High-Grade Cervical Intraepithelial Neoplasia: Impact of Colposcopic Lesion Area on Systemic Immune Responses by Mantoani PTS, Micheli DC, Jammal MP, Vieira JH, Michelin MA, Ferreira CGX, Silva HN, Murta EFC, Nomelini RS

“…Priscila Thaís Silva Mantoani,1,2 Douglas Côbo Micheli,2 Millena Prata Jammal,2 Julia Hailer Vieira,3 Márcia Antoniazi Michelin,3 Caroline Gabriela Xavier Ferreira,2 Henrique Nascimento Silva,2 Eddie Fernando Candido Murta,2 Rosekeila Simões Nomelini1,2 1Graduate Program in Gynecology and Obstetrics of the Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil; 2Laboratory of Applied Sciences for Women (LaCam)/Department of Gynecology and Obstetrics; Federal University of Triângulo Mineiro, Uberaba, MG, Brazil; 3Research Institute of Oncology (IPON); Discipline of Immunology; Federal University of Triângulo Mineiro, Uberaba, MG, BrazilCorrespondence: Rosekeila Simões Nomelini, Laboratory of Applied Sciences for Women (LaCam)/Department of Gynecology and Obstetrics, UFTM, Av. Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil, Tel +55 34 3318 5326, Fax +55 34 3318 5342, Email rosekeila@terra.com.brBackground: The progression of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer is accompanied by a reduction in the immune response. …”
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Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines by Juan Manuel Calleja-Castillo, Dora Luz De La Cruz-Aguilera, Joaquín Manjarrez, Marco Antonio Velasco-Velázquez, Gabriel Morales-Espinoza, Julia Moreno-Aguilar, Maria Eugenia Hernández, Lucinda Aguirre-Cruz, Lenin Pavón

“…We included the respective control (C) and sham (S) groups (n=6 rats per group). DBS treated rats had higher levels of TNF-α (120%; P<0.01) and IFN-γ (305%; P<0.001) but lower corticosterone concentration (48%; P<0.001) than C and S. …”
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Reflections by a member of the Editorial Board by Kevin T. Smith

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Emulsifying Properties of Dried Soy-Whey, Dried Tofu-Whey, and Their Isolated Proteins by Sobral Pablo A., Ossa J. Sebastian Henao, Palazolo Gonzalo G., Wagner Jorge R.

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Electrophysiological and Structural Changes in Chinese Patients with LHON by Min Wang, Hong Guo, Shiying Li, Gang Wang, Yanling Long, Xiaohong Meng, Bo Liu, Yong Liu, Anthony G. Robson, Zheng Qin Yin

“…Pattern ERG (PERG) P50 amplitude was normal, but the N95/P50 ratio reduced in most of group 1 (4 of 5 eyes) and in all of group 2 (11 eyes). …”
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Therapeutic alliance impact on analgesic outcomes in a real-world clinical setting: An observational study by Barrachina Jordi, Margarit César, Andreu Blanca, Zandonai Thomas, Ballester Pura, Muriel Javier, Cutillas Esperanza, Peiró Ana M.

“…A cross-sectional observational study was conducted on outpatients (n = 69) using opioids on a long-term basis for the treatment of chronic non-cancer pain, where clinical pharmacologists and pharmacists advised patients about their opioid treatment. …”
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Modelling of structural, mechanical, electronic, and optical properties of Rb2TlXF6 (X = Ir, Rh) double perovskite compounds through density functional theory by Wasi Ullah, Nasir Rahman, Mudasser Husain, Wafa Mohammed Almalki, Khamael M. Abualnaja, Ghaida Alosaimi, Soufyane Belhachi, Bashar.M. Al-Khamiseh, Vineet Tirth, Ahmed Azzouz-Rached, Hanan A. Althobaiti, Farooq Ali

“…The optical properties were analyzed through key parameters: refractive index n(ω), optical conductivity σ(ω), reflectivity R(ω), absorption coefficient α(ω), and extinction coefficient k(ω). …”
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Clinical and anamnestic characteristics of patients with clinical manifestations of peripheral artery disease as a function of Т(–786)С polymorphism of the endothelial NO-synthase... by V.I. Tseluyko, L.M. Yakovleva, O.D. Yarova

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Heterogeneity of motivations among crowdinvestors: Evidence from the football industry by Szczepan Kościółek

