What strategies are used to select patients for direct admission under acute medicine services? A protocol paper for a systematic review of the literature by Elizabeth Sapey, Catherine Atkin, Samuel Evans, Austin Hunt, Georgina Ball, Charlotte Cassidy, Alexander Costley-White, Louise Toy, Rebecca Wilding

“…Both title and abstract screening and full-text screening will be done by two reviewers independently. The risk of bias of included studies will be assessed using the methods introduced in the Cochrane Handbook for Systematic Reviews of Interventions and the tool used will be dependent on the type of study. …”
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Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma by Yuji Uehara, MD, Hiroki Izumi, MD, PhD, Tetsuro Taki, MD, PhD, Tetsuya Sakai, MD, PhD, Hibiki Udagawa, MD, PhD, Eri Sugiyama, MD, PhD, Shigeki Umemura, MD, PhD, Yoshitaka Zenke, MD, PhD, Shingo Matsumoto, MD, PhD, Kiyotaka Yoh, MD, PhD, Shoko Kubota, MD, PhD, Keiju Aokage, MD, PhD, Naoya Sakamoto, MD, PhD, Shingo Sakashita, MD, PhD, Motohiro Kojima, MD, PhD, Michiko Nagamine, MD, PhD, Yukio Hosomi, MD, PhD, Masahiro Tsuboi, MD, PhD, Koichi Goto, MD, PhD, Genichiro Ishii, MD, PhD

“…In the multivariable analysis, solid predominant histology and high-podoplanin expression in CAFs were independently associated with worse PFS. In the cohorts of The Cancer Genome Atlas Program and Singapore Oncology Data Portal, EGFR-mutated lung adenocarcinoma with solid predominant histology or high-podoplanin expression exhibited significantly higher HGF expression. …”
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The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review and meta-analysis protocol [version 2; peer review: 3... by Michael Norton, Brian O'Donoghue, Mary Clarke, Karen O'Connor, Jennifer Murphy, Anna Zierotin

“…Two reviewers will independently screen titles, abstracts, and full-text articles. …”
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Characterization of the Effects of a Six-Month Dancing as Approach for Successful Aging by Maria Grazia Vaccaro, Giulia Izzo, Alessandro Ilacqua, Silvia Migliaccio, Carlo Baldari, Laura Guidetti, Andrea Lenzi, Aldo Quattrone, Antonio Aversa, Gian Pietro Emerenziani

“…Interestingly, trait of anxiety significant decreased (p<0.05) and perception of retrospective memory significantly increased (p=0.05) after training independently of gender. Our preliminary results suggest that, even in older intermediate-level dancer, the practice of social dance might positively influence body composition and also increase fitness performance, memory functions, and anxiety. …”
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Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study by Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Fabio Angeli, Carlo Maria Barbagallo, Bruno Berardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Lanfranco D’Elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Egidio Imbalzano, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Claudio Borghi, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

“…Conclusions Both IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. …”
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Pain management in trauma: the need for trauma-informed opioid prescribing guidelines by Ben L Zarzaur, Suresh Agarwal, Colleen Trevino, Amelia Baltes, David M Horton, Julia Malicki, Randall T Brown

“…Focus group transcripts were independently coded and analyzed using a modified grounded theory approach to identify themes related to the facilitators and barriers of opioid prescribing guidelines in trauma and acute care.Results Three major themes were identified as impactful to opioid-related prescribing and care provided in the setting of traumatic injury; these include (1) acute treatment strategies; (2) patient interactions surrounding pain management; and (3) the multifactorial nature of trauma on pain management approaches.Conclusion Providers and staff at four Wisconsin trauma centers called for trauma-specific opioid prescribing guidelines in the setting of trauma and acute care. …”
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#emergencymedicine: A TikTok Content Analysis of Emergency Medicine-related Content by Madison Stolly, Erika Wilt, Nathan Gembreska, Mohamad Nawras, Emily Moore, Kelly Walker, Rhonda Hercher, Mohamad Moussa

“…Methods: Five second-year medical students using newly created TikTok accounts independently downloaded the first 100 videos to appear using the hashtag #emergencymedicine. …”
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Associations between contextual and compositional characteristics of early childcare facilities with health, health behaviours and well-being among young children aged 0 to 6 years... by Jennifer Hilger-Kolb, Sven Schneider, Raphael Herr, Nina Osenbruegge, Stephanie Hoffmann, Max Herke, Claudia Pischke, Leonie Sundmacher, Katharina Diehl

“…First, two reviewers will independently screen titles/abstracts of all potentially eligible articles by applying a set of previously defined inclusion and exclusion criteria. …”
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Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis proto... by Amalia Karahalios, Allan G Kermode, Yvonne C Learmonth, Julia Lyons, Stephanie Campese, Alexandra Metse, Claudia H Marck

