Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids by Xiao Han, Yuanlin He, Yuanhao Wang, Wenzhu Hu, Chu Chu, Lei Huang, Yuan Hong, Lu Han, Xu Zhang, Yao Gao, Yuan Lin, Hongxia Ma, Hongbing Shen, Xiaoyan Ke, Yan Liu, Zhibin Hu

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Nestin Forms a Flexible Cytoskeleton by Means of a Huge Tail Domain That Is Reversibly Stretched and Contracted by Weak Forces by Ayana Yamagishi, Rina Tokuoka, Kazuki Imai, Mei Mizusawa, Moe Susaki, Koki Uchida, Saku T. Kijima, Akira Nagasaki, Daijiro Takeshita, Chiaki Yoshikawa, Taro Q. P. Uyeda, Chikashi Nakamura

“…NTDs were elongated to approximately 80% of their maximum length at weak forces < 150 pN. Repeated tensile tests revealed that the NTD refolded quickly and behaved like a soft elastic material. …”
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Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections by Ryosuke Yamamura, Yu Nagayoshi, Kayo Nishiguchi, Hitomi Kaneko, Keiichi Yamamoto, Koki Matsushita, Miho Shimamura, Akihiro Kunisawa, Korin Sakakida, Takeshi Chujo, Masataka Adachi, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Kazuhito Tomizawa

“…Additionally, mice infected with wild-type E. coli showed higher levels of m2A in their urine than mice infected by m2A-deficient rlmN KO E. coli. This suggests that m2A from the infected bacteria is excreted in the urine. …”
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Mamá Empoderada: study protocol for a pilot trial of a novel parenting and mental health prevention intervention for migrant mothers with young children at the Mexico-US border by Gudelia Rangel, Shira M Goldenberg, Eileen Pitpitan, Kaylee Ramage, Ietza Bojorquez-Chapela, Cecilia Martinez-Torteya, Katherine Rosenblum, Chelsie Hernandez, Monica Alvarez

“…We have recently adapted this intervention for MMC in Mexico and will conduct a pilot randomised controlled trial (RCT) of the intervention with MMC (n=100; Ntreatment=50; Ncontrol=50). The intervention group (IG) will receive 10 group and three individual sessions addressing attachment-based parenting skills, linkage to resources (eg, food, shelter), social support, and self-care and resilience over a 5-week period. …”
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Species Diversity, Biomass Production and Carbon Sequestration Potential in the Protected Area of Uttarakhand, India by Geetanjali Upadhyay, Lalit M. Tewari, Ashish Tewari, Naveen Chandra Pandey, Sheetal Koranga, Zishan Ahmad Wani, Geeta Tewari, Ravi K. Chaturvedi

“…The <i>Quercus leucotrichophora</i>, <i>Rhododendron arboreum</i> and <i>Quercus floribunda</i> (QL-RA-QF) community(higher altitudinal zone) exhibited the highest tree biomass (568.8 Mg ha⁻¹), while the (<i>Pinus roxburghii</i> and <i>Quercus leucotrichophora</i>) PR-QL (N) community (lower altitudinal zone) in the north aspect showed the lowest (265.7 Mg ha⁻¹). …”
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Not just about pills: Findings from a national survey of pharmacists to understand their views on addressing social determinants of health by Katherine A. Meehan, Austin R. Waters, Mary Wangen, Olufeyisayo O. Odebunmi, Renée M Ferrari, Macary W. Marciniak, Alison T. Brenner, Stephanie B. Wheeler, Parth D. Shah

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Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammat... by Wen Zhang, Junke Song, Wan Li, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du

“…The translocation of HMGB1 and NF-κB were studied by immunofluorescence assay. The HMGB1/NeuN, HMGB1/GFAP, and HMGB1/Iba1 double staining was carried out to observe the localization of HMGB1 in different cells. …”
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Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B by Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung

“…BoNTs comprise three functional domains: a light-chain enzymatic domain (LC), a heavy-chain translocation domain (HC_N), and a heavy-chain receptor-binding domain (HC_C). …”
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Effect of drinking water salinity on lactating cows’ water and feed intake, milk yield, and rumen physiology by A. Iritz, D. Espinoza, M.G. Taye, F. Salhab, Y. Portnik, U. Moallem, Y.A. Ben Meir

“…We analysed the total tract apparent digestibility, rumen fluid volatile fatty acids and NH3, and mineral concentrations (Na, Cl, K, and N) in water, urine, faeces, and milk. Drinking water salinity was positively correlated with DM intake and energy-corrected milk yield, the latter showing the greatest response between EC of 400 and 600 µS/cm. …”
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Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients by Rayra P. Santiago, Magda O. S. Carvalho, Camylla V. B. Figueiredo, Luciana M. Fiuza, Rodrigo M. Oliveira, Sètondji C. M. A. Yahouédéhou, Valma M. L. Nascimento, Isa M. Lyra, Théo Araujo-Santos, Nívea F. Luz, Milena M. Aleluia, Caroline C. Guarda, Valéria M. Borges, Marilda S. Goncalves

