CMPK2 promotes NLRP3 inflammasome activation via mtDNA‐STING pathway in house dust mite‐induced allergic rhinitis by YaoMing Zheng, YaDong Xie, JiaYing Li, YuJie Cao, Min Li, Qing Cao, MiaoMiao Han, HongFei Lou, YiLai Shu, Hui Xiao, HuaBin Li

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Evaluation of parent reminder-recall letters to promote human papillomavirus vaccination by Joan M. Griffin, Xuan Zhu, Wei Yi Kong, Robert M. Jacobson, Kathy L. MacLaughlin, Jennifer L. St. Sauver, Jeph Herrin, Gregory D. Jenkins, Nicole L. Larson, Lila J. Finney Rutten

“…Methods: This cross-sectional evaluation included data from parents (n = 1165) of adolescents ages 11–12 from six primary care practices who received letters about their child's HPV vaccination status. …”
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Determination of a normal orogenic palaeo-geothermal gradient with clay mineral and organic matter indices: a review by Rafael Ferreiro Mählmann, Meinert Rahn, Sébastien Potel, Lan Nguyen-Thanh, Rainer Petschick

“…The following correlation is calculated for a moderate geotherm (55 to 74 mWm2, mean = 61 mWm2) and normal temperature gradient conditions (25 to 35 °Ckm−1): KI = 1.134e−0.305VR, (R2 = 0.880, n = 462) with VR given as %Rmax, KI as Δ°2θ (limited to values between 0.2 to 1.0 Δ°2θ). …”
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An interval bilateral regulation framework of water resources supply and demand in irrigation area under water sources uncertainty by Zhan Shu, Yan Kang, Ying Gao, Xuemai Shi, Wanxue Li, Shuo Zhang, Songbai Song, Lingjie Li

“…Compared to the current scenario, annual average economic benefit has been increased by 19.6 %-24.9 %, irrigation water has been reduced by 10.3 %-12.5 %, and water shortage rates have been reduced to 2.1 %-2.9 % under water supply scenarios A-W, A-N, A-D, and A-E in the interval bilateral regulation framework. …”
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Rationale and design of a randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated phase 2a study to investigate the efficacy and safety of elobixibat i... by Atsushi Nakajima, Takeharu Yamanaka, Koji Yamamoto, Yasushi Honda, Kento Imajo, Masato Yoneda, Yuji Ogawa, Takaomi Kessoku, Takashi Kobayashi, Anna Ozaki, Satoru Saito, Michihiro Iwaki, Yusuke Saigusa, Haruki Usuda, Koichiro Wada

“…The patients will be randomly assigned to receive the combination therapy of 10 mg EXB and 9 g CTM powder (4 g CTM), 10 mg EXB monotherapy, 9 g CTM powder monotherapy or a placebo treatment (n=25 per group). Blood tests and MRIs will be performed 16 weeks following treatment initiation. …”
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Effects of brown alga, Stoechospermum marginatum extract on growth performance, body chemical compositions and some serum biochemical parameters in grey mullet, Mugil cephalus (Lin... by Nazanin Kiani, Paria Akbary

“…Materials and methods: The experiment was conducted in a completely randomized design with 120  grey mullet (with average weight of 9.56 ± 1.02 g) in 4 treatments and 3 replicates (n = 10 in each replicate) including: control group (T1) without using algae extract, 5 (T2), 10 (T3) and 15 g (T4)  brown algae per kg of diet. …”
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Tau oligomers impair memory and synaptic plasticity through the cellular prion protein by Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forloni

“…Surface plasmon resonance indicated a high-affinity binding between TauOs and PrPC with a K D of 20–50 nM. Immunofluorescence analysis of naïve and PrPC-overexpressing HEK293 cells exposed to TauOs showed a PrPC dose-dependent association of TauOs with cells over time, and their co-localization with PrPC on the plasma membrane and in intracellular compartments, suggesting PrPC-may play a role in TauO internalization. …”
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Genomic adaptation of Clostridium perfringens to human intestine by Ke Wu, Juan Wang, Zelin Yan, Yanyan Zhu, Shaolin Wang, Bo Fu, Chengtao Sun, Ruichao Li, Edward M. Fox, Séamus Fanning, Li Bai, Yang Wang, Yizhi Tang, Zhe Yin, Rong Zhang, Hongning Wang

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Observational cohort study of a group-based VR program to improve mental health and wellbeing in people with life-threatening illnesses by Hannes Kettner, Hannes Kettner, David R. Glowacki, David R. Glowacki, Justin Wall, Justin Wall, Justin Wall, Robin L. Carhart-Harris, Robin L. Carhart-Harris, Leor Roseman, Leor Roseman, Joseph L. Hardy, Joseph L. Hardy

“…Participants were individuals suffering from LTIs that self-selected to participate in the CL program. A total of N = 15 participants were evaluated based on assessments 1 week before and after the program, using self-report measures of anxiety, depression, wellbeing, and secondary psychological outcomes.ResultsThe intervention was well-tolerated among participants. …”
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Crosslinker effect on composite synthesis of alginate with activated carbon and nanocellulose as micronutrient slow-release fertilizer by Zainuddin Muchtar, Siti Rahmah, Moondra Zubir, Putri Faradilla, Rini Selly, Ahmad Shafwan Pulungan, Lisna Efiyanti, Riska Cahyati, Atikah Nur Syahirah

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Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity by Yang Wang, Jianguo Xu, Wanchun You, Haitao Shen, Xiang Li, Zhengquan Yu, Haiying Li, Gang Chen

