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  1. 45561
  2. 45562
  3. 45563
  4. 45564

    浸润性乳腺癌近似分子亚型的临床意义

    Published 2009-01-01
    “…【目的】 探讨浸润性乳腺癌近似分子亚型的临床意义65377; 【方法】 回顾性分析浸润性乳腺癌患者,依据免疫组化雌激素受体(ER)65380;孕激素受体(PR)65380;HER2水平将其近似划分为Luminal A (ER+ 和/或 PR+,HER2-)65380;Luminal B (ER+ 和/或 PR+,HER2+)65380;HER2+(EP-,PR-,HER2+)和Basal-like(EP-,PR-,HER2-) 4个分子亚型,各36265380;10765380;86和148例,对比分析该4型患者的分布比例65380;发病年龄65380;绝经状态65380;病理组织学类型65380;病理分级65380;肿瘤大小65380;淋巴结状态等临床特征及首次复发时间和部位的特点65377;【结果】 所有703例患者中,Luminal A型比例最高,占51.5%;Luminal B和HER2+型所占比例最少65377;整体人群发病年轻,90.8%的患者在59岁以下65377;其中40岁以下患者Luminal A型最多65377;不同分子亚型病理分级构成差异显著,Luminal A型中,组织学1级患者比例最高,并且T1期肿瘤比例明显高于其他各亚型,HER2+型则以T4期肿瘤最多65377;各亚型间淋巴结分布无明显差异,仅在Luminal B和HER2+型出现N3高比例分布趋势65377;复发转移患者中,Luminal A型首次复发时间最长,HER2+型最短,且HER2+和Basal-like型肺转移率高65377;与国外报道不同,本研究未显示出各亚型中局部复发与远处转移的分布差异65377; 【结论】 蛋白标记近似分子分型简单明了,切实可行65377;国人乳腺癌具有蛋白标记近似的不同分子亚型,与国外大体相似,Luminal A型临床特征相对较好,HER2+型与Basal-like型具有较高的肺转移率65377;但仍有不同之处,尤其是Luminal A型年龄分布呈现年轻化65377;…”
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  5. 45565
  6. 45566

    Black Carbon Exposure Characteristics in Diesel Engine Vehicle-related Jobs by Sangjun Choi, Ju-Hyun Park, Won Kim, Seung Won Kim, Kyong-Hui Lee, Taejin Chung, Jihoon Park, Seung-Hun Ryu, Jungah Shin, Dong-Hee Koh, Dong-Uk Park

    Published 2021-05-01
    “…The workers chosen for this study (N = 106) measured their exposure every minute using an AE51 microAethalometer affixed to a microcyclone and also recorded their time-activity patterns and whereabouts in detail during working hours. …”
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  7. 45567
  8. 45568

    Le tourisme et l’imaginaire érotique à Paris durant la guerre : Français et Allemands pendant l’Occupation, 1940-1944 by Bertram M. Gordon

    Published 2018-05-01
    “…Une unité spéciale de la Wehrmacht y a ainsi organisé des séjours pour des milliers de ses jeunes soldats, dont beaucoup n’avaient jamais quitté leurs villes et villages d’origine. …”
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  9. 45569

    Maximal strength, sprint and jump performance in elite kumite karatekas by Fahri Safa Cinarli, Onur Aydogdu, Yalcin Aydin, Gürkan Tokgöz, Abdulselam Kahraman, Ayşegül Beykumül, Caner Aygoren, Nurkan Yılmaz, Rodrigo Ramirez-Campillo

    Published 2025-01-01
    “…Methods Male elite/international level (tier 4) kumite karatekas (n = 14; age, 20.79 ± 1.67 year; height, 1.77 ± 0.06 m; weight, 72.21 ± 5.20 kg) were recruited. …”
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  10. 45570
  11. 45571

    Study of unusable liquid propellant residues evaporation processes parameters in the tanks of launch vehicle worked-off stage in microgravity by V. I. Trushlyakov, V. A. Urbansky

    Published 2019-06-01
    “…Two options are considered as boundary conditions for liquid rocket propellant residues: a) liquid drop distribution in N identical drops, which surface decreases during evaporation and b) the liquid location in the lower tank bottom and the mirror presence, which area decreases during evaporation. …”
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  12. 45572

    Determination of Organophosphorus Esters in Fall Protection Equipment by Accelerated Solvent Extraction and Solid-Phase Extraction Coupled with LC-MS/MS Detection by Haihong Li, Mingli Ye, Fangfang Wu, Xuyang Zhao, Lifeng Wang, Yili Wei, Shengyi Xie, Hairong Cui

