Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin by Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee, Hyunju Cho

“…Here, we engineer the ATP-independent cytosolic chaperone PEX19, which targets peroxisomal membrane proteins to peroxisomes, to remove mHttex1 aggregates. …”
Get full text

Vapor pressure deficit (VPD) downscaling based on multi-source remote sensing, in-situ observation, and machine learning in China by Mi Wang, Zhuowei Hu, Xiangping Liu, Wenxing Hou

“…VPD station data were computed based on meteorological data from 2481 meteorological stations in China, and two independent experiments (station-to-station and year-to-year) were employed to evaluate the estimation accuracy of RF-VPD using this data as a reference. …”
Get full text

Prevalence of and factors associated with tobacco smoking in the Gambia: a national cross-sectional study by Abu Naser Zafar Ullah, Md Shariful Islam, Md Golam Rabbani, Haifaa AlWajeah, Md Ferdous, Nusrat Sharmin Mahfuza, Daniel Konka, Eva Silenga

Get full text

Modular-based psychotherapy (MoBa) versus cognitive–behavioural therapy (CBT) for patients with depression, comorbidities and a history of childhood maltreatment: study protocol fo... by Elisabeth Schramm, Martin Hautzinger, Carolin Jenkner, Moritz Elsaesser, Sabine Herpertz, Hannah Piosczyk

“…A modular-based psychotherapy (MoBa) approach provides a treatment model of independent and flexible therapy elements within a systematic treatment algorithm to combine and integrate existing evidence-based approaches. …”
Get full text

Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma by Ainiwaerjiang Abudourousuli, Zumulaiti Aierken, Hasiyati Mamuti, Tuxunayi Yimamu, Chengli Da

“…High AATF levels serve as an independent marker of poor OS and DSS. These findings support AATF as a valuable prognostic biomarker and a potential therapeutic target in OSCC, warranting further investigation.…”
Get full text

Metabolic Syndrome May Not be a Good Predictor of Coronary Artery Disease in the Iranian Population: Population-Specific Definitions are Required by Mahmoud Ebrahimi, Seyyed Mohammad Reza Kazemi-Bajestani, Majid Ghayour-Mobarhan, Mohsen Moohebati, Roghaye Paydar, Mohsen Azimi-Nezhad, Habib Ollah Esmaily, Gordon A. A. Ferns

“…Of the parameters assessed, age, total cholesterol, and low serum HDL cholesterol were the strongest independent predictors of angiographically defined CAD (p < 0.01, p < 0.01, p < 0.05, respectively). …”
Get full text

Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…The engineered variants showed pH-independent and cross-reactive binding to both mouse and human CTLA-4. …”
Get full text

Characterising COVID-19 empirical research production in Latin America and the Caribbean: A scoping review. by Cristián Mansilla, Cristian A Herrera, Laura Boeira, Andrea Yearwood, Analia S Lopez, Luis E Colunga-Lozano, Eva Brocard, Tatiana Villacres, Marcela Vélez, Gabriel Di Paolantonio, Ludovic Reveiz

“…All titles and abstracts, and full texts were screened by two independent reviewers. Data from included studies was extracted by one reviewer and checked by a second independent reviewer.…”
Get full text

Indoor ventilation frequency and cognitive function among Chinese old adults: the multiple mediation effect of anxiety and self-rated health by Lu Lin, Pingping He, Sihui Qiu, Xiaohui Qiu, Jiangping Chen

“…Indoor ventilation frequency not only has a direct positive impact on the cognitive function of older people (effect = 0.1427; Standard error = 0.0201; 95%CI: LL = 0.1034, UL = 0.1821), but also indirectly affected cognitive function through three pathways: independent mediation of anxiety (effect = 0.0078; Standard error = 0.0021; 95%CI: LL = 0.0041, UL = 0.0121), independent mediating effect of self-rated health (effect = 0.0154; Standard error = 0.0030; 95%CI: LL = 0.0098, UL = 0.0215), and the chain mediating effect between anxiety and self-rated health (effect = 0.0046; Standard error = 0.0009; 95%CI: LL = 0.0029, UL = 0.0065). …”
Get full text

Airborne observations reveal the fate of the methane from the Nord Stream pipelines by Friedemann Reum, Julia Marshall, Henry C. Bittig, Lutz Bretschneider, Göran Broström, Anusha L. Dissanayake, Theo Glauch, Klaus-Dirk Gottschaldt, Jonas Gros, Heidi Huntrieser, Astrid Lampert, Michael Lichtenstern, Scot M. Miller, Martin Mohrmann, Falk Pätzold, Magdalena Pühl, Gregor Rehder, Anke Roiger

