Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability by Nathan Koch, Quentin Bourcy, Olivier Jennotte, Patrice Chiap, Anna Lechanteur, Jean-Michel Cardot, Brigitte Evrard

“…Neutral media enabled a relatively good prediction of the extent of absorption observed in vivo, whereas the rate of absorption was more complicated to predict. …”
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Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IF... by Lúcia Cristina Jamli Abel, Ludmila Rodrigues Pinto Ferreira, Isabela Cunha Navarro, Monique Andrade Baron, Jorge Kalil, Ricardo Tostes Gazzinelli, Luiz Vicente Rizzo, Edecio Cunha-Neto

“…We therefore decided to further investigate the in vitro cytokine production profile from human mononuclear cells from uninfected donors exposed to T. cruzi as well as tGPI-mucins. We observed that both living T. cruzi trypomastigotes and tGPI-mucins are potent inducers of IL-12 by human peripheral blood monocytes and this effect depends on CD40-CD40L interaction and IFN-γ. …”
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YPEL2 regulates the efficacy of BRD4-EZH2 dual targeting in EZH2Y641mut germinal center-derived lymphoma by Aránzazu Chamorro-Jorganes, Núria Profitós-Pelejà, Clara Recasens-Zorzo, Juan G Valero, Diana Reyes-Garau, Laura Magnano, Ray Butler, Antonio Postigo, Patricia Pérez-Galán, Marcelo Lima Ribeiro, Gaël Roué

“…Here we undertook the simultaneous evaluation of two epigenetic drugs targeting EZH2 methyltransferase activity and BRD4-mediated control of MYC transcription, CPI169 and CPI203, using preclinical models of DLBCL and FL with distinct EZH2 mutational status. We observed a specific and synergistic antiproliferative effect of these compounds in EZH2-mutated cells and mouse xenograft models, that was related to the abrogation of MYC transcriptional program and to tumor cell proliferation blockade at the G1 cell cycle phase. …”
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Safety and Efficacy of 188-Rhenium-Labeled Antibody to Melanin in Patients with Metastatic Melanoma by M. Klein, M. Lotem, T. Peretz, S. T. Zwas, S. Mizrachi, Y. Liberman, R. Chisin, J. Schachter, I. G. Ron, G. Iosilevsky, J. A. Kennedy, E. Revskaya, A. W. de Kater, E. Banaga, V. Klutzaritz, N. Friedmann, E. Galun, G. L. DeNardo, S. J. DeNardo, A. Casadevall, E. Dadachova, G. B. Thornton

“…The mean effective half-life of 188Re-6D2 was 12.4 h. Transient HAMA was observed in 9 patients. Six patients met the RECIST criteria for stable disease at 6 weeks. …”
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Gene Structures, Classification, and Expression Models of the DREB Transcription Factor Subfamily in Populus trichocarpa by Yunlin Chen, Jingli Yang, Zhanchao Wang, Haizhen Zhang, Xuliang Mao, Chenghao Li

“…Taken together, these observations may lay the foundation for future functional analyses to unravel the biological roles of Populus’ DREB genes.…”
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Do the Microshear Test Variables Affect the Bond Strength Values? by Andrea M. Andrade, Eugenio Garcia, Sandra Kiss Moura, Alessandra Reis, Alessandro Loguercio, Luciana Mendonça Silva, Gustavo H. D. Pimentel, Rosa Helena Miranda Grande

“…Groups 1 and 2 resulted in statistically similar mean μSBS (); however, a greater number of pretest failures were observed for Group 1. Higher μSBS values were detected for Group 3, irrespective of adhesive system used (). …”
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Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study by Praveen Sripad, Jessica Rosenberg, Frank Boers, Christian P. Filss, Norbert Galldiks, Karl-Josef Langen, Ralf Clauss, N. Jon Shah, Jürgen Dammers

“…Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. …”
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Molecular origin of asymmetric yield surface of crosslinked epoxy polymers by Jinyoung Kim, Kyeongmin Hong, Yong-Seok Choi, Dayoung Jang, Jang-Woo Han, Hyungbum Park

“…Notably, a more accelerated expansion of the yield surface in the biaxial compression direction was observed at higher degrees of crosslinking, which is attributed to a deformation mechanism that more effectively accommodates stress in this loading direction. …”
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Stretchable Full‐Color Phosphorescent PVA‐Based Ionogels for Multimodal Sensing‐Visual Integration Applications by Xuefeng Wei, Zexi Gou, Jianting Ye, L. H. Shi, Jianwei Zhao, Lei Yang, Linbo Zhang, Kun Zhang, Ruonan Jia

“…This strategy is applicable to chromophores with color‐tunable phosphorescence. By leveraging observable full‐color RTP and real‐time electrical signals in response to diverse stimuli (i.e., stretching and pressing), an intelligent grasping strategy is developed for robust hand pose reconstruction. …”
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Molecular, Metabolic, and Physiological Responses to Progressive Biotic Stress Caused by Cucumber Mosaic Virus and Turnip Mosaic Virus in Saffron by Marzieh Shamshiri, Conchi Sánchez, Saleta Rico, Ali Mokhtassi-Bidgoli, Mahdi Ayyari, Hassan Rezadoost, Masoud Shams-Bakhsh

