A Study to Inform the Design of a National Multicentre Randomised Controlled Trial to Evaluate If Reducing Serum Phosphate to Normal Levels Improves Clinical Outcomes including Mor... by Ramya Bhargava, Philip A. Kalra, Paul Brenchley, Helen Hurst, Alastair Hutchison

“…Background. Retrospective, observational studies link high phosphate with mortality in dialysis patients. …”
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Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review by Shangwu Liu, Runhong Zhang, Jamal Hallajzadeh

“…The altered ncRNA profiles may contribute to the neuroprotective and therapeutic effects observed with exercise interventions. However, more research is needed to fully understand the underlying mechanisms and to further explore the potential of exercise-induced ncRNA signatures as biomarkers and therapeutic targets for neurodegenerative disorders.…”
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Experimental Investigation on Permeability and Mechanical Deformation of Coal Containing Gas under Load by Runsheng Lv, Bing Li, Zhimin Song, Gaofeng Liu

“…However, clear differences were observable at the postfracture stage. The seepage abilities of the coal specimens were more sensitive to stress than temperature in the same condition.…”
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Application of Radial Basis Function Neural Network Coupling Particle Swarm Optimization Algorithm to Classification of Saudi Arabia Stock Returns by Khudhayr A. Rashedi, Mohd Tahir Ismail, Nawaf N. Hamadneh, S. AL Wadi, Jamil J. Jaber, Muhammad Tahir

“…An outlier is defined as a data point that deviates too much from the rest of the observations in a data sample. Based on the Engle and Granger Causality test, we selected inflation rate, repo rate, and oil prices as input variables. …”
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Digital measurement of ocular microtremor in Parkinson's disease: Protocol for a pilot study to assess reliability and clinical validation. by Lisa Graham, Rodrigo Vitorio, Richard Walker, Alan Godfrey, Rosie Morris, Samuel Stuart

“…This is an exploratory, observational study that will use a novel handheld device-The iTremor ONE, which has been developed to rapidly, non-invasively assess and evaluate OMT frequency. …”
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Structural and Physicochemical Characteristics of Granular Malic Acid-Treated Sweet Potato Starch Containing Heat-Stable Resistant Starch by Chinwoo Kwon, Ha Ram Kim, Tae Wha Moon, Seung Hyun Lee, Chang Joo Lee

“…Sweet potato starch mixed with various concentrations of malic acid solution underwent either thermal or nonthermal treatment. Observation of samples under a light microscope ensured the maintenance of granular shape and the Maltese cross. …”
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An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish by Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N. Meyer, Richard Di Giulio, Caren Weinhouse

“…However, PAH-tolerant fish reared in clean water recover CYP1A inducibility, indicating a non-genetic effect. We observed epigenetic control of this reversible memory of generational PAH stress in F1 PAH-tolerant embryos. …”
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Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies by Gamil A. Al-Hazmi, Khlood S. Abou-Melha, Nashwa M. El-Metwaly, Kamel A. Saleh

“…The rocky shape is the observable surface morphology from SEM images. Thermal analysis verifies the presence of water of crystallization with all coordination spheres. …”
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Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy by Chunhuan Jin, Xinyu Zhou, Minhui Xu, Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai

“…The U-shaped conformation adopted by nanvuranlat when bound to LAT1 likely contributes to its high affinity, selectivity, sustained inhibitory effect, and non-transportable nature observed in this study. These insights into nanvuranlat’s mechanism and metabolic impact provide essential information for understanding its clinical efficacy and advancing LAT1-targeted cancer therapies.…”
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Meeting deepwater drilling challenges in Niger-Delta with high performance water-based mud by Chimezie Sidney Uduba, Ibrahim Ademola Fetuga, Olabode Thomas Olakoyejo, Monica Wobo, Antônio Marcos de Oliveira Siqueira, Joshua Kolawole Gbegudu, Franklin Onah Onazi

“…The properties of the high-performance water-based mud was observed at different salinity concentration. The study shows that the density and viscosity tend to increase with increasing temperature where the mud has high salinity concentration of 7% to 9%. …”
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Vaccination status and hepatitis A immunity in children: insights from a large-scale study in Turkey by Metin Yigit, Furkan Kalayci

“…Additionally, a notable decrease in antibody levels was observed in the unvaccinated group as age increased (r = -0.365, p < 0.001). …”
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Beta-Blockers for Primary Prevention of Anthracycline-Induced Cardiac Toxicity: An Updated Meta-Analysis of Randomized Clinical Trials by Armin Attar, Arman Karimi Behnagh, Mehrasa Hosseini, Foad Amanollahi, Paria Shafiekhani, Ali Kabir

