FAN score predicts prognosis after platinum-based first-line chemotherapy in patients with metastatic urothelial carcinoma by Yu Ishizuya, Atsunari Kawashima, Yuki Horibe, Akinaru Yamamoto, Masaru Tani, Akihiro Yoshimura, Liu Yutong, Sassi Nesrine, Toshiki Oka, Yohei Okuda, Toshihiro Uemura, Gaku Yamamichi, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Koji Hatano, Norio Nonomura

“…Multivariable analysis showed that Fib-4 index (HR 3.85, 95% CI 1.09–13.58, p = 0.036), ALBI score (HR 1.53, 95% CI 1.01–2.31, p = 0.045), and NLR (HR 1.76, 95% CI 1.14–2.71, p = 0.010) were independently associated with PFS. The FAN score was also associated with PFS (HR 2.56, 95% CI 1.62–4.05, p < 0.001). …”
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Prevalence and sociodemographic characteristics of functional impairment in community-dwelling older adults in China: a cross-sectional study by Yun Li, Li Zhang, Zhe Tang, Lina Ma, Pan Liu, Xiaxia Li, Wenhua Yu, Yaxin Zhang

“…Furthermore, after adjusting for related variables, functional impairment was independently associated with disability (OR=138.5, 95% CI 70.0 to 273.9), frailty (OR=13.7, 95% CI 10.3 to 18.3), immobility (OR=6.9, 95% CI 5.4 to 8.9), fractures (OR=2.2, 95% CI 1.5 to 3.3) and falls (OR=2.6, 95% CI 1.8 to 3.7).Conclusion Approximately one-third of Chinese community-dwelling older adults experienced functional impairment, and its prevalence was associated with socio-psychological characteristics, lifestyle, chronic diseases and geriatric syndromes.…”
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The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study by Huayan Gu, Teng Zhu, JiaLing Ding, Zhi Yang, Yiqiao Lu, Guilong Guo

“…Logistic regression model further revealed that sarcopenia was a prognostic factor that was independently associated with both DFS (p = 0.001) and OS (p = 0.006).ConclusionsAmong women with TNBC, sarcopenia is associated with worse clinical outcomes. …”
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Internet-based cognitive–behavioural therapy for insomnia (ICBT-i): a meta-analysis of randomised controlled trials by Jia Chen, Juan Liu, Yuan-yuan Ye, Ni-ka Chen, Ling Lin, Ya-zhen Liu, Ying Lang, Xun-jun Li, Xin-ju Yang, Xiao-jiang Jiang

“…Objective To evaluate the effectiveness of internet-based cognitive–behavioural therapy for insomnia (ICBT-i) in adults.Design A meta-analysis of ICBT-i.Data sources Systematic searches of randomised controlled trials of ICBT-i were performed in the PubMed, EMBASE, PsycINFO and Cochrane Library databases up to 19 June 2016.Review method 2 reviewers independently performed study selection, quality assessment and data extraction. …”
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Inter-reader agreement for diagnosing thymic cysts on chest MRI in two tertiary referral centers by Yura Ahn, Sang Min Lee, Chu Hyun Kim, Sehee Kim, Jooae Choe, Joon Beom Seo, Ho Yun Lee

“…Four and three radiologists independently reviewed internal and external reading sets. …”
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Surgical treatment after neoadjuvant systemic therapy for HER2-positive invasive breast cancer in the Netherlands: 10-Year trends and the influence an accompanying DCIS component by Roxanne A.W. Ploumen, Thiemo J.A. van Nijnatten, Loes F.S. Kooreman, Adri C. Voogd, Kristien B.M.I. Keymeulen, Sabine Siesling, Marjolein L. Smidt

“…Percentage of ypT0 was significantly lower in patients with IBC+DCIS (38.7 %), compared to IBC only (47.3 %, p < 0.001) Multivariable logistic regression analyses showed presence of DCIS (OR 1.69, 95%CI 1.47–1.95, p < 0.001) to be independently associated with mastectomy. Conclusion: Rate of mastectomy decreased significantly in HER2+ IBC treated with NST between 2010 and 2019. …”
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Developing a master of science in health research ethics program in Northern Nigeria: a needs assessment by Caitlin Bieniek, Fatimah I. Tsiga-Ahmed, Aishatu L. Adamu, Usman J. Wudil, C. William Wester, Zubairu Iliyasu, Muktar H. Aliyu, Elisa J. Gordon, Elizabeth S. Rose

“…We used the Interpretative Phenomenological Analysis (IPA) method to analyze interview transcriptions. Two authors independently read and coded each respondent’s transcript to identify emergent themes that represented each respondent’s answers. …”
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Radiomic prediction for durable response to high‐dose methotrexate‐based chemotherapy in primary central nervous system lymphoma by Haoyi Li, Mingming Xiong, Ming Li, Caixia Sun, Dao Zheng, Leilei Yuan, Qian Chen, Song Lin, Zhenyu Liu, Xiaohui Ren

“…This signature was independently associated with the DR in both cohorts. …”
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Host-symbiont-gene phylogenetic reconciliation by Menet, Hugo, Trung, Alexia Nguyen, Daubin, Vincent, Tannier, Eric

“…These interactions range from independence or conflict to cooperation and coevolution, which results in them having a common history. …”
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Evaluation of the potential value of artificial intelligence (AI) in public health using fluoride intake as the example by Wei Wei, Tianshu Gu, Yanhong Cao, Shuqiu Sun, Dan Wei, Minghui Li, Alyce D. Fly, Weikuan Gu, Lan Yao, Dianjun Sun