“…The lowest contents of leaf pigments, flowering performance, petal anthocyanin, greenness, and photosynthesis properties were observed in plants infected with CMV and TuMV. According to high-performance liquid chromatography (HPLC) analysis, CMV inoculation led to the highest reduction in crocin and safranal content, while inducing the highest increase in picrocrocin compared to the mock treatment. …”
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GC-FID and Olfactometry-Assisted Assessment of Odors from Polymeric Foams under Normal and Repeated-Use Conditions by Alena Capíková, Daniela Tesařová, Josef Hlavaty, Adam Ekielski, Pawan Kumar Mishra

“…Any new compound or increase in odor intensity was not observed in long-term measurements and simulated repeated-use conditions.…”
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Methotrexate for the Treatment of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation by Amr Nassar, Ghada Elgohary, Tusneem Elhassan, Zubeir Nurgat, Said Y. Mohamed, Mahmoud Aljurf

“…Despite several limitations in data collection and analysis, weekly administration of methotrexate at a median dose of 7.5 mg/m2 seems to be safe with minimal toxicities in the context of both aGVHD and cGVHD treatments. The observed overall response (OR) in patients with aGVHD to MTX treatment in the published studies was 69.9%, with complete response (CR) in 59.2% and PR in 10.6%. …”
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Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin by J Blahova, P Mikula, P Marsalek, Z Svobodova

“…Numerous changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, as well as lipid peroxidation, were observed especially in the caudal kidney in the group exposed to 100 μg/l. …”
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Unveiling the Original Polychromy of Archaic Architecture: The Gigantomachy on the West Pediment of the Temple of Apollo at Delphi (6th c. B.C.) by Giasemi G. Frantzi, Georgios P. Mastrotheodoros, Panayiotis Theoulakis, Sotiria Kogou, Athanasia Psalti, Hariclia Brecoulaki

“…The adopted methodology includes exclusively non-destructive techniques and advanced imaging methods, such as portable X-ray fluorescence spectrometry, visible-induced luminescence (VIL), and 3D microscope observation. Analytical results confirmed the presence of extensive traces of once-vibrant colors on the plaster’s surface, which were often invisible to the naked eye. …”
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Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves’ Orbitopathy by Hiroyuki Eguchi, Junichi Tani, Saori Hirao, Munehisa Tsuruta, Ichiro Tokubuchi, Kentaro Yamada, Masataka Kasaoka, Yasuo Teshima, Tatsuyuki Kakuma, Yuji Hiromatsu

“…Liver dysfunction was more frequently observed in males, in patients receiving high-dose methylprednisolone, and patients aged over 50 years. …”
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Screening and enhancing intellectual capital consistency: A scoping review of systematised literature reviews by Eugénia Pedro, João Leitão, Helena Alves

“…We found evidence of the beginning of the fifth stage around 2018 due to the change in the research paradigm observed in this study and the development of new themes, such as innovation, digitalisation, knowledge, sustainability, and entrepreneurship, contributing to the ecosystem development of cities, regions, and nations. …”
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Temperature Effect Study on Growth and Survival of Pathogenic Vibrio parahaemolyticus in Jinjiang Oyster (Crassostrea rivularis) with Rapid Count Method by Yuan Wang, Hai-yan Zhang, Essy Kouadio Fodjo, Cong Kong, Run-Run Gu, Feng Han, Xiao-Sheng Shen

“…The similar survival trend of pathogenic V. parahaemolyticus in JO slurry and live JO was observed under 5, 25, and 35°C, except the delayed growth or decline profile compared to APW. …”
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Symptom clusters and resting cardiovascular autonomic measures in adolescents: From acute concussion to recovery by Wenjie Ji, Haley M. Chizuk, John J. Leddy, Sue A. Sisto, Mohammad N. Haider

“…Although some correlations between individual symptom domains and ANS activity were observed, they were not significantly different from asymptomatic controls, limiting the ability to interpret these findings.…”
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A Novel Air-to-Ground Communication Scheme for Advanced Big Data Collection in Smart Farming Using UAVs by Georgios A. Kakamoukas, Thomas D. Lagkas, Vasileios Argyriou, Sotirios K. Goudos, Panagiotis Radoglou-Grammatikis, Stamatia Bibi, Panagiotis G. Sarigiannidis

“…These findings underscore the potential of AERO-FL in a variety of scanning applications, including traffic monitoring, environmental observation, disaster response, and military operations. …”
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The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: A First Report from the Central Africa by Honoré Kalombayi Tshamala, Loukia Aketi, Pierre Manianga Tshibassu, Mathilde Bothale Ekila, Eric Musalu Mafuta, Patrick Kalambayi Kayembe, Michel Ntetani Aloni, Joseph Diayisu Shiku

“…Mixed form was rarely observed in this series. The frequency of hypertriglyceridemia was not different between the 3 groups (p>0.05). …”
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