Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Ibrutinib, FDA-approved lymphoma agent, inhibits Bruton tyrosine kinase (BTK) and has previously been shown to independently impair aortic endothelial adhesion and increase rodent glioma model survival in combination with cytotoxic therapy. …”
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Risk factors for thromboembolic and bleeding events in anticoagulated patients with atrial fibrillation: the prospective, multicentre observational PREvention oF thromboembolic eve... by Raffaele De Caterina, Kurt Huber, Richard Schilling, Miklos Rohla, Thomas W Weiss, Ladislav Pecen, Giuseppe Patti, Jolanta M Siller-Matula, Renate B Schnabel, Dipak Kotecha, Markus Lucerna, Paulus Kirchhof

“…The incidence of thromboembolic and major bleeding events was 2.34% (95% CI 1.93% to 2.74%) and 2.84% (95% CI 2.41% to 3.33%) after 1-year of follow-up, respectively.Abnormal liver function, prior stroke or transient ischaemic attack, labile international normalised ratio (INR), concomitant therapy with antiplatelet or non-steroidal anti-inflammatory drugs, heart failure and older age (≥75 years) were independently associated with both thromboembolic and major bleeding events.With the exception of unstable INR values, these risk factors were validated in patients treated with NOACs (PREFER in AF Prolongation Study, 72±9 years, 40% female, CHA2DS2-VASc 3.3±1.6). …”
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Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis by Paul Garner, Lawrence Mbuagbaw, Jason W Busse, Dena Zeraatkar, Thomas Agoritsas, Ariel Izcovich, Tari Turner, Lyn Turkstra, Roger S McIntyre, Rachel J Couban, Tyler Pitre, Sarah Kirsh, Tanvir Jassal, Michael Ling, Samantha Chakraborty, Signe A Flottorp

“…We will identify eligible studies by searching MEDLINE, EMBASE, CINAHL, PsycINFO, AMED and CENTRAL from inception, without language restrictions.Reviewers will work independently and in duplicate to screen search records, collect data from eligible trials, including trial and patient characteristics and outcomes of interest and assess risk of bias. …”
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Left atrial strain predicts paroxysmal atrial fibrillation recurrence after catheter ablation: a 1-year study using three-dimensional speckle-tracking echocardiography by Rui Zhang, He Li, Yan Wang, Tianle Yu, Jiacheng Li, Yumeng Wu, Zhiwen Yu, Cuixing Liang, Dan Yu, Li Xue

“…Our multivariate regression analysis revealed that left atrial reservoir strain (LASr) independently predicted the recurrence of AF [odds ratio (OR), 1.19, 95% confidence interval (CI), 1.05–1.35, p = 0.005]. …”
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Effect of differences in vascular anatomy on surgical outcomes of left pancreatectomy: a retrospective study by Masahiro Fukada, Noriki Mitsui, Takeshi Horaguchi, Yuji Hatanaka, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Shigeru Kiyama, Yoshihiro Tanaka, Katsutoshi Murase, Nobuhisa Matsuhashi

“…In all LP cases, the pancreatic resection line (above the portal vein: odds ratio [OR] 3.47; 95% confidence interval [CI] 1.69–11.18; p < 0.01), the SpA type (type 2; OR 2.77; 95% CI 1.16–6.94; p = 0.02), and surgery type (MIS; OR 5.24; 95% CI 2.17–14.00; p < 0.001) were independently associated with prolonged operation times. …”
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Using the HBSC Symptom Checklist to measure junior secondary school students’ psychosomatic complaints in the Chinese Mainland: Rasch-based validation, population-based norm, and n... by Yuhang Zhu, Xianzhu Cong, Zhenliang Qiu, Ricky Jeffrey, Ranran Li, Li Jing, Gaopei Zhu, Xi Yang, Shuang Li, Jinling Wang, Xu Xu, Hongliu Zhu, Xinjian Wang, Ling Huang, Xueqin Sun, Di Wu, Kai Zhang, Xunhong Miao, Rui Wen, Qinglang Huang, Zhuang He, Juan Li, Alina Cosma, Fuyan Shi, Suzhen Wang, the PROSQoL-JSSS research group

“…This version also exhibited good unidimensionality and local independence. The Rasch model generated two kinds of reliability indicators, with the item indicators performing well. …”
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Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China by Shuang Zhao, Han Yang, Haijuan Zhao, Miao Miao, Qingqing Wang, Yaru Wang, Yuying Yin, Xin Wang

“…Impairment in the subdomain of naming foods (AHR = 1.12, 95% CI 1.04–1.21), registration (AHR = 1.18, 95% CI 1.11–1.26), attention and calculation (AHR = 1.13, 95% CI 1.07–1.21), copy figure (AHR = 1.13, 95% CI 1.06–1.20), delayed recall (AHR = 1.14, 95% CI 1.07–1.20) and language (AHR = 1.14, 95% CI 1.05–1.24) were independently associated with increased mortality risk among participants. …”
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A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response by Emilie Crouchet, Nuno Almeida, Sarah C. Durand, Marie Parnot, Marine A. Oudot, Fabio Giannone, Cloé Gadenne, Natascha Roehlen, Antonio Saviano, Emanuele Felli, Patrick Pessaux, Hong Tuan Duong, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Thomas F. Baumert, Catherine Schuster

