Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial by Jianli Zhao, Yunfang Yu, Wei Ren, Linxiaoxiao Ding, Yongjian Chen, Peng Yuan, Jian Yue, Yaping Yang, Guorong Zou, Tao Chen, Jie Chai, Li Zhang, Wenjing Wu, Yinduo Zeng, Xiujuan Gui, Yangyang Cai, Simin Luo, Zhongyu Yuan, Kang Zhang, Herui Yao, Ying Wang

“…The ORR was 32.5%, and the DCR was 97.5%. Responses were observed in patients with low tumor mutation burden and ZNF217 mutation. …”
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Attitude towards research and self-study in Cuban medical science students during COVID-19 by Juan Arturo Berenguer Gouarnaluses, Margarita Montes de Oca Carmenaty, Adrián Alejandro Vitón-Castillo, Elizabeth Melissa Tablada Podio, Maritza del Carmen Berenguer Gouarnaluses

“…<br /><strong>Method:</strong> multicenter, observational, descriptive and cross-sectional study in Cuban Medical Sciences students in the month of July 2020. …”
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Diagnosis and Treatment of Symptomatic Multiple Sacral Perineural Cysts-Technical Note by Masashi Tsujino, Akinobu Suzuki, Hidetomi Terai, Minori Kato, Hiromitsu Toyoda, Shinji Takahashi, Koji Tamai, Hiroaki Nakamura

“…At an average follow-up of 39 months, no recurrence was observed on the MRI. Conclusions: This case series reports the diagnostic and surgical methods for multiple sacral perineural cysts and their outcomes. …”
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AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volun... by Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar

“…Statistically significant association between the AKR1D1*36 allele and the increased IBP metabolism (low AUC0-t and 0–∞, high Cltot and short tmax values for both enantiomers) was observed in subjects carrying the CYP2C9 *1/*3 or CYP2C9*1/*1 genotype. …”
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The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study by Sînziana Oprițescu, Gabriela Viorela Nițescu, Mihaela Golumbeanu, Dora Boghițoiu, Elena Iuliana Ioniță, Diana-Andreea Ușurelu, Cristian Lucaci, Adriana Negoiță, Elena Moroșan

“…The aim of our research was to investigate and observe the clinical characteristics of children diagnosed with HSP and to explore the correlation between infectious diseases and HSP. …”
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A Candidate High-velocity Exoplanet System in the Galactic Bulge by Sean K. Terry, Jean-Philippe Beaulieu, David P. Bennett, Aparna Bhattacharya, Jon Hulberg, Macy J. Huston, Naoki Koshimoto, Joshua W. Blackman, Ian A. Bond, Andrew A. Cole, Jessica R. Lu, Clément Ranc, Natalia E. Rektsini, Aikaterini Vandorou

“…The ∼10 yr baseline between the microlensing event and the Keck follow-up observations allows us to detect the faint candidate lens host (star) at K = 22.3 mag and confirm the distant lens system interpretation. …”
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A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression by Xie-He Kong, Yue Zhao, Zhi Chen, Li Zeng, Rong Han, Xiao-Qing Dong, Xiao-Cong Guo, Zheng Shi, Guang Yang, Yan-Ting Yang, Dan Zhang, Xing-Tao Zhou, Xiao-Peng Ma

“…Adjunctive AAS compared with 0.01% A monotherapy slowed myopic progression in Chinese children by a statistically small amount, but had no effect on axial elongation and choroidal thickness during this 6-month observation. The trial is registered with ChiCTR1900021316.…”
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<i>Hermetia illucens</i> in the Process of Kitchen Waste Biodegradation: The Effect of Different Approaches to Waste Storage on the Microbiological Profile and Nutritional Paramete... by Zuzana Mašková, Juraj Medo, Eduard Kolesár, Dana Tančinová, Eva Ivanišová, Dana Urminská, Lukáš Hleba, Jana Urminská, Monika Mrvová, Zuzana Barboráková

