Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma by Hideo Suzuki, Motoyuki Kohjima, Masatake Tanaka, Takeshi Goya, Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori, Mariko Tsuda, Motoi Takahashi, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Akifumi Kuwano, Masaki Kato, Seiji Okada, Makoto Nakamuta, Yoshihiro Ogawa

“…Same metabolic alterations were observed in noncancer tissue as the liver disease progresses from healthy liver to chronic hepatitis, cirrhosis, and HCC. …”
Get full text

Hopping backward to move forward: Single-leg backward hopping can better detect decreased quadriceps strength induced by a fatigue protocol compared to forward and vertical hopping by Yu Song, Lauren Salsgiver, Kaden Van Valkenburg, Natalie Christofferson, Yessica Lo, Zhichen Feng, Brenna McGuinness, Boyi Dai

“…Background: Deficits in quadriceps strength of the injured leg have been observed in patients following anterior cruciate ligament (ACL) reconstructions and may contribute to ACL re-injury risk. …”
Get full text

Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract by Shahla Korani, Khodabakhsh Rashidi, Mona Hamelian, Ali R. Jalalvand, Ahmad Tajehmiri, Mitra Korani, Thozhukat Sathyapalan, Amirhossein Sahebkar

“…Based on the results of FTIR spectroscopy, various functional oxygenated groups such as hydroxyl, carboxyl, and nitrogenous groups were observed. XRD confirmed the crystalline nature of the nanoparticles. …”
Get full text

Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

“…All subjects (54) completed the studies and no safety signals or clinically meaningful changes in blood chemistry, urinalysis, hematology, ECG, vital signs or ocular endpoints were observed. Mean levels of systemic complement factor B (FB) were reduced up to 38 % after single administration and 69 % after repeated administration. …”
Get full text

Toxicity of the Herbicide Roundup Original DI^® in Tadpoles of <i>Physalaemus erikae</i> and <i>Physalaemus cicada</i> (Anura: Leptodactylidae) by Mario Barbosa da Silva Junior, Renan Nunes Costa, Iuri Ribeiro Dias, Yvonnick Le Pendu, Mirco Solé, Caio Vinícius de Mira-Mendes, Victor Goyannes Dill Orrico

“…Also, at chronic concentrations, morphological changes were observed in the tadpoles of <i>P. erikae</i>, with the changes being mainly in the tadpoles’ tail and body shapes. …”
Get full text

Spatial genetic characterization of the red fox (Vulpes vulpes) in the area between the Alps and the Central Dinaric Mountains by A. Devedžić, F. F. Urzi, B. Pokorny, G. Vengušt, D. Ž. Vengušt, F. Janžekovič, L. Velić, T. Eterović, B. K. Stroil, E. Bužan

“…Additionally, our findings highlighted that populations from the Alps and northern Dinaric Mountains exhibit higher genetic diversity and observed heterozygosity compared to their counterparts in the Central Dinaric Mountains. …”
Get full text

Morphology of 137 Fast Radio Bursts Down to Microsecond Timescales from the First CHIME/FRB Baseband Catalog by Ketan R. Sand, Alice P. Curtin, Daniele Michilli, Victoria M. Kaspi, Emmanuel Fonseca, Kenzie Nimmo, Ziggy Pleunis, Kaitlyn Shin, Mohit Bhardwaj, Charanjot Brar, Matt Dobbs, Gwendolyn M. Eadie, B.M. Gaensler, Ronniy C. Joseph, Calvin Leung, Robert Main, Kiyoshi W. Masui, Ryan Mckinven, Ayush Pandhi, Aaron B. Pearlman, Masoud Rafiei-Ravandi, Mawson W. Sammons, Kendrick Smith, Ingrid H. Stairs

“…Our measured values are compared with those in the first CHIME/FRB intensity catalog, revealing that nearly one-third of our sample exhibits additional burst components at higher time resolutions. We observe no correlations between scattering time and dispersion measure, rotation measure, or linear polarization fraction, with the latter suggesting that depolarization due to multipath propagation is negligible in our sample. …”
Get full text

Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease by Maria Galluzzo, Elisa Ciraolo, Monica Lucattelli, Eriola Hoxha, Martina Ulrich, Carlo Cosimo Campa, Giuseppe Lungarella, Gerd Doring, Zhe Zhou-Suckow, Marcus Mall, Emilio Hirsch, Virginia De Rose

“…Treatment with the PI3Kγ inhibitor AS-605240 decreased the number of neutrophils in BALF of βENaC-Tg mice, reproducing the effect observed with genetic deletion of the enzyme. Conclusions. …”
Get full text

Residential Indoor and Outdoor PM Measured Using Low-cost Monitors during the Heating Season in Monroe County, NY by Andrea R. Ferro, Naděžda Zíková, Mauro Masiol, Gursumeeran P. Satsangi, Thomas Twomey, David C. Chalupa, David Q. Rich, Philip K. Hopke

“…Short-term PM increases greater than 100 µg m–3 were periodically observed in homes with and without wood-burning appliances operating. …”
Get full text

Knowledge and attitudes about human papillomavirus infection and prevention methods among medical science students in Novi Sad, Serbia: a cross-sectional study by Nikola Denda, Nemanja Maletin, Aleksandar Rašković, Dušan Prodanović, Zoran Golušin, Biljana Vučković, Marko Nemet, Milica Paut Kusturica

“…Statistical significance was observed in the difference between the responses of students who attended education in comparison to those who did not attend education in the past year (75.5% versus 63.3%, p < 0.001). …”
Get full text

