Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study by Umberto Vespasiani-Gentilucci, Chiara Dell’Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati, Paolo Gallo, Francesco Valentini, Franca Del Nonno, Davide Rosati, Sergio Morini, Raffaele Antonelli-Incalzi, Antonio Picardi

“…No differences were observed for SOD2 and LPIN1 SNPs. When compared to a score of 0, a score of 1-2 quadrupled, and a score of 3-4 increased 20-fold the risk of noncirrhotic NAFLD; a score of 3-4 quadrupled the risk of NASH-cirrhosis. …”
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Metagenomic and Transcriptomic Analysis Reveals Crosstalk Between Intratumor Mycobiome and Hosts in Early‐Stage Nonsmoking Lung Adenocarcinoma Patients by Yaohui Sun, Zhiming Gan, Shijiancong Liu, Sheng Zhang, Wei Zhong, Jian Liu, Xiuting Huang, Wei He, Hongcheng Zhong, Qingdong Cao

“…Concurrently, microbial functional analysis revealed significant alterations associated with genes such as ribosomal proteins and histones. We observed correlations between Yarrowia lipolytica, Saccharomyces paradoxus, and tumor‐infiltrating immune cells (TIICs), and identified a strong association (|rho| > 0.7) between S. paradoxus and 14 transcription factors. …”
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THE INFLUENCE OF SELF-EFFICACY AND JOB STRESS TOWARD JOB BURNOUT AT A PACKAGING COMPANY IN SURABAYA by Hayyu Fathil Hasanah, Noeroel Widajati, Indriati Paskarini, Tri Martiana, Aisy Rahmania

“…Method: It was an analytical observational research with a cross-sectional approach. …”
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Role of artificial intelligence in imaging and endoscopy for the diagnosis, monitoring and prognostication of inflammatory bowel disease: a scoping review protocol by Mallory Chavannes, Bram Verstockt, Mariangela Allocca, David T Rubin, Kerri Novak, Lynn Kysh, Noa Krugliak Cleveland, Michael Todd Dolinger, Tom S Robbins, Shintaro Sagami

“…We will include both observational studies and clinical trials. Study characteristics will be extracted using a data extraction form. …”
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Income-related inequalities in the prevalence of dental pain intensity in adults: gender differences by Carolina Veloso Lima, Alanna Barros de Arruda, Mayara dos Santos Noronha, Aline Araujo Sampaio, Marise Fagundes Silveira, Andrea Maria Eleuterio de Barros Lima Martins, Raquel Conceição Ferreira, Aline Netto de Godoy, Daniela Marques da Silva Sousa, Patrick Pereira Garcia, Cyrene Piazera Silva Costa, João Gabriel Silva Souza, Bárbara Emanoele Costa Oliveira

“…The same pattern was observed when stratified by gender, but it was not statistically significant.ConclusionThus, the contexts of income inequalities can contribute to more severe dental pain intensity among adults. …”
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Identification of dominant species of submerged vegetation based on Sentinel-2 red-edge band: A case study of Lake Erhai, China by Xiaohan Wang, Yu Zhang, Yanhong Yu, Yunmei Li, Heng Lyu, Junda Li, Xiaolan Cai, Xianzhang Dong, Gaolun Wang, Jianzhong Li, Mengmeng Song, Lanlan Chen

“…The correlation coefficient reached 0.98, indicating a pronounced influence, with WT contributing substantively to the observed variance in SAV, accounting for 63.3%. The proposed method highlights the potential of Sentinel-2 red-edge bands for ecological monitoring and management of SAV, with implications for broader environmental applications.…”
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Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma by Giuseppina De Filpo, Elisa Contini, Viola Serio, Andrea Valeri, Massimiliano Chetta, Daniele Guasti, Daniele Bani, Massimo Mannelli, Elena Rapizzi, Michaela Luconi, Mario Maggi, Tonino Ercolino, Letizia Canu

“…This mutation was also associated with an increased number of mitochondria through the electron microscopy compared with wild-type tissues as suggestive for mitochondria neoformation compensatory to the mitochondrial autophagic figures observed. Our results underline the usefulness of next-generation sequencing in the presence of multiple tumor predisposition genes and how, at the same time, its use may result challenging for the clinicians. …”
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Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction by Longxiang Su, Lin Feng, Qing Song, Hongjun Kang, Xingang Zhang, Zhixin Liang, Yanhong Jia, Dan Feng, Changting Liu, Lixin Xie

