The SGLT-2 Inhibitors and their Role in the Treatment of Heart Failure - A Review of Literature by Silvia Ciraolo, Agnieszka Kulczycka-Rowicka, Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec

“…While several mechanisms have been proposed, further research is necessary to rule which are most critical. The benefits observed with SGLT2 inhibitors stress their potential as a cornerstone in HF management, regardless of a patient’s diabetes status.       …”
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Analysis of the High-Performance Liquid Chromatography Fingerprints and Quantitative Analysis of Multicomponents by Single Marker of Products of Fermented Cordyceps sinensis by Li-hua Chen, Yao Wu, Yong-mei Guan, Chen Jin, Wei-feng Zhu, Ming Yang

“…No significant difference between the two methods was observed. In conclusion, the method established herein was efficient, successful in identifying the products of fermented Cordyceps sinensis, and scientifically valid to be applicable in the systematic quality control of fermented Cordyceps sinensis products.…”
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Vegetation Dynamics and Sensitivity Responds to Climate Change in the Upstream of the Yellow River, China by XiangYu Lan, RuoWei Li, Xin Wang, TianCai Zhou, YunHui Li, JieJi Duo, Jian Sun

“…Our results indicated that the higher and lower NDVI were observed in the western and eastern URYR, respectively, and that the NDVI in more than 89% area of the URYR experienced a positive change during the past 30 years. …”
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The Optimization of Biosilica and Humic Acid to Increase Soil Nutrient Availability and Nutrient Uptake in Rice Plant in Sandy Soil by Wanti Mindari, M. Ghufron Chakim, Bakti Wisnu Widjajani, Purnomo Edi Sasongko, Haidar Fari Aditya, Ahmad Mustapha Mohamad Pazi, Seca Gandaseca

“…The impact of the treatment was observed 90 days after application on the parameters of soil pH, organic C, total N, and exchangeable K. …”
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Effect of ectoparasite Ichthyophthirius multifiliis on the histopathology and gill and gut microbiota of goldfish (Carassius auratus) by Xialian Bu, Xialian Bu, Xianqi Peng, Xianqi Peng, Lei Huang, Lei Huang, Yu Zhao, Jinbiao Jiao, Jinbiao Jiao, Jian Zhu, Jing Chen, Jing Chen, Xiaohong Huang, Xiaohong Huang, Aqin Zheng, Aqin Zheng, Huantao Qu, Jiayun Yao, Jiayun Yao

“…Meanwhile, 16S rRNA gene amplicon sequencing was conducted to analyze the difference of gill and gut microbiota between I. multifiliis-infected and uninfected goldfish.ResultsHistopathological examination revealed that I. multifiliis has induced significant damage to the gills of goldfish, characterized by lamellae fusion, cell hyperplasia, cell hyperaemia, inflammatory infiltration, necrosis and desquamation. 16S rRNA gene sequencing result showed that alpha and beta diversity of gill microbiota was significantly reduced in the I. multifiliis-infected group, while no significant changes were observed in gut microbiota. Genus Candidatus Megaira exhibited the highest relative abundance in the I. multifiliis-infected group. …”
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Response characterization on the microstructure, and mechanical and corrosion behavior of clad rebars of different weld materials by Zecheng Zhuang, Xuehai Qian, Lei Zeng, Weiping Lu, Zhen Li, Yong Xiang

“…The microstructure of the welded joints of four different types of welding metals was observed using a metallographic microscope, the hardness distribution of the welded joints was measured using a Vickers hardness tester, and the corrosion resistance and corrosion behavior of four types of welding materials were investigated through electrochemical corrosion experiments using a scanning electron microscope (SEM). …”
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Assessing the feasibility of a bowel management program for patients with neurogenic bowel function after spinal cord injury by Jiayi Feng, Jiayi Feng, Jiayi Feng, Xingyi Mu, Xingyi Mu, Lei Xu, Lei Xu, Tongxia Xia, Tongxia Xia

