Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan by Chyi-Liang Chen, Yi-Ching Chen, Hsuan-Ling Hsiao, Yi-Jung Chang, Hsin-Chieh Li, Merve Arslan Aydin, Cheng-Hsun Chiu

“…An increase in the number of influenza cases with severe complications in Taiwan was observed after October 2022. Following these viral infections, cases of invasive pneumococcal disease (IPD) began to increase from September 2022 onward. …”
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Influence of SARS-CoV2 Pandemic on Colorectal Cancer Diagnosis, Presentation, and Surgical Management in a Tertiary Center: A Retrospective Study by Roman Taulean, Roxana Zaharie, Dan Valean, Lia Usatiuc, Mohammad Dib, Emil Moiș, Calin Popa, Andra Ciocan, Alin Fetti, Nadim Al-Hajjar, Florin Zaharie

“…Further studies are required to observe the long-term effects in terms of morbidity and mortality, regarding the delay of diagnosis and oncological treatment.…”
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Activity of sorghum aphid and its natural enemies in the context of agroecological and weather conditions by Tomasz E. Koralewski, Tomasz E. Koralewski, Michael J. Brewer, Leonel L. Deleon, Norman C. Elliott, Kristopher Giles, Adrianna Szczepaniec, Ashleigh M. Faris, Ashleigh M. Faris

“…Both landscape and weather factors have been shown to affect the abundance and numerical responses of these insects, consistent with observations in other aphid species. In this study we used data on counts of sorghum aphids, lady beetles (Coleoptera: Coccinellidae), and parasitoid wasps Aphelinus nigritus Howard (Hymenoptera: Aphelinidae) and Lysiphlebus testaceipes (Cresson) (Hymenoptera: Braconidae) collected in Kansas, Oklahoma and Texas states of the United States. …”
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Storm‐Time Ring Current Plasma Pressure Prediction Based on the Multi‐Output Convolutional Neural Network Model by Yun Yan, Zi‐Kang Xie, Chao Yue, Jiu‐Tong Zhao, Fan Yang, Lun Xie, Qiu‐Gang Zong, Xu‐Zhi Zhou, Shan Wang

“…The application of this model is in line with previous observations and simulations, which can be utilized for quantitative analysis of storm‐time ring current dynamics.…”
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Impact of the COVID-19 pandemic on the volume and diagnoses of patients admitted to the paediatric emergency department: a retrospective analysis from a third-level hospital in Nor... by Paulina Blanco-Murillo, Ricardo J Estrada-Mendizabal, Katheryne Paola Madrazo-Aguirre, Manuel Guillermo Ruelas-Martinez, Lucia Escobedo-Berumen, Rommy Elizabeth Pineda-Magaña, Maria Guadalupe Garcia-Lima, Oscar Tamez-Rivera

“…This study aimed to analyse the changes in volume and discharge diagnoses of patients admitted to a third-level paediatric ED in northeastern Mexico before and during the COVID-19 pandemic.Methods A retrospective observational study was carried out to compare the number of admissions and discharge diagnoses between two 3-month periods: December 2020–February 2021 (prepandemic) and December 2019–February 2020 (pandemic). …”
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Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening mo... by Virginia Marugan-Hernandez, Javier Regidor-Cerrillo, Luis Ortega-Mora, Sara Arias-Maroto, Kelsilandia Aguiar-Martins

“…In this study we have proved that the miniaturisation into a 96-well plate format perfectly mimics the invasion and replication observed before in the 24-well plate format. In addition, the 96-well plate format has allowed the simultaneous pre-screening of higher numbers of anticoccidial drugs at different concentrations following streamlined protocols in a more cost-effective way, factors that are beneficial for a wider uptake of the model by other researchers investigating anticoccidial compounds.…”
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Highly efficient assessment and selective determination of pancreatic cancer biomarker CA-19-9 using co-electrodeposited MXene-AgNPs nanocomposite by Mahsa Mirzayi, Balal Khalilzadeh, Sattar Akbari Nakhjavani, Rahim Mohammad-Rezaei

“…The repeatability and reproducibility were successfully inspected for ten repeated mensuration and the lowest RSD percentages were observed as about 5 % for the concentration of 1, 10 and 20 nU/mL. …”
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Energy and CO2 fluxes in the early stage development of reclaimed and unreclaimed post-mining areas by Aysan Badraghi, Ondřej Mudrák, Jiří Kučera, Leonardo Montagnani, Jan Frouz

“…Significant differences in NEE, gross primary production (GPP), ecosystem respiration (Reco), and LE were observed between the two sites. Initially (2020 and 2021), the effect of alder seedlings was negligible. …”
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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver

“…Epigenetic age acceleration was observed in patients with IgG4-SC, but not in those with PSC or UC. meQTL analyses to identify genetic determinants of methylation revealed a strong human leucocyte antigen (HLA) signal in both PSC and IgG4-SC (HLA-DQB2, HLA-DPA1, HLA-F and HLA-DRA). …”
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Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling by Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang

