Herald Patch as the Only Evidence of Pityriasis Rosea: Clinical, Laboratory and Pathogenetic Features by Francesco Drago, Astrid Herzum, Serena Varesano, Gaetano Serviddio, Francesco Broccolo, Giulia Ciccarese

“…The present work aimed to examine the clinical and laboratory features of the PR cases characterized by the herald patch as the sole cutaneous manifestation and to compare them with the classic form of PR. An observational, retrospective study was conducted on patients presenting with herald patch as the only sign of PR (cases) and on a series of age- and sex-matched patients who presented with a typical PR pattern (controls). …”
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Long-Term Intracranial Progression-Free Survival in Lung Cancer Brain Metastases Extended Beyond 50 Months with Gubenxiaoyi Formula (GBXY): A Groundbreaking Case Study by Zhengzheng Yang, Haiming Li, Lei Chen, Shujiao Li, Dong Chen, Taicheng Lu, Tongjing Ding, Ruiyang Han, Peiyu Cheng, Xiaomin Wang

“…After treatment, a significant reduction of about 50% in intracranial lesions was observed, accompanied by an extension of both Intracranial Progression-Free Survival (IPFS) and Cognitive Deterioration-Free Survival (CDFS) exceeding 50 months. …”
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Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer by Danyang Zhou, Ying Wu, Zhenyu Lin, Liangliang Shi, Lei Zhao, Tao Liu, Dandan Yu, Tao Zhang

“…In a subgroup analysis for patients with advanced gastric cancer (AGC), we observed that the level of RDW + NLR was markedly associated with OS and PFS. …”
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Disk in the Circumstellar Envelope of Carbon Mira V Cygni by Boris S. Safonov, Sergey G. Zheltoukhov, Andrey M. Tatarnikov, Ivan A. Strakhov, Victor I. Shenavrin

“…The determination of outflow parameters is often hindered by the unknown geometry of the circumstellar environment, creating a demand for high-angular resolution observations. We use our near-infrared spectra and photometry of the carbon AGB star V Cyg, along with literature data, to construct its spectral energy distribution over a wide range of wavelengths. …”
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Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus by Caroline Pereira Domingueti, Rodrigo Bastos Fóscolo, Janice Sepúlveda Reis, Fernanda Magalhães Freire Campos, Luci Maria S. Dusse, Maria das Graças Carvalho, Karina Braga Gomes, Ana Paula Fernandes

“…Elevated levels of INF-γ, VWF, ADAMTS13 antigen, D-Dimer, and reduced ADAMTS13 activity/antigen ratio were observed in patients with nephropathy as compared to those without nephropathy (P=0.001, P<0.001, P<0.001, P<0.001, and P<0.001, resp.). …”
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Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization by Wei Yang, Xuanxuan Yan, Rui Chen, Xin Xin, Shuang Ge, Yongxiang Zhao, Xinlong Yan, Jinhua Zhang

“…The role of Smad4 in the occurrence and development of NAFLD was determined by monitoring the body weight of mice, detecting triglycerides and free fatty acids in serum and liver tissue homogenates, staining the tissue sections to observe the accumulation of liver fat, and RT-qPCR detecting the expression of genes related to lipogenesis, fatty acid intake, and fatty acid β oxidation. …”
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Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants by Alain J. Benitez, Ceylan Tanes, Elliot S. Friedman, Joseph P. Zackular, Eileen Ford, Jeffrey S. Gerber, Patricia A. DeRusso, Andrea Kelly, Hongzhe Li, Michal A. Elovitz, Gary D. Wu, Babette Zemel, Kyle Bittinger

“…In the short-term substudy, we observed microbiome differences only in the first 2 weeks following antibiotics initiation, mainly a decrease in Bifidobacterium bifidum. …”
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Individual Differences in Behavioural Despair Predict Brain GSK-3beta Expression in Mice: The Power of a Modified Swim Test by Tatyana Strekalova, Nataliia Markova, Elena Shevtsova, Olga Zubareva, Anastassia Bakhmet, Harry M. Steinbusch, Sergey Bachurin, Klaus-Peter Lesch

“…Unexpectedly, floating behaviour and brain glycogen synthase kinase-3 beta (GSK-3beta) mRNA levels, a factor of synaptic plasticity as well as a marker of distress and depression, were increased during the additional swimming session that was prevented by imipramine. Observed increases of GSK-3beta mRNA in prefrontal cortex during delayed testing session correlated with individual parameters of behavioural despair that was not found in the classic Porsolt test. …”
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Comprehensive GC-MS Characterization and Histochemical Assessment of Various Parts of Three <i>Colchicum</i> Species from Bulgarian Flora by Ivayla Dincheva, Ilian Badjakov, Vasil Georgiev, Ivanka Semerdjieva, Radka Vrancheva, Ivan Ivanov, Atanas Pavlov

“…Moderate acetylcholinesterase inhibitory activity (AChE) was observed across various plant organs. Statistical analyses demonstrated significant interspecies and organ-specific chemical differentiation, with certain metabolites serving as key markers. …”
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Predictive value of preoperative pan-immune-inflammation value index in the prognosis of oral cancer patients undergoing radical resection by Weihai Huang, Yulan Lin, Enling Xu, Yanmei Ji, Jing Wang, Fengqiong Liu, Fa Chen, Yu Qiu, Bin Shi, Lisong Lin, Baochang He

