Functional Analysis of DNMT1 SNPs (rs2228611 and rs2114724) Associated with Schizophrenia by Sonal Saxena, Pranay Amruth Maroju, Sumana Choudhury, Vidhya Chitta Voina, Poonam Naik, Kavitha Gowdhaman, Poornima Kkani, Kiranmai Chennoju, S. Ganesh Kumar, C. Ramasubramanian, G. Prasad Rao, Trinath Jamma, Kumar Pranav Narayan, K. Naga Mohan

“…To gain insights into the functional effects of the two SNPs on the levels of DNMT1 transcripts, quantitative real-time PCR experiments were performed using peripheral blood monocytes from 10 individuals each with T/T–T/T (homozygous minor allele), C/T–C/T (heterozygous), and C/C–C/C (homozygous major allele) haplotypes. Independently, the levels of DNMT1 protein were also compared in three individuals each by immunofluorescence. …”
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Glyphosate treatment mediates the accumulation of small discrete 5^′ and 3^′-terminal fragments of 18S rRNA in plant cells by A. V. Zhigailov, A. S. Nizkorodova, K. O. Sharipov, N. S. Polimbetova, B. K. Iskakov

“…This result suggests that discrete fragmentation of 18S rRNA may constitute a regulatory mechanism of mRNA translation in response to stress and may occur in plant cells in parallel with and independently of eIF2α phosphorylation. The identified small 5’and 3’-terminal fragments of 18S rRNA that accumulate during various stresses may serve as stress resistance markers in the breeding of economically important plant crops.…”
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Inter-reader agreement for diagnosing thymic cysts on chest MRI in two tertiary referral centers by Yura Ahn, Sang Min Lee, Chu Hyun Kim, Sehee Kim, Jooae Choe, Joon Beom Seo, Ho Yun Lee

“…Four and three radiologists independently reviewed internal and external reading sets. …”
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Surgical treatment after neoadjuvant systemic therapy for HER2-positive invasive breast cancer in the Netherlands: 10-Year trends and the influence an accompanying DCIS component by Roxanne A.W. Ploumen, Thiemo J.A. van Nijnatten, Loes F.S. Kooreman, Adri C. Voogd, Kristien B.M.I. Keymeulen, Sabine Siesling, Marjolein L. Smidt

“…Percentage of ypT0 was significantly lower in patients with IBC+DCIS (38.7 %), compared to IBC only (47.3 %, p < 0.001) Multivariable logistic regression analyses showed presence of DCIS (OR 1.69, 95%CI 1.47–1.95, p < 0.001) to be independently associated with mastectomy. Conclusion: Rate of mastectomy decreased significantly in HER2+ IBC treated with NST between 2010 and 2019. …”
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Radiomic prediction for durable response to high‐dose methotrexate‐based chemotherapy in primary central nervous system lymphoma by Haoyi Li, Mingming Xiong, Ming Li, Caixia Sun, Dao Zheng, Leilei Yuan, Qian Chen, Song Lin, Zhenyu Liu, Xiaohui Ren

“…This signature was independently associated with the DR in both cohorts. …”
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Duvelisib is a novel NFAT inhibitor that mitigates adalimumab-induced immunogenicity by Aboli Bhingarkar, Yuyin Wang, Keito Hoshitsuki, Katherine Marie Eichinger, Katherine Marie Eichinger, Sanjay Rathod, Yin Zhu, He Lyu, Andrew T. McNutt, Larry W. Moreland, Lee McDermott, David R. Koes, Christian A. Fernandez

“…Our results suggest that DV inhibits NFAT independently of PI3K by interfering with nuclear NFAT binding to the NFAT consensus promoter sequence. …”
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Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer r... by А. А. Timofeeva, V. I. Minina, A. V. Torgunakova, О. А. Soboleva, R. А. Тitov, Ya. А. Zakharova, M. L. Bakanova, А. N. Glushkov

“…MDR analysis also showed a close interaction and mutual enhancement of effects between the APEX1 and SOD2 loci and the independence of the effects of these loci from the CAT locus in the formation of luminal B subtype breast cancer.…”
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HPV vaccination and Native Americans: protocol for a systematic review of factors associated with HPV vaccine uptake among American Indians and Alaska Natives in the USA by Sameer Vali Gopalani, Ami E Sedani, Amanda E Janitz, Shari C Clifton, Julie Stoner, Jennifer Peck, Ashley Comiford, Alicia L Salvatore, Janis Campbell

“…Studies will be screened and selected independently in two stages. In stage 1, titles and abstracts will be screened. …”
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Host-symbiont-gene phylogenetic reconciliation by Menet, Hugo, Trung, Alexia Nguyen, Daubin, Vincent, Tannier, Eric

“…These interactions range from independence or conflict to cooperation and coevolution, which results in them having a common history. …”
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Estimating the global cost of vision impairment and its major causes: protocol for a systematic review by Nathan Congdon, Thomas Butt, Peng Tee Khaw, Andrew Bastawrous, Tasanee Braithwaite, Rupert R A Bourne, Matthew J Burton, Serge Resnikoff, Jacqueline Ramke, Kevin Frick, Hugh Taylor, Iris Gordon, Ana Patricia Marques, John Cairns, Justine H Zhang, Hannah B Faal, Iain Jones, Marty Jovic, Allyala Nandakumar

“…The review will include any study published from 1 January 2000 to November 2019 that provides information about costs of illness, burden of disease and/or loss of well-being in participants with VI due to an unspecified cause or due to one of the seven leading causes globally.Two reviewers will independently screen studies and extract relevant data from included studies. …”
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Evaluation of the potential value of artificial intelligence (AI) in public health using fluoride intake as the example by Wei Wei, Tianshu Gu, Yanhong Cao, Shuqiu Sun, Dan Wei, Minghui Li, Alyce D. Fly, Weikuan Gu, Lan Yao, Dianjun Sun

