Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP by Yi Wang, Weiwei Qiu, Stace Kernodle, Carly Parker, Marc-Antonio Padilla, Jiaao Su, Abigail J. Tomlinson, Stephanie Oldham, Joss Field, Elise Bernard, David Hornigold, Christopher J. Rhodes, David P. Olson, Randy J. Seeley, Martin G. Myers, Jr

“…Results: Although Prlhr played a crucial role in the restraint of food intake and body weight in HFD-fed control animals, the combined absence of Prlhr and Npffr2 was required to abrogate the restraint of food intake in NTSPrlhOX mice. p52 suppressed feeding independently of both receptors, however. Conclusions: Hence, each receptor can participate in the NTSPrlh-mediated suppression of food intake and body weight gain, while PrRP analog treatment can mediate its effects via distinct systems. …”
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Clonal hematopoiesis in patients with autoimmune thrombocytopenia: an international multicenter study by Bruno Fattizzo, Alfredo Marchetti, Alessandro Bosi, Carmelo Gurnari, Juri Alessandro Giannotta, Giacinto Luca Pedone, Elena Rossi, Valentina Carrai, Andrea Guido, Filippo Brioschi, Monica Carpenedo, Monica Crugnola, Domenica Caramazza, Livia Leuzzi, Monia Marchetti, Gabriele Merati, Simona Malato, Fabrizio Vianello, Andrea Patriarca, Hussein Awada, Marta Bortolotti, Marta Canzi, Niccolò Bolli, Marco Capecchi, Frederick Chen, Andrea Artoni, Jaroslaw P. Maciejewski, Wilma Barcellini

“…Additionally, clonal hematopoiesis was associated with increased thrombotic risk (26% vs 8% in NGS-negative cases; P = .01), independently from TPO-RA exposure, though with an age effect. …”
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Playful brains: a possible neurobiological pathway to cognitive health in aging by Yulia Golland, Yulia Golland, Boaz M. Ben-David, Boaz M. Ben-David, Boaz M. Ben-David, Mara Mather, Mara Mather, Mara Mather, Shoshi Keisari, Shoshi Keisari, Shoshi Keisari

“…Healthy cognitive aging emphasizes preserving cognitive functions essential for independence and well-being. Developing interventions that promote cognition and resilience in older individuals is crucial. …”
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Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement by Emaddin Kidher, Vanash M. Patel, Petros Nihoyannopoulos, Jon R. Anderson, Andrew Chukwuemeka, Darrel P. Francis, Hutan Ashrafian, Thanos Athanasiou

“…Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). …”
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Comorbidity Assessment in Skin Cancer Patients: A Pilot Study Comparing Medical Interview with a Patient-Reported Questionnaire by Erica H. Lee, Rajiv I. Nijhawan, Kishwer S. Nehal, Stephen W. Dusza, Amanda Levine, Amanda Hill, Christopher A. Barker

“…Comorbidities are conditions that occur simultaneously but independently of another disorder. Among skin cancer patients, comorbidities are common and may influence management. …”
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A stomatal optimization model integrating leaf stomata-photosynthetic capacity regulation in response to soil water stress by Yong Liu, Tiesong Hu, Rui Zhu, Qiuwen Chen, Xiang Zeng, Peiran Jing, Yifan Huang

“…Different from previous studies that achieved stomatal and non-stomatal regulation in stomatal optimization models by linearly simplifying or independently optimizing Vcmax25, this study hypothesizes that Vcmax25 and gs are co-regulated by balancing intercellular CO₂ concentration (Ci). …”
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Assessing research methodologies used to evaluate inequalities in end-of-life cancer care research: a scoping review protocol by Sam Harper, Natalie G Coburn, Alyson L Mahar, Laura E Davis, Julie Hallet, Peter Tanuseputro, Geetanjali D Datta, Colleen Webber, Allison Wiens, Lauren Konikoff

“…We will systematically search Medline, Embase, CINAHL and PsycINFO electronic databases for quantitative and qualitative studies that examined equity stratifiers in relation to end-of-life cancer care and/or outcomes published in English or French between 2010 and 2021. Two authors will independently review all titles, abstracts and full texts to determine which studies meet the inclusion criteria. …”
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Successful Management of Refractory Heart Failure and Multi-Organ Dysfunction in a Patient with CRT-D and Acute Pulmonary Edema: A Case Report by Marsela Goga, Saimir Kuci, Alfred Ibrahimi, Ermal Likaj, Alvi Cela, Romina Teliti, Ormir Shurdha, Erilda Selimi, Jacob Zeitani

“…Over three weeks, the patient regained hemodynamic stability, renal function, and respiratory independence. This case demonstrates the potential for recovery in patients with severe heart failure complicated by acute pulmonary edema and multi-organ dysfunction when treated with an integrated, multidisciplinary approach. …”
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Metabolic conversion of phenol to polyhydroxyalkanoate (PHA) for addressing dual environmental challenges: A review by Izzati Sabri, Mohd Zulkhairi Mohd Yusoff, Nor Azlan Nor Muhammad, Li Sim Ho, Norhayati Ramli

“…In this review, the mechanisms of phenol biodegradation and PHA biosynthesis are first independently elucidated to comprehend the role of bacteria in these processes. …”
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A Novel Construction of Substitution Box Based on Polynomial Mapped and Finite Field With Image Encryption Application by Abid Mahboob, Muhammad Asif, Imran Siddique, Aysha Saleem, Muhammad Nadeem, Dariusz Grzelczyk, Jan Awrejcewicz