“…Further, allopregnanolone level in the dorsal spinal cord was observed to decrease in CINP rats, and intragastric administration of exogenous allopregnanolone dose-dependently alleviated PTX-induced mechanical hypersensitivity. …”
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Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival by Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk

“…Furthermore, we examined the therapeutic potential of these observations by treating a cohort of primary AML patient samples with KL-11743 and witnessed similar dependency on mitochondrial respiration for sustained cellular survival. …”
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Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia by Ricardo P. P. Moreira, Larissa G. Gomes, Guiomar Madureira, Berenice B. Mendonca, Tânia A. S. S. Bachega

“…Results. Obesity was observed in 31.7% of patients and was not correlated with GC doses and treatment duration. …”
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Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children by Yali Zhang, Yali Zhang, Yingying Xu, Yingying Xu, Ling Hu, Ling Hu, Xiaomei Wang

“…Furthermore, variations have been observed across different studies. Additionally, it is crucial to further evaluate the safety and potential long-term side effects associated with probiotic use in children with RRTIs. …”
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases by Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

“…Although we could not find a common pattern of circadian variance, we observed daily variation in histone H3 acetylation levels, and their coefficient of variances (CVs) were approximately 48.3%. …”
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Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with ApcMin/+ Mutation by Michele Barone, Maria Principia Scavo, Raffaele Licinio, Michele Piombino, Nicola De Tullio, Rosanna Mallamaci, Alfredo Di Leo

“…At 4 and 7 weeks after transplantation, a progressive significant reduction of polyp number and volume was observed in WT-Tx-Apc mice. Moreover, the number of WT-Tx-Apc mice with a high-grade dysplastic polyps significantly decreased as compared to Apc-Tx-Apc mice. …”
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Intensification of Natural Disasters in the State of Pará and the Triggering Mechanisms Across the Eastern Amazon by Everaldo B. de Souza, Douglas B. S. Ferreira, Luciano J. S. Anjos, Alan C. Cunha, João Athaydes Silva, Eliane C. Coutinho, Adriano M. L. Sousa, Paulo J. O. P. Souza, Waleria P. Monteiro Correa, Thaiane S. Silva Dias, Alexandre M. C. do Carmo, Carlos B. B. Gutierrez, Giordani R. C. Sodré, Aline M. M. Lima, Edson J. P. Rocha, Bergson C. Moraes, Luciano P. Pezzi, Tercio Ambrizzi

“…A clear seasonal pattern was observed, with Hydrological disasters (Inundations, Flash floods, and Heavy rainfall) peaking between February and May, while Climatological disasters (Droughts and Forest fires) were most frequent from August to October. …”
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Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor by Abhishek Srivastava, Abhishek Srivastava, Simrata Bedi, Abhishesh Kumar Mehata, Datta Maroti Pawde, Ketan Vinayakrao Hatware, Mohammad Ahmad Khan, M. S. Muthu, Uma Bhandari

“…From the results, we observed∼64% enhancements in the oral bioavailability of the Ticagrelor relative to the marketed formulation. …”
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Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer by Sushma Yadav, Claudia M. Kowolik, Daniel Schmolze, Yuan Yuan, Min Lin, Arthur D. Riggs, David A. Horne

“…Approximately 40% of breast cancer tissue exhibited cytoplasmic/membranous localization of p-SMC1A, whereas nuclear expression was observed in normal breast tissues. Moreover, elevated phosphorylation levels were significantly associated with higher tumor grade and metastasis.…”
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Evaluation of Cinnamon Essential Oil and Its Emulsion on Biofilm-Associated Components of <i>Acinetobacter baumannii</i> Clinical Strains by Tea Ganić, Ilinka Pećinar, Biljana Nikolić, Dušan Kekić, Nina Tomić, Stefana Cvetković, Stefana Vuletić, Dragana Mitić-Ćulafić

“…Gene expression was monitored with RT-qPCR, while treated biofilms were observed with Raman spectroscopy. Results: A particularly strong potential against pre-formed biofilm with a decreased biomass of up to 66% was found. …”
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Cytotoxic Activity of Bisphosphonic Derivatives Obtained by the Michaelis–Arbuzov or the Pudovik Reaction by Zsuzsanna Szalai, Janka Bednárik, Boldizsár Szigfrid Tóth, Angéla Takács, Szilárd Tekula, László Kőhidai, Konstantin Karaghiosoff, László Drahos, György Keglevich

“…While myeloma (U266) cells indicated greater sensitivity overall, the most significant reductions in cell viability were observed in PANC-1 cancer cells, raising potential therapeutic applications of bisphosphonates beyond myeloma-associated bone disease, particularly for malignancies like pancreatic ductal adenocarcinoma.…”
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