Length of stay after colorectal surgery in Italy: the gap between “fit for” and “actual” discharge in a prospective cohort of 4529 cases by Lorenzo Pandolfini, Duccio Conti, Piercarlo Ballo, Silvia Rollo, Alessandro Falsetto, Gian Matteo Paroli, Paolo Ciano, Michele Benedetti, Leonardo Antonio Montemurro, Giacomo Ruffo, Massimo Giuseppe Viola, Felice Borghi, Gianandrea Baldazzi, Massimo Basti, Pierluigi Marini, Mariano Fortunato Armellino, Vincenzo Bottino, Giovanni Ciaccio, Alessandro Carrara, Gianluca Guercioni, Marco Scatizzi, Marco Catarci, the Italian ColoRectal Anastomotic Leakage (iCral) study group

“…Abstract Background It is common to observe a gap between the day on which the discharge criteria are reached and the actual day of discharge after colorectal surgery. …”
Get full text

J Point and ST Elevation Resembling Brugada: A Marker of Mortality in Methanol Toxicity by Mohammad Hossein Nikoo, Alireza Estedal, Kiana Khatami, Maryam Pakfetrat, Alireza Arjangzadeh, Shahrokh Sadeghi Boogar, Sina Danesh, Seyed Taghi Heydari

“…Results. The ECG (BrP) was observed in a total of 20 (5.6%) patients. Its presence was associated with increased mortality, Glasgow coma scale score <3, and blood sugar levels and was inversely associated with PH, O2 saturation, and calcium levels (P<0.05). …”
Get full text

Pulp stones and kidney stones-related gene: An investigation of single nucleotide polymorphisms in the gene encoding parathyroid hormone by Prescila Mota de Oliveira Kublitski, Bruna de Souza Romano, Vania Gomes Moraes, Manoel Damião Sousa-Neto, Lívia Azeredo Alves Antunes, Erika Calvano Küchler, Leonardo Santos Antunes, João Armando Brancher, Edgard Michel-Crosato, Marilisa Carneiro Leão Gabardo

“…No statistically significant association was observed between the groups regarding the presence of KS. …”
Get full text

Colonic Wall Thickening Reported in Abdominal CT: Does It Always Imply Malignancy? by A. Akbas, H. Bakir, M. F. Dasiran, H. Dagmura, E. Daldal, Z. Ozsoy, Z. Ozmen, O. Demir, I. Okan

“…In this study, we aimed to examine the effect of the age, hemoglobin (Hb), albumin, neutrophil lymphocyte ratio (NLR), thrombocyte lymphocyte ratio (PLR), and mean platelet values (MPV) on the separation of benign and malignant diseases in patients with suspected colon wall thickness (CWT) observed in abdominal computed tomography (CT) examination. …”
Get full text

Enhanced energy storage in electric double-layer capacitors using boron-doped graphene and upcycled carbon quantum dots derived from spent coffee grounds as electrode materials by Grishika Arora, Nuur Syahidah Sabran, Bo Zhang, H.K. Jun

“…At a scan rate of 5 mV/s, the BG-CQD EDLC device achieved a specific capacitance of 43.5 F/g, higher than the 3.61 F/g observed in EDLC with electrode material consists of boron-doped graphene alone. …”
Get full text

iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study by Peter D. Westenskow, Felicitas Bucher, Stephen Bravo, Toshihide Kurihara, Daniel Feitelberg, Liliana P. Paris, Edith Aguilar, Jonathan H. Lin, Martin Friedlander

“…In this follow-up study, we longitudinally monitored the same implanted iPS-RPE, in the same animals. We observed no gross abnormalities in the eyes, livers, spleens, brains, and blood in aging rats with iPSC-RPE grafts. iPS-RPE cells that integrated into the subretinal space outlived the photoreceptors and survived for as long as 2 1/2 years while nonintegrating RPE cells were ingested by host macrophages. …”
Get full text

The Effect of Land Cover Change on Soil Properties around Kibale National Park in South Western Uganda by J. G. M. Majaliwa, R. Twongyirwe, R. Nyenje, M. Oluka, B. Ongom, J. Sirike, D. Mfitumukiza, E. Azanga, R. Natumanya, R. Mwerera, B. Barasa