“…Results: The model was successfully established independently from cancer etiology and grade from 22 HCC tissues. …”
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Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a prospect... by Zeyan Liu, Jinbo Wang, Yanfang Yang, Jinglin Cheng, Min Yang, Ye Zhang

“…Cox multivariate regression analysis indicated that EAMI was independently associated with MACE (HR = 2.349, 95% CI 1.770–3.177, P &lt; 0.001). …”
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Analisis Kredit Pembayaran Biaya Kuliah Dengan Pendekatan Pembelajaran Mesin by Arliyanti Nurdin, Rizqa Amelia Zunaidi, Muhammad Arkan Fauzan Wicaksono, Agi Lobita Japtara Martadinata

“…This also occurs in private educational institutions where financial management is carried out independently and most of funding sources come from students. …”
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Unraveling Online Mental Health Through the Lens of Early Maladaptive Schemas: AI-Enabled Content Analysis of Online Mental Health Communities by Beng Heng Ang, Sujatha Das Gollapalli, Mingzhe Du, See-Kiong Ng

“…To identify associations, we conducted chi-square tests of independence and calculated odds ratios (ORs) with the dataset. …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…Abstract Background Parasitism as a life strategy has independently evolved multiple times within the eukaryotic tree of life. …”
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Problems And Challenges Of Attendance In Medical Students by Muhammad Khurram

“…Failure to complete essential teaching and training in Medicine, Surgery, Gynecology, and Pediatrics can leave significant gaps in a doctor to be student's education and preparation for medical practice.1 Without this training, such person will lack necessary clinical skills, experience, and competence to diagnose and treat patients independently. Moreover, they cannot meet standards expected from a qualified doctor which jeopardizes patient safety and well-being. …”
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Productivity and ecological functions of naturally regrown pine forests of the Ukrainian Polissia by Petro Lakyda, Volodymyr Blyshchyk

“…In the Ukrainian Polissia, the category of self-seeded areas received perhaps the largest representation in the country due to the fairly high forest cover of the region, where forest tracts border on agricultural lands which lost the profitability of cultivation by their owners during the period of Ukraine's independence. The main forest-forming tree species found in these naturally regrown forests on agricultural lands is Scots pine, which became the object of the study. …”
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Preoperative prediction of IDH genotypes and prognosis in adult-type diffuse gliomas: intratumor heterogeneity habitat analysis using dynamic contrast-enhanced MRI and diffusion-we... by Xingrui Wang, Zhenhui Xie, Xiaoqing Wang, Yang Song, Shiteng Suo, Yan Ren, Wentao Hu, Yi Zhu, Mengqiu Cao, Yan Zhou

“…Multivariable logistic regression models were constructed and validated using leave-one-out cross-validation, and the contrast-enhanced subgroup was analyzed independently. Kaplan-Meier and Cox proportional hazards regression analyses were used to investigate the relationship between tumor habitats and progression-free survival (PFS) in the two IDH groups. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…In the two clinical Phase II studies dose-dependent increases in hemoglobin and prolonged response duration were independently observed. Pegmolesatide showed significant PK-PD dual prolongation effects and was well tolerated. …”
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The role of the TAPSE/sPAP ratio as a predictor of mortality in Pulmonary Arterial Hypertension: Its value for patient risk stratification by Paul Palacios-Moguel, MD, Guillermo Cueto-Robledo, MD, Héctor González-Pacheco, MD, Jorge Ortega-Hernández, MD, María Berenice Torres-Rojas, MD, Dulce Iliana Navarro-Vergara, MD, Marisol García-Cesar, MD, Cinthia Alejandra González-Nájera, MD, Carlos Alfredo Narváez-Oríani, MD, Julio Sandoval, MD

“…A TAPSE/sPAP ratio <0.18 mm/mmHg independently predicted mortality (AUC: 0.859, 95% CI: 0.766– 0.952; P < 0.001). …”
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Evolution of burnout syndrome in Spanish healthcare professionals during and after the COVID-19 pandemic: psychosocial variables involved by Fernanda Gil-Almagro, Fernanda Gil-Almagro, Fernanda Gil-Almagro, F. Javier Carmona-Monge, Fernando J. García-Hedrera, Cecilia Peñacoba-Puente

“…The preceding literature also points to the need to consider the three elements of burnout independently, as they appear to have different evolutionary trends and possibly different buffering and amplifying variables, although these aspects have hardly been explored.MethodsThe aim of the present investigation is precisely to shed light on these latter issues. …”
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Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review by Bashir MBA, Milani GP, De Cosmi V, Mazzocchi A, Zhang G, Basna R, Hedman L, Lindberg A, Ekerljung L, Axelsson M, Vanfleteren LEGW, Rönmark E, Backman H, Kankaanranta H, Nwaru BI

“…Additional sources included conference proceedings, reference lists, and expert recommendations. Two reviewers independently screened studies for eligibility, extracted data, and assessed study quality. …”
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Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort by Cyrille Delpierre, Raphaële Castagné, Eloïse Berger, Gianluca Severi, Marie-Christine Boutron-Ruault, Laura Baglietto, Laure Dossus, Amandine Gelot, Richard Dudouet

“…Many studies support the hypothesis that education has a distinctive effect on physiological processes associated with health, independently of known risk factors.Objectives In this study, we aimed to determine whether the biological embodiment of education could be part of the observed social inequalities in BC risk. …”
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