Associations between prior healthcare use, time to diagnosis, and clinical outcomes in inflammatory bowel disease: a nationally representative population-based cohort study by Alex Bottle, Sonia Saxena, Richard C G Pollok, Jonathan Blackwell, Irene Petersen, Hanna Creese, Nishani Jayasooriya, Richard CG Pollok

“…We used multivariable Cox regression to examine the association of primary care consultation frequency (n=1, 2, >2), annual consultation intensity, hospitalisations for gastrointestinal symptoms, and time to diagnosis with a range of key clinical outcomes following diagnosis.Results We identified 2645 incident IBD cases (CD: 782; UC: 1863). …”
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Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…While this treatment resulted successful in two patients (#1, Kv7.2 G310S variant; #3, Kv7.3 V359L + Kv7.3 D542N), it resulted detrimental in the remaining case (#2, Kv7.2 D535E), requiring drug withdrawal. …”
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Investigating variability of craft microbreweries spent grains for classification and incorporation into precision diet formulation through multivariate analyses by Arturo Macias Franco, Aghata E.M. Silva, Tio Brody, Graham Holton, Macy Rockwell, Nelcino F. De Paula, Leilson R. Bezerra, Mozart A. Fonseca

“…The third cluster (CL3), characterized by low protein content, had significantly lower NH3-N concentrations after fermentation (P < 0.05). …”
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A compilation of surface inherent optical properties and phytoplankton pigment concentrations from the Atlantic Meridional Transect by T. M. Jordan, G. Dall'Olmo, G. Tilstone, R. J. W. Brewin, F. Nencioli, R. Airs, C. S. Thomas, L. Schlüter

“…Here we present a compilation of particulate absorption–attenuation spectrophotometric data measured underway on nine Atlantic Meridional Transect (AMT) cruises between 50° N and 50° S from 2009–2019. The compilation includes coincident high-performance liquid chromatography (HPLC) phytoplankton pigment concentrations, which are used to calibrate transects of total chlorophyll <span class="inline-formula"><i>a</i></span> (Tot_Chl_a) concentrations derived from the <span class="inline-formula"><i>a</i>_p(<i>λ</i>)</span> line-height method. …”
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A rare haplotype of the GJD3 gene segregating in familial Meniere’s disease interferes with connexin assembly by Alba Escalera-Balsera, Paula Robles-Bolivar, Alberto M. Parra-Perez, Silvia Murillo-Cuesta, Han Chow Chua, Lourdes Rodríguez-de la Rosa, Julio Contreras, Ewa Domarecka, Juan Carlos Amor-Dorado, Andrés Soto-Varela, Isabel Varela-Nieto, Agnieszka J. Szczepek, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez

“…Results We found an enrichment of rare missense variants in the GJD3 gene when comparing allelic frequencies in FMD (N = 94) with the Spanish reference population (OR = 3.9[1.92–7.91], FDR = 2.36E-03). …”
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Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysisResearch in context by Xiaoqing Huang, Xiaodan Di, Suiwen Lin, Minrong Yao, Suijin Zheng, Shuyi Liu, Wayan Lau, Zhixin Ye, Zilian Wang, Bin Liu

“…Funding: National Natural Science Foundation of China (No.82371689, N0.81771602), and National Key Research and Development Program of China (No.2021YFC2700703).…”
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Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…However, shedding or downregulation of NKG2D ligands (NKG2DL) can prevent NKG2D activation, resulting in escape of cancer cells from NKG2D-dependent immune surveillance.Methods To enable tumor-specific targeting of NKG2D-expressing effector cells independent of membrane-anchored NKG2DLs, we generated a homodimeric recombinant antibody which harbors an N-terminal single-chain fragment variable (scFv) antibody domain for binding to NKG2D, linked via a human IgG4 Fc region to a second C-terminal scFv antibody domain for recognition of the tumor-associated antigen ErbB2 (HER2). …”
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Effects of Digital Storytelling Package on Students’ Motivation and Attitude to Christian Religious Studies (CRS) in Junior Secondary Schools by Adetunmbi L. Akinyemi, Jonathan Iyanuoluwa Makinde

“…En outre, aucun effet significatif du sexe sur la motivation et l'attitude des étudiants à l'égard du C.R.S. n'a été observé. Sur la base de ces résultats, il est recommandé, entre autres stratégies, que les enseignants qui enseignent les cours de Religion Chrétienne dans les écoles secondaires envisagent d'adopter des stratégies pédagogiques telles que la narration numérique pour renforcer la motivation et l'attitude des élèves, ce qui pourrait influencer leurs valeurs morales de manière significative. …”
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KiKli Fit: Investigating the Implementation of a Physical Activity Program in Pediatric Cancer by Lars Rehbein, Ann Christin Schneider, Christina Hillebrech, Christina Schindera, Amika Singh, Katharina Eva, Valentin Benzing

“…., Ellis, K., & Culos-Reed, S. N. (2021). Synthesizing the literature on physical activity among children and adolescents affected by cancer: Evidence for the international Pediatric Oncology Exercise Guidelines (iPOEG). …”
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Physical Activity Behavior in Swiss Secondary School Students: A Segmented Analysis by Marion Gasser, Andrea-Maria Nadenbousch, Fabienne Egger, Mario Kamer, Stefan Valkanover, Mirko Schmidt