Get full text

Magnitude and Its Associated Factors of Urinary Tract Infection among Adult Patients Attending Tigray Region Hospitals, Northern Ethiopia, 2019 by Abrha Hailay, Kidane Zereabruk, Guesh Mebrahtom, Woldu Aberhe, Degena Bahrey

“…A binary logistic regression model was used to test the association between dependent and independent variables. Result. The magnitude of urinary tract infection was 86 (18.2%) (95% CI: 14.6%–21.6%). …”
Get full text

Risk factors for pelvic lymph node metastasis in cervical cancer: a retrospective analysis of 186 patients by Xingyu Sun, Lijuan He, Shaohua Wang

“…Multivariate logistic regression analysis identified high-risk HPV infection (OR 4.13, 95% CI: 2.09-8.17, p&lt;0.001), lymphovascular invasion (OR 7.87, 95% CI: 4.05-15.29, p&lt;0.001), and tumor size &gt;4 cm (OR 6.24, 95% CI: 3.24-12.02, p&lt;0.001) as independent risk factors for pelvic lymph node metastasis.ConclusionThis study identifies several independent risk factors for pelvic lymph node metastasis in cervical cancer, including high-risk HPV infection, lymphovascular invasion, and tumor size greater than 4 cm. …”
Get full text

A cross-sectional study of the current status of psychological health and its correlation with academic performance in medical students: taking medical students in a medical univer... by Han Chunhong, Han Chunhong, Ding Jingjing, He Huan, Zheng Peiyao, Zhang Xiaona, Yang Xiaowen, Zheng Aiming

“…The PHQ-9 scores and major categories were identified as independent factors influencing the average GPA.ConclusionThe undergraduates face significant challenges in depression, anxiety, insomnia, and perceived stress, and these have negative effects on their academic performances; in particular, the depressive symptoms and perceived stress can significantly reduce their academic performances. …”
Get full text

Retrospective Observational Study on the Characteristics of Pain and Associated Factors of Breakthrough Pain in Advanced Cancer Patients by Rongrong Fan, Xuying Li, Siyu Yang, Xiaofan Bu, Yongyi Chen, Ying Wang, Cuiling Qiu

“…BTP pain intensity was independently associated with bloating. Symptom numbers were an independent factor and positively associated with BTP episodes. …”
Get full text

Bør krigen i Ukraina påvirke vårt syn på atomvåpen? by Torgeir E. Fjærtoft

“…The EU should coordinate an independent European pillar in NATO within established procedures for consultation. …”
Get full text

Identifying Risk Factors Associated With False‐Negative Results in US‐Guided Percutaneous Transthoracic Needle Lung Biopsy of Subpleural Pulmonary Lesions by Jiawei Yi, Mengjun Shen, Junhui He, Runhe Xia, Xinyu Zhao, Yin Wang

“…In the retrospective cohort, comparative and logistic regression analyses were performed to identify independent risk factors for false‐negative biopsy results. …”
Get full text

Diabetes and Hemoglobin A1c as Risk Factors for Nosocomial Infections in Critically Ill Patients by Eirini Tsakiridou, Demosthenes Makris, Vasiliki Chatzipantazi, Odysseas Vlachos, Grigorios Xidopoulos, Olympia Charalampidou, Georgios Moraitis, Epameinondas Zakynthinos

“…Independent risk factors for BSI in ICU included BSI on admission 2.45 (1.14–5.29; P=0.022) and stroke on admission2.77 (1.12–6.88; P=0.029). …”
Get full text

Association between previous consumption of sugar-sweetened beverages and diabetes remission in patients with newly diagnosed type 2 diabetic ketoacidosis by Shanshan Li, Jinying Wang, Junping Zhang, Yun Zou, Yuanyuan Deng, Jixiong Xu

“…SSBs and BCr were independent risk factors for DR. The amalgamation of these markers could more accurately predict DR.…”
Get full text

CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI by Yanfei Ren, Xinjia Du, Maochen Li, Lei Chen, Jiahua Liu, Yixuan Wu, Yuan Lu

“…Age, LVEF, EATV, T1*,ECV, T2 are independent risk factors for new onset atrial arrhythmias and have good predictive value.…”
Get full text

Calcium Activation of the Androgen Receptor in Prostate Cells by Zeina W. Sharawi, Sawsan M. Khatrawi, Qiaochu Wang, Hongzhao Zhou, Kedra Cyrus, Gai Yan, Becky Hoxter, Bassem R. Haddad, Mary Beth Martin

“…Our previous study shows that heavy metal cadmium activates the AR through a ligand-independent mechanism. Cadmium mimics calcium in biological systems due to their similar ionic charge and radius. …”
Get full text