Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer by Xiao-Xia Cai, Guo-Ming Chen, Zi-Qi Zheng, Yi-Xin Yin, Shuang Wang, Li Qiao, Xiao-Jiang Chen, Bai-Wei Zhao, Jin-Ling Duan, Cheng-Cai Liang, Ruo-Peng Zhang, Cheng-Zhi Wei, Fei-Yang Zhang, Bo-Wen Huang, Ze-Xian Liu, Zhi-Wei Zhou, Dan Xie, Mu-Yan Cai, Shu-Qiang Yuan, Yuan-Fang Li, Run-Cong Nie

“…We developed a comprehensive, integrated nomogram score, including the PM risk score, pT, pN, and tumor size, which could effectively predict the 5-year pRFS with an Area under the curve of 0.79 (95% CI: 0.71-0.88). …”
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The prognosis and metabolite changes of NSCLC patients receiving first‐line immunotherapy combined chemotherapy in different M1c categories according to 9th edition of TNM classifi... by Liang Zheng, Fang Hu, Wei Nie, Jun Lu, Bo Zhang, Jianlin Xu, Shuyuan Wang, Ying Li, Xiaoxuan Zheng, Wei Zhang, Yinchen Shen, Runbo Zhong, Tianqing Chu, Baohui Han, Hua Zhong, Xueyan Zhang

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Weighted Gene Co-Expression Network of Growth Differentiation-Related lncRNAs and mRNAs in Plectropomus leopardus by Jin GAO, Jinye LIU, Fuxiao CHEN, Yongbo WANG, Shuyuan FU

“…Mmt1 is an essential gene for mammalian development, serving as a major N-myristoyltransferase during early embryogenesis. …”
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Complete Genomic Landscape Reveals Hidden Evolutionary History and Selection Signature in Asian Water Buffaloes (Bubalus bubalis) by Jingfang Si, Dongmei Dai, Neena Amatya Gorkhali, Mingshan Wang, Sheng Wang, Saroj Sapkota, Ram Chandra Kadel, Amir Sadaula, Aashish Dhakal, Md Omar Faruque, Abdullah Ibne Omar, Eka Meutia Sari, Hidayat Ashari, Muhammad Ihsan Andi Dagong, Marnoch Yindee, Hossam E. Rushdi, Hussein Elregalaty, Ahmed Amin, Mohamed A. Radwan, Lan Doan Pham, W. M. M. P. Hulugalla, G. L. L. Pradeepa Silva, Wei Zheng, Shahid Mansoor, Muhammad Basil Ali, Farhad Vahidi, Sahar Ahmed Al‐Bayatti, Alfredo Pauciullo, Johannes A. Lenstra, J. Stuart F. Barker, Lingzhao Fang, Dong‐Dong Wu, Jianlin Han, Yi Zhang

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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes by Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

“…While plitidepsin inhibits cap- or internal ribosome entry sites (IRES)-mediated translation, its impact on N6-methyladenosine (m6A) translation is limited. …”
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Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin by Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Mônica Silveira Wagner, Kayo Moreira Bagri, Erick Gabriel Alves Ferreira, Romulo Galvani, Romulo Galvani, Romulo Galvani, Romulo Galvani, Claudia Mermelstein, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Wilson Savino, Wilson Savino, Wilson Savino, Wilson Savino, Emiliano Barreto, Emiliano Barreto

“…In addition, increased contents of mesenchymal markers, namely, vimentin, N-cadherin, and fibronectin in TGF-β1-induced A549 cells, were downregulated by uvaol treatment. …”
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An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape by Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen

“…In contrast, IGHV2-5*01 antibodies using the N56 allele show increased binding resistance to the K444T mutation on RBD.DiscussionThis study provides valuable insights into humoral immune responses from the perspective of Ig alleles and population genetics. …”
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Investigation of GAM zonal flows near the pedestal region of H-mode on EAST tokamak by Xi Feng, AhDi Liu, Ge Zhuang, Chu Zhou, X.L. Zou, HaiQing Liu, Lei Ye, ZongLiang Dai, FeiFei Long, S.X. Wang, L. Wang, L.Q. Xu, H.L. Zhao, J. Zhang, X.M. Zhong, M.Y. Wang, S.F. Wang, L.T. Gao, W.X. Shi, S.C. Qiu, L.X. Li, Y.F. Feng, X.Y. Chen, Y.Y. Zhang, T. Lan, H. Li, W.Z. Mao, Z.X. Liu, W.X. Ding, J.L. Xie, W.D. Liu, Z.B. Shi

“…Based on the Gyro-kinetic simulation, the QCM is the low n trapped electron mode (TEM) and that the GAM is driven by TEM. …”
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The JWST-SUSPENSE Ultradeep Spectroscopic Program: Survey Overview and Star Formation Histories of Quiescent Galaxies at 1 < z < 3 by Martje Slob, Mariska Kriek, Aliza G. Beverage, Katherine A. Suess, Guillermo Barro, Rachel Bezanson, Gabriel Brammer, Chloe M. Cheng, Charlie Conroy, Anna de Graaff, Natascha M. Förster Schreiber, Marijn Franx, Brian Lorenz, Pavel E. Mancera Piña, Danilo Marchesini, Adam Muzzin, Andrew B. Newman, Sedona H. Price, Alice E. Shapley, Mauro Stefanon, Pieter van Dokkum, Daniel R. Weisz

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Geological, alteration, mineralogy and geochemical studies of the Copper deposit in the Kalatehno prospect area, northwest of Gonabad (Khorasan Razavi province) by Sedigheh Zirjanizadeh, Roohollah Miri Bydokhti

