Association of tumour mutation burden with prognosis and its clinical significance in stage III gastric cancer by Ya-Lin Han, Li Chen, Xu-Ning Wang, Mao-Lin Xu, Rui Qin, Fang-Ming Gong, Peng Sun, Hong-Yi Liu, Zhi-Peng Teng, Zhao-Xia Li, Guang-Hai Dai

“…The Cox regression analysis revealed that age, not TMB, was an independent prognosis factor. Furthermore, genes with high-frequency mutations were significantly enriched in the RTK-RAS and Notch signalling pathways. …”
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Model for End-Stage Liver Disease and Sodium Velocity Predicts Overall Survival in Nonmetastatic Hepatocellular Carcinoma Patients by Justin Y. Tang, Nitin Ohri, Rafi Kabarriti, Santiago Aparo, Jennifer Chuy, Sanjay Goel, Jonathan M. Schwartz, Milan Kinkhabwala, Andreas Kaubisch, Chandan Guha

“…In this report, we explore the value of the rate of short-term changes in MELD-Na as an independent predictor of mortality in patients with nonmetastatic HCC. …”
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Digital Gaming and Subsequent Health and Well-Being Among Older Adults: Longitudinal Outcome-Wide Analysis by Atsushi Nakagomi, Kazushige Ide, Katsunori Kondo, Koichiro Shiba

“…MethodsData were drawn from 3 survey waves (2020 prebaseline, 2021 baseline, and 2022 follow-up) of the Japan Gerontological Evaluation Study, which targets functionally independent older adults. The exposure variable, digital gaming, was defined as regular video game play and was assessed in 2021. …”
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A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC₅₀ Inhibition Values of FLT3 Tyrosine Kinase by Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

“…Rigorous internal validation via leave-one-out and 10-fold cross-validation yielded <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi mathvariant="normal">Q</mi><mn>2</mn></msup></semantics></math></inline-formula> values of 0.926 and 0.922, respectively, while external validation on 270 independent compounds resulted in an R² value of 0.941 with a standard deviation of 0.237. …”
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MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 by Yue Zu, Qianyan Gao, Yisheng He, Qiao Deng, Guodong Li, Xiping Li, Tianze Shang, Xinwei Cheng, Chenglong Zhu, Jianqiao Wang, Dong Liu, Chengliang Zhang

“…Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow. Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localization of MRP2; however, PDZK1’s role and regulatory machinery in MRP2-mediated estrogen-induced cholestasis (EIC) remain unclear. …”
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The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study by Lingling Xu, Dongling Li, Zongwei Song, Jin Liu, Yang Zhou, Junwei Yang, Ping Wen

“…In the multivariable logistic regression analysis, we observed independent associations between MHR (per 1 SD increase) and CKD, as well as low eGFR and proteinuria, with odds ratio (ORs) and 95% confidence intervals (95%CIs) of 1.206 (1.186–1.225), 1.289 (1.260–1.319), and 1.150 (1.129–1.171), respectively (p < .001). …”
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Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade by Nicholas H. Adamstein, MD, Jean G. MacFadyen, BA, Brittany N. Weber, MD, PhD, Peter Libby, MD, Daniel H. Solomon, MD, MPH, Paul M Ridker, MD, MPH

“…After multivariable adjustment for a minimal set of potential confounders, SU independently predicted all 3 endpoints. Associations were unchanged after IL-1β blockade with canakinumab. …”
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Factors Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus by Bin-Bin He, Li Wei, Yun-Juan Gu, Jun-Feng Han, Ming Li, Yu-Xiang Liu, Yu-Qian Bao, Wei-Ping Jia

“…Logistic regression analysis revealed that duration of diabetes, SBP, DN, anemia, PA, and C-peptide were each independent risk factors of DR. Conclusion. The duration of diabetes, SBP, DN, anemia, and PA are positively associated with DR in Chinese T2DM patients, while C-peptide is negatively associated with DR. …”
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The perceived workload of first-line healthcare professionals during neonatal resuscitation by Hai-Bo Huang, Kui Sang, Ming Zhou, Lin Yi, Jiang-Qin Liu, Chuan-Zhong Yang, Brenda H.Y. Law, Georg M. Schmölzer, Po-Yin Cheung

“…The NASA-TLX data on mental, physical, temporal demand, performance, effort, and frustration were independently rated by participants and collated to a composite score of all dimensions. …”
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Comparison of Survival Outcomes of Lymphovascular Space Invasion-Negative and Lymphovascular Space Invasion - Positive Women with Stage IIIC Endometrioid Endometrial Cancer: A Case... by Zeliha Firat Cuylan, Mehmet Mutlu Meydanli, Murat Öz, Ahmet Taner Turan, Ozgur Akbayir, Murat Dede, Ali Ayhan

