Biomimetic Versatile Anisotropic, Electroactive Cellulose Hydrogel Scaffolds Tailored from Fern Stem Serving as Nerve Conduit and Cardiac Patch by Qinghui Liang, Shuhui Chen, Shaofeng Hua, Weihong Jiang, Jiamian Zhan, Chunyi Pu, Rurong Lin, Yutong He, Honghao Hou, Xiaozhong Qiu

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Bonding performance of universal adhesive systems with dual-polymerising resin cements to various dental substrates: in vitro study by Shunsuke Takano, Rena Takahashi, Tomoko Tabata, Chen Zeng, Masaomi Ikeda, Yasushi Shimada

“…Micro-shear bond strength (μSBS) was measured after 0 thermal cycles (0TC) or 10,000 thermal cycles (10kTC) (n = 20). Statistical analyses were conducted using t-tests and Welch's t-tests with Bonferroni correction (α = 0.05), and failure modes were examined. …”
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High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells by Jiajun Lu, Minjie Sheng, Panpan Yao, Chaochao Ran, Hao Liu, Li Chen, Rui Liu, Bing Li

“…Meanwhile, the effects of N-acetyl-L-cysteine (NAC), an active oxygen inhibitor, on the experimental results were observed. …”
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Oxidative stress promotes lipid-laden macrophage formation via CYP1B1 by Yin Zhu, Saugata Dutta, Yohan Han, Dooyoung Choi, Francesca Polverino, Caroline A. Owen, Payaningal R. Somanath, Xiaoyun Wang, Duo Zhang

“…CYP1B1 expression and LLM formation were effectively suppressed by antioxidant N-acetylcysteine (NAC) and carvedilol. The formation of LLM was also associated with classically activated M1 but not the M2 state. …”
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Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review... by Chenqi Xie, Jianbao Gong, Chenglong Zheng, Junwei Zhang, Jie Gao, Chunyan Tian, Xiaofei Guo, Shiyou Dai, Tianlin Gao

“…However, there was no significant effect of vitamin K supplementation on other bone metabolism markers, such as cross-linked telopeptide of type 1 collagen (NTx), bone alkaline phosphatase (BAP), and procollagen I N-terminal propeptide (PINP). Subgroup analysis revealed that vitamin K notably enhanced bone health in females by increasing lumbar spine BMD (p = 0.028) and decreasing ucOC (p < 0.001). …”
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Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment by Xiuping Lai, Di Cheng, Huixin Xu, Jingshu Wang, Xiaozhi Lv, Herui Yao, Liuning Li, Junyan Wu, Suiwen Ye, Zhihua Li

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A comprehensive analysis of the effect of quorum-sensing molecule 3-oxo-C12-homoserine lactone on Candida auris and Candida albicans by Fruzsina Kovács, Ágnes Jakab, Noémi Balla, Zoltán Tóth, Dávid Balázsi, Lajos Forgács, Andrea Harmath, Aliz Bozó, Ágota Ragyák, László Majoros, Renátó Kovács

“…To gain deeper insights into this relationship, phenotypic and transcriptomic analyses were conducted in the presence of the primary P. aeruginosa quorum-sensing molecule, N-(3-oxododecanoyl)-l-homoserine lactone (HSL), against C. auris, with the results compared to those of C. albicans. …”
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IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers by Sunita Mathur, John Muscedere, David M Maslove, Miranda Hunt, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Michelle Tryon, Natasha Arianne Jawa, Michaela Hanley, Robin Westphal, Afolasade Fakolade

“…We define high risk as ICU stay ≥4 days or involving 1+ of mechanical ventilation, tracheostomy, delirium or lack of access to a primary care physician (PCP). 20 ICU survivor-primary caregiver dyads will be enrolled (n=10 dyads per group) and randomised 1:1 to the intervention versus control group. …”
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Can electronic monitoring with a digital smart spacer support personalised medication adherence and inhaler technique education in patients with asthma?: Protocol of the randomised... by Job F. M. van Boven, Boudewijn H.J. Dierick, Maria Achterbosch, Sandra Been-Buck, Titia Klemmeier, Susanne J. van de Hei, Paul Hagedoorn, Huib A.M. Kerstjens, Janwillem W.H. Kocks

“…At t=−1, patients with asthma ≥18 years using inhaled corticosteroids±long-acting beta-agonists±short-acting beta-agonists administered with a pressurised-metered-dose-inhaler and spacer (n=40) will use a smart spacer for 1 month. The rechargeable CE-marked smart spacer (Aerochamber Plus with Flow Vu) includes a sensor that monitors adherence and inhalation technique to prescribed dosing regimen of both maintenance and reliever inhalers. …”
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Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL... by Filipa Mascarenhas-Melo, Filipe Palavra, Daniela Marado, José Sereno, Edite Teixeira-Lemos, Isabel Freitas, Maria Isabel-Mendonça, Rui Pinto, Frederico Teixeira, Flávio Reis