Effect of comorbidity classes on survival of patients with gastrointestinal tract cancer by Linna Gao, Tian Yao, Shaohua Ge, Jiuwei Cui, Wei Li, Zengqing Guo, Hongxia Xu, Min Weng, Suyi Li, Qinghua Yao, Wen Hu, Lan Zhou, Junqiang Chen, Xianghua Wu, Qingchuan Zhao, Hongli Li, Hanping Shi, Yi Ba, He Huang, The Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) Group

“…Methods In a multicenter prospective observational study from 2012 to 2021, we grouped the comorbidities of patients with GTC by latent class analysis, obtaining two comorbidity classes. …”
Get full text

Feruloyl-amides as natural antimicrobials for crop and food protection by Denise Dozio, Sharmila Ghosh, Daniele Alessandro Consolini, Josè Luis Ermini Starna, Loris Pinto, Federico Baruzzi, Martina Letizia Contente, Andrea Pinto, Paolo Cortesi, Salvatore Princiotto, Andrea Kunova, Sabrina Dallavalle

“…Conclusions The obtained results evidenced that the effect of this class of compounds is mainly related to blocking fungal virulence mechanisms, mediated by a significant effect on appressorium maturation, rather than to mycelium growth inhibition. Together with the observed in vitro antibacterial activity against foodborne bacterial pathogens, we conclude that PAs are promising candidates for future developments in the agri-food sector. …”
Get full text

Detection and quantification of pathogens in saliva of adolescents with cerebral palsy: a cross-sectional study by Rosemeire Arai Yoshida, Tiago Bertola Lobato, Renata Gorjão, Lucas Santiago França, Lívia Araujo Alves, Maria Teresa Botti Rodrigues Santos

“…A significant contrast was observed for the pathogen P. intermedia when comparing the difference in the control group (p = 0.0396). …”
Get full text

Prevalence of Dental Caries in Schoolchildren from the Galapagos Islands: ESSO-Gal Cohort Report by Ana Armas-Vega, Juan Marcos Parise-Vasco, María Cristina Díaz-Segovia, David Alejandro Arroyo-Bonilla, María José Cabrera-Dávila, María Christel Zambrano-Bonilla, Ingrid Ordonez-Romero, Andrea Caiza-Rennella, Andrea Zambrano-Mendoza, Celia Ponce-Faula, Andrés Viteri-García

“…A statistically significant difference was observed among the different islands regarding the cutoff point for ICDAS II codes 3–6 (p≤0.001). …”
Get full text

The PREPARE Study: Acceptability and Feasibility of a Telehealth Trimodal Prehabilitation Program for Women with Endometrial Neoplasia by Elise P. Legault, Paula A. B. Ribeiro, Danielle Moreau-Amaru, Emmanuelle Robert, Sara Forte, Alain S. Comtois, Vanessa Samouëlian, François Tournoux

“…No serious adverse events occurred. We observed a positive impact on different outcomes across the different groups, such as in the Functional Assessment of Cancer Therapy quality of life score (SPP; delta = 6.1 [CI: 0.9; 12.6]) and functional capacity measured using the 30″ sit-to-stand test (PACS delta = 2.4 [CI: 1.2; 3.6]). …”
Get full text

Experimental study of the effects of siestas on the nocturnal sleep quality and thermal comfort levels under thermoneutral environment in summer by Huili Yu, Xue Zhao, Liping Chen, Xiaohui Tian, Shimin Liang, Songtao Hu

“…Results showed that the siesta group had a significant increase in self-reported nocturnal sleep quality (p < 0.05), although slight decreases in slow-wave sleep (SWS) duration and rapid eye movement (REM) duration were observed. Additionally, higher TCV and TSV values were reported in the siesta group (p < 0.05). …”
Get full text

High-entropy assisted capacitive energy storage in relaxor ferroelectrics by chemical short-range order by Tongxin Wei, Jinzhu Zou, Xuefan Zhou, Miao Song, Yan Zhang, Cewen Nan, Yuanhua Lin, Dou Zhang

“…Atomic-scale scanning transmission electron microscopy observations show that Nb exhibits a chemical short-range order structure, with Nb enriched regions displaying ultrasmall polar nanoregions and more flexible polarization configurations, which is conducive to achieving high maximum polarization and low residual polarization. …”
Get full text

Alpha-1 Antitrypsin Deficiency and Pulmonary Morbidity in Patients with Primary Immunodeficiency Disease: A Single-Center Experience by Georg Evers, Arik Bernard Schulze, Michael Thrull, Jan-Philipp Hering, Christoph Schülke, Rainer Wiewrodt, Helmut Wittkowski, Lars Henning Schmidt, Michael Mohr

“…With regard to the genotype, PI∗ZZ was found in 2 patients, whereas PI∗MZ was observed in 5 patients. Independent of the underlying phenotype, obstructive lung diseases were found in 2 patients with PI∗ZZ and 2 patients with PI∗MZ. …”
Get full text

Spatial analysis of teen births near the New Bedford Harbor Superfund site by Nicole V DeVille, Carolina Villanueva, Susan A Korrick, Verónica M Vieira

“…The highest risk was observed north and northeast of the harbor (OR: 95% CI—3.19: 2.08, 4.88 and 2.93: 1.47, 5.82), which aligns with the prevailing wind direction from the harbor. …”
Get full text

Treatment of Miller I Mandibular Gingival Recessions Using PRF vs. Connective Graft by Hernan S. Garzon, Camilo Alfonso, Francisco J. Vega, Andrea García, Ana Muñoz, Gustavo Jaimes, Katherine Isaza, Katherine Rivera

“…Less EI and PaD were obtained using CAF + PRF (p < 0.05). No change was observed in GR, KT, and TS values in the intergroup or intragroup comparisons. …”
Get full text