“…The program is based on evidence-based nursing, expert meeting and pre-experiment construction, the construction process is standardized and scientific, and the content is comprehensive, mainly includes 4 dimensions of bowel assessment, bowel intervention, assessment indices and discharge follow-up, which were carried out at the time of admission (T1), discharge (T2) and 1 month after discharge (T3) of patients in the experimental group, while the control group used routine orthopedic bowel management, and bowel function indices, quality of life and laboratory tests were used as outcome indices, and differences in the observed indices of patients in the two groups were compared to validate the effect of the program. …”
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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

“…Furthermore, we leveraged a novel 15N-Met labeling technique of the antibody to directly observe structural perturbations at the oxidation sites. …”
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Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience by Alexandra F. Bonthrone, Manuel Blesa Cábez, A. David Edwards, Jo V. Hajnal, Serena J. Counsell, James P. Boardman

“…Before harmonization, large cohort differences were observed. Harmonization removed all voxel-wise differences from MD maps and all metric means and histogram widths, however small voxel-wise differences (<1.5 % of voxels) remained in FA, AD and RD. …”
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Microstructure and Mechanical Properties of High-Entropy Alloy FeCoNiCr(X) Produced by Laser Directed Energy Deposition Process: Effect of Compositional Changes by Ekaterina Kovalenko, Igor Krasanov, Ekaterina Valdaytseva, Stanislav Stankevich, Olga Klimova-Korsmik, Marina Gushchina

“…Fine-grained and dendrite structures were observed. Cu-element is mainly found in cracks. The HEA FeCoNiCrCu alloy was compared with another HEA FeCoCrMnNi, successfully obtained by the same L-DED technology. …”
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Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC by Yulin Zhang, Yixu Wang, Jilin Peng, Kun Zhao, Ling Li, Yuan Zhang, Ziyu Zhai, Sijie Yuan, Shichao Li, Shichao Li, Shichao Li, Fanglei Ye, Le Wang

“…Gene Expression Omnibus (GEO), normal and tumor tissue microarrays (TMA), and tumor tissue samples from patients with HNSCC were observed that a high level of HNRNPC expression was closely linked to a poor prognosis among patients. …”
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Lack of Association of C677T Methylenetetrahydrofolate Reductase Polymorphism with Breast Cancer Risk in Mali by Brehima Diakite, Yaya Kassogue, Mamoudou Maiga, Guimogo Dolo, Oumar Kassogue, Jane L. Holl, Brian Joyce, Jun Wang, Kadidiatou Cisse, Fousseyni Diarra, Mamadou L. Keita, Cheick B. Traore, Bakarou Kamate, Sidi B. Sissoko, Bourama Coulibaly, Adama S. Sissoko, Drissa Traore, Fatoumata M. Sidibe, Sekou Bah, Ibrahim Teguete, Madani Ly, Sellama Nadifi, Hind Dehbi, Kyeezu Kim, Robert Murphy, Lifang Hou

“…We found no statistical association between the C677T polymorphism and breast cancer risk for the codominant models CT and TT p>0.05. The same trend was observed when the analysis was extended to other genetic models, including dominant (p = 0.50), recessive (p = 0.87), and additive (p = 0.50) models. …”
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Feasibility, acceptability, and perceived benefits of a creative arts intervention for elementary school children living with speech, language and communication disorders by T. Léger-Goodes, C. M. Herba, C. M. Herba, Z. Moula, A. Mendrek, A. Mendrek, K. Hurtubise, J. Piché, M. Gilbert, M. Bernier, K. Simons, N. Bélanger, J. Smith, C. Malboeuf-Hurtubise, C. Malboeuf-Hurtubise

