Recommendations for the primary prevention of atherosclerotic cardiovascular disease in primary care: a systematic guideline review by Maren Bredehorst, Ana I. González-González, Lara Schürmann, Dennis Firmansyah, Christiane Muth, Jörg Haasenritter, Veronika van der Wardt, Svetlana Puzhko

“…IntroductionThis study systematically reviews and synthesizes recommendations from national and international clinical practice guidelines (CPGs) regarding the primary prevention of atherosclerotic cardiovascular disease (ASCVD) in adults in primary care settings.MethodsCPGs were retrieved from MEDLINE, Trip, guideline repositories, and websites of guidelines-producing societies. Two reviewers independently screened the guidelines for eligibility, assessed their quality, and extracted study characteristics and relevant recommendations for further consistency analysis. …”
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The effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, and health-related quality of life in adults with malig... by Charlotte Groenset, Magnus N. Bech, Mary Jarden, Nina Høgdal, Martin Hutchings, Charlotte Suetta, Jan Christensen

“…All study authors were contacted to obtain unpublished subgroup data. Two reviewers independently screened and extracted data and assessed the quality of evidence using the revised Cochrane risk-of-bias tool for randomized trials. …”
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The influence of weather and urban environment characteristics on upper respiratory tract infections: a systematic review by Henna Hyrkäs-Palmu, Henna Hyrkäs-Palmu, Timo T. Hugg, Timo T. Hugg, Jouni J. K. Jaakkola, Jouni J. K. Jaakkola, Tiina M. Ikäheimo, Tiina M. Ikäheimo, Tiina M. Ikäheimo

“…BackgroundWeather can independently affect the occurrence of respiratory tract infections (RTIs) in urban areas. …”
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Development and design validation of a novel network meta-analysis presentation tool for multiple outcomes: a qualitative descriptive study by Lehana Thabane, Jason W Busse, Behnam Sadeghirad, Gordon H Guyatt, Mohit Bhandari, Romina Brignardello-Petersen, Fernando Kenji Nampo, Carlos A Cuello-Garcia, Raveendhara R Bannuru, Mark R Phillips, Yu Jia Guo, Sofia Bzovsky

“…Through an iterative process, we assessed the validity of both formats to maximise their clarity and ease of interpretation.Participants 26 participants including 20 clinicians who routinely provide patient care, 3 research staff/research methodologists and 3 residents.Main outcome measures Two team members used qualitative content analysis to independently analyse transcripts of all interviews. …”
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Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer by Yuwei Wang, Yadong Long, Ye Xu, Zuqing Guan, Peng Lian, Junjie Peng, Sanjun Cai, Guoxiang Cai

“…In Cox regression analysis, CIMP positive epigenotype was independently related with poor DFS with HR = 2.935 and 95% CI: 1.193–7.220 (P=0.019). …”
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A real–time distributed optimization control for power sharing and voltage restoration in inverter–based microgrids by Asad Khan, Muhammad Mansoor Khan, Jiang Chuanwen, Danish Khan

“…Each sub–problem, containing at most two GFM sources and multiple GFL sources with a single distributed agent, is solvable independently using local and neighboring node information. …”
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FAN score predicts prognosis after platinum-based first-line chemotherapy in patients with metastatic urothelial carcinoma by Yu Ishizuya, Atsunari Kawashima, Yuki Horibe, Akinaru Yamamoto, Masaru Tani, Akihiro Yoshimura, Liu Yutong, Sassi Nesrine, Toshiki Oka, Yohei Okuda, Toshihiro Uemura, Gaku Yamamichi, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Koji Hatano, Norio Nonomura

