilization pathways in bovine isolates. …”
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Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…Apoptosis of HSCs was observed in vivo after HepLPC treatment. HepLPC-secretomes exhibited potent inhibition of TGF-β1-induced HSC activation and promoted apoptosis through signal transducer and activator of transcription (STAT)1-mediated pathways in vitro. …”
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Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria by Hewa Warawitage Dilanthi, Kandana Liyanage Subhashinie Jayasena, Nambage Dona Priyani Dhammika, Neluwa Liyanage Ruwan Indika, Matara Mahavidanage Nishani De Silva, Imalke Kankananarachchi, Pushpa Malkanthi Gardiye Punchihewa, Dharma Irugalbandara, Sabine Schroeder, Kosala Karunaratne, Eresha Jasinge

“…The genotypic spectrum observed in Sri Lankan patients is unique and mostly associated with pyridoxine non‐responsiveness. …”
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Impact of Different Metabolic Indicators on Ventricular Repolarization Indices in Obese Children: A Case Control Study by Asmaa A El Sehmawy, Rasha Abd El Samad Fawaz, Nadia Ahmed Agiba, Eman Aziz Elsherbiny, Nglaa Fathi Agaba, Doaa Sayed Mohammed, Haidy Mahmoud Nasr, Fatma Elzhraa AE Diab, Amal M Ahmed, Shorouk Issa Mahfouz, Heba T Okda, Doaa Sadek Ahmed

“…Conclusion: Greater JTc dispersion (ms) and QTc dispersion (ms) were observed in obese children with a positive correlation to waist circumference, BMI, and insulin resistance.…”
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Exploring the operator experience in automated shuttles: Fatigue, attention, and gaze behaviour by Christer Ahlström, My Weidel, Anna Sjörs Dahlman, Ashleigh Filtness, Anna Anund

“…Study B involved naturalistic observations over two months, examining sleep, sleepiness and stress.Study B found that 27% of work shifts occurred following less than six hours of sleep. …”
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Cardioembolic but Not Other Stroke Subtypes Predict Mortality Independent of Stroke Severity at Presentation by Latha Ganti Stead, Rachel M. Gilmore, M. Fernanda Bellolio, Anunaya Jain, Alejandro A. Rabinstein, Wyatt W. Decker, Dipti Agarwal, Robert D. Brown

“…Methods. We conducted an observational study of a consecutive cohort of patients presenting with AIS to a single tertiary academic center. …”
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Quality of life in idiopathic pulmonary fibrosis in Latin American countries by H. Aguilar-Duran, M. Fernández, M. González-García, E. Rincón-Alvarez, M. Alberti, F. Caro, E. Tavera, E. Vásquez, N. Cortez, M. Salinas, M. Florenzano, C. Florestano, Ivette Buendia-Roldan

“…We found that 28% presented anxiety and 35% depression. Besides, we observed that patients requiring oxygen had a worse quality of life (total SGRQ-I 62 ± 22 vs. 45 ± 22, p = 0.003) without finding differences in antifibrotic therapy. …”
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Assessing the Accuracy of Dermoscopy for Scabies Diagnosis in Dark African Skin by Nkechi Anne Enechukwu, Ikenna Akuakolam, Iloduba N Aghanya, Chetanna C Anaje, Ogochukwu I Ezejiofor, Enzo Errichetti

“…Results: Dermoscopic and microscopic evidence was observed in 48.3% and 46.7% respectively. While the serpiginous tract had a sensitivity and specificity of 75.9% and 80.6% respectively, delta sign was 75% and 55.4% respectively. …”
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Intratesticular Angiolipoma: A Rare Case of Adipose Tissue Presence in the Testis by V. Kalyvas, C. Gkekas, D. Papadopoulos, A. Malioris, S. Milias, M. Papathanasiou, N. Kalinderis, K. Moysidis, K. Hatzimouratidis

“…No recurrences have been observed in the follow-up period. Discussion. Angiolipomas, which mainly occur in the trunk and extremities, are classified as infiltrating and noninfiltrating. …”
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Autoencoder Reconstruction of Cosmological Microlensing Magnification Maps by Somayeh Khakpash, Federica B. Bianco, Georgios Vernardos, Gregory Dobler, Charles Keeton

“…We develop metrics to study various aspects of the autoencoder generated maps and show that the reconstruction is reliable. Even though we observe a mild loss of resolution in the generated maps, we find this effect to be smaller than the smoothing effect of convolving the original map with a source of a plausible size for its accretion disk in the red end of the optical spectrum and larger wavelengths and particularly one suitable for studying the broad-line region of quasars. …”
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Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles by Xi Tang, Jingke He, Qin Huang, Yi Chen, Ke Chen, Jing Liu, Yingyu Tian, Hui Wang