“…Screening, data extraction and risk of bias assessment (using the Risk of Bias 2 tool) will be conducted independently by two reviewers. If possible, we will synthesise the evidence by fitting a frequentist network meta-analysis model with multivariate random effects, or a pairwise random-effects meta-analysis model. …”
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Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…Participants were aged 18 or older, able to complete the questionnaire independently or with assistance and included individuals from diverse demographic backgrounds.Primary and secondary outcome measures Primary outcomes included KAP scores related to pulmonary rehabilitation. …”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

“…The ArcA transcription factor activates genes related to metabolism, membrane permeability, and virulence, and its presence is required for pathogenicity in Salmonella Typhimurium, which can be phosphorylated independently of its cognate sensor, ArcB. In this study, we aimed to characterize the transcriptional response to hypochlorous acid (HOCl) mediated by the presence of the ArcB sensor. …”
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The Specific Characteristics of Entrepreneurship Process in Tourism Industry by İge Pırnar

“…Yet, it is also understood that tourism entrepreneurs seem to be highly motivated by life-style, quality of life QOL issues, locational preferences and other non-economic motives which are not common in general business entrepreneurs whose main motive seem to be profit maximization and financial independence…”
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Serum metalloproteinase-7 as a biomarker of progressive pulmonary fibrosis by Márcia Araújo, Marília Beltrão, Oksana Sokhatska, Natália Melo, Patrícia Caetano Mota, Helder Novais Bastos, André Terras, David Coelho, Luís Delgado, António Morais

“…Significantly higher levels of MMP-7, but not MMP-1, were detected in the PPF group (p=0.01). MMP-7 was independently associated with PPF (adjusted OR 1.263, 95% CI 1.029–1.551; p=0.026) after adjustment for sex, age and smoking history. …”
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Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Are Correlated with Complicated Diverticulitis and Hinchey Classification: A Simple Tool to Assess Disease Severity in th... by Amir Mari, Tawfik Khoury, Ahmad Lubany, Mohammad Safadi, Moaad Farraj, Amir Farah, Anas Kadah, Wisam Sbeit, Mahmud Mahamid

“…Conclusion. The NLR and PLR independently associated with diverticulitis severity and positively correlated with advanced Hinchey classification. …”
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Association among Blink Rate, Changes in Ocular Surface Temperature, Tear Film Stability, and Functional Visual Acuity in Patients after Cataract Surgery by Takashi Itokawa, Yukinobu Okajima, Takashi Suzuki, Tatsuhiko Kobayashi, Yuto Tei, Koji Kakisu, Yuichi Hori

“…Multiple regression analysis showed that the ΔOST independently contributed to the blink rate. Conclusions. …”
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Home-modification interventions addressing falls and participation in activities of daily living among older adults: a scoping review protocol by Gifty M Georlee, Abiram U, Pham Ngoc Dat, Nguyen Khac Tuan, Shashank Mehrotra

“…Two reviewers will independently screen eligible studies for inclusion. …”
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Association of Cardiovascular Autonomic Neuropathy and Distal Symmetric Polyneuropathy with All-Cause Mortality: A Retrospective Cohort Study by Orsolya E. Vági, Márk M. Svébis, Beatrix A. Domján, Anna E. Körei, Ildikó Istenes, Zsuzsanna Putz, Szilvia Mészáros, Noémi Hajdú, Magdolna Békeffy, Solomon Tesfaye, Péter Kempler, Viktor J. Horváth, Adam G. Tabák

“…In type 2 diabetes, both DSPN and CAN independently increased mortality (HR 1.32, 95% CI: 1.07-1.64, and HR 1.44, 95% CI: 1.17-1.76). …”
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Production of subtilisin proteases in bacteria and yeast by A. S. Rozanov, S. V. Shekhovtsov, N. V. Bogacheva, E. G. Pershina, A. V. Ryapolova, D. S. Bytyak, S. E. Peltek

“…., thermal stability, general resistance to detergents and specif ic resistance to various oxidants, high activity in various temperature ranges, independence from metal ions, and stability in the absence of calcium. …”
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Strategies to mitigate the impact of the COVID-19 pandemic on child and youth well-being: a scoping review protocol by Jeanna Parsons Leigh, Henry T Stelfox, Perri R Tutelman, Diane L Lorenzetti, Melanie C Anglin, Kirsten M Fiest, Stephana Julia Moss, Emily A FitzGerald, Stacie Smith, Micaela Harley, Kathryn Birnie, Sara J Mizen

“…Two reviewers will calibrate screening criteria and the data abstraction form and will independently screen records and abstract data. Data synthesis will be performed according to the convergent integrated approach described by the Joanna Briggs Institute.Ethics and dissemination Ethical approval is not applicable as this review will be conducted on published data. …”
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Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease by Silvia Bueno Garofallo, Vera Lucia Portal, Melissa Medeiros Markoski, Lucinara Dadda Dias, Alexandre Schaan de Quadrosa, Aline Marcadenti

“…Monocyte subtypes are correlated with inflammation in patients with stable CAD independently of BMI, whereas traditional and nontraditional indicators of adiposity are correlated differently with inflammatory markers and monocytes, according to the nutritional status.…”
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