“…METHODOLOGY: In this study, the survey research method was used for a sample (n = 793) of crowdinvestors from the Wisla Krakow football club, and a two-step motivation-based segmentation approach was applied. …”
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Efficacy of intranasal naloxone compared to other administration routes in prehospital opioid overdose management and beyond: a narrative review by Luigi Venuso, Francesco Ricciardi, Antonio Del Prete, Michele Virgolesi, Gianluca Pucciarelli, Luigi Langella, Teresa Rea

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Effects of Artemisia argyi leaf water extract (AWE) on growth performance, muscle quality, intestinal microbial, and metabolomics of common carp (Cyprinus carpio) by Di Sun, Nanyang Zeng, Yingjia Pan, Qingsong Shu, Jixing Zou, Yingshi Huang, Guoxia Wang, Jun Shi

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Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway by Sisi Wei, Xinyi Fan, Xiaoya Li, Wei Zhou, Zhihua Zhang, Suli Dai, Huilai Lv, Yueping Liu, Baoen Shan, Lianmei Zhao, Qimin Zhan, Yongmei Song

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Landscape of the Peripheral Immune Response Induced by Intraoperative Radiotherapy Combined with Surgery in Early Breast Cancer Patients by Danian Dai, Xuerui Li, Hongkai Zhuang, Yun Ling, Lezi Chen, Cheng Long, Jinhui Zhang, Yunjie Wang, Yuehua Li, Hailin Tang, Bo Chen

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Evaluation of the Effects of Retro-Cavity Preconditioning with or Without Ethylenediaminetetraacetic Acid on Root Surface pH and Dislodgement Resistance of NeoMTA2 and Mineral Trio... by Sedigheh Khedmat, Seyyed Ali Abaee, Hadi Assadian, Antonio Signore, Stefano Benedicenti

“…The samples were randomly divided into two groups of A and B (<i>n</i> = 24 each). In group A, retro-cavities were preconditioned with 2.5% NaOCl, followed by 17% EDTA solution, whereas in group B, preconditioning was performed using 2.5% NaOCl before final irrigation with normal saline. …”
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Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study by Yang Z, Liang X, Ji Y, Zeng W, Wang Y, Zhang Y, Zhou F

“…After calculating the amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VMHC) and degree centrality (DC) imaging, the radiomic features (n = 819) of bilateral hippocampi were extracted from these images, respectively. …”
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Time-resolved Hubble Space Telescope UV Observations of an X-Ray Quasiperiodic Eruption Source by T. Wevers, M. Guolo, S. Lockwood, A. Mummery, D. R. Pasham, R. Arcodia

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Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity by Parichehr Amiri, Seyed Ahmad Hosseini, Maryam Saghafi-Asl, Amin Akbari-Naserkiadeh, Seyedeh Asal Jenani Zavieh, Sara Arefhosseini, Samira Asghari, Neda Roshanravan

“…Taken together, NaBu supplementation could exert favorable anti-obesity effects through molecular pathways, while further research is recommended.This study was registered in Iranian Registry of Clinical Trials (https://irct.behdasht.gov.ir/user/trial/56967/view), (IRCT20190303042905N3).…”
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IMPACTOS DE LA VARIABILIDAD CLIMÁTICA SOBRE LA VEGETACIÓN DE LA CUENCA DEL RÍO SAUCE GRANDE (ARGENTINA) by Andrea Soledad Brendel

“…Por lo tanto, se evidenció un aumento en la frecuencia de los períodos secos y un incremento en la magnitud de estos eventos, que fue creciente en sentido N-S durante el mes febrero y opuesto durante octubre. …”
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Clinical calculator based on clinicopathological characteristics predicts local recurrence and overall survival following radical resection of stage II-III colorectal cancer by Fei Huang, Ran Wei, Shiwen Mei, Tixian Xiao, Wei Zhao, Zhaoxu Zheng, Qian Liu

“…We stratified patients into different risk groups according to the established model to predict their prognosis and guide clinical practice.ResultsThe clinical risk calculator incorporated six variables: tumor thrombus, perineural invasion, tumor grade, pathology T-stage, pathology N-stage, and whether more than 12 lymph nodes were harvested. …”
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Snow as an indicator of atmospheric transport of anthropogenic particles (microplastics and microfibers) from urban to Arctic regions by Jasmine T. Yu, Miriam L. Diamond, Eric Ward, Jennifer K. Adams, Amaya Cherian-Hall, Mary Gamberg, Tyler Obediah, Michael Palmer, Andrew Platt, Cassandra Worthy, Sarah A. Finkelstein, Liisa M. Jantunen

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