“…Multivariable analysis showed that Fib-4 index (HR 3.85, 95% CI 1.09–13.58, p = 0.036), ALBI score (HR 1.53, 95% CI 1.01–2.31, p = 0.045), and NLR (HR 1.76, 95% CI 1.14–2.71, p = 0.010) were independently associated with PFS. The FAN score was also associated with PFS (HR 2.56, 95% CI 1.62–4.05, p < 0.001). …”
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Prevalence and sociodemographic characteristics of functional impairment in community-dwelling older adults in China: a cross-sectional study by Yun Li, Li Zhang, Zhe Tang, Lina Ma, Pan Liu, Xiaxia Li, Wenhua Yu, Yaxin Zhang

“…Furthermore, after adjusting for related variables, functional impairment was independently associated with disability (OR=138.5, 95% CI 70.0 to 273.9), frailty (OR=13.7, 95% CI 10.3 to 18.3), immobility (OR=6.9, 95% CI 5.4 to 8.9), fractures (OR=2.2, 95% CI 1.5 to 3.3) and falls (OR=2.6, 95% CI 1.8 to 3.7).Conclusion Approximately one-third of Chinese community-dwelling older adults experienced functional impairment, and its prevalence was associated with socio-psychological characteristics, lifestyle, chronic diseases and geriatric syndromes.…”
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Anatomy-Informed Multimodal Learning for Myocardial Infarction Prediction by Ivan-Daniel Sievering, Ortal Senouf, Thabo Mahendiran, David Nanchen, Stephane Fournier, Olivier Muller, Pascal Frossard, Emmanuel Abbe, Dorina Thanou

“…<italic>Results:</italic> The results of our framework on a clinical study of 445 patients admitted with acute coronary syndromes confirms that multimodal learning increases the predictive power and achieves good performance (AUC: <inline-formula><tex-math notation="LaTeX">$0.67\pm 0.04$</tex-math></inline-formula> &amp; F1-Score: <inline-formula><tex-math notation="LaTeX">$0.36\pm 0.12$</tex-math></inline-formula>), which outperforms the prediction obtained by each modality independently as well as that of interventional cardiologists (AUC: 0.54 &amp; F1-Score: 0.18). …”
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Tax-Deductible Provisions for Gluten-Free Diet in Canada Compared with Systems for Gluten-Free Diet Coverage Available in Various Countries by Maria Ines Pinto-Sanchez, Elena F Verdu, Maria C Gordillo, Julio C Bai, Stephen Birch, Paul Moayyedi, Premysl Bercik

“…An ideal balanced approach would involve subsidizing gluten-free products through controlled vouchers or direct food provision to those who most need it, independently of ‘ability or willingness to pay’. Moreover, if the cost of such a program is inhibitive, the value of the benefits could be made taxable to ensure that any patient contribution, in terms of additional taxation, is directly related to ability to pay. …”
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Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes by Ping Gu, Wei Wang, Yue Yao, Yixin Xu, Liping Wang, Pu Zang, Jian Ma, Cuihua Yang, Junya Liang, Bin Lu, Jiaqing Shao

“…Using logistic regression analysis, plasma chemerin concentrations were independently associated with the presence of nephropathy and retinopathy, not neuropathy. …”
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Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms by Zdenek Krejcik, David Kundrat, Jiri Klema, Andrea Hrustincova, Iva Trsova, Monika Belickova, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Michaela Dostalova Merkerova

“…Importantly, the upregulation of PIWIL2, which encodes a key factor in the piRNA pathway, independently predicted poor prognosis in MDS patients, underscoring its potential as a valuable disease marker. …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…Three AAMRGs, DNMT1, F2R, and GPX3, could independently predict the course of STAD. Pyrimidine metabolism appeared to be significantly associated with these by GSEA and clustering analyses. …”
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Investigating the relationship between thought interference, somatic passivity and outcomes in patients with psychosis: a natural language processing approach using a clinical reco... by Robert Stewart, Anna Kolliakou, Jyoti Sanyal, Rashmi Patel, Thibault Thierry Magrangeas