“…These hypotheses were then evaluated independently by three evaluators. Finally, summaries were made through group discussions among all the authors. …”
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Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease by Nour Rahnama, MD, Arthur Colson, MD, PhD, Pamela Baldin, MD, PhD, Agnès Pasquet, MD, PhD, Damien Gruson, MD, PhD, David Vancraeynest, MD, PhD, Christophe Beauloye, MD, PhD, Frédéric Debiève, MD, PhD, Sophie Pierard, MD, PhD

“…CHD pregnancies had a higher incidence of adverse obstetric and neonatal outcomes, which were independently associated with MVM (RR: 7.2, P = 0.002). …”
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Development and validation of a risk prediction model for PICC-related venous thrombosis in patients with cancer: a prospective cohort study by Zeyin Hu, Mengna Luo, Ruoying He, Zhenming Wu, Yuying Fan, Jia Li

“…Univariate and multivariate regression analyses were used to identify independently associated risk factors of PICC-RVT and develop a risk prediction model. 275 patients were finally included for data analysis, and 18 (6.5%) developed PICC-RVT. …”
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A synergistic effect of secondhand smoke with vitamin D deficiency on cognitive impairment in older adults: a cross sectional study by Yan Li, Qianqian Shen, Chengyu Chen, Xueru Yin, Xinru Wang, Xiyue Yang, Xueqian Zhang, Lei Chen, Jian Xu, Guifang Gong

“…The possible synergistic effect of SHS with VDD on cognitive impairment was evaluated by using a multivariable logistic regression model.ResultsVDD was independently associated with risk of low the Digit Symbol Substitution Test (DSST) scores, increased by nearly 60% [&lt; 34, adjusted odds ratio (aOR) = 1.62, 95% CI: 1.03 ~ 2.53]. …”
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Substrate system outperforms water-culture systems for hydroponic strawberry production by George Kerrigan Hutchinson, Lan Xuan Nguyen, Zilfina Rubio Ames, Krishna Nemali, Rhuanito Soranz Ferrarezi

“…Both systems have been independently studied for CEA strawberry production, but direct comparisons between them are still limited. …”
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Dendriform pulmonary ossification in military combat veterans: A case series by Jeremy T. Hua, Carlyne D. Cool, Tami J. Bang, Silpa D. Krefft, Richard C. Kraus, Cecile S. Rose

“…Chest imaging was independently reviewed and scored by a thoracic radiologist, and all cases had undergone lung tissue biopsy. …”
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Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review by Jing Luo, Guo-Yan Yang, Di-Er Jin, Ying-Ze Zhang, Jian-Ming Wang, Wei-Ping Kong, Qing-Wen Tao

“…Two reviewers will independently extract data on participants, interventions, comparisons, outcomes, etc. …”
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Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies by Jacinta Cheng, Tia Solomon, Mahnuma Estee, Flavia M. Cicuttini, Yuan Z. Lim

“…Risk of bias assessment and data extraction were conducted by three reviewers independently. Qualitative evidence synthesis was performed and prospectively registered on PROSPERO (CRD42024522782 and CRD42024522787). …”
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Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD) by John R Hurst, Jennifer K Quint, Hana Müllerova, Liam Smeeth, Harriet Forbes, Susan Eaton, Rachael L DiSantostefano, Kourtney Davis

“…All information received was reviewed independently by two respiratory physicians whose opinion was taken as the gold standard.Primary outcome measure The primary measure of accuracy was the positive predictive value (PPV), the proportion of people identified by each algorithm for whom COPD was confirmed.Results 951 questionnaires were sent and 738 (78%) returned. …”
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Effects of traditional Chinese exercises on brain-derived neurotrophic factor in middle-aged and older adults: A systematic review and meta-analysis of randomized controlled trials by Jianyu Gan, Jiya He, Kaixiang Zhou, Zhangyuting Shang, Gengxin Dong, Dapeng Bao, Junhong Zhou

“…Methods: The search was conducted in November 2024 in seven Chinese and English databases. Two reviewers independently reviewed the search results, extracted the data, and assessed the risk of bias and certainty of evidence. …”
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Investigating the relationship between thought interference, somatic passivity and outcomes in patients with psychosis: a natural language processing approach using a clinical reco... by Robert Stewart, Anna Kolliakou, Jyoti Sanyal, Rashmi Patel, Thibault Thierry Magrangeas

“…Objectives We aimed to apply natural language processing algorithms in routine healthcare records to identify reported somatic passivity (external control of sensations, actions and impulses) and thought interference symptoms (thought broadcasting, insertion, withdrawal), first-rank symptoms traditionally central to diagnosing schizophrenia, and determine associations with prognosis by analysing routine outcomes.Design Four algorithms were developed on deidentified mental healthcare data and applied to ascertain recorded symptoms over the 3 months following first presentation to a mental healthcare provider in a cohort of patients with a primary schizophreniform disorder (ICD-10 F20-F29) diagnosis.Setting and participants From the electronic health records of a large secondary mental healthcare provider in south London, 9323 patients were ascertained from 2007 to the data extraction date (25 February 2020).Outcomes The primary binary dependent variable for logistic regression analyses was any negative outcome (Mental Health Act section, &gt;2 antipsychotics prescribed, &gt;22 days spent in crisis care) over the subsequent 2 years.Results Final adjusted models indicated significant associations of this composite outcome with baseline somatic passivity (prevalence 4.9%; adjusted OR 1.61, 95% CI 1.37 to 1.88), thought insertion (10.7%; 1.24, 95% CI 1.15 to 1.55) and thought withdrawal (4.9%; 1.36, 95% CI 1.10 to 1.69), but not independently with thought broadcast (10.3%; 1.05, 95% CI 0.91 to 1.22).Conclusions Symptoms traditionally central to the diagnosis of schizophrenia, but under-represented in current diagnostic frameworks, were thus identified as important predictors of short-term to medium-term prognosis in schizophreniform disorders.…”
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