“…In addition, the expression of Myelin Basic Protein was downregulated and that of anti-hypophosphorylated neurofilament H (N52) was upregulated after SAH. In experiments three and four, Rufy3 overexpression (LV-Rufy3) increased the interactions between Rufy3 and Rap1, the level of Rap1-GTP, and the ratio of Rap1-GTP/total GTP. …”
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Using photovoice to define “community” in substance use disorder research engaging service users, providers, and policymakers by McGladrey Margaret L, Marisa Booty, Ramona Olvera, Peter Balvanz, Hilary L. Surratt, Shannon Matthews, Susannah Stitzer, Owusua Yamoah, Sylvia Ellison, Kevin Campbell, Amy Farmer, Bethany Gealy, Mike Greenwell, Felicia Harris, Amy Kuntz, Sara Szelagowski, Alexandrea Shouse, Carrie B. Oser

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Brimonidine as an additional treatment for moderate glaucoma by I.R. Gazizova, V.E. Korelina

“…Korelina^2,3</b> </p> <p> <b>¹N.P. Bekhtereva Institute of the Human Brain, Saint Petersburg, Russian Federation</b> </p> <p> <b>²LLC “American Medical Clinic”, Saint Petersburg, Russian Federation</b> </p> <p> <b>³I.I. …”
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Prognostic prediction for inflammatory breast cancer patients using random survival forest modeling by Yiwei Jia, Chaofan Li, Cong Feng, Shiyu Sun, Yifan Cai, Peizhuo Yao, Xinyu Wei, Zeyao Feng, Yanbin Liu, Wei Lv, Huizi Wu, Fei Wu, Lu Zhang, Shuqun Zhang, Xingcong Ma

“…Kaplan–Meier analysis was performed for survival analyses. Results: Race, N stage, M stage, molecular subtype, history of chemotherapy and surgery, and response to neoadjuvant therapy were identified as independent predictive factors for the OS of IBC patients. …”
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IMPACTO DO PROGRAMA DE PROMOÇÃO DE ATIVIDADE FÍSICA NA MÍDIA NÃO PAGA: EXPERIÊNCIA DO PROGRAMA AGITA SÃO PAULO by Aylton Figueira Junior, Luís Carlos de Oliveira, Timóteo Leandro de Araújo, Sandra M. Matsudo, Douglas Roque Andrade, Erinaldo Luís Andrade, Victor K. R. Matsudo

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Analysis of Circulating Plasma MicroRNA Profile in Low-Grade and High-Grade Glioma – A Cross-Sectional Study [version 1; peer review: 2 approved, 1 approved with reservations, 1 no... by Sekar Safitri, Rachmat Andi Hartanto, Rusdy Ghazali Malueka, Bo Sun, Ery Kus Dwianingsih, Kusumo Dananjoyo, Ahmad Asmedi, Endro Basuki, Christina Megawimanti Sianipar, Yeshua Putra Krisnugraha

“…Eighteen blood plasma samples from glioma patients and 6 healthy controls were analyzed for 798 human miRNA profiles using NanoString nCounter Human v3 miRNA Expression Assay. The differential expressions of miRNAs were then analyzed to identify the differences in miRNA expression between LGG and HGG. …”
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Health and tuberculosis systems resilience, the role of the private sector and pandemic preparedness: insights from a cross-country qualitative study with policy-makers in India, I... by Madhukar Pai, Poshan Thapa, Charity Oga-Omenka, Angelina Sassi, Vijayashree Yellappa, Petra Heitkamp, Bony Wiem Lestari, Surbhi Sheokand, Nathaly Aguilera Vasquez, Laura Jane Brubacher, Bolanle Olusola-Faleye, Joel Shyam Klinton

“…The objectives of this study were to (1) explore policy-makers’ perspectives on the impact of the COVID-19 pandemic on private sector TB service delivery in India, Indonesia and Nigeria and (2) identify cross-cutting insights for pandemic preparedness with respect to TB service delivery.Methods From May to November 2021, 33 interviews were conducted with key policy-makers involved in health service administration, TB service delivery and/or the COVID-19 response in India, Indonesia and Nigeria (n=11 in each country). Interviews focused on the impact of COVID-19 on TB services and lessons learnt for pandemic preparedness with respect to TB in each study context. …”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…<h4>Background</h4>Recombinant Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) formulated on Alhydrogel (Na-GST-1/Alhydrogel) is being developed to prevent anemia and other complications of N. americanus infection. Antibodies induced by vaccination with recombinant Na-GST-1 are hypothesized to interfere with the blood digestion pathway of adult hookworms in the host. …”
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Efficacy of Fetal Wharton’s Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome by Illayaraja Krishnan, Magdalene Tan Mei Ling, Min Hwei Ng, Jia Xian Law, Mohd Rafizul Mohd Yusof, Thavachelvi Thangarajah, Zalina Mahmood, Nurul Izzati Uda Zahli, Shathiya Rajamanickam, Baskar Subramani, Yogeswaran Lokanathan

“…Method: Twenty-four rats were fed with a high-fat and high-fructose diet to induce MetS for 16 weeks and randomized into three groups (<i>n</i> = 8/group): a MetS Control group treated with normal saline, MetS Low Dose (LD) group treated with a LD of sEVs preparations (3 × 10⁹ particle/rat), and MetS High Dose (HD) group treated with a HD of sEVs preparations (9 × 10⁹ particles/rat). …”
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Maternal-related factors associated with development and improvement of peripartum cardiomyopathy and therapeutic outcomes of bromocriptine by I Gusti Bagus Mulia Agung Pradnyaandara, Ryan Saktika Mulyana, Jane Carissa Sutedja, Gusti Ngurah Prana Jagannatha, I Bagus Satriya Wibawa, Fanny Deantri, I Wayan Agus Surya Pradnyana, Bryan Gervais de Liyis

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