Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non–Small Cell Lung Cancer With High Programmed... by Alvin H.K. Cheung, MBBS, PhD, Zeta Mui, MPhil, Walter W. Yeung, PhD, Chit Chow, PhD, Mandy F. Yu, BSc, Olivia H. Chen, MD, PhD, Kit-Yee Wong, MPhil, Fuda Xie, MPhil, Yat Ming Lau, MBBS, Alfred S-L. Cheng, PhD, Wei Kang, PhD, Ka-Fai To, MBChB, Tony S. Mok, MD, Molly S.C. Li, MBBS

“…The HLA allele expression was correlated with tumor response, disease survival, and the occurrence of pneumonitis. Results: It was observed that the germline HLA-C homozygosity and HLA-DRB1∗13 expression were related to a worse progression-free survival and treatment response. …”
Get full text

The integration of hospital pharmacists into primary care settings in Shenzhen, China: a qualitative study by Zhiling Deng, Pengxiang Zhou, Yiting Lu, Zhengrong Li, Mi Yao, Yang Li, Chuan Zou, Haixin Li, Songtao Cai, Yi Guo, Yuling Tong, Yang Zhao, Zhijie Xu

“…Methods From May 1 to November 30, 2022, a qualitative study gathered key informant interviews and on-site observations at three community health centers (CHCs) in Shenzhen. …”
Get full text

Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India by Thomas Alexander, Jagdish S. Hiremath, Jitendra P. S. Swahney, Subhash Chandra, Peeyush Jain, Praveen Chandra, Nakul Sinha, T. Sashikanth, Yugandhar Bachhu, Anil Balachandran, Pathiyil Balagopalan Jayagopal, T. Govindan Unni, Tiny Nair, Kumaresan Kannan, Dorairaj Prabhakar, M. Chenniappan, Ajay U. Mahajan, Rajiv D. Karnik, Chandrashekhar K. Ponde, Prashant Advani, Idris Ahmed Khan, Brij Mohan Goyal, P. R. Vaidyanathan, Hiren Prajapati, Willem J. Verberk

“…ABSTRACT This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross‐sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. …”
Get full text

Genome‐Wide Analysis of the APETALA2/Ethylene‐Responsive Factor Gene Family in Carthamus tinctorius L. by Zheng‐Wei Tan, Dan‐Dan Lu, Yong‐Liang Yu, Lei Li, Lan‐Jie Xu, Wei Dong, Chun‐Ming Li, Qing Yang, Hui‐Zhen Liang

“…Cis‐acting elements in the promoters of the AP2/ERF genes were analyzed, and a degree of safflower specificity was observed among different safflower species. Tissue‐specific expression analysis showed that 23, 21, 15, and 9 genes were most abundantly expressed in the roots, leaves, flowers, and buds, respectively, while only eight genes were highly expressed in all tissues examined. …”
Get full text

Age and diet affect self-resilience of intestinal microbiome in mice by Chenyi Shao, Shenmin Chen, Huan Yang, Mufan Li, Yinhui Liu, Shu Wen, Jing Xiao, Li Tang

“…Microscopy was used to observe morphological changes in the mucosa. In addition, 16S rRNA sequencing and polymerase chain reaction-denaturing gradient gel electrophoresis were performed to identify the bacterial taxa and microbiome structure, respectively.ResultsThe diversity of the gut microbiota in infant mice was recovered by the sixth week, while relative abundance of Ruminococcaceae_UCG_014 was low and did not return to normal levels. …”
Get full text

Descriptive epidemiology of muscle-strengthening activities in Japanese middle-aged and older adults: the Hisayama Study by Jun Hata, Toshiharu Ninomiya, Takanari Kitazono, Takanori Honda, Mao Shibata, Satoko Sakata, Emi Oishi, Yoshihiko Furuta

“…The prevalence was generally comparable across subgroups of covariates, while an even lower prevalence was observed for some specific subpopulations, including individuals with diabetes and current smokers.Conclusions The prevalence of muscle-strengthening activities was estimated to be low in a general Japanese adult population. …”
Get full text

Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile by Luz María Medrano, Carlos Taxonera, Cristina González-Artacho, Virginia Pascual, María Gómez-García, Manuel Barreiro-de Acosta, José L. Pérez-Calle, Fernando Bermejo, Antonio López-Sanromán, Dolores Martín Arranz, Javier P. Gisbert, Juan Luis Mendoza, Javier Martín, Concepción Núñez, Elena Urcelay

“…Following genotyping, differences between responders and nonresponders to IFX were observed in haplotypes of the studied regions: S100A8-S100A9 (rs11205276*G/rs3014866*C/rs724781*C/rs3006488*A; P=0.05); G0S2 (rs4844486*A/rs1473683*T; P=0.15); TNFAIP6 (rs11677200*C/rs2342910*A/rs3755480*G/rs10432475*A; P=0.10); and IL11 (rs1126760*C/rs1042506*G; P=0.07). …”
Get full text

Clinical Presentation and Management Strategies in Intraorbital Foreign Bodies by Samreen Khanam, Ayushi Agarwal, Ruchi Goel, Neha Rathie, Akash Raut, Shweta Raghav, Sumit Kumar, Mohit Chhabra, Sonam Singh, Sushil Kumar

“…The authors present a retrospective, observational case study of seven patients, who presented with retained Intra-Orbital Foreign Bodies (IOrbFBs) following penetrating orbital injury at a tertiary eye hospital over a period of one year. …”
Get full text

A LASSO-derived clinical score to predict severe acute kidney injury in the cardiac surgery recovery unit: a large retrospective cohort study using the MIMIC database by Qi Guo, Jingjing Huang, Yuewei Li, Hongwei Li, Jingfeng Wang, Yong Xie, Tucheng Huang, Wanbing He, Wenyu Lv, Jieping Huang, Yangxin Chen

“…The calibration curves showed good agreement between the predictions and observations. Decision curve analysis demonstrated that the model could achieve a net benefit.Conclusion A clinical score built by using LASSO regression and logistic regression to screen multiple clinical risk factors was established to estimate the probability of severe AKI in CSRU patients. …”
Get full text

Oral condition of patients hospitalized for Covid-19 and its impact on quality of life by Lara Ribeiro Feitosa DUAILIBE, Laise Nunes RODRIGUES, Alanna Barros de ARRUDA, Robinson SABINO-SILVA, Rayenne Augusta Mota FERREIRA, Rudys Rodolfo de Jesus TAVAREZ, Cyrene Piazera Silva COSTA, Meire Coelho FERREIRA

“…The prevalence of COVID-19 was associated with gender (p = 0.038), with a higher incidence observed in male patients (61.9%). Moreover, there was a correlation between the hospitalization sector (p = 0.037) and the frequency of ICU admissions (53.7%). …”
Get full text

Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients by Vinod Umare, Vandana Pradhan, Milind Nadkar, Anjali Rajadhyaksha, Manisha Patwardhan, Kanjaksha K. Ghosh, Anita H. Nadkarni

“…Correlation between IL-6, TNF-α, and IL-1β serum levels and SLEDAI score was observed (r=0.20, r=0.27, and r=0.38, resp.). This study supports the role of these proinflammatory cytokines as inflammatory mediators in active stage of disease.…”
Get full text

“The impact of orthognathic surgery on articulation proficiency and speech intelligibility in skeletal Class III malocclusion: 18 months follow up” by Chaman Lal, Mukul Kumar, Sanjeev Verma, Vinay Kumar, Raj Kumar Verma, Satinder Pal Singh, Vidya Rattan, Sanjay Munjal

“…The total articulation errors decreased to zero at 9 months and no significant increase was observed till 18 months (P < 0.05). Speech intelligibility showed statistically non-significant improvement at any time interval. …”
Get full text

Feeding Behavior of Mice under Different Food Allocation Regimens by Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

“…No behavioral change was observed in comparison to the same food condition. …”
Get full text