“…Introduction The Kalatehno area is situated 23 km northwest of Gonabad city, Khorasan Razavi province, and in geographic latitude 34°28´30̋ to 34°29´30̋ N and longitude 58°31´30̋ to 58°32´30̋ E. This area is located in the north of the Lut Block zone. …”
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Desafios e perspectivas da formação docente para o desenvolvimento de uma Educação Integral e inclusiva na contemporaneidade by Aline Novaes Conceição, Priscila Caroline Miguel, Adriana Alonso Pereira, Andressa Santos Rebelo

“…Assim, a política educacional de ampliação do tempo escolar denominada Programa Escola em Tempo Integral de que trata a Lei n.º 14.640 (Programa de Escola em Tempo Integral, 2023), não pode ser confundida com uma Educação Integral, ou seja, uma educação que busca a formação ampla do ser humano, pois essa não se resume a extensão do período de permanência na escola. …”
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First assessment of biofouling assemblages in the northern Red Sea, an important region for marine non-indigenous species transfer by Juan Sempere-Valverde, Juan Sempere-Valverde, Eva Aylagas, Vitaly Syomin, Vitaly Syomin, Marcos A. L. Teixeira, Glafira D. Kolbasova, Glafira D. Kolbasova, Sofía Ruiz-Velasco, Sahar Chebaane, Arthur Anker, João Curdia, Ronald Cadiz, Dylan M. Cottrell, Andrea Desiderato, Luiz F. Andrade, Chakkiath Paul Antony, Carolina Bocanegra-Castano, Matilde Marzucchi, Angelo Poliseno, Doaa Baker, Basmah Alabdulaziz, Flor Torres, Ameer A. Eweida, Ameer A. Eweida, Susana Carvalho, Susana Carvalho

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Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

“…The ependymal cells close to the ventricular system rely on AJs with N-cadherin at the core to maintain their normal morphology and function. …”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…Encouragingly, representative compound 8 exhibited a PI3Kα enzymatic IC50 value of 9.11 nM and 10.41/16.99/37.53-fold relative to the biochemical selectivity for PI3Kβ/γ/δ, respectively. …”
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Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…Methods: Quantification of apolipoproteins was performed on maternal plasma samples (N = 243 trios) collected at preconception, 26–28 weeks’ pregnancy, and three months postpartum in the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) cohort study. …”
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NSUN5 Facilitates Hepatocellular Carcinoma Progression by Increasing SMAD3 Expression by Hexu Han, Chengcheng zhang, Wenbo Shi, Jiawei Wang, Wenhui Zhao, Yanping Du, Zhibin Zhao, Yifan Wang, Maosong Lin, Lei Qin, Xiaoxue Zhao, Qianqian Yin, Yiyi Liu, Zhongqi Wang, Jing Zhang, Xiaomin You, Guoxiong Zhou, Honghui Wu, Jun Ye, Xianzhong He, Weizhong Tian, Hong Yu, Yin Yuan, Qiang Wang

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Medical Assistance in Dying for Persons Suffering Solely from Mental Illness in Canada by Chloe Eunice Panganiban, Srushhti Trivedi

“…,” n.d., https://www.government.nl/topics/euthanasia/is-euthanasia-allowed.; “Information on Requesting Euthanasia or Assisted Suicide,” n.d., https://guichet.public.lu/en/citoyens/sante/fin-vie/euthanasie/euthanasie-assistance-suicide.html…”
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Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation by Oana Hangiu, Oana Hangiu, Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Laura Rubio-Pérez, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Laura Díez-Alonso, Laura Díez-Alonso, Laura Díez-Alonso, Marina Gómez-Rosel, Marina Gómez-Rosel, Marina Gómez-Rosel, Noelia Silva-Pilipich, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Cristian Smerdou, Kenneth A. Howard, Laura Sanz, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Marta Compte

“…The mRNA encoding these bispecific antibodies contains an N1-methylpseudouridine modified nucleoside and regulatory sequences to ensure proper expression and stability. …”
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Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta... by Leiling Liu, Zhiqi Li, Wenrui Ye, Pu Peng, Yurong Wang, Luqing Wan, Jiangnan Li, Mei Zhang, Yihua Wang, Runqi Liu, Danyan Xu, Jingjing Zhang

“…Findings: A total of 154 randomised controlled trials (n = 112,515 participants) were included. Tirzepatide had the greatest weight-loss effect (WMD −11.69, 95% CI −19.22 to −4.15; P = 0.0024; I2 = 100.0%; moderate certainty), followed by semaglutide (−8.48, −12.68 to −4.27; P < 0.0001; I2 = 100.0%; moderate certainty). …”
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Association of exposure to second-hand smoke during childhood with blood DNA methylation by Marta Cosin-Tomas, Thanh Hoang, Cancan Qi, Giulietta S. Monasso, Ryan Langdon, Simon Kebede Merid, Lucinda Calas, Paula de Prado-Bert, Rebecca Richmond, Vincent VW Jaddoe, Liesbeth Duijts, John Wright, Isabella Annesi-Maesano, Regina Grazuleviciene, Marianna Karachaliou, Gerard H. Koppelman, Erik Melén, Olena Gruzieva, Martine Vrijheid, Paul Yousefi, Janine F. Felix, Stephanie J. London, Mariona Bustamante

“…Methods: Six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium (total N = 2,695), with SHS data and child blood DNAm (aged 7–9 years) measured with the Illumina 450K array were included in the meta-analysis. …”
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