Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder by Kira Furlano, Henning Plage, Sebastian Hofbauer, Sarah Weinberger, Bernhard Ralla, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha

“…The association with survival was independent of pT and pN (p = 0.0081). p63 expression was associated with GATA3 expression (p < 0.0001), a luminal cell type marker associated with favourable disease. …”
Get full text

Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

“…Study design: The study targeted specific AD-related proteins, including acetylcholinesterase (AChE), alpha serine/threonine-protein kinase (AKT-1), β-secretase-1 (BACE-1), cyclooxygenase-2 (COX-2), caspase-3, glycogen synthase kinase-3 (GSK-3), interleukin-6 (IL-6), mitogen-activated protein kinase-2 (MAPK-2), matrix metalloproteins-8 (MMP-8), N-methyl-d-aspartate receptor (NMDAR), Peptidyl arginine deiminase-2 (PAD-2), Presenilin-1 (PSEN-1), mitogen-activated protein kinase-14 (MAPK-14/P38), and tumor necrosis factor-alpha (TNF-α). …”
Get full text

Cardiac secreted HSP90α exacerbates pressure overload myocardial hypertrophy and heart failure by Le Pan, Chenxing Huang, Xuejuan Jin, Jian Wu, Kejia Jin, Jingyi Lin, Ying Wang, Jianxuan Li, Chao Yin, Xiang Wang, Lei Zhang, Guoping Zhang, Hangming Dong, Junli Guo, Issei Komuro, Yuxiang Dai, Yunzeng Zou, Hui Gong

“…Further analysis revealed that eHSP90α interacted with EC1-EC2 region of N-cadherin to activate β-catenin, enhancing the transcription of hypertrophic genes by TCF7, resulting in cardiac hypertrophy and dysfunction under pressure overload. …”
Get full text

Dysfunction of ATP7B Splicing Variant Caused by Enhanced Interaction With COMMD1 in Wilson DiseaseSummary by Donghu Zhou, Huaduan Zi, Xiaoxi Yang, Xiaojin Li, Yanmeng Li, Anjian Xu, Bei Zhang, Wei Zhang, Xiaojuan Ou, Jidong Jia, Jian Huang, Hong You

“…This study focused on the ATP7B c.1543+1G>C variant, to reveal a universal pathogenic mechanism of the ATP7B mutants with altered N-terminus. Methods: The splicing assay and RNA pull-down were performed to explore the mechanism of the aberrant splicing. …”
Get full text

The Protocol for the Multi-Ethnic, multi-centre raNdomised controlled trial of a low-energy Diet for improving functional status in heart failure with Preserved ejection fraction (... by Noelle Robertson, Melanie J Davies, Thomas Yates, Gerry P McCann, Gaurav Singh Gulsin, Emer M Brady, Joanne V Wormleighton, Eylem Levelt, Oliver Rider, Jiliu Pan, Christopher Miller, Iain Squire, Mehak Asad, Fardad Soltani, Michelle Hadjiconstantinou, Rachel L Brown, Joanna M Bilak

“…This pragmatic randomised trial aims to evaluate the efficacy of MRP-directed weight loss on exercise intolerance, symptoms, quality of life and cardiovascular remodelling in a multiethnic cohort with obesity and HFpEF.Methods and analysis Prospective multicentre, open-label, blinded endpoint randomised controlled trial comparing low-energy MRP with guideline-driven care plus health coaching. Participants (n=110, age ≥18 years) with HFpEF and clinical stability for at least 3 months will be randomised to receive either MRP (810 kcal/day) or guideline-driven care for 12 weeks. …”
Get full text

Spatial-temporal distribution of phytoplankton HAB species and contamination status of oyster toxins under intensive oyster farming in Jiangmen coasts, the South China Sea by Jian Zou, Yayuan Xiao, Jiaqi Su, Yang Liu, Peng Wu, Teng Wang, Lin Lin, Chunhou Li, Yu Liu, Yong Liu

“…Only spring oyster samples were detected paralytic shellfish toxins (PSTs) (1/15), and the composition included gonyautoxins (GTX1&2) and decarbamoyl gonyautoxin 2 (dcGTX2), with a total toxicity level of 9.96 µg STXeq kg−1. N-sulfocarbamyl (C1) and decarbamoyl gonyautoxin 3 (dcGTX3) were observed in the net-concentrated phytoplankton samples. …”
Get full text

Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the Che... by Enriqueta Felip, David P. Carbone, Martin Reck, Luis Paz-Ares, Yong Yuan, Nan Hu, Niels Reinmuth, Xiaoqing Zhang, Thomas John, Ying Cheng, Shun Lu, Manuel Cobo, Michael Schenker, Tudor-Eliade Ciuleanu, Stéphanie Bordenave, Oscar Juan-Vidal, Juliana Menezes, Eduardo Richardet, Hideaki Mizutani, Bogdan Zurawski, Aurelia Alexandru, Javed Mahmood, Tuli De, Irene Santi, John R. Penrod, Adam Lee