“…We assessed randomized trials and observational studies where a prophylactic intervention was compared with a control arm in patients with a normal left ventricular ejection fraction (LVEF) receiving Anthracyclines. …”
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APLASTIC SYNDROME IN A PREGNANT WOMAN ON THE BACKGROUND OF COVID-19: A CLINICAL CASE by Индира Венеровна Сахаутдинова, Ирина Борисовна Фаткуллина, Ирина Робинзоновна Рахматуллина, Игорь Сергеевич Засядкин, Анна Юрьевна Лазарева

“…Regression of infectious complications was observed, persistent normothermia (36-36.6°C), according to the control computed tomography, positive dynamics, a decrease in the amount of fluid in the right pleural cavity was noted. …”
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Plio–Quaternary Tectonic Activity in the Northern Nubian Belts: The Main Driving Forces by Enzo Mantovani, Marcello Viti, Daniele Babbucci, Caterina Tamburelli

“…This geodynamic context might explain some features of the seismicity time pattern observed in the Tell system.…”
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The short-term and long-term results of three-stage surgical treatment of ulcerative colitis with formation of ileal J-pouch by P. V. Tsarkov, A. Yu. Kravchenko, I. A. Tulina, Yury Ye. Kitsenko

“…Stool frequency was 6,1±2,45 times per day, every fifth patient had nighttime defecation; 19 of 21 patients could distinguish type of their reservoir contents and were able to provide its retention. Pouchitis was observed in 21% of cases. The pouch malfunction requiring its resection occurred in 4%. …”
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A quantum-optimized approach for breast cancer detection using SqueezeNet-SVM by Anas Bilal, Ali Alkhathlan, Faris A. Kateb, Alishba Tahir, Muhammad Shafiq, Haixia Long

“…Notably, on the CBIS-DDSM dataset, the Q-BGWO-SQSVM achieved remarkable results at 99% accuracy, 98% sensitivity, and 100% specificity in 15-fold cross-validation. Finally, it can be observed that the performance of the designed Q-BGWO-SQSVM model is excellent, and its potential realization in other datasets and imaging conditions is promising. …”
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Serum assisted PD-L1 aptamer screening for improving its stability by Yu Zhou, Haozhe Zhang, Yujing Ding, Changyuan Yu, Hao Li

“…Significantly, Apt-S1 exhibited a lower degradation rate in 10% diluted serum or pure human serum, under the physiological temperature and pH value, compared to Apt-A2. This observation suggested that Apt-S1 possesses higher stability and is more resistant to damage caused by the serum environmental factors, highlighting the superior stability of Apt-S1 over Apt-A2. …”
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Mycobacterium spp. exposure, childhood vaccinations, and early childhood brain and CNS cancers by Samer Singh, Rakesh K. Singh

“…However, a lack of definitive theoretical and practical frameworks to explain conflicting observations has impaired progress. When we analyze the epidemiological data of European region countries with different childhood vaccination policies but more similar socioeconomic conditions, access to medical services, and genetic makeup as compared to other parts of the world, the coverage of seven major childhood (0-1Y-olds) vaccines does not significantly associate with BCNS cancer incidences in the same cohort of 0-4Y-olds (2020). …”
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Is leisure sedentary time associated with mental health issues? Evidence from China Health and Nutrition Survey by Hao Li, Hao Li, Weihong Zeng, Weihong Zeng

“…This study aims to provide evidence on leisure sedentary behaviors on mental health using longitudinal data, along with its moderating and mediating roles.MethodsWe utilized data from four waves (2006–2015) of the China Health and Nutrition Survey (CHNS), focusing on adults who completed their education, with a total sample of 23,693 observations. Leisure sedentary time, the independent variable, was measured based on self-reported data, while mental health issues were the dependent variables based on the Simplified Symptom Self-Rating Scale (SCL) and the Perceived Stress Scale (PSS-14). …”
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The Prognostic Significance of TRs in Hepatocellular Carcinoma: Insights from TCGA and GEO Databases by Hao Zhou, Weijie Wang, Ruopeng Liang, Rongtao Zhu, Jiahui Cao, Chenguang Sun, Yuling Sun

“…Background: Reduced expression of thyroid hormone receptors (TRs) has been observed in various human malignancies, though its predictive value in hepatocellular carcinoma (HCC) remains uncertain. …”
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