“…The calibration curves exhibited good concordance between the predicted survival probabilities and actual observations. Time-dependent C-index curves, integrated discrimination improvement, net reclassification index, and decision curve analysis showed that the nomogram outperformed FIGO staging.ConclusionThis study established and validated a nomogram combining CBC and lipid profiles to predict RFS in patients with optimally debulked EOC, which is expected to aid gynecologists in individualized prognosis assessment and clinical management.…”
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Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering by Ryohei Yamamura, Makoto Kinoshita, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Tomohiro Yata, Keigo Kihara, Daisuke Motooka, Daisuke Motooka, Naoyuki Shiraishi, Yasuko Sugiyama, Shohei Beppu, Hisashi Murata, Naoshi Koizumi, Itsuki Sano, Toru Koda, Tatsusada Okuno, Hideki Mochizuki

“…All patients were positive for anti-AQP4 antibodies and had no history of biologic use.ResultsIn one relapsed patient, gene groups with decreased expression at relapse were observed predominantly in monocytes, with upregulation in anti-inflammatory pathways such as IL-10, while the upregulated genes were related to interferon signaling. …”
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Development of an Augmented Reality-Based Practicum E-Module Integrated with Local Wisdom of Salak Fruit by Heni Mulyani Pohan, Adi Syaputra, Fatma Suryani Harahap, Dinda Yunita, Rabiyatul Adawiyah Siregar, Anouar Ben Mabrouk

“…Instruments included validation sheets (for material, media, and language), observation, user response questionnaires, and pretest-posttest tests to assess students' spatial intelligence. …”
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Risk and Prevention of Meningococcal Disease among Education Workers: A Review by Philippe De Wals, Pierre Deshaies, Gaston De Serres, Bernard Duval, Lise Goulet, Bernard Pouliot, Sylvie Ricard, Maurice Poulin

“…The aims of the present study were to review the risk of invasive meningococcal disease (IMD) among education workers, particularly pregnant women, and to evaluate preventive measures, in a context of endemicity, outbreak or epidemic as observed in the province of Quebec. The literature was reviewed and persons in charge of IMD surveillance in France, Quebec, the United Kingdom and the United States were interviewed. …”
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Healthy at home for COPD: an integrated digital monitoring, treatment, and pulmonary rehabilitation intervention by Laurel O’Connor, Stephanie Behar, Seanan Tarrant, Pamela Stamegna, Caitlin Pretz, Biqi Wang, Brandon Savage, Thomas Scornavacca, Jeanne Shirshac, Tracey Wilkie, Michael Hyder, Adrian Zai, Shaun Toomey, Marie Mullen, Kimberly Fisher, Emil Tigas, Steven Wong, David D. McManus, Eric Alper, Peter K. Lindenauer, Eric Dickson, John P. Broach, Vik Kheterpal, Apurv Soni

“…On average, a 2.48-point improvement (p = 0.03) in COPD Assessment Test Score was observed from baseline to study completion. The adherence and symptom improvement metrics were not associated with baseline patient activation measures. …”
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‘No one cares about the animal like me.’ Indian veterinarians’ experiences of improving animal welfare through Continuing Professional Development by Emma L Rayner, Ranjita Bastola, Sumanth Bedre, Andrew D Gibson, Luke Gamble, Jill RD MacKay

“…We describe three themes: (1) ‘career vs calling’, where veterinarians’ extrinsic and intrinsic motivational factors were identified, such as their desire to protect animal welfare; (2) being ‘willing to learn but can’t’, with context-specific barriers, such as accessing reliable CPD information; and (3) ‘real interactions matter’, where participants described how pedagogical design influenced their choices, e.g. being able to observe animal welfare improvements through practical teaching. …”
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Varicella Zoster Virus-induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19 by Kiana Hassanpour, Faezeh Khorasanizadeh, Mahmood Nabavi, Narsis Daftarian, Alireza Ramezani

“…Conclusion: A case of VZV-induced ARN following acute meningoencephalitis was observed in association with presumed COVID-19. This could be an incidental finding during the COVID-19 pandemic; however, it could also suggest that COVID-19 might trigger ARN in cases with latent herpes family viruses. …”
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Effect of metformin on the neuronal morphology of frontal cortex and hippocampal regions in lipopolysaccharide induced neuroinflammation in male Wistar rats by Vandana Blossom, Sheetal D. Ullal, Rajalakshmi Rai, Amit Massand, Chettiar Ganesh Kumar, Teresa Joy, Melisha Michael D souza, B.V. Murlimanju

“…Conclusion: The histological analysis and clinical observation by the rotarod test revealed that, metformin attenuated the neuroinflammatory damage, suggesting that it has a neuroprotective role. …”
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