“…In contrast, OS-T storage supported spoilage fungi (<i>Mucor</i>, <i>Rhizopus</i>) and elevated total aerobic counts (7.28 log CFU/g), indicating higher microbial risks. The observed trends in waste reduction and protein content most probably relate to differences in microbial profiles, as controlled cooling affected microbial dynamics, preserving substrate quality and supporting larval growth. …”
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A concise practical clinical guide to identifying spasticity in neurological shoulder dysfunction by Damon Hoad, Stephen Ashford, Stephen Ashford, Ganesh Bavikatte, Rachel Farrell, Rachel Farrell, Adrian Robertson, Jörg Wissel, Jörg Wissel

“…During an in-person meeting in March 2023, a consensus-building process was used to discuss four topics: a checklist/tool to identify shoulder involvement in upper limb spasticity, measurements/scales for assessing shoulder spasticity, ‘red flags’ for other conditions affecting the shoulder, and assessment limitations and practicalities.ResultsWhere there was full agreement on a topic, recommendations to overcome challenges for initial and ongoing assessment of shoulder spasticity and goal-setting were developed, and categorized as Posture, Purposeful activity and Pain (‘the three Ps’). Posture should be observed when sitting and walking, as appropriate for the person, and compared to published shoulder spasticity patterns. …”
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Reversed link between central pacific ENSO and Greenland–Barents sea ice by Yuxin Xie, Anmin Duan, Chao Zhang, Chuangzhi He, Qi Mao, Bingxian Liu

“…Here, we identify a reversed relationship between the autumn Central Pacific (CP)-type ENSO and the winter GBS SIC around the mid-1980s. Observational and model experiments demonstrate that, before the mid-1980s, CP ENSO triggered a double wave pattern propagating toward the Arctic, generating a positive geopotential height anomaly in the Arctic. …”
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Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009–2013 by Sachin Kumar, Shashi Khare, Bano Saidullah, Inderjeet Gandhoke, Hanu Ram, Supriya Singh, L. S. Chauhan, Arvind Rai

“…Mutations like K62R, K131Q, L147R, and A202P were observed for the first time in NS1 protein and their function remains to be determined.…”
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Exposure to Volatile Organic Compounds in Relation to Visceral Adiposity Index and Lipid Accumulation Product Among U.S. Adults: NHANES 2011–2018 by Ziyi Qian, Chenxu Dai, Siyan Chen, Linjie Yang, Xia Huo

“…Nonlinear relationships between certain mVOCs and the VAI or the LAP were also observed. In the WQS model, co-exposure to mVOCs was positively correlated with the VAI [β (95%CI): 0.084 (0.022, 0.147)]; CEMA (25.24%) was the major contributor. …”
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Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients by Kai Bartkowiak, Parinaz Mossahebi Mohammadi, Paula Nissen, Stefan Werner, David Agorku, Antje Andreas, Maria Geffken, Sven Peine, Karl Verpoort, Thomas M. Deutsch, Laura L. Michel, Andreas Schneeweiss, Verena Thewes, Andreas Trumpp, Olaf Hardt, Volkmar Müller, Sabine Riethdorf, Hartmut Schlüter, Klaus Pantel

“…This resulted in upregulation of ER-alpha, the tumor progression protein GRP78 (78-kDa glucose-regulated protein) and downregulation of the tumor suppressor protein PDCD4 (programmed cell death protein 4). We observed downregulation of SUSD2 and PDCD4 after hypoxia and simulation of re-oxygenation in the blood in MCF-7 and MDA-MB-468, while in CTC-ITB-01 SUSD2 levels remained unchanged, and only PDCD4 was downregulated under hypoxia. …”
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Clinical and Onychoscopy Patterns in Fingernail Onychomycosis—A Study by the International Dermoscopy Society Trichoscopy And Onychoscopy Task Force by Matilde Iorizzo, Bianca Maria Piraccini, Aurora Alessandrini, Francesca Bruni, Laura Vollono, Francesca Pampaloni, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio, Juan Jimenez-Cahue, Chander Grover, Zoe Apalla, Asmahne Souissi, Awatef Kelati, Eirini Kyrmanidou, Elizabeth Lazaridou, Michela Starace