“…Similar findings were observed by Wang et al. (2006) in commercial tea plantations in China that received nitrogen fertilizers.…”
Get full text

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells by Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee

“…Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We observe that approximately 1–5% of CD4+ T cells from the blood of people living with HIV-1 exhibit over-duplicated centrioles, suggesting that centrosome amplification underlies the development of HIV-1-associated cancers by driving aneuploidy. …”
Get full text

Triiodothyronine treatment in mice improves stroke outcome and reduces blood–brain barrier damage by Daniel Ullrich, Dagmar Führer, Heike Heuer, Steffen Mayerl, Steffen Haupeltshofer, Linda-Isabell Schmitt, Markus Leo, Rebecca D Szepanowski, Tim Hagenacker, Markus Schwaninger, Christoph Kleinschnitz, Friederike Langhauser

“…Results: We demonstrated a dose-dependent protective effect of T3 reducing infarct volumes with an optimal T3 dosage of 25 μg/kg. In addition, we observed a time-dependent effectiveness that was most profound when T3 was administered 1 h after tMCAO (P < 0.001), with a gradual reduction in efficacy at 4.5 h (P = 0.066), and no reduction in infarct volumes when T3 was injected with an 8-h delay (P > 0.999). …”
Get full text

Distinct relative abundances in pathogens detected in mechanically ventilated patients with suspected pneumonia in the intensive care unit at King Abdulaziz University Hospital by Haifa Algethamy, Diyaa H. Bokhary, Ibrahim Abushoshah, Abdulrahman A. Alalyani, Maan K. Baamer, Dalya M. Attallah, Ruba M. Alotaibi, Shehla N. Amin, Shaza A. Mass, Nisreen R. Tashkandy

“…K. pneumoniae and S. maltophilia were the most common taxa detected in the samples, although some variations in microbial composition were observed. We conclude that Intensive Care Units exhibit distinct patterns of microbial colonization.…”
Get full text

Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single‐Gene BDH1... by A. A. Kashevarova, M. E. Lopatkina, O. Yu. Vasilyeva, D. A. Fedotov, A. D. Lobanov, E. A. Fonova, I. Z. Zhalsanova, A. A. Zarubin, O. A. Salyukova, E. O. Belyaeva, V. V. Petrova, E. G. Ravzhaeva, A. A. Agafonova, A. D. Cheremnykh, N. B. Torkhova, S. L. Vovk, I. N. Lebedev

“…Most of the phenotypes were observed in both groups but were significantly less common among individuals with 3q29 duplications. …”
Get full text

The first multiple center prospective study of rhFSH CTP in patients undergoing assisted reproductive technology in China by Longmei Wu, Huayan Yin, Lingfang Guan, Guanjian Li, Junqiang Zhang, Qunshan Shen, Xiaoqing Ni, Chao Wang, Tianjuan Wang, Hao Geng, Chuan Xu, Yunxia Cao, Xiaojin He, Bing Song

“…In the rhFSH-CTP group, no cases of severe OHSS were observed, which was a significant improvement compared to the 1.4% incidence in the rhFSH group. …”
Get full text

Diversity and Conservation of Carnivores in Saudi Arabia by Ali Al Ahmari, Farah Neyaz, Faisal Shuraim, Abdul Rahman Al Ghamdi, Ahmad Al Boug, Mesfer Alhlafi, Sharif Al Jbour, Francesco M. Angelici, Saleh Alaamri, Khalid Al Masabi, Zuhair Sami Amr

“…The striped hyena was the most recorded species in 13 locations, with the highest number of observations made at Raydah Protected Area, followed by the red fox and the Arabian wolf. …”
Get full text

Safety and Biodistribution of an Autologous Bone Marrow-Derived Mononuclear Cell Infusion into Renal Arteries in Patients with Focal Segmental Glomerulosclerosis: A Phase 1 Study by Bruno Freire Botelho, André Luis Barreira, Marcio Gomes Filippo, Karina Dutra Asensi, Lanuza A P Faccioli, Anna Beatriz dos Santos Salgado, Elizabeth Figueiredo de Salles, Carlos Eduardo Cruz Marques, Pedro Leme Silva, Regina Coeli dos Santos Goldenberg, Angelo Maiolino, Bianca Gutfilen, Sergio Augusto Lopes de Souza, Maurilo Leite Junior, Marcelo Marcos Morales

