A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance by Alexander Mazein, Marcio Luis Acencio, Irina Balaur, Adrien Rougny, Danielle Welter, Anna Niarakis, Anna Niarakis, Diana Ramirez Ardila, Ugur Dogrusoz, Piotr Gawron, Venkata Satagopam, Venkata Satagopam, Wei Gu, Wei Gu, Andreas Kremer, Reinhard Schneider, Reinhard Schneider, Marek Ostaszewski, Marek Ostaszewski

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Investigating the Activity Status of Inflammatory Bowel Disease and its Related Factors: A Study Protocol by Mehrnaz Asgharnezhad, Ehsan Amini-Salehi, Niloofar Faraji, Soheil Hassanipour, Saman Maroufizadeh, Adele Isanazar, Marjan Mahdavi-Roshan, Zahra Hedayatzadeh, Farahnaz Joukar, Fariborz Mansour Ghanaei

“…Regression models will be employed to control for potential confounders and assess the independent effects of each variable. Conclusion: The findings from this study are expected to provide valuable insights into the activity status of IBD and its related factors in Guilan Province, Iran. …”
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Agreement Between Provider-Completed and Patient-Completed Preoperative Frailty Screening Using the Clinical Risk Analysis Index: Cross-Sectional Questionnaire Study by Mehraneh Khalighi, Amy C Thomas, Karl J Brown, Katherine C Ritchey

“…In total, 41% (20/49) of participants completed and returned an independent postvisit RAI-C assessment before surgery and within 180 days of their initial evaluation. …”
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Outcomes of total hip replacement in adults with septic arthritis of the native hip joint: A systematic review by Teddy Cheong, Surya Varma Selvakumar, Ryan Kwang Jin Goh, Ing How Moo

“…Literature retrieval and data extraction were conducted by three independent reviewers. Re-infection rate and various functional outcomes, measured in terms of the Harris Hip Score (HHS), Visual Analogue Scale (VAS), Merle D'Aubigne and Postel (MAP), Western Ontario, McMaster Universities Arthritis Index (WOMAC) Short Form 12-Item (SF-12) scores, were analyzed. …”
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The Effects of Active Teaching and Learning Methods on The Pupils' Academic Performance in Four Selected Primary Schools in Bugamba Sub-County in Rwampara District. by Ampurire, Motion

“…There was critical review of the issues that have explored and studied both theoretically and empirically in the existing literature on active teaching as an independent variable and pupils' academic performance as the dependent variable and the methods of data collection were put into action. …”
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The Impact of Family Conflicts on Socio-Economic Prosperity: A Case Study of Muko Sub-County Rubanda District. by Akankwasa, Winfred

“…There was a critical review of the issues that have been explored and studied both theoretically and empirically in the existing literature on of family conflicts as an independent variable socio socio-economic prosperity as the dependent variable and the methods of data collection were put into action. …”
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The Contribution Of Universal Education Towards Girl Child Education: A Case Study Of Nyarubuye Sub-County Kisoro District. by Nizeyimana, Bakunzi Moses

“…In chapter two, there was a critical review of the issues that have been explored and studied both theoretically and empirically in the existing literature on universal education as an independent variable and sustainable girl-child education as a dependent variable. …”
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Role of Faith Based Organizations (FBO’s) in Responding to the Socio-Economic Impact of Covid-19 in Nyakinama Sub-County Kisoro District. by Mukabera, Charity

“…In chapter two, there was a critical review of the issues that have been explored and studied both theoretically and empirically in the existing literature on Faith-based organizations as an independent variable and the socio-economic impact of COVID-19 on rural areas as the dependent variable. …”
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Role of Social Factors in Social Economic Status of Families in Kabale Municipality Kabale District. by Atukunda, Brian

“…There was a critical review of the issues that have been explored and studied both theoretically and empirically in the existing literature on social factors as an independent variable socio-economic prosperity as the dependent variable and the methods of data collection were put into action. …”
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Agricultural Innovation Characteristics and Their Utilisation: A Case of National Agricultural Research Organization by Barekye, Alex

“…The study was guided by a conceptual framework which considered agricultural innovation characteristics and market attributes as independent variables and utilization as a dependent variable. …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Conversely, sex was not prognostic in the independent cohorts of patients with MSI-H CRCs not treated with ICIs. …”
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Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer by Yong-Cheng Liu, Jun Shen