“…Major clinical and onychoscopic features observed included onycholysis, subungual hyperkeratosis, leukonychia, chromonychia and absence of the cuticles. …”
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Clostridium Scindens Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling by Jintao Xiao, Yanliang Hou, Xingyang Luo, Yuhao Zhu, Wenhu Li, Bingbing Li, LinXiang Zhou, Xia Chen, Ying Guo, Xiaomei Zhang, Haiyue He, Xiaowei Liu

“…Similar effects are observed in mice treated with engineered Escherichia coli Nissle 1917 that are capable of expressing bile acid 7α‐dehydratas (BaiE) from C. scindens (EcN‐BaiE). …”
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The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized... by Aryan Tavakoli, Camellia Akhgarjand, Hastimansooreh Ansar, Hirad Houjaghani, Amirhossein Khormani, Kurosh Djafarian, Abdolrahman Rostamian, Mahsa Ranjbar, Gholamreza Mohammadi Farsani

“…No significant differences were observed in the other measured parameters between groups. …”
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Mechanical Thrombectomy in Medium Vessels Occlusion (MeVOs): An Institutional Experience with M2 Divisions of Middle Cerebral Artery by Bheru Dan Charan, Shailesh B Gaikwad, Savyasachi Jain, Ajay Garg, Leve Joseph Devarajan Sebastian, M V Padma Srivastava, Rohit Bhatia, Awadh Kishore Pandit, Shashank Sarad Kale

“…The successful recanalisation rate was 72.33%, with notably higher success observed in cases of inferior division occlusion. The primary outcome of our study was the mTICI recanalisation status, categorised as successful recanalisation (mTICI = 2b or mTICI = 3) and unsuccessful recanalisation (mTICI = 1 or mTICI = 2a) and mRS at 6 months. …”
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Candida albicans Fungaemia following Traumatic Urethral Catheterisation in a Paraplegic Patient with Diabetes Mellitus and Candiduria Treated by Caspofungin by Subramanian Vaidyanathan, Bakul Soni, Peter Hughes, Gordon Ramage, Leighann Sherry, Gurpreet Singh, Paul Mansour

“…Both isolates formed consistently high levels of biofilm formation in vitro as assessed using a biofilm biomass stain, and high levels of resistance to voriconazole were observed. Both amphotericin B and caspofungin showed good activity against the biofilms. …”
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Comprehensive analysis of ESCRT transcriptome-associated signatures and identification of the regulatory role of LMO7-AS1 in osteosarcoma by Shibing Zhao, Dasheng Tian, Fei Huang, Lei Wang, Jinhao Cheng, Zhitao He, Qitian Shen, Shuai Liang, Deliang Gong, Jun Liu, Chengfeng Yi, Chun Zhang, Erbao Bian, Juehua Jing, Tao Wang

“…Abstract Osteosarcoma (OS) is a commonly observed malignant tumor in orthopedics that has a very poor prognosis. …”
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Urbanization enhances consumer protist-driven ARGs dissemination in riverine ecosystems by Bob Adyari, Lanping Zhang, Ana Maravić, Jiaxin Chen, Laiyi Li, Mahmoud Gad, Chang-Ping Yu, Anyi Hu

“…A higher total abundance of ARGs and a greater number of co-shared ARGs between pathogen and non-pathogen bacteria were observed in the more urbanized western tributary. Structural equation modeling revealed that consumer protist-bacteria and algae-bacteria cohesions predominantly influenced the resistome in the western and northern tributaries, respectively. …”
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