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21641
Clinical characterization of a novel episodic ataxia in young working Cocker Spaniels
Published 2025-01-01“…Neither autonomic nor vestibular signs nor hyperkinetic movements were observed. Duration of episodes ranged from 30 minutes up to 24 hours, and their frequency varied from weekly to once every 5 months. …”
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21642
CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression
Published 2023-08-01“…The half-life extension and high affinity for CD19 led to significant antitumor activity in murine lymphoma models at very low doses of CLN-978. In primates, we observed a long serum half-life, deep and sustained depletion of normal B cells, and remarkable tolerability, in particular, reduced cytokine release when CLN-978 was administered subcutaneously.Conclusions CLN-978 warrants further exploration. …”
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21643
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21644
Consolidating Back Office with a Shared-Services Center:
Published 2021-11-01“…Practical Implications: The paper shows that by observing the network of all relevant stakeholders at the sectorial level, based on the information flow of core data, back-office problems can be identified, whereby the Shared-Services Center proves itself as a suitable solution. …”
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21645
Flexural Properties of UHPFRC Beams with an Initial Notch
Published 2023-02-01“…Results showed that finer mesh leads to negligible stiffer results with similar observations for the maximum sustained stress by the modulus of elasticity, compressive strength, and width variations. …”
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21646
Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study
Published 2025-01-01“…Background: Numerous observational studies have posited that gastroesophageal reflux disease (GERD) might amplify the risk of chronic airway conditions such as chronic obstructive pulmonary disease (COPD) and asthma. …”
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21647
Changes in Shoulder and Lumbar Injury Incidence in Swimmers After Physical Examination and Exercise Programs
Published 2024-12-01“… # Study Design Observational Cohort study # Methods Thirty-one male high school and college student swimmers underwent a physical examination. …”
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21648
Assessing the diagnostic potential of SATB2 and β-catenin as biomarkers and therapeutic targets in pancreatic ductal adenocarcinoma
Published 2025-01-01“…We found a positive correlation between SATB2 expression assessed by IHC and the concentration of SATB2 in both serum and tissue samples measured by ELISA. We observed a positive correlation between β-catenin expression assessed by IHC and β-catenin levels measured by qPCR. …”
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21649
Fetuin-B and oxidative stress disrupt placental trophoblasts during maternal undernourishment
Published 2025-12-01“…Just as MUN can affect the mother and foetus, it can adversely affect the vital placental interface between the two. We suspect an observed increase in fetuin-B and oxidative stress in MUN placentas could be major players responsible for the placental insufficiency often seen with MUN.Methods To establish a model of MUN during pregnancy, a reduced protein chow was fed to pregnant dams at a caloric deficit. …”
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21650
Sex differences in the murine HPA axis after acute and repeated restraint stress
Published 2025-12-01“…Acute stress-induced signs of anxiety-like behavior were observed in male mice only suggesting that female mice may be more resilient to the anxiogenic effects of acute stress. …”
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21651
Psychological impacts of "screen time" and "green time" for children and adolescents: A systematic scoping review.
Published 2020-01-01“…Technological developments in recent decades have increased young people's engagement with screen-based technologies (screen time), and a reduction in young people's contact with nature (green time) has been observed concurrently. This combination of high screen time and low green time may affect mental health and well-being. …”
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21652
Water Supply Risk Analysis Based on Runoff Sequence Simulation with Change Point under Changing Environment
Published 2019-01-01“…Among the three methods, the copula function stochastic simulation method with the mixed distribution model which is improved on the basis of copula function stochastic simulation method in this study performs best in simulating the observed monthly runoff series during 1956–2016, and the water supply risk indices including reliability (time-based and volume-based), resilience, vulnerability, drought risk index (DRI), and sustainability index (SUI) are evaluated for Panjiakou reservoir and analyzed by using the stochastic simulation results. …”
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21653
The Economic Impact of COVID-19 Treatment at a Hospital-level: Investment and Financial Registers of Brazilian Hospitals
Published 2021-04-01“…The analysis included variations in occupation rates and billing from 2019 to 2020 observed in each institution, and the investments for medical equipment, individual protection materials and building construction per patient treated. …”
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21654
Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients
Published 2024-12-01“…According to the TAC level, they were subdivided into LL-TAC, NL-TAC, and HL-TAC groups.Results A decrease in MDA levels, SOD activity, and an increase in GSH levels and GPx activity were observed in patients with late PT compared to those with early and intermediate PT (p < 0.05). …”
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21655
Distribution features of the red squirrel (Sciurus vulgaris) in the south of Ukraine: a case study of Mykolaiv Oblast
Published 2024-12-01“…In the city Pervomaisk on the river the species was observed for the first time in Southern Bug in 1980, in the northeast of the region in 2002, near the city of Mykolaiv — 1997. …”
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21656
The effects of processing steps on avenanthramides, avenacosides and β-glucan content during the production of oat-based milk alternatives
Published 2025-03-01“…Avenanthramides and avenacosides were measured using liquid chromatography-mass spectrometry, with β-glucan determined spectrophotometrically using a modified enzymatic assay.An overall reduction of 42 % was observed in measured β-glucan, with a decanting stage a main contributing factor. …”
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21657
Elastic Optimization for Stragglers in Edge Federated Learning
Published 2023-12-01“…We consider data heterogeneity from two aspects: high dimensional data generated at edge devices where the number of features is greater than that of observations and the heterogeneity caused by partial device participation. …”
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21658
La influencia médico-nutricionista en los libros de capacitación docente 1940-1960
Published 2025-01-01“…Por todo ello es que este trabajo plantea que existe una intención de control social observable a través de la instrumentalización de la ciencia nutricional y que esto fue un eje rector de la política educativa en materia de alimentación en las medianías del siglo XX en México. …”
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21659
Sense of Happiness and Wellness Among Adolescents and Their School Environment
Published 2025-01-01“…The study included 1992 students (females 50.2%) with a mean age of 14.53 ± 1.12. Results: It was observed that male students felt healthier and happier than females. …”
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21660
MECHANISMS AND CLINICAL PERSPECTIVES OF ALLERGEN-SPECIFIC IMMUNOTHERAPY
Published 2024-12-01“… Introduction: Allergic rhinitis (AR) is a prevalent condition in Kazakhstan, characterized by high sensitization to weed pollens, particularly Artemisia, with sensitization levels significantly exceeding those observed in Europe. AR often leads to complications such as bronchial asthma (BA) and other respiratory conditions. …”
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