“…A transient increase in creatinine was observed after the cell therapy, with improvement on day 30. 99mTc-BMDMCs were detected in both kidneys and counts were higher after 2 hr compared with 24 hr. …”
Get full text

Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling by Katherine A. Kentistou, Brandon E. M. Lim, Lena R. Kaisinger, Valgerdur Steinthorsdottir, Luke N. Sharp, Kashyap A. Patel, Vinicius Tragante, Gareth Hawkes, Eugene J. Gardner, Thorhildur Olafsdottir, Andrew R. Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R. Day, Susan E. Ozanne, Andrew T. Hattersley, Stephen O’Rahilly, Kari Stefansson, Ken K. Ong, Robin N. Beaumont, John R. B. Perry, Rachel M. Freathy

“…We identify 9 genes; 5 with fetal-only effects on birth weight, 1 with maternal-only effects, 3 with both, and observe directionally concordant associations in an independent sample. …”
Get full text

Study of Bone Marrow Mesenchymal and Tendon-Derived Stem Cells Transplantation on the Regenerating Effect of Achilles Tendon Ruptures in Rats by Mohanad Kh Al-ani, Kang Xu, Yanjun Sun, Lianhong Pan, ZhiLing Xu, Li Yang

“…Similar higher tendency in Col-I/III gene expression level during weeks 1, 2, and 4 was observed in TDSCs treated group with an upregulation of 1.5-fold and 1.1-fold than the other two study groups. …”
Get full text

Predatory bacteria can intensify lung-injury in a multidrug-resistant Acinetobacter baumannii pneumonia model in rat by Zeinab Mohsenipour, Farzaneh Kianian, Behnaz Jahanbin, Hamid Reza Abtahi, Tooba Ghazanfari, Maryam Edalatifard, Saeid Amanpour, Mikael Skurnik, Parya Arazi, Mohammad Mehdi Feizabadi, Mohammad Mehdi Feizabadi

“…Removal of excess endotoxin from the predator suspension was performed with the help of organic solvents before inoculation of rats.ResultsThe most successful treatment was observed in the group treated with colistin followed by combined treatment. …”
Get full text

AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of V... by Junting Cai, Jianxin Wei, Shuang Li, Tomeka Suber, Jing Zhao

“…Further, in LPA1 silencing cells, we observed that AM966-increased lung endothelial permeability as well as phosphorylation of VE-cadherin and focal adhesion kinase (FAK) were attenuated. …”
Get full text

Mono-HOPE Versus Dual-HOPE in Liver Transplantation: A Propensity Score-Matched Evaluation of Early Graft Outcome by Dominik Thomas Koch, Dominik Thomas Koch, Micol Tamai, Malte Schirren, Malte Schirren, Moritz Drefs, Moritz Drefs, Severin Jacobi, Severin Jacobi, Christian M. Lange, Christian M. Lange, Matthias Ilmer, Matthias Ilmer, Matthias Ilmer, Hanno Nieß, Hanno Nieß, Bernhard Renz, Bernhard Renz, Jens Werner, Jens Werner, Markus Guba, Markus Guba, Dionysios Koliogiannis, Dionysios Koliogiannis

“…One-year death-censored graft survival was similarly comparable (91.2% vs. 93.3%, p = 0.893). NAS were observed in 10.96% in the mono-HOPE and 8.22% in the dual-HOPE group (p = 0.574). …”
Get full text

Acute pain pathways: protocol for a prospective cohort study by Christine Lee, Joseph S Ross, Molly Moore Jeffery, Nilay D Shah, David B Page, Nancy Chang, Fernanda Bellolio, Sam Torbati, Jessica D Ritchie, Gregg H Gilbert, Lindsay Emanuel, Mitra Ahadpour, Summer Allen, Richardae Araojo, Laura Ciaccio, Jonathan Fillmore, Patricia Koussis, Heather Lipkind, Celeste Mallama, Tamra Meyer, Megan Moncur, Teryl Nuckols, Michael A Pacanowski, Elektra Papadopoulos, Mat Soukup, Christopher O St. Clair, Stephen Tamang, Douglas W Wallace, Yueqin Zhao, Rebekah Heckmann

“…An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses.Methods and analysis This multicentre prospective observational study will recruit 1550 opioid-naïve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. …”
Get full text