“…These hypotheses were then evaluated independently by three evaluators. Finally, summaries were made through group discussions among all the authors. …”
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Antithrombotic therapy in adults with ectatic coronary artery disease: a systematic review and network meta-analysis by Alireza Azarboo, Mohammad Shahabaddin Daneshvar, Alireza Sattari Abroy, Ramin Assempoor, Aryan Taghvaei, Ali Nasrollahizadeh, Mohsen Hajiqasemi, Amirhossein Ghaseminejad-Raeini, Kaveh Hosseini

“…Study selection, data extraction, and risk-of-bias assessments were independently performed by two reviewers. The pairwise meta-analysis compared the odds of MACE among patients receiving different antithrombotic therapies versus no treatment. …”
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Potential implications of thyroid autoantibodies in children, adolescents, and young adults with thyroid nodules in Japan: The Fukushima Health Management Survey by Rina Tazaki, Yurie Kobashi, Nana Nakahata, Mahiro Asano, Norikazu Abe, Haruka Ejiri, Ayako Sato, Natsuki Nagamine, Chisato Takahashi, Yukie Yamaya, Manabu Iwadate, Takashi Matsuzuka, Satoshi Suzuki, Tetsuya Ohira, Satoru Suzuki, Fumihiko Furuya, Hiroki Shimura, Shinichi Suzuki, Susumu Yokoya, Shunichi Yamashita, Hitoshi Ohto, Seiji Yasumura

“…Tab positivity was independently associated with a large thyroid, the presence of DG, the presence of PTC, and a high TSH concentration in patients with nodules. …”
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Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease by Nour Rahnama, MD, Arthur Colson, MD, PhD, Pamela Baldin, MD, PhD, Agnès Pasquet, MD, PhD, Damien Gruson, MD, PhD, David Vancraeynest, MD, PhD, Christophe Beauloye, MD, PhD, Frédéric Debiève, MD, PhD, Sophie Pierard, MD, PhD

“…CHD pregnancies had a higher incidence of adverse obstetric and neonatal outcomes, which were independently associated with MVM (RR: 7.2, P = 0.002). …”
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Thickness of Subcutaneous Fat Is a Predictive Factor of Incisional Surgical Site Infection in Crohn’s Disease Surgery: A Retrospective Study by Xingchen Cai, Weisong Shen, Zhen Guo, Yi Li, Lei Cao, Jianfeng Gong, Weiming Zhu

“…Preoperative TSF and CRP independently affect iSSI in patients with CD undergoing intestinal resections.…”
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A Review of Integrated Optimization Method of Batch Planning and Scheduling for Steelmaking-Continuous Casting-Hot Rolling Production Under Uncertain Environment Based on Lagrangia... by Liangliang Sun, Xirang Hao, Yunpeng Li, Jinghan Xue, Natalia M. Matsveichuk, Yuri N. Sotskov, Qichun Zhang

“…However, due to the traditional “divide and conquer” management mode and the influence of many uncertain factors, it is difficult to ensure the flexible balance between the demand and capacity, as well as a reasonable matching of logistics and resources among the production processes that operate independently. Considering the uncertain environment and the integration of SM-CC-HR, this paper summarizes the research status of previous scholars from three aspects: mathematical modeling, model optimization, and algorithm optimization based on the Lagrangian framework. …”
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Effect of Laryngeal Mask Airway Insertion on Intraocular Pressure Response: Systematic Review and Meta-Analysis by Mohammed Suleiman Obsa, Zewde Zema kanche, Robera Olana Fite, Tilahun Saol Tura, Bulcha Guye Adema, Aseb Arba Kinfe, Melkamu Worku kercho, Kebreab Paulos chanko, Getahun Molla Shanka, Atkuregn Alemayehu Lencha, Gedion Asnake Azeze, Lolemo Kelbiso Hanfore, Nefsu Awoke Adulo, Blen Kassahun Dessu, Getahun Dendir Wolde, Shimelash Bitew Workie

“…All original peer-reviewed papers which reported the mean and standard deviation of IOP before and after airway instrumentation in both groups were included. Two reviewers independently extracted the data using a standardized data extraction format for eligibility and appraised their quality. …”
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The importance of Ki-67 proliferation index in small cell lung cancer by Seda Beyhan Sağmen, Coşkun Doğan, Sevda Cömert, Nesrin Kıral, Elif Torun Parmaksız, Ali Fidan, Nagehan Ozdemir Barisik, Sule Karabulut Gul

“…In Cox regression analysis, Ki-67 PI < 68.7 was found that increased mortality by 2742 times independently. Conclusions Patients with a high Ki-67 had a better survival effect than those with low Ki-67, and patients with complete responses had a higher Ki-67 value.…”
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Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population by Xueying Chen, Han Guo, Xinwei Li, Yang Liu, Xinxin Li, Zhengshuo Cui, Huijuan Ma, Jianxun He, Zhechun Zeng, Huina Zhang

“…The present study reveals that the elevated levels of serum EV‐derived SPARC were independently associated with hypertension.…”
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Functional outcomes following injury in pediatric patients without traumatic brain injury by Ryo Yamamoto, Lillian Liao, Keitaro Yajima, Akira Endo, Kazuma Yamakawa, Junichi Sasaki

“…The GEE model revealed that female sex, physical disability before injury, prehospital transfusion, lower Glasgow Coma Score (GCS) score on arrival, neck surgery, and higher AIS in the neck and extremity/pelvis were independently associated with unfavorable function at discharge. …”
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