“…In patients who discontinued all components of nivolumab plus ipilimumab with chemotherapy due to TRAEs (n=61), the 4-year OS rate was 41%. With treatment-switching adjustment for the 36% of patients receiving subsequent immunotherapy in the chemotherapy arm, the estimated HR of nivolumab plus ipilimumab with chemotherapy versus chemotherapy was 0.66 (95% CI 0.55 to 0.80). …”
Get full text

Tobacco control environment: cross-sectional survey of policy implementation, social unacceptability, knowledge of tobacco health harms and relationship to quit ratio in 17 low-inc... by Annika Rosengren, Li Wei, Khalid Yusoff, Martin McKee, Clara K Chow, Rajeev Gupta, Koon Teo, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Rafael Diaz, Alvaro Avezum, Fernando Lanas, Noorhassim Ismail, Romaina Iqbal, Jephat Chifamba, Gilles Dagenais, Salim Yusuf, Anna B Gilmore, Scott Lear, Wang Yang, Omar Rahman, Katarzyna Zatonska, Prem Mony, Rajesh Kumar, Afzalhussein Yusufali, Daniel J Corsi, Ehimario Igumbor, V Mohan, Annamarie Kruger, Krishnapillai Vijayakumar, Yuksel Altuntas, Ahmad Bahonar

“…Objectives This study examines in a cross-sectional study ‘the tobacco control environment’ including tobacco policy implementation and its association with quit ratio.Setting 545 communities from 17 high-income, upper-middle, low-middle and low-income countries (HIC, UMIC, LMIC, LIC) involved in the Environmental Profile of a Community's Health (EPOCH) study from 2009 to 2014.Participants Community audits and surveys of adults (35–70 years, n=12 953).Primary and secondary outcome measures Summary scores of tobacco policy implementation (cost and availability of cigarettes, tobacco advertising, antismoking signage), social unacceptability and knowledge were associated with quit ratios (former vs ever smokers) using multilevel logistic regression models.Results Average tobacco control policy score was greater in communities from HIC. …”
Get full text

Implementasi Program “Menjelajah Desa Menjemput Pajak” Pada Kantor Badan Pendapatan Kabupaten Langkat” by Dwi Nur Anisya Putri, Badaruddin Badaruddin, Abdul Kadir

“…Jakarta: Putra Grafika Dunn, W.N. (1998). Muhadjir Darwin (Penyunting). Pengantar Analisis Kebijakan Publik. …”
Get full text

ارزیابی تنوع توده های بومی زنبق مردابی (Iris pseudacorus) بر پایه صفات ریخت شناسی by نیره قربانی, اسماعیل چمنی, علی اکبر شکوهیان, سیده ساناز رمضانپور

“…بدین صورت که توده‌‌های F، P، H، M، O، K، E، و G در گروه اول، توده‌‌های B، J، I، L، A و N گروه دوم، توده C گروه سوم و توده Q گروه چهار خوشه‌بندی شدند. …”
Get full text

Ce se scria în secolul al XVIII-lea în țările române? by Maria Magdalena Székely

“…Bien que les manuscrits étudiés soient pleins de toutes sortes d’histoires, généralement tirées de la Bible, du Paterikon ou des Vies des saints, aucun d’entre eux n’a stimulé les copistes à faire des exercices personnels en prose. …”
Get full text

Sex differences in murine MASH induced by a fructose-palmitate-cholesterol-enriched diet by Lakshmi Arivazhagan, Sofie Delbare, Robin A. Wilson, Michaele B. Manigrasso, Boyan Zhou, Henry H. Ruiz, Kaamashri Mangar, Ryoko Higa, Emily Brown, Huilin Li, Michael J. Garabedian, Ravichandran Ramasamy, Kathryn J. Moore, Edward A. Fisher, Neil D. Theise, Ann Marie Schmidt

“…Methods: Female and male C57BL/6J mice were fed a fructose-palmitate-cholesterol (FPC)-NASH diet vs. standard chow for 16 weeks (n = 40 mice). At sacrifice, plasma and liver were retrieved, the latter for single-nucleus RNA sequencing. …”
Get full text

The efficacy of sodium-glucose transporter 2 inhibitors in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis by Hongsheng Li, Yanli Hou, Wenyong Xin, Lina Ding, Ying Yang, Yikun Zhang, Wenqi Wu, Zhibin Wang, Wenyu Ding

“…The mean differences (MD or SMD) and 95 % confidence intervals (CIs) were calculated via random-effects models. Eleven articles (n = 805 patients with NAFLD) were included in this study. …”
Get full text