“…Objectives We aimed to apply natural language processing algorithms in routine healthcare records to identify reported somatic passivity (external control of sensations, actions and impulses) and thought interference symptoms (thought broadcasting, insertion, withdrawal), first-rank symptoms traditionally central to diagnosing schizophrenia, and determine associations with prognosis by analysing routine outcomes.Design Four algorithms were developed on deidentified mental healthcare data and applied to ascertain recorded symptoms over the 3 months following first presentation to a mental healthcare provider in a cohort of patients with a primary schizophreniform disorder (ICD-10 F20-F29) diagnosis.Setting and participants From the electronic health records of a large secondary mental healthcare provider in south London, 9323 patients were ascertained from 2007 to the data extraction date (25 February 2020).Outcomes The primary binary dependent variable for logistic regression analyses was any negative outcome (Mental Health Act section, &gt;2 antipsychotics prescribed, &gt;22 days spent in crisis care) over the subsequent 2 years.Results Final adjusted models indicated significant associations of this composite outcome with baseline somatic passivity (prevalence 4.9%; adjusted OR 1.61, 95% CI 1.37 to 1.88), thought insertion (10.7%; 1.24, 95% CI 1.15 to 1.55) and thought withdrawal (4.9%; 1.36, 95% CI 1.10 to 1.69), but not independently with thought broadcast (10.3%; 1.05, 95% CI 0.91 to 1.22).Conclusions Symptoms traditionally central to the diagnosis of schizophrenia, but under-represented in current diagnostic frameworks, were thus identified as important predictors of short-term to medium-term prognosis in schizophreniform disorders.…”
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Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Lei Li, Wuping Yang, Yawei Xu, Jingcheng Zhou, Kaifang Ma, Kenan Zhang, Hongkai Zhuang, Yanqing Gong, Kan Gong

“…Kaplan-Meier survival analysis and Cox regression analysis suggested that downregulated FXYD2 could independently predict poor survival of ccRCC patients. …”
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Student nurse education and preparation for palliative care: A scoping review. by Abiola Durojaiye, Ruth Ryan, Owen Doody

“…Screening was performed independently by two reviewers against eligibility criteria with meetings to discuss included papers and form a consensus. …”
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Association between impaired brachial flow-mediated dilation and early neurological deterioration in acute ischemic stroke: a retrospective analysis by Sang Hee Ha, Bo Hye Yoon, Bon Gook Koo, Dong Hoon Shin, Yeong-Bae Lee, Bum Joon Kim

“…Multivariate analysis revealed that a history of stroke (adjusted odds ratio [aOR] = 1.728; 95% confidence interval [CI] 1.159–2.578; P = 0.007) and low % were independently associated with END. Subgroup analysis revealed that low %FMD was significantly associated with END within the small vessel disease (SVD) category (aOR = 0.789; 95% CI 0.679–0.920; P = 0.002). …”
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Effects of Root Cooling on Plant Growth and Fruit Quality of Cocktail Tomato during Two Consecutive Seasons by F. He, B. Thiele, M. Watt, T. Kraska, A. Ulbrich, A. J. Kuhn

“…A root temperature of 10°C was controlled independently from air temperature (18–23°C in winter and 21–29°C in summer) by circulating cooling water. …”
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Adiponectin Gene Polymorphisms and Possible Susceptibility to Metabolic Syndrome among the Sudanese Population: A Case-Control Study by Altaf S. Mosad, Ghada A. Elfadil, Alsadig Gassoum, Khanssa M. Elamin, Nazik Elmalaika Obaid Seid Ahmed Husain

“…Multivariate logistic regression analysis showed hypertension, hyperglycemia, BMI, WC, serum TG, ADIPOQ rs2241766 (TG allele), and ADIPOQ rs1501299 (GT allele) had independently predicted the incidence of metabolic syndrome in the Sudanese population. …”
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Historical aspect of the european understanding of the rule of law by Kelbya S.

“…It was determined that although Ukraine has taken significant steps to prevent corruption since independence, the country’s legal system still requires significant changes.It is also found that the current state of the European rule of law shows mixed trends. …”
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