“…Patients with cardiovascular risk factors (n=169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. …”
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Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition by Wenzhe Yang, Feilong Pan, Tong Zhao, Fangfang Chen, Wenqi Shao, Jinhao Wang, Shirui Wang, Zichen Zhao, Kexiang Liu, Shuchen Zhao, Lijia Zhao

“…In the present study, TM3 cells were used as an experimental model in combination with a reactive oxygen species (ROS) scavenger (N-acetylcysteine), Caspase-3 inhibitor (Ac-DEVD-CHO), autophagy activator (Torin2), and autophagy inhibitor (Chloroquine) to investigate the potential mechanisms by which BPA causes TM3 cell damage in vitro. …”
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Detection of atrial fibrillation in primary care with radial pulse palpation, electronic blood pressure measurement and handheld single-lead electrocardiography: a diagnostic accur... by Wim A M Lucassen, Henk C P M van Weert, Bjorn Winkens, Henri E J H Stoffers, J André Knottnerus, Steven B Uittenbogaart, Nicole Verbiest-van Gurp, Petra M G Erkens

“…We present pooled diagnostic parameters.Setting 47 general practices participated between September 2015 and August 2018.Participants In the electronic medical record system of the participating general practices (n=47), we randomly marked 200 patients of ≥65 years without AF. …”
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Promoção de Relações de Intimidade Saudáveis: Efetividade do Programa Desenvolvido com Adolescentes by Armando Manuel Marques Silva, Isabel Maria Pinheiro Borges Moreira, Maria Neto Cruz Leitão, Cristina Maria Figueira Veríssimo, Maria Conceição Gonçalves Marques Alegre Sá, Maria Isabel Domingues Fernandes

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Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry and nanoscale liquid chromatograp... by Sekkarin Ploypetch, Apisit Pornthummawat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sabrina Wahyu Wardhani, Sitthichok Lacharoje, Somporn Techangamsuwan

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Anticoagulant management of cancer-associated thrombosis and thrombocytopenia: a retrospective chart review by Umaima Abbas, Robin MacKenzie, Ushra Khan, Rija Fatima, Tzu-Fei Wang, Rong Luo, Caroline Hamm, Andrea Cervi

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The Role of P‐Wave Variables in Enhancing Prediction of New‐Onset Atrial Fibrillation in Patients With Acute Myocardial Infarction by Na Yang, Xiaoyan Li, Bo Wu, Longhao Dai, Shaobin Yang, Qinning Zhang, Shaobin Jia

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Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains by Daria Bortolotti, Claudio Trapella, Alessandra Bragonzi, Paolo Marchetti, Vinicio Zanirato, Andrea Alogna, Valentina Gentili, Carlo Cervellati, Giuseppe Valacchi, Mariangela Sicolo, Giulia Turrin, Anna Fantinati, Dario Di Luca, Roberta Rizzo

“…In this work, we synthesized already known QS inhibitors (QSi) designed on the scaffold of the N-(3-oxododecanoyl) homoserine lactone (3O-C12-HSL) QS molecule and conjugated them with ciprofloxacin to inhibit P. aeruginosa biofilm formation and increase the antibiotic susceptibility of clinical strains. …”
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Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/... by Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan

“…In TCGA cohorts, higher PTCD1 expression was substantially associated with a poorer clinical stage, histological grading, T stage, N stage, M stage, and survival outcomes. The results of multivariate analysis showed that PTCD1 was an independent variable affecting the survival outcomes of ccRCC patients (p < 0.001). …”
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Effect of self-paced sprint interval training and low-volume HIIT on cardiorespiratory fitness: the role of heart rate and power output by Katie L. Hesketh, Katie L. Hesketh, Sam O. Shepherd, Anton J. M. Wagenmakers, Matthew Cocks, Juliette A. Strauss

“…When grouping participants into tertiles based on HR and PO responses (n = 27), those achieving a low HR had similar changes in VO2peak compared to the high HR group in both interventions (P &gt; 0.05). …”
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Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives by Assem Barakat, Hazem A. Ghabbour, Abdullah Mohammed Al-Majid, Qurat-ul-ain, Rehan Imad, Kulsoom Javaid, Nimra Naveed Shaikh, Sammer Yousuf, M. Iqbal Choudhary, Abdul Wadood

“…The results of bioassay show that compounds 4a, 4b, 4c, 4d, 4e, 4f, and 4g are potent antioxidants in comparison to the tested standards, butylated hydroxytoluene (BHT), and N-acetylcysteine. Compounds 4a–4e (IC50=101.8±0.8–124.4±4.4 μM) and 4g (IC50=104.1±1.9 μM) were more potent antioxidants than the standard (BHT, IC50=128.8±2.1 μM). …”
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