Structure and function of a β-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium by Yutaka Nakazawa, Masumi Kageyama, Tomohiko Matsuzawa, Ziqin Liang, Kaito Kobayashi, Hisaka Shimizu, Kazuki Maeda, Miho Masuhiro, Sei Motouchi, Saika Kumano, Nobukiyo Tanaka, Kouji Kuramochi, Hiroyuki Nakai, Hayao Taguchi, Masahiro Nakajima

“…The 2-hydroxy group and the anomeric methyl group of methyl β-galactopyranose faces in the direction of subsite −1 and the solvent, respectively. This observation is consistent with the substrate specificity of the enzyme regarding linkage position and chain length. …”
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Surveillance of pathogenic Leptospira among rodents and small mammals in enzootic areas of plague in Pasuruan Indonesia by Siti Amanah Febriani, Kurnia Ritma Dhanti, Kurniawan Kurniawan, Ristiyanto Ristiyanto, Arief Junaedi, Caecilia Hapsari Ceriapuri Sukowati, Farida Dwi Handayani

“…This study belongs to the type of observational analytic research with a cross-sectional study design. …”
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Methodological bases for monitoring technological transformation of regional industry by M. A. Miller

“…The definition of the concept of monitoring the technological transformation of industry is given, the means, methods, information base and observed parameters of the monitoring process are identified and described. …”
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Effects of Severe Hypoxia on Bone Marrow Mesenchymal Stem Cells Differentiation Potential by Claudia Cicione, Emma Muiños-López, Tamara Hermida-Gómez, Isaac Fuentes-Boquete, Silvia Díaz-Prado, Francisco J. Blanco

“…Our work underlines that severe hypoxia slows cell differentiation by means of molecular mechanisms since a decrease in the expression of adipocyte-, osteoblast-, and chondrocyte-specific genes was observed.…”
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Markers of Biological Stress and Mucosal Immunity during a Week Leading to Competition in Adolescent Swimmers by E. Papadopoulos, C. Muir, C. Russell, B. W. Timmons, B. Falk, P. Klentrou

“…No day-to-day changes or significant differences between weeks were observed for sIgA (47.9±4.4 versus 54.9±5.2 μg/mL for control versus competition week, resp.), sC (2.7±0.2 versus 2.5±0.2 ng/mL for control versus competition week, resp.), and T/C ratio (83.4±7.0 versus 77.9±7.7 for control versus competition week, resp.). …”
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Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse by Sara Carmela Credendino, Nicole Lewin, Miriane de Oliveira, Swaraj Basu, Barbara D’Andrea, Elena Amendola, Luigi Di Guida, Antonio Nardone, Remo Sanges, Mario De Felice, Gabriella De Vita

“…Interestingly, databases report a similar expression profile for human Klhl14-AS. Our observations suggest that this lncRNA could play cell type-specific roles in several organs and pave the way for functional characterization of this gene in appropriate biological contexts.…”
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Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study by Silvio Buscemi, Pierfilippo Chiarello, Carola Buscemi, Davide Corleo, Maria Fatima Massenti, Anna Maria Barile, Giuseppe Rosafio, Vincenza Maniaci, Valentina Settipani, Loretta Cosentino, Carla Giordano

“…HOMA-IR, high sensitivity C-reactive protein, and the carotid intima-media thickness were significantly different in the 4 subgroups (P<0.001), with higher values observed in the MUH normal-weight and obese groups. …”
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Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic: A Randomized, Double-Blind, Controlled Trial by Kambiz Masoumi, Arash Forouzan, Ali Asgari Darian, Maryam Feli, Hassan Barzegari, Ali Khavanin

“…No significant difference was observed between the two groups in regard to sex (P=0.13), mean age (P=0.54), and baseline visual analogue score (P=0.21). …”
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The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients by Hongqi Ren, Xuan Zhou, Zhiyong Luan, Xiaomei Luo, Shujing Han, Qing Cai, Wang Rui, Yan Li

“…No significant differences between the CAS group and the non-CAS group were observed with respect to age, dialysis duration, DBP, BUN, Cr, TC, TG, HDL, LDL, and Hb. …”
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Immunological Changes in Peripheral Blood of Ankylosing Spondylitis Patients during Anti-TNF-α Therapy and Their Correlations with Treatment Outcomes by Rongjuan Chen, Hongyan Qian, Xiaoqing Yuan, Shiju Chen, Yuan Liu, Bin Wang, Guixiu Shi

“…Thirty-five AS patients receiving the treatment of anti-TNF-α therapy were included into this prospective observational study. The frequencies of immune cells including Th1, Th2, Th17, regulatory T cell (Treg), T follicular helper cell (Tfh), and regulatory B cell (Breg) in the peripheral blood were measured by flow cytometry at baseline and 4 time points after therapy. …”
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BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia by Yongguang Yang, Yanmin Feng, Xue Feng, Shangying Liao, Xiuxia Wang, Haiyun Gan, Lixian Wang, Xiwen Lin, Chunsheng Han

“…While exogenous BMP4 by itself did not induce the expression of Stra8 and c-Kit, two marker genes of differentiating spermatogonia, a significant cooperative effect of BMP4 and retinoic acid (RA) was observed. Moreover, pretreatment of cultured spermatogonia with the BMP4 antagonist Noggin could inhibit RA-induced expression of these two marker genes. …”
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An Exploration of the Cellular Microenvironment of the Female Pig Urethra: Translational Insights for Urological Research by Agustín Cartes, Caroll Stoore, María Soledad Baquedano, Christian Hidalgo, Felipe Lillo, Eduardo Landerer, Galia Ramírez-Toloza, Rodolfo Paredes

“…Notably, significant differences in muscular area and tissue distribution were identified between the proximal, middle, and distal segments of the urethra (<i>p</i> < 0.001). The observed anatomical variations, along with the cellular similarities between pigs and humans, establish the female pig as a crucial translational model for advancing urological research. …”
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Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial by Seyed Babak Mojaveraghili, Sina Hassannasab, Mansour Deylami, Tahereh Chavoshi, Avasadat Mirkatouli, Nasser Behnampour

“…Given the relative advantages observed about intrathecal injection of pethidine, including fewer side effects, and longer postoperative analgesia, in combination with effective sensory, motor, and sympathetic blocks, we sought to compare the influence of intrathecal injection of pethidine and bupivacaine on the hemodynamics of patients. …”
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Genetic Evidence of Killer Whale Predation on White Sharks in Australia by Isabella M. M. Reeves, Andrew R. Weeks, Alison V. Towner, Rachael Impey, Jessica J. Fish, Zach S. R. Clark, Paul A. Butcher, Lauren Meyer, David M. Donnelly, Charlie Huveneers, Nicky Hudson, Adam D. Miller

“…Notably, a series of such predation events have been reported from South Africa over the last decade, with killer whales specifically targeting sharks' liver. However, observations of these interactions are rare, and knowledge of their frequency across the world's oceans remains limited. …”
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Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure? by Anna C. Roberts, Jai Gohil, Laura Hudson, Kyle Connolly, Philip Warburton, Rakesh Suman, Peter O’Toole, David J. O’Regan, Neil A. Turner, Kirsten Riches, Karen E. Porter

“…Significant inhibition of Akt and eNOS, but not ERK phosphorylation, was observed in T2DM cells. Hyperglycaemia did not modify ND-EC function, but TNF-α and palmitate significantly reduced angiogenic capacity (by 27% and 43%, resp.), effects mimicked by Akt inhibition. …”
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Fuzzy Nonbalanced Hedonic Scale (F-NBHS): A New Method for Treatments of Food Preference Data Collected with Hedonic Scales of Points by Katieli Tives Micene, Pedro Miguel Ferreira Martins Arezes, Fernanda Gomes de Andrade, Bengie Omar Vazquez Reyes, Marcia Danieli Szeremeta Spak, Airton Kist, João Carlos Colmenero

“…Findings showed that the structure of the proposed scale is observed in the behavior of experimental data and intermediate areas, which indicated the intensity of perception and variability of different responses from other areas of the scale. …”
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Thermal-Hydraulic Analysis of Coolant Flow Decrease in Fuel Channels of Smolensk-3 RBMK during GDH Blockage Event by A. Lombardi Costa, M. Cherubini, F. D'Auria, W. Giannotti, A. Moskalev

“…The start time of the oscillations in mass flow rate depends strongly on the attributed power to each FC. It was also observed that, during the event, the fuel channels at higher thermal power values tend to undergo first cladding rupture leaving the reactor to scram and safeguarding all the other FCs connected to the affected GDH.…”
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Sprayed and Spin-Coated Multilayer Antireflection Coating Films for Nonvacuum Processed Crystalline Silicon Solar Cells by Abdullah Uzum, Masashi Kuriyama, Hiroyuki Kanda, Yutaka Kimura, Kenji Tanimoto, Hidehito Fukui, Taichiro Izumi, Tomitaro Harada, Seigo Ito

“…With a single TiO2-compact film on the surface of a crystalline silicon wafer, 5.3% average reflectance (the reflectance average between the wavelengths of 300 nm and 1100 nm) was observed. Reflectance decreased further down to 3.3% after forming spin-coated ZrO2 on the spray-deposited TiO2-compact film. …”
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Fluid dynamics of planetary differentiation by Deguen, Renaud, Huguet, Ludovic, Landeau, Maylis, Lherm, Victor, Maller, Augustin, Wacheul, Jean-Baptiste

“…After having summarised the main observational constraints on core-mantle differentiation, the article follows the sequence of processes that led to the formation of planetary cores, focusing on the contributions of laboratory fluid dynamics experiments to our understanding of these processes, and discussing the relevance and limitations of this approach to this problem. …”
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Study on the Large Deformation Characteristics and Disaster Mechanism of a Thin-Layer Soft-Rock Tunnel by Xiulian Zhang, Manchao He, Fengnian Wang, Gan Li, Shengxin Xu, Zhigang Tao

“…The results show that (1) the deformation of the surrounding rock of the tunnel has remarkable asymmetry, the deformation of the initial support of the tunnel is significant, and the buried depth of the area where the maximum deformation of the tunnel exceeded 1 m is greater than 500 m; (2) the main factors influencing the deformation of a thin-layer slate tunnel include joint inclination, buried depth, water absorption, and softening of the surrounding rock; and (3) the maximum deformation of the surrounding rock is observed for a joint angle of 45°, at which the buried depth is directly proportional to the deformation and failure of the tunnel. …”
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