“…Advanced age (58 years) (HR 3.73; 95% CI: 1.19-11.69, p=0.02), grade 3 tumor (HR 2.57; 95% CI: 1.002-6.62, p=0.048) and cervical involvement (HR 2.62; 95% CI: 1.03-6.67, p= 0.04) appeared to be as independent predictors of decreased overall survival (OS). …”
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Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population by Rocco Capuano, Federica Marchese, Raffaella Sica, Eduardo Capuano, Marzia Manilia, Anna Grazia Iannone, Alessandro D’Ambrosio, Alvino Bisecco, Gioacchino Tedeschi, Antonio Gallo, Vincenzo Capuano

“…Only 13.3% of females and 11.1% of males showed adequate serum concentrations of 25(OH)D (≥30 ng/ml), while 59.3% of females and 55.1% of males showed 25(OH)D deficient levels (<20 ng/ml). We observed an independent association between 25(OH)D concentrations and metabolic syndrome score, LDL cholesterol, HDL cholesterol, and corrected QT (cQT). …”
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Depression Paradox in Cardiovascular Outcomes of Adult Patients with Obstructive Sleep Apnea: Insights from 2 Million Nationwide Hospitalizations by Rupak Desai, Sashwath Srikanth, Shaylika Chauhan, Zainab Gandhi, Warda Shahnawaz, Aleen Rahman, Bisharah Rizvi, Akhil Jain

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Formalin Fixation as Tissue Preprocessing for Multimodal Optical Spectroscopy Using the Example of Human Brain Tumour Cross Sections by Mona Stefanakis, Anita Lorenz, Jörg W. Bartsch, Miriam C. Bassler, Alexandra Wagner, Marc Brecht, Axel Pagenstecher, Jens Schittenhelm, Barbara Boldrini, Sabrina Hakelberg, Susan Noell, Christopher Nimsky, Marcos Tatagiba, Rainer Ritz, Karsten Rebner, Edwin Ostertag

“…Tissue type classifications deduced by optical spectroscopy are highly comparable and independent from the preparation and the fixation protocol. …”
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Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils by Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki

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Pushing the Atacama Large Millimeter/submillimeter Array to the Limit: 140 pc Resolution Observations of a z = 6.6 Quasar–Galaxy Merger Resolve Strikingly Different Morphologies of... by Romain A. Meyer, Bram Venemans, Marcel Neeleman, Roberto Decarli, Fabian Walter

“…\limits^{^{\prime\prime} }026$ (140 pc) resolution Atacama Large Millimeter/submillimeter Array observations of [C ii ] 158 μ m and dust continuum emission of the z = 6.6 quasar J0305–3150, resolved over ~​​​​​​300–400 independent resolution elements. The dust continuum emission is compact with ~80% recovered within $r\lt 0\mathop{.}…”
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,,Cura animarum" of the Preachers Order in the Background of the Medieval Monkhoods Soul Salvation Development by Slawomir Zonenberg

“…Dominic Guzman and his order were given the bulla "Gratiarum omnium" from the Pope, Honorius III (1216-1227), which approved their idea of preaching and spreading the Gospel; thus they became independent from the bishops because they received their traditional regulations in that field. …”
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The Predictive Value of Growth Differentiation Factor-15 in Recurrence of Atrial Fibrillation after Catheter Ablation by Ying Wei, Shuwang Liu, Haiyi Yu, Yuan Zhang, Wei Gao, Ming Cui, Lei Li

“…In the multivariate Cox regression, baseline GDF-15(HR 1.053, 95% CI 1.007-1.100, P=0.022) and LAD (HR 1.124, 95% CI 1.011-1.250, P=0.030) were independent predictors of AF recurrence after RFCA. …”
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Desmoglein-2 was a novel cancer-associated fibroblasts-related biomarker for oral squamous cell carcinoma by Jin Liu, Zhonghao Sun, Shihui Cao, Hao Dai, Ze Zhang, Jingtao Luo, Xudong Wang

“…The hub gene related immune characteristics were analyzed in independent cohorts, and gene expression differences between different immunotherapy response groups were investigated using Pearson correlation analysis. …”
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Iron deposition is associated with motor and non-motor network breakdown in parkinsonism by Fangda Leng, Yue Gao, Fan Li, Luhua Wei, Yunchuang Sun, Fang Liu, Ying Zhu, Jianxing Qiu, Zhaoxia Wang, Yiwei Zhang

“…Cerebellar network, sensorimotor network, default mode network and language networks were segregated using independent analysis. Network and iron deposition status were evaluated in relation to diagