Partly cloudy with a chance of mosquitoes: Developing a flexible approach to forecasting mosquito populations by Travis McDevitt‐Galles, Arthur T. Degaetano, Sarah C. Elmendorf, John R. Foster, Howard S. Ginsberg, Mevin B. Hooten, Shannon LaDeau, Katherine M. McClure, Sara Paull, Erin Posthumus, Ilia Rochlin, Daniel Grear

“…As climate change will have variable effects on mosquito demography and phenology across species it is vital that we identify associated traits that may explain the observed variation. Here, we review a suite of modeling approaches that could be applied to generate forecasts of mosquito activity under climate change and evaluate the strengths and weaknesses of the different approaches. …”
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Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease by Tomonori Sugita, Katsushi Amano, Masanori Nakano, Noriko Masubuchi, Masahiro Sugihara, Tomokazu Matsuura

“…In the UDCA therapy (−) subgroup, a significantly lower level of TLCA was observed in the ALD group, with lower levels of CDCA, DCA, and GLCA noted in biliary tract diseases group compared to viral hepatitis group. …”
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Discrimination of superficial lymph nodes using ultrasonography and tissue metabolomics coupled with machine learning by Lu Li, Xinyue Wang, Hongyan Deng, Wenjuan Lu, Yasu Zhou, Xinhua Ye, Yong Li, Jie Wang

“…Metabolomics revealed the difference in metabolic profiles among lymph nodes. We observed significant increases in many amino acids, organic acids, lipids, and nucleosides in both lymphoma and metastasis groups, compared to the benign group. …”
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Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma by David A. Rowbotham, Katey S. S. Enfield, Victor D. Martinez, Kelsie L. Thu, Emily A. Vucic, Greg L. Stewart, Kevin L. Bennewith, Wan L. Lam

“…However, the described <10% VHL mutation rate cannot account for the high frequency of hypoxic response observed. Indeed, little is known about genetic mechanisms disrupting other complex component genes. …”
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Inhibition of Growth and Induction of Apoptosis in Fibrosarcoma Cell Lines by Echinophora platyloba DC: In Vitro Analysis by Fatemeh Zare Shahneh, Samira Valiyari, Abbas Azadmehr, Reza Hajiaghaee, Saeid Yaripour, Ali Bandehagh, Behzad Baradaran

“…Our results demonstrated that the extract decreased cell viability, suppressed cell proliferation, and induced cell death in a time- and dose-dependent manner in WEHI-164 cells (IC50 = 196.673 ± 12.4 μg/mL) when compared with a chemotherapeutic anticancer drug, Toxol. Observation proved that apoptosis was the major mechanism of cell death. …”
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Crystallite size and phase purity in Pb1-xSrxTiO3 ferroelectric perovskites for biomedical applications via controlled sintering by Rahmat Doni Widodo, Samsudin Anis, Deni Fajar Fitriyana, Maykel Manawan, Joni Sah, Aji Santiko, Rizalman Bin Mamat, Abdulfatah Abdu Yusuf, Muhammad Imam Ammarullah

“…The most significant crystal growth was observed at 900°C, while the optimal phase purity and crystallite size (91.5 nm) were achieved at 1100°C, producing 100% single-phase PST. …”
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Pan-cancer analysis of SOX2: Prognostic implications and potential as a therapeutic target in immune checkpoint modulation by Shoukai Yu, Lingmei Qian, Liling Xu, Jun Ma

“…Significant downregulation of SOX2 expression was observed in colorectal adenocarcinoma, esophageal carcinoma, rectum adenocarcinoma, stomach adenocarcinoma, and testicular germ cell tumors, whereas its expression was upregulated in cervical squamous cell carcinoma, glioblastoma multiforme, lower grade glioma, lung adenocarcinoma, and lung squamous cell carcinoma.Survival analysis showed that low SOX2 expression correlated with better prognosis in bladder cancer, liver hepatocellular carcinoma, kidney renal clear cell carcinoma, and sarcoma, whereas high SOX2 expression was associated with poor prognosis in lung adenocarcinoma, and lung squamous cell carcinoma, glioblastoma multiforme, lower grade glioma. …”
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Attribution Identification of Runoff Changes Based on the Budyko Elasticity Coefficient Method: A Case Study of the Middle and Upper Reaches of the Jinghe River in the Yellow River... by Xueliang Wang, Haolin Li, Weidong Huang, Lemin Wei, Junfeng Liu, Rensheng Chen

“…Compared to the previous period, a change of −29%, in relative terms, in the runoff at the YJP hydrological station is observed. The interaction of human activities and climate change in the watershed contributes to the sharp decrease in runoff, with precipitation, potential evapotranspiration, and human activities accounting for −14.3%, −15.1%, and 70.6% of the causes of the change in runoff, respectively. …”
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Stability Analysis and Monitoring Method for the Key Block Structure of the Basic Roof of Noncoal Pillar Mining with Automatically Formed Gob-Side Entry by Jianning Liu, Manchao He, Yajun Wang, Ruifeng Huang, Jun Yang, Xichun Tian, Can Ming, Shan Guo

“…When the gangue bulking coefficient fell outside the safe range, the convergence was larger, and cracks were observed. The key block may be vulnerable to instability. …”
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E-Assessment for Character Evaluation in Elementary Schools by Asrial Asrial, Syahrial Syahrial, Dwi Agus Kurniawan, Fhadira Insani Putri, Rahmat Perdana, Rahmi Rahmi, Susbiyanto Susbiyanto, Febri Tia Aldila

“…Significant differences in patriotism and discipline were observed between Elementary School 034/I Teratai and Elementary School 064/I Muara Bulian, and in tolerance between Elementary School 045I Sridadi and Elementary School 064/I Muara Bulian. …”
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A Novel Minimal Invasive Mouse Model of Extracorporeal Circulation by Shuhua Luo, Menglin Tang, Lei Du, Lina Gong, Jin Xu, Youwen Chen, Yabo Wang, Ke Lin, Qi An

“…All animals (n=20) survived 30 min ECC and subsequent 60 min observation. Blood analysis after ECC showed significant increases in levels of tumor necrosis factor α, interleukin-6, and neutrophil elastase in plasma, lung, and renal tissues, as well as increases in plasma creatinine and cystatin C and decreases in the oxygenation index. …”
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Reducing Colorectal Cancer Incidence and Disparities: Performance and Outcomes of a Screening Colonoscopy Program in South Carolina by Sudha Xirasagar, Yi-Jhen Li, James B. Burch, Virginie G. Daguisé, Thomas G. Hurley, James R. Hébert

“…We found that patient navigation and a medical home setting resulted in a successful and high-quality screening program. The observed high adenoma rate among younger AAs calls for more research with larger cohorts to evaluate the appropriateness of the current screening guidelines for AAs, given that they suffer 47% higher colorectal cancer mortality than Whites.…”
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Polychlorinated Biphenyls Water Pollution along the River Nile, Egypt by Ayman Mohamed Megahed, Hesham Dahshan, Mahdy A. Abd-El-Kader, Amr Mohamed Mohamed Abd-Elall, Mariam Hassan Elbana, Ehab Nabawy, Hend A. Mahmoud

“…An increasing trend in PCB levels from the upper stream to the Nile estuaries was observed. The calculated flux of PCBs indicated that 6.8 tons of PCBs is dumped into the Mediterranean Sea each year from the River Nile. …”
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High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis by Fouad Aoun, Ksenija Limani, Alexandre Peltier, Quentin Marcelis, Marc Zanaty, Alexandre Chamoun, Marc Vanden Bossche, Thierry Roumeguère, Roland van Velthoven

“…No statistically significant difference in metastasis-free, cancer specific, and overall survivals was observed between the two groups. Conclusion. HIFU and brachytherapy are safe with no significant difference in cancer specific survival on long term oncologic follow-up. …”
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Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway by Dacheng Wu, Keyan Wu, Qingtian Zhu, Weiming Xiao, Qing Shan, Zhigang Yan, Jian Wu, Bin Deng, Yan Xue, Weijuan Gong, Guotao Lu, Yanbing Ding

“…Furthermore, in the foundation of administrating MCC950 to inhibit activation of NLRP3 inflammasome, we failed to observe the protective effects of formononetin on acute colitis in mice. …”
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Postdigital Bystanding: Youth Experiences of Sexual Violence Workshops in Schools in England, Ireland, and Canada by Jessica Ringrose, Debbie Ging, Faye Mishna, Betsy Milne, Tanya Horeck, Kaitlynn Mendes

“…In this paper, we report on creative- and arts-based sexual violence and bystander intervention workshops we developed and researched in England, Ireland, and Canada, through evaluation surveys, observations, and focus group interviews with nearly 1200 young people (aged 13–18). …”
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A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast c... by Jingshu Wang, Xiuping Lai, Herui Yao, Hui Yang, Xiaolong Cao, Xiaochen Wang, Ying Wang, Weiqi Nian, Xiaodong Zheng, Qingxiu Mai, Anding Liu, Xiaozhi Lv, Xiaoying Bi, Junyi Chen, Junyan Wu, Suiwen Ye

“…Throughout the trial, all adverse events observed in the patients were meticulously assessed. …”
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Methylation Status of Vitamin D Receptor Gene Promoter in Benign and Malignant Adrenal Tumors by Catia Pilon, Andrea Rebellato, Riccardo Urbanet, Vincenza Guzzardo, Rocco Cappellesso, Hironobu Sasano, Ambrogio Fassina, Francesco Fallo

“…Methylation in the promoter region of VDR gene was found in 3/8 ACCs, while no VDR gene methylation was observed in normal adrenals and adrenocortical adenomas. …”
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Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis by Jie Ma, Chenlu Zhu, Bin Ma, Jie Tian, Samuel Essien Baidoo, Chaoming Mao, Wei Wu, Jianguo Chen, Jia Tong, Min Yang, Zhijun Jiao, Huaxi Xu, Liwei Lu, Shengjun Wang

“…It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. …”
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Locally Different Endothelial Nitric Oxide Synthase Protein Levels in Ascending Aortic Aneurysms of Bicuspid and Tricuspid Aortic Valve by Salah A. Mohamed, Arlo Radtke, Roza Saraei, Joern Bullerdiek, Hajar Sorani, Rolf Nimzyk, Antje Karluss, Hans H. Sievers, Gazanfer Belge

“…Dysregulated expression of the endothelial nitric oxide synthase (eNOS) is observed in aortic aneurysms associated with bicuspid aortic valve (BAV). …”
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