“…High PIV was significantly associated with worse survival in OSCC patients (hazard ratio [HR] = 1.62, 95% confidence interval [CI]: 1.15–2.29, P = 0.006). The same trend was observed in PSM (HR = 1.55,95% CI: 1.03–2.23, P = 0.035). …”
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Mapping TB incidence across districts in Uganda to inform health program activities by N.J. Henry, S. Zawedde-Muyanja, R.K. Majwala, S. Turyahabwe, R.V. Barnabas, R.C. Reiner, Jr, C.E. Moore, J.M. Ross

“…The case notification completeness surface was fit jointly using observed case notifications and estimated incidence. …”
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Electromagnetic compatibility of active cardiovascular implants to occupational magnetic field environments: impact of the field direction by Hammen, Lucien, Pichon, Lionel, Le Bihan, Yann, Bensetti, Mohamed , Fleury, Gérard

“…It appears that the magnetic field direction has an impact on the PM’s functioning and is consequently a relevant parameter for evaluating their EMC. These observations led us to the hypothesis that the lead in bipolar mode is more sensitive to electric field than magnetic field. …”
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Transmission of Genetic Variation from the Adult Generation to Naturally Established Seedlings of Fagus orientalis in the Hyrcanian Forest by Hamed Yousefzadeh, Malek Nasiri, Narjes Amirchakhmaghi, Seyedeh Alemeh Sabbagh, Łukasz Walas, Gregor Kozlowski

“…The results showed that the expected heterozygosity (He) varied from 0.83 to 0.92 (mean value 0.88), and a significant difference was detected between the expected and observed heterozygosity. In total, 75 private alleles were detected; of these, 56 were rare and had a frequency below 0.05. …”
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Soybean cultivars under the foliar application of a compounded biofertilizer in different plant phenological stages and doses by Fernando Simoni Bacilieri, Roberta Camargos de Oliveira, Ludyellen Cristina Medeiros Santos, Mara Lúcia Martins Magela, Regina Maria Quintão Lana, Ernane Miranda Lemes

“…In area 2, the BF application presented a similar or greater soybean yield compared to control (no BF). The divergences observed between areas may be related to interactions between the soil-climatic conditions and the soybean cultivars.Conclusion Choosing a more appropriate soybean cultivar is fundamental to obtaining higher yields. …”
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Impact of leukemia subtype and demographics on patient quality of life in 76 countries: a cross-sectional study by Sam Salek, Samantha Nier, Zack Pemberton-Whiteley, Tatyana Ionova, Giuseppe Ianni, Giovanni Tripepi, Nick York, Nicole Schroeter, Kathryn Huntley, Michael Rynne, Denis Costello, Lidija Pecova, Esther Natalie Oliva

“…BackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy Patient Reported Outcomes (HM-PRO) questionnaire to assess the impact of leukemia subtype, age, sex, and years living with the disease on QoL of patients with leukemia.ResultsOverall, 2,628 patients responded: 45.7% had chronic lymphocytic leukemia (CLL), 34.0% had chronic myeloid leukemia (CML), 11.8% had acute myeloid leukemia (AML), and 3.5% had acute lymphoblastic leukemia (ALL). …”
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The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases by Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman

“…That Pah1 is a physiological target of sertraline in S. cerevisiae is supported by the observations that the overexpression of PAH1 rescued the sertraline-mediated inhibition of pah1Δ mutant cell growth, the lethal effect of overexpressing Pah1-CC was rescued by sertraline supplementation, and that a sublethal dose of the drug resulted in a 2-fold decrease in TAG content.…”
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Tailor-Made, Linear, and “Comb-Like” Polyester-Based Copolymers: Synthesis, Characterization, and Thermal Behavior of Potential 3D-Printing/Electrospinning Candidates by Franco L. Redondo, Mario D. Ninago, Augusto G. O. de Freitas, Cristiano Giacomelli, Andrés E. Ciolino, Marcelo A. Villar

“…The macromolecular structure exerts a noticeable effect on the PCL block behavior when compared to the PCL homopolymer, at least for the temperature range studied (16–24°C): less differences in thermal properties were observed for linear block copolymers, whereas for “comb-like” graft copolymers their final crystallization capacity strongly depends on the presence of branches. …”
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Diagnosis and clinical significance of prostate calcification using computed tomography by Seong Cheol Kim, Tae Young Lee, Woocheol Kang, Hoyoung Bae, Ji Hyung Yoon, Sungchan Park, Kyung Hyun Moon, Sang Hyeon Cheon, Taekmin Kwon

“…Only a small number of calcifications were observed in the peripheral zone (0.9%). Multivariate analysis revealed that both age and prostate calcification were significant predictors of urinary symptoms. …”
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Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report by Christian Koch, Patrick Roth, Juliane Fleischer, Todor Popov, Karl Frontzek, Bettina Schreiner, Markus G. Manz, Simone Unseld, Antonia M. S. Müller, Norman F. Russkamp

“…In line with current treatment guidelines for GBS, intravenous immunoglobulin was administered and gradual but incomplete recovery was observed over the course of several months.Conclusions This case report highlights the risk of rare but severe neurological adverse events, such as acute GBS or cDI, in patients treated with CAR-T cells. …”
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Opioid System and Epithelial–Mesenchymal Transition by Marzena Łazarczyk, Dominik Skiba, Michel-Edwar Mickael, Kinga Jaskuła, Agata Nawrocka, Piotr Religa, Mariusz Sacharczuk

“…During last few years, an increasing trend for seeking relationships between opioids and epithelial–mesenchymal transition (EMT) in cancer research can be observed. Transiently lasting EMT is desirable during wound healing, but in cancer, or vital organ fibrogenesis, EMT appears to be an obstacle to overcome, forcing to adjust treatment strategies that would reduce the risk for worsening of the disease outcome and patient prognosis. …”
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