“…Lastly, to examine the validity of the suggested S-box we used various tests such as nonlinearity (NL), bit independence criteria (BIC), strict avalanche criteria (SAC), differential uniformity (DU) and linear approximation probability (LAP) which all certify algebraic properties of S-box. …”
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Improving photovoltaic water pumping system performance with ANN-based direct torque control using real-time simulation by Ikram Saady, Btissam Majout, Ismail El Kafazi, Mohammed Karim, Badre Bossoufi, Najib El Ouanjli, Said Mahfoud, Ahmed Althobaiti, Thamer A. H. Alghamdi, Mohammed Alenezi

“…Abstract Photovoltaic Water Pumping Systems (PVWPS) have become increasingly important as a renewable energy solution in rural areas, providing energy independence, cost savings, and environmental friendliness. …”
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The impact of family members on aging persons’ technology use intentions by Freek Van Baelen, Melissa De Regge, Bart Larivière, Katrien Verleye, Kristof Eeckloo

“…Technology plays a growing role in allowing aging persons to live independently. However, it is often difficult to motivate aging persons to use these new technologies. …”
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Tumor resting-state fMRI connectivity to extralesional brain is associated with cognitive performance in glioma patients by Chuh-Hyoun Na, Hans Clusmann, Martin Wiesmann, Kerstin Jütten, Verena Mainz

“…Introduction: Functional coupling of the tumor to extralesional brain areas and the pretherapeutic cognitive performance status have each independently been identified as prognostically relevant in glioma patients. …”
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GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…An eight-gene prognostic model, including M2-like TAM-related genes, independently predicted poor outcomes in OC. GNA15 emerged as a hub gene positively correlated with M2-like TAMs infiltration, predicting unfavorable outcomes across OC cohorts. …”
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Relationship between subjective masticatory performance assessed by food acceptance questionnaire and comprehensively assessed oral function in older outpatients at a dental hospit... by Ryota Futatsuya, Yohei Hama, Mitsuzumi Okada, Mayuko Matsuzaki, Linjing Xiong, Kohei Yamaguchi, Kanako Noritake, Yoshiyuki Sasaki, Manabu Kanazawa

“…Conclusions This study demonstrated that subjective masticatory performance was independently associated with tongue pressure, objective masticatory performance, swallowing function, number of functional teeth, geriatric depression, and oral health-related quality of life.…”
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Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study by Gian Luca Erre, Matteo Piga, Anna Laura Fedele, Silvia Mura, Alessandra Piras, Maria Luisa Cadoni, Ignazio Cangemi, Martina Dessi, Gabriele Di Sante, Barbara Tolusso, Elisa Gremese, Alberto Cauli, Arduino Aleksander Mangoni, Pier Sergio Saba, Ciriaco Carru, Gianfranco Ferraccioli, Alessandro Mathieu, Giuseppe Passiu

“…Peripheral microvascular ED was documented in one-third of RA patients (33.5%); in multiple logistic regression analysis, ACPA negativity and higher triglycerides concentrations were independently associated with the presence of peripheral ED [OR (95% CI) = 1.708 (1.218–2.396), p<0.01 and OR (95% CI) = 1.005 (1.002–1.009), p<0.01, respectively]. …”
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Prevalence, incidence and determinants of QuantiFERONTM positivity in South African schoolchildren by J. Stewart, N. Walker, K. Jennings, C. Delport, J Nuttall, A.K. Coussens, R Dyers, D.A. Jolliffe, J.C.Y. Tang, W.D. Fraser, R.J. Wilkinson, L.-G. Bekker, A.R. Martineau, K. Middelkoop

“…RESULTS: QuantiFERON-positivity at baseline (prevalence: 22.6%, 95% CI 20.9–24.4), was independently associated with increasing age (aOR 1.24 per additional year, 95% CI 1.15–1.34) and household exposure to TB during the participant’s lifetime (aOR 1.87, 95% CI 1.46–2.40). …”
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Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India by Mohit Chowdhry, R. N. Makroo, Mandhata Singh, Manoj Kumar, Yogita Thakur, Vandana Sharma

“…Preformed MICA antibodies independently increase the risk of kidney rejection and therefore recommend that guidelines should be formed for mandatory testing of these antibodies prior to renal transplant.…”
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Thresholds of handgrip strength for all-cause mortality in patients with chronic kidney disease: a secondary systematic review with dose-response meta-analysis by Hao Chen, Fan Zhang, Liuyan Huang, Yan Bai, Yifei Zhong, Yi Li

“…The included cohort was a CKD population not limited to disease stage, and their handgrip strength was objectively measured. Two researchers independently screened studies, extracted data, and assessed the risk of bias. …”
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5‐Hydroxymethylcytosine Profiles of cfDNA in Urine as Diagnostic, Differential Diagnosis and Prognostic Markers for Multiple Myeloma by Weiwei Xie, Xuehui Li, Hangyu Chen, Jinlin Chu, Lei Zhang, Bo Tang, Wenrong Huang, Linlin Li, Jian Lin, Yujun Dong

“…In addition, the prognostic prediction model also effectively predicted the prognosis of patients with MM (p < 0.01), of which 4 differential markers (RAPGEF2, BRD1, TET2, TRAF3IP2) could independently predict the prognosis of MM. Conclusions Together, our findings showed the value of urine cfDNA hydroxymethylcytosine markers in the diagnosis, differential diagnosis and prognosis of MM. …”
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