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky [version 2; peer review: 1 approved, 2 approved with reservations] by Pamela Klaassen, Mark Booth, Thomas Stanke, Evanthia Hatziminaoglou, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen, John Orlowski-Scherer, Tomasz Kamiński, Joe Bright, Atul Mohan, Michael Koss, Sigurd Næss, Francisco Miguel Montenegro-Montes, Paola Severgnini, Claudio Ricci, Jochen Greiner, Cristian Vignali

Get full text

LungDiag: Empowering artificial intelligence for respiratory diseases diagnosis based on electronic health records, a multicenter study by Hengrui Liang, Tao Yang, Zihao Liu, Wenhua Jian, Yilong Chen, Bingliang Li, Zeping Yan, Weiqiang Xu, Luming Chen, Yifan Qi, Zhiwei Wang, Yajing Liao, Peixuan Lin, Jiameng Li, Wei Wang, Li Li, Meijia Wang, YunHui Zhang, Lizong Deng, Taijiao Jiang, Jianxing He

Get full text

واسنجی مدل SWAT با تلفیق الگوریتم تکاملی PSO و روش تاگوچی by حسین شیرانی, انیس اسدی, سمیه صدر, علی اصغر بسالت پور, عیسی اسفندیار پور

“…با توجه به ماهیت متغیر پاسخ در این پژوهش، برای تحلیل نتایج آزمایش تاگوچی از شاخص S/N "هر‌چه کمتر، بهتر" استفاده شد. مرحله انتخاب آرایه‌ها و محاسبات در نرم‌افزار Minitab 16 انجام گرفت. …”
Get full text

Predicting Interplanetary Shock Occurrence for Solar Cycle 25: Opportunities and Challenges in Space Weather Research by Denny M. Oliveira, Robert C. Allen, Livia R. Alves, Séan P. Blake, Brett A. Carter, Dibyendu Chakrabarty, Giulia D’Angelo, Kevin Delano, Ezequiel Echer, Cristian P. Ferradas, Matt G. Finley, Bea Gallardo‐Lacourt, Dan Gershman, Jesper W. Gjerloev, John Bosco Habarulema, Michael D. Hartinger, Rajkumar Hajra, Hisashi Hayakawa, Liisa Juusola, Karl M. Laundal, Robert J. Leamon, Michael Madelaire, Miguel Martínez‐Ledesma, Scott M. McIntosh, Yoshizumi Miyoshi, Mark B. Moldwin, Emmanuel Nahayo, Dibyendu Nandy, Bhosale Nilam, Katariina Nykyri, William R. Paterson, Mirko Piersanti, Ermanno Pietropaolo, Craig J. Rodger, Trunali Shah, Andy W. Smith, Nandita Srivastava, Bruce T. Tsurutani, S. Tulasi Ram, Lisa A. Upton, Bhaskara Veenadhari, Sergio Vidal‐Luengo, Ari Viljanen, Sarah K. Vines, Vipin K. Yadav, Jeng‐Hwa Yee, James W. Weygand, Eftyhia Zesta

Get full text

Voltaire et Contant d’Orville: le 'Voltaire portatif' (1766), une lettre inconnue, un remerciement à l’auteur, et une réplique voilée à l’archevêque d’Auch by John R. Iverson

“…L’article commence par la transcription de la lettre complète de Contant d’Orville, imprimée dans une brochure en 1766 avec la réponse de Voltaire, mais qui n’a pas été incluse par la suite dans les éditions de la correspondance de celui-ci. …”
Get full text

Promise and Peril: Stellar Contamination and Strict Limits on the Atmosphere Composition of TRAPPIST-1 c from JWST NIRISS Transmission Spectra by Michael Radica, Caroline Piaulet-Ghorayeb, Jake Taylor, Louis-Philippe Coulombe, Björn Benneke, Loic Albert, Étienne Artigau, Nicolas B. Cowan, René Doyon, David Lafrenière, Alexandrine L’Heureux, Olivia Lim

“…For high mean molecular weight atmospheres, where O _2 or N _2 is the background gas, our spectrum disfavors partial pressures of more than  ∼10 mbar for H _2 O, CO, NH _3 , and CH _4 at the 2 σ level. …”
Get full text

Lidar Network for Temperature and Wind Measurements in the Mesosphere and Lower Thermosphere Region by Y. Yang, F. Li, X. Cheng, G. Yang, D. Lyu, X. Lin, L. Liu, X. Fang, J. Zheng, L. Du, W. Wang, L. Ren, J. Wang, J. Liang, K. Ji, L. Xu, Z. Chen, K. Ji, H. Zheng, X. Wang, Y. Wang, J. Jiao, X. Wang, X. Xue, Y. Xia, Y. Li, Z. Lin, L. Chen, Z. Chen, J. Xu, G. Li, L. Hu, S. Gong

Get full text