“…Although PCT and sTREM-1 are good markers to identify severity, sTREM-1 is more reliable, which proved to be a risk factor related to sepsis. During a 14-day observation, sCD163, sTREM-1, PCT, and SOFA scores continued to climb among nonsurvivors, while their WBC and CRP went down. …”
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Effect of Elicitors as Stimulating Substances on Sensory Quality Traits in Color Sweet Bell Pepper (Capsicum annuum L. cv. Fascinato and Orangela) Grown under Greenhouse Conditions by Jimenez-Garcia Sandra N., Vázquez-Cruz Moisés A., Miranda-Lopez Rita, Garcia-Mier Lina, Guevara-González Ramon G., Feregrino-Perez Ana A.

“…A strong correlation between varieties and treatments 2 (36 mM H2O2) and 4 (0.1 mM SA and 36 mM H2O2) with PC1 was observed. Treatments 2 and 4 were related to changes in aroma and flavor traits. …”
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Placental Vimentin Expression in Preeclampsia and Gestational Diabetes Mellitus by Fırat Asir, Suleyman Cemil Oglak, Tugcan Korak, Fatih Tas, Mehmet Yilmaz, Fikri Erdemci, Firat Sahin, Hayat Ayaz, Emine Zeynep Yilmaz, Gokhan Bolluk

“…Bioinformatic analysis showed that the AGE-RAGE signaling pathway and cancer-related pathways were mainly observed in Vimentin-associated pathways, which finally activate inflammatory pathways in both preeclampsia and GDM. …”
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Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study by Jijo Francis, Honey Sebastian, Saley Daniel, Leyon Varghese, Sareena Gilvaz, Ragitha Thenkattil Sankarankutty, Siji Susan George, Pulikkottil Raphael Varghese, Suresh Kumar Raveendran

“…Since no study was reported from the Indian population, we aimed to explore theassociation of the MCP-1 -2518A/G polymorphism (rs1024611) with PCOS.Materials and Methods: In this case-control study, to analyse the distribution and association of rs1024611 with PCOS,polymerase chain reaction-fragment length polymorphism (PCR-RFLP) analysis was carried out in 202 patients whoexhibited PCOS from menarche onwards or with higher severity of symptoms and 122 age-matched controls.Results: In our study, no significant correlation was observed in rs1024611 polymorphism with PCOS patients incomparison with control. …”
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Chemical Changes of Enamel Produced by Sodium Fluoride, Hydroxyapatite, Er:YAG Laser, and Combined Treatments by Alma Yadira Ceballos-Jiménez, Laura Emma Rodríguez-Vilchis, Rosalía Contreras-Bulnes, Jesús Arenas Alatorre, Rogelio José Scougall-Vilchis, Ulises Velazquez-Enriquez, María de los Angeles Moyaho-Bernal

“…After treatment, a significant increase in F at% was observed in the NaF group (2.71 ± 1.41). The irradiated groups showed significant increases in Ca and P at% and the Ca/P ratio. …”
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Explaining the γγ + X excesses at ≈151.5 GeV via the Drell-Yan production of a Higgs triplet by Saiyad Ashanujjaman, Sumit Banik, Guglielmo Coloretti, Andreas Crivellin, Siddharth P. Maharathy, Bruce Mellado

“…However, because no ZZ signal at this mass has been observed, this implies that the new boson could be the neutral component of an SU(2)L triplet with zero hypercharge. …”
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Circulation of Respiratory Syncytial Virus (RSV) in Poland Between Seasons of 2009/2010 and 2022/2023 Based on SENTINEL System by Karol Szymański, Anna Poznańska, Katarzyna Kondratiuk, Ewelina Hallmann, Katarzyna Łuniewska, Aleksander Masny, Lidia B. Brydak