“…Teachers gained deeper insights into their students, fostering positive classroom relationships. Observational data triangulated these findings.ConclusionThis innovative project suggests that art-based interventions can potentially benefit students’ emotional expression, but further experimental studies are needed to substantiate these effects.…”
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Gaia-4b and 5b: Radial Velocity Confirmation of Gaia Astrometric Orbital Solutions Reveal a Massive Planet and a Brown Dwarf Orbiting Low-mass Stars by Gudmundur Stefánsson, Suvrath Mahadevan, Joshua N. Winn, Marcus L. Marcussen, Shubham Kanodia, Simon Albrecht, Evan Fitzmaurice, Onė Mikulskytė, Caleb I. Cañas, Juan I. Espinoza-Retamal, Yiri Zwart, Daniel M. Krolikowski, Andrew Hotnisky, Paul Robertson, Jaime A. Alvarado-Montes, Chad F. Bender, Cullen H. Blake, J. R. Callingham, William D. Cochran, Megan Delamer, Scott A. Diddams, Jiayin Dong, Rachel B. Fernandes, Mark R. Giovinazzi, Samuel Halverson, Jessica Libby-Roberts, Sarah E. Logsdon, Michael W. McElwain, Joe P. Ninan, Jayadev Rajagopal, Varghese Reji, Arpita Roy, Christian Schwab, Jason T. Wright

“…Here we present RV follow-up observations of 28 M and K stars with candidate astrometric substellar companions, which led to the confirmation of two systems, Gaia-4b and Gaia-5b, identification of five systems that are single lined but require additional data to confirm as substellar companions, and the refutation of 21 systems as stellar binaries. …”
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A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism by Xiao He, Fang Xie, Ying Nie, Xuefeng Wang, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun

“…These genes included FABP4, FABP5, CPT1A, and UBC, consistent with the high levels of acylcarnitines observed in the longissimus dorsi muscles of the Lantang breed, as determined by lipidomic analysis. …”
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The Role of Prenatal Exposure to Lead and Manganese in Child Cognitive Neurodevelopment at 18 Months: The Results of the Italian PHIME Cohort by Valentina Rosolen, Fabiano Barbiero, Marika Mariuz, Maria Parpinel, Luca Ronfani, Liza Vecchi Brumatti, Maura Bin, Luigi Castriotta, Francesca Valent, D’Anna Latesha Little, Janja Snoj Tratnik, Darja Mazej, Ingrid Falnoga, Milena Horvat, Fabio Barbone

“…No clear effects were observed in girls or the entire cohort at these levels of exposure. …”
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Anther transcriptomes in cold-tolerant rice cultivars tend to show insensitive responses by Koichi Yamamori, Seiya Ishiguro, Kei Ogasawara, Kayyis Muayadah Lubba, Kaien Fujino, Kazumitsu Onishi, Yutaka Sato, Yuji Kishima

“…When examining the overall expression patterns in anthers at low temperature, the cold-tolerant lines tended to have relatively few highly expressed genes, and the expression levels of ribosome-related genes tended to be lower in cold-tolerant lines than in cold-sensitive lines. Importantly, we observed these different expression patterns between the cold-tolerant and -sensitive lines regardless of whether cold stress had been applied. …”
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Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in... by Marta D. Van Loan, Nancy L. Keim, Sean H. Adams, Elaine Souza, Leslie R. Woodhouse, Anthony Thomas, Megan Witbracht, Erik R. Gertz, Brian Piccolo, Andrew A. Bremer, Michael Spurlock

“…No diet differences were observed in weight, fat, or IAAT loss; nor SAT mRNA expression of inflammation, circulating cytokines, fasting lipids, glucose, or insulin. …”
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Neurodevelopmental outcomes of very low birth weight preterm infants during the COVID-19 pandemic by Yen-Chen Lin, Hung-Yang Chang, Chia-Huei Chen, Jui-Hsing Chang, Wai-Tim Jim, Chyong-Hsin Hsu, Chia-Ying Lin, Yu-Xiang Song, Cheng-Wei Chen, Tzu-Yu Liu, Mary Hsin-Ju Ko

“…No significant differences were observed in the composite cognitive, language, and motor scores between two groups. …”
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Is the benefit of sequential 5-fluorouracil and daylight photodynamic therapy versus daylight photodynamic therapy alone sustained over time? – 12-month follow-up of a randomized c... by Stine Regin Wiegell, Gabriella Fredman, Flemming Andersen, Peter Bjerring, Uwe Paasch, Merete Haedersdal

“…Background: Since recurrences and new AKs commonly are observed after treatment long-term effects of field-directed therapies for AKs are crucial. …”
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