    Published 2021-01-01
    “…Safety ropes displayed a higher concentration of OPEs than ones in safety helmets, with the pollutants being mainly triphenyl phosphate, 2-ethylhexyl diphenyl phosphate (EHDPP), tri(2-ethylhexyl) phosphate, and tri-n-butyl phosphate in the range of 11.07 ng/g‒815.53 ng/g. …”
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  13. 45573

    Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers by Hoon Kim, Jongyeob Kim, Byungdoo Hwang, SangYong Park, Ji-Yeon Shin, EunByeol Go, Jae Sil Kim, Youngjin Roh, SoonChul Myung, Seok-Joong Yun, YungHyun Choi, Wun-Jae Kim, Sung-Kwon Moon

    Published 2024-11-01
    “…KO treatment stimulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 signaling. In addition, KO changed the expression of BPH-related markers (5α-reductase, androgen receptor, FGF, Bcl-2, and Bax) and the activity of the proliferation-mediated NF-κB binding motif. …”
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  14. 45574

    Pulmonary aspiration during pregnancy or immediately postpartum in the UK: A population-based case-control study [version 1; peer review: 2 approved] by Ruth Tunn, Marian Knight, Alison Gooda, Nuala Lucas

    Published 2025-01-01
    “…Between September 2013 and August 2016, all UK consultant-led obstetric units prospectively identified cases of pulmonary aspiration among parturient women using a pre-defined case definition, and reported them via the UK Obstetric Surveillance System (UKOSS). Controls (n=1982) were obtained from four UKOSS studies conducted between 2005 and 2014. …”
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  15. 45575

    A decomposition analysis of sociodemographic factors and non-cigarette tobacco use as contributors to the change in smoking rates in South Africa between 2017/18 and 2021 by K Kali, O Ayo-Yusuf

    Published 2024-06-01
    “…Data from three waves (2017, 2018 and 2021) of the South African Social Attitudes Survey (total N=8 140) were analysed. The sociodemographic correlates of current daily and non-daily use of factory-manufactured cigarettes (FMCs), roll-your-own (RYO) cigarettes, waterpipe/hubbly, electronic cigarettes (ECigs), snuff (a smokeless tobacco) and any combination of FMCs, RYO cigarettes and waterpipe/hubbly (‘current smoking’) in 2017/18 (pre-pandemic) were compared with those for 2021 (during the pandemic). …”
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  16. 45576
  17. 45577

    Cardiovascular risk and mortality in men receiving testosterone replacement therapy for Klinefelter syndrome in Denmark: a retrospective cohort studyResearch in context by Simon Chang, Lars Pedersen, Anne Skakkebæk, Agnethe Berglund, Claus H. Gravholt

    Published 2025-04-01
    “…Findings: We identified 557 KS-TRT, and matched these with unexposed men with KS born the same year (total KS n = 950). We similarly identified a comparison cohort of 50,150 men from the background population matched on month and year of birth. …”
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  18. 45578

    Comprehensive analysis of advanced glycation end-products in commonly consumed foods: presenting a database for dietary AGEs and associated exposure assessment by Qiaozhi Zhang, Huatao Li, Ruixing Zheng, Lili Cao, Shufen Zhang, Shuifeng Zhang, Huadong Sheng, Yuhao Jiang, Yanbo Wang, Linglin Fu

    Published 2024-07-01
    “…The contents of these AGEs were detected in 334 foods covering all main groups consumed in Western and Chinese populations. Nε-Carboxymethyllysine, methylglyoxal-derived hydroimidazolone isomers, and glyoxal-derived hydroimidazolone-1 are predominant AGEs found in most foodstuffs. …”
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  19. 45579

    Effect of the gut microbiome in glaucoma risk from the causal perspective by He Chen, Meng Zhou, Zicheng Zhang, Siqi Bao, Jia Qu, Yaxuan Wu, Ronghua Shi

    Published 2024-05-01
    “…Genome-wide association study summary statistics of 196 GM taxa (n=18 340) and glaucoma (18 902 cases and 358 375 controls) were obtained from MiBioGen and FinnGen Consortium. …”
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  20. 45580

    It’s Like Doing Simultaneous Mind Puzzles: Exploring How Care is Understood and Experienced by Nursing Assistants Working in Sweden with Older Persons by Lilienthal A, Farias L, Boström AM, Patomella AH, Asaba E

    Published 2025-01-01
    “…The aim of this study was to explore how care, in the context of worker perspectives, is understood and experienced in home or residential care facilities.Participants and Methods: Focus-group interviews were conducted with experienced nursing assistants (n = 14) working in urban municipalities in Sweden. …”
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