“…References Bringolf-Isler, B., Probst-Hensch, N., Kayser, B., & Suggs, S. (2016). Schlussbericht zur SOPHYA-Studie [Final report on the SOPHYA study]. …”
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Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth by Giorgia Picci, Nathan M. Petro, Chloe C. Casagrande, Lauren R. Ott, Hannah J. Okelberry, Danielle L. Rice, Anna T. Coutant, Grace C. Ende, Erica L. Steiner, Yu-Ping Wang, Julia M. Stephen, Vince D. Calhoun, Tony W. Wilson

“…Therefore, the current study sought examine whether anterior PG volume mediates associations between DHEA levels and changes in dysregulation symptoms in an adolescent sample (N = 114, 9 –17 years, Mage = 12.87, SD = 1.88). …”
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Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival? by Hester F Lingsma, David van Klaveren, Arjan A van de Loosdrecht, Anna van Rhenen, Otto Visser, Valery E P P Lemmens, Nikki van Leeuwen, Gerwin Huls, Z L Rana Kaplan, Eduardus F M Posthuma, Danielle van Lammeren-Venema, Tjeerd J F Snijders, Catharina H M J van Elssen, Peter A von dem Borne, Nicole M A Blijlevens, Jan J Cornelissen, Marc H G P Raaijmakers, Avinash G Dinmohamed

“…Regional variance was assessed for the entire population and age subgroups (ie, ≤60 years and &gt;60 years) using multivariable mixed effects logistic and Cox proportional hazard regression analyses, expressed via median OR (MOR) and median HR (MHR).Results Including all adult AML patients from 2014 to 2018 (N=4060 patients; 58% males; median age, 70 years), 1761 (43%) received ICT. …”
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Spectrum and Location of Ongoing Extreme Particle Acceleration in Cassiopeia A by Jooyun Woo, Kaya Mori, Charles J. Hailey, Elizabeth Spira-Savett, Aya Bamba, Brian W. Grefenstette, Thomas B. Humensky, Reshmi Mukherjee, Samar Safi-Harb, Tea Temim, Naomi Tsuji

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Factors associated with uptake and acceptability of cervical cancer screening among female sex workers in Northeastern Uganda: A cross-sectional study. by Ronald Opito, Emmanuel Tiyo Ayikobua, Hellen Akurut, Susan Alwedo, Saadick Mugerwa Ssentongo, Walter Drake Erabu, Lazarus Oucul, Musa Kirya, Lameck Lumu Bukenya, Elly Ekwamu, Abraham Ignatius Oluka, Samuel Kabwigu, Emmanuel Othieno, Amos Deogratius Mwaka

“…The self-reported HIV prevalence was 21.5% (n = 91). There were 138 (32.6%) participants who had ever been screened for cervical cancer (uptake), while 397 (93.9%) were willing to be screened (acceptability). …”
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Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry by Jae Myeong Kang, Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, Sarah Tomaszewski Farias, Michael W. Weiner, Rachel L. Nosheny

“…Additionally we assessed the ability of ECog to identify ‘decliners’, who exhibited the worst PAL progression slopes corresponding to the fifth percentile and below. Results Participants (n = 16,683) had an average age of 69.07 ± 7.34, 72.04% were female, and had an average of 16.66 ± 2.26 years of education. …”
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Country-Specific Roadmaps for Scaling Up Integrated Care in Belgium, Slovenia, and Cambodia – Lessons Learned from the SCUBY Project by Martin Heine, Monika Martens, Daniel Boateng, Grace Marie Ku, Roy Remmen, Edwin Wouters, Srean Chhim, Por Ir, Antonjia Poplas Susič, Wim van Damme, Josefien van Olmen, Kerstin Klipstein-Grobusch, on behalf of the SCUBY consortium

“…Methods: Thematic analysis was used to derive crucial roadmap elements from key SCUBY documents (n = 20), including policy briefs, interim reports, research outputs, and consortium meeting notes. …”
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Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping by Qiuyue Zhao, Subinuer Maimaitiaili, Yan Bi, Ming Li, Xin Li, Qian Li, Xinyi Shen, Min Wu, Linqing Fu, Zhengyang Zhu, Xin Zhang, Jiu Chen, Anning Hu, Zhou Zhang, Wen Zhang, Bing Zhang

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3D Printed Swordfish‐Like Wireless Millirobot by Xingcheng Ou, Yu Sheng, Jiaqi Huang, Dantong Huang, Xiaohong Li, Ran Bi, Guoliang Chen, Weijie Hu, Shuang‐Zhuang Guo

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A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction by Gwyneth Kong, Jaycie Koh, Jobelle Chia, Bryan Neo, Yiming Chen, Grace Cao, Bryan Chong, Mark Muthiah, Hui Wen Sim, Gavin Ng, Chieh Yang Koo, Chin Meng Khoo, Mark Yan-Yee Chan, Poay-Huan Loh, Nicholas W. S. Chew

“…In the T2DM group, one-quarter was lean (N = 1324), while the vast majority (74.5%) was non-lean. …”
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Epidemiology of hereditary eye disease in the populations of Russian Federation by V.V. Kadyshev, E.K. Ginter, S.I. Kutsev, Zh.G. Oganezova, R.A. Zinchenko

“…Zinchenko^1,3</b> </p> <p> <b>¹Research Center for Medical Genetics, Moscow, Russian Federation</b> </p> <p> <b>²Pirogov Russian National Research Medical University, Moscow, Russian Federation</b> </p> <p> <b>³N.A. Semashko National Research Institute of Public Health, Moscow, Russian Federation</b> </p> <p> <i><b>Aim</b>: genetic epidemiological study of hereditary eye diseases in various populations of the Russian Federation and comparative analysis of these findings.…”
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