“…This study is aimed at investigating associations between levels of TGF-β1 and classical laboratory biomarkers and inflammatory mediators, as well as the tissue inhibitor of metalloproteases-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9), in pediatric patients (n=123) with SCD in steady state: 84 with sickle cell anemia (HbSS) and 39 with hemoglobin SC disease (HbSC). …”
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The roles of cannabis potency and gender in cannabis dependence and anxiety in recent cannabis users with trauma exposure histories by T. Snooks, S.H. Stewart, P. Romero-Sanchiz, S. DeGrace, S.P. Barrett, H.C.R. Bernusky, P.G. Tibbo

“…Additionally, there are issues with how cannabis potency is calculated via the THC:CBD ratio that may contribute to inconsistencies in the literature. N = 202 (55.8 % women) recent cannabis users (>1 g in the past month) with trauma histories – a group at high risk for anxiety and cannabis dependence – completed an online survey including a self-report measure of THC and CBD levels in participants’ typically-used cannabis product. …”
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Petrogenesis of REE-rich two-mica granite from the Indosinian Xiekeng pluton in South China Block with implications for REE metallogenesis by Defu Zhang, Defu Zhang, Tingting Lv, Xiangaung Wang, Xiangaung Wang, Mingxuan Cao, Xiquan Chen, Xiquan Chen, Yongwen Zhang, Liangxin Gong

“…The total rare earth element (ΣREY = ΣREE + Y) contents range from 224.7 to 353.12 ppm, with a relative enrichment in light rare earth elements (ΣLREE/ΣHREY) of 1.55–5.36, and significant fractionation between light and heavy rare earth elements with (La/Yb)N = 3.36–18.48, and pronounced negative Eu anomalies (Eu/Eu* = 0.08–0.41). …”
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PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+/HER2− breast cancer by Eduardo Terán, Rebeca Lozano, César A. Rodríguez, Mar Abad, Luis Figuero, José Antonio Muñoz, Belén Cigarral, Aline Rodrígues, Magdalena Sancho, M. Asunción Gómez, Daniel Morchón, Juan Carlos Montero, José María Sayagués, M. Dolores Ludeña, Emilio Fonseca

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A canadian response to the iconography of war propaganda in the British Empire: Nellie McClung’s Politeia Pax Feminina by Karin Ikas

“…Cependant, « le Canada n’a jamais été un enfant de chœur dans le concert des nations ; il a participé à des guerres et a négocié ses avantages comme tous les autres. …”
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Investigating Falls Risk Awareness in Hospitals Using the Self‐Awareness of Falls Risk Measure (SAFRM): Empirical Research Quantitative by Elissa Dabkowski, Simon J. Cooper, Jhodie Duncan, Karen Missen

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Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective by Camila D. Odio, Jedas Veronica Daag, Maria Vinna Crisostomo, Charlie J. Voirin, Ana Coello Escoto, Cameron Adams, Lindsay Dahora Hein, Rosemary A. Aogo, Patrick I. Mpingabo, Guillermo Raimundi Rodriguez, Saba Firdous, Maria Abad Fernandez, Laura J. White, Kristal An Agrupis, Jacqueline Deen, Aravinda M. de Silva, Michelle Ylade, Leah C. Katzelnick

“…The EDIII and NS1 assays measure binding antibodies, and the PRNTs measure neutralizing antibodies to each specific DENV serotype. Healthy children (n = 1206) in Cebu, Philippines were followed for 5 years. …”
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Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

“…Colostrum of excellent quality had greater (P < 0.05) abundance of serpin A3-7 (A2I7N3), complement factor I (A0A3Q1MIF4), lipocalin/cytosolic fatty-acid binding domain-containing protein (A0A3Q1MRQ2), complement C3 (E1B805), complement component 4 binding protein alpha (A0AAF6ZHP5), and complement component C6 (F1MM86). …”
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Comparison of Oncological Outcomes After Curative Resection for Right-side Colon Cancer and Left-side Colon Cancer: a Retrospective Observational Study by Mehmet Torun, Orhan Uzun, Mustafa Duman, Erdal Polat, Aziz Serkan Senger, Mürşit Dinçer, Ömer Özduman, Selçuk Gülmez, Ahmet Orhan Sunar

“…No significant differences were found between the groups regarding age, gender, body mass index, carcinoembryonic antigen value, tumor size, T/N stage, lymphovascular/perineural invasion, positive lymph nodes, and hospital stay. …”
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A Study on the Inflammatory Response of the Brain in Neurosyphilis by Qiyu Zhang, Jie Ma, Jia Zhou, Hanlin Zhang, Mansheng Li, Huizi Gong, Yujie Wang, Heyi Zheng, Jun Li, Ling Leng

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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…A combination of protein structure modeling and extensive mutagenesis was used to identify residues mediating binding of transiently expressed CD2v to erythrocytes. The N-terminal Ig-like domain AGFCC′C″ β sheet was identified as the putative CD2v erythrocyte-binding area. …”
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