“…PubMed, EMBASE, OVID, Web of Science, Scopus, and Cochrane Library were systematically searched for relevant studies published up to August 25, 2024. Two independent researchers screened the literature according to predefined inclusion and exclusion criteria and extracted relevant data. …”
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Patterns of failure and prognosis in nasopharyngeal carcinoma according to Epstein-Barr virus DNA status by Lin-Feng Guo, Guan-Zhong Lu, Zhen-Zhen Lu, Yi-Feng Yu, San-Gang Wu

“…Multivariate analysis showed that liver metastasis (P = 0.012) and EBV-DNA levels ≥ 3,525 copies/mL at progression (P = 0.009) independently correlated with poorer overall survival. …”
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Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects – a hurdle for vaccination? by Jonah Clegg, Jonah Clegg, Malgorzata E. Mnich, Malgorzata E. Mnich, Alberto Carignano, Giovanni Cova, Simona Tavarini, Chiara Sammicheli, Bruna Clemente, Megan Smith, Megan Smith, Emilio Siena, Monia Bardelli, Michela Brazzoli, Fabio Bagnoli, Rachel M. McLoughlin, Elisabetta Soldaini

“…Using an activation induced marker assay to sort for S. aureus-specific CD4+ T cells in an effector function-independent manner, single cell transcriptomic analysis was conducted. …”
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Sensitive windows for within- and trans-generational plasticity of anti-predator defences by Tariel-Adam, Juliette, Luquet, Émilien, Plénet, Sandrine

“…This suggests that transgenerational plasticity, although linked to within-generational plasticity by the embryonic sensitive window, may also be induced via a specific channel, independent of within-generational plasticity induction and expression. …”
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Correlation analysis of Hashimoto’s thyroiditis with papillary thyroid carcinoma occurrence and its central lymph node metastasis: a single center experience by Kang Sun, Kang Sun, Xiaoming Wang, Dexuan Chen, Chaoqun Ma

“…Through univariate and multivariate logistic regression, we proved that tumor position, Capsule + Extrathyroidal extension (ETE), multifocal tumors, and the total number of CLN dissected were independent risk factors for CLNM. Multiple linear regression analysis told us that invasion (β= 0.093, p=0.048) had a positively predictive impact on CLN positive rate.ConclusionFemale PTC patients are more prone to concurrent HT, which elevates the levels of TSH, TPOAb, and TgAb. …”
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Fast and Slow Roasting of Alcohol- and Honey-infused Coffee Blends: A Comparative Study of PAH and N-PAH Emissions by Hsin-Chieh Kung, Chung-Hsien Hung, Kun-Hui Lin, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chien

“…These results narrow the research gap on toxic emissions during coffee roasting and would be of particular interest in independent coffee shops where roasting is done in-house.…”
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Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma by Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

“…Our statistical results demonstrate that as two new optical biomarkers, TACS- and M-TACS-score, are independent prognostic factors and have good discriminatory ability (high AUC) as well as risk stratification (high HR) comparing with traditional clinical model (combining seven clinical risk factors, age, sex, TNM stage, tumor location and differentiation, perineural and lymph-vascular invasion) in predicting overall survival (OS) of patients with PDAC, highlighting their potential prognostic and predictive value. …”
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Food safety practice and its associated factors among food handlers working in food and drinking establishments in Hargeisa, Somaliland by Mohamed Mussa Abdilahi, Jonah Kiruja, Abdisamad Shukri Ismail, Soheir H. Ahmed, Faisal Nooh, Ayanle Suleiman Ahmed, Abdiqathar Rashid Kulmie

“…Descriptive analysis summarized respondents’ socio-demographic characteristics, while bivariate and multivariable analyses examined relationships in the data. Independent variables with a p-value below 0.25 were included in multivariable logistic regression to identify significant factors, using adjusted odds ratios (AORs) and a 95% confidence interval (CI), with a significance threshold of p < 0.05. …”
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Utility of Visceral Adiposity Index and Lipid Accumulation Products to Define Metabolically-Unhealthy Polycystic Ovary Syndrome in Asian Indian Women - A Cross Sectional Study by R. A. Shreenidhi, Reeta Mahey, Monika Rajput, Rohitha Cheluvaraju, Ashish D. Upadhyay, Jai Bhagwan Sharma, Garima Kachhawa, Neerja Bhatla

“…Statistical Analysis Used: Univariate and multivariate logistic regression analysis was used to study the independent role of VAI and LAP to predict MetS. Adjusted and unadjusted odds ratios were calculated. …”
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