Factors Associated with Medication Nonadherence among Hypertensives in Ghana and Nigeria by Vincent Boima, Adebowale Dele Ademola, Aina Olufemi Odusola, Francis Agyekum, Chibuike Eze Nwafor, Helen Cole, Babatunde L. Salako, Gbenga Ogedegbe, Bamidele O. Tayo

“…Poor BP control was observed in 69.7% and there was significant association between MNA and poor BP control (P=0.006). …”
Get full text

(-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms by Maria Elaine Cristina Araruna, Edvaldo Balbino Alves Júnior, Catarina Alves de Lima Serafim, Matheus Marley Bezerra Pessoa, Michelle Liz de Souza Pessôa, Vitória Pereira Alves, Marianna Vieira Sobral, Marcelo Sobral da Silva, Adriano Francisco Alves, Maria Carolina de Paiva Sousa, Aurigena Antunes Araújo, Leônia Maria Batista

“…Furthermore, increased immunostaining for zonula occludens 1 (ZO-1) was observed. Conclusions: (-)-fenchone has intestinal anti-inflammatory activity related to cytoprotection of the intestinal barrier, as well as antioxidant and immunomodulatory effects.…”
Get full text

Comparison of PM2.5 Chemical Compositions during Haze and Non-haze Days in a Heavy Industrial City in North China by Menghui Li, Liping Wu, Xiangyan Zhang, Xinwu Wang, Wenyu Bai, Jing Ming, Chunmei Geng, Wen Yang

“…Additionally, an elevated TE concentration was observed during the episode (exceeding the pre- and post-haze values by 54.70% and 31.98%, respectively), with crustal elements (K, Al, Ca, Si, Na, Fe and Mg), the most abundant elemental components, accounting for 88.64%. …”
Get full text

Effect of p-InGaN Cap Layer on Low-Resistance Contact to p-GaN: Carrier Transport Mechanism and Barrier Height Characteristics by Mohit Kumar, Laurent Xu, Timothée Labau, Jérôme Biscarrat, Simona Torrengo, Matthew Charles, Christophe Lecouvey, Aurélien Olivier, Joelle Zgheib, René Escoffier, Julien Buckley

“…A transition in current conduction mechanisms was also observed, shifting from recombination tunneling to space-charge-limited conduction across different voltage ranges. …”
Get full text

Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks by Cheng-long Jin, Sheng-lin Wang, Shuang Wang, Ya-nan Zhang, Wei-guang Xia, Chang Zhang, Xue-bing Huang, Kai-chao Li, Chun-tian Zheng, Wei Chen

“…Fortunately, medium supplemented with Ca channel-activator A23187 enhanced GC viability, antioxidant ability, tight junction ability, and increased cAMP concentration by improved cAMP metabolism, otherwise, the opposite changes were observed with Ca2+-chelating agent EGTA or Ca channel-inhibitor Verapamil supplementation. …”
Get full text

The link between sleep bruxism and oxidative stress based on a polysomnographic study by Michal Fulek, Weronika Frosztega, Mieszko Wieckiewicz, Anna Szymanska-Chabowska, Pawel Gac, Rafal Poreba, Grzegorz Mazur, Milena Sciskalska, Marta Kepinska, Adrian Martuszewski, Helena Martynowicz

“…In the investigated group of patients we observed the relationship between bruxism and the examined parameters: total antioxidant status (TAS), advanced protein products (AOPP) and thiobarbituric acid-reacting substances (TBARS). …”
Get full text

X-ray crystallographic diffraction study by whole powder pattern fitting (WPPF) method: Refinement of crystalline nanostructure polymorphs TiO2 by Md. Ashraful Alam, Shanawaz Ahmed, Raton Kumar Bishwas, Sabrina Mostofa, Shirin Akter Jahan

“…`This reduction in crystal structure defects and strain, alongside a smaller lattice volume improved stability and high crystalline anatase predominant (101) was observed at low temperatures.…”
Get full text