“…Data indicate that RSV is predominantly diagnosed in pediatric populations; however, since the 2017/2018 season, there has been an increase in RSV diagnoses among other age groups. Given the observed shifts in the seasonal peak following the SARS-CoV-2 pandemic, ongoing surveillance is required to ascertain whether these changes are permanent or transient.…”
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Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: R... by John Porter, Donald K. Bowden, Marina Economou, Jacques Troncy, Arnold Ganser, Dany Habr, Nicolas Martin, Adam Gater, Diana Rofail, Linda Abetz-Webb, Helen Lau, Maria Domenica Cappellini

“…Low levels of treatment satisfaction, adherence, and persistence were also observed. HRQOL improved following treatment with deferasirox, particularly among β-thalassemia patients. …”
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Agro-Morphological Characterization of Kenyan Slender Leaf (Crotalaria brevidens and C. ochroleuca) Accessions by Fridah A. Mwakha, Bernard M. Gichimu, Johnstone O. Neondo, Peter K. Kamau, Eddy O. Odari, Joshua K. Muli, Nancy L. M. Budambula

“…This study sets the basis for genetic improvement of slender leaf in Kenya since the observed diversity can be exploited in selection for intraspecific and interspecific hybridization.…”
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Are deprivation-specific cancer survival patterns similar according to individual-based and area-based measures? A cohort study of patients diagnosed with five malignancies in Engl... by Lucy Elliss-Brookes, Aurélien Belot, Matthew Baker, Fiona C Ingleby, Laura M Woods, Iain M Atherton

“…Objective To investigate if measured inequalities in cancer survival differ when using individual-based (‘person’) compared with area-based (‘place’) measures of deprivation for three socioeconomic dimensions: income, deprivation and occupation.Design Cohort study.Setting Data from the Office for National Statistics Longitudinal Study of England and Wales, UK, linked to the National Cancer Registration Database.Participants Patients diagnosed with cancers of the colorectum, breast, prostate, bladder or with non-Hodgkin’s lymphoma during the period 2008–2016.Primary and secondary outcome measures Differentials in net survival between groups defined by individual wage, occupation and education compared with those obtained from corresponding area-level metrics using the English and Welsh Indices of Multiple Deprivation.Results Survival was negatively associated with area-based deprivation irrespective of the type analysed, although a trend from least to most deprived was not always observed. Socioeconomic differences were present according to individually-measured socioeconomic groups although there was an absence of a consistent ‘gradient’ in survival. …”
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Physical education curriculum systematizing based on action research: a collaborative network between teacher-researchers from public schools in Quixadá — Ceará, Brazil by Rener Victor Oliveira de Souza, Maurício Teodoro de Souza, Luciano Nascimento Corsino, Willian Lazaretti da Conceição, Carla Ulasowicz, Luciana Venâncio, Luciana Venâncio, Luiz Sanches Neto, Luiz Sanches Neto

“…Our qualitative itinerary has action research as a method of intervention, including class observations, group meetings and field diary. Data has been analyzed through thematic analysis, characterizing a collaborative network between participants. …”
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Frequent Glacial Hazard Deformation Detection Based on POT-SBAS InSAR in the Sedongpu Basin in the Himalayan Region by Haoliang Li, Yinghui Yang, Xiujun Dong, Qiang Xu, Pengfei Li, Jingjing Zhao, Qiang Chen, Jyr-Ching Hu

“…To accurately monitor and research these glacier hazards, Sentinel-1 Synthetic Aperture Radar images observed between 2014 and 2022 were collected to extract surface motion using SBAS-POT technology. …”
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Adaptive Immune Response to Model Antigens Is Impaired in Murine Leukocyte-Adhesion Deficiency-1 Revealing Elevated Activation Thresholds In Vivo by Thorsten Peters, Wilhelm Bloch, Oliver Pabst, Claudia Wickenhauser, Claudia Uthoff-Hachenberg, Susanne V. Schmidt, Georg Varga, Stephan Grabbe, Daniel Kess, Tsvetelina Oreshkova, Anca Sindrilaru, Klaus Addicks, Reinhold Förster, Werner Müller, Karin Scharffetter-Kochanek

“…In contrast, robust hapten- and protein-specific immune responses were observed after immunization with highly haptenated antigens such as (4-hydroxy-3-nitrophenyl)21 acetyl chicken γ globulin (NP21-CG), even though regularly structured germinal centers with specificity for the defined antigens/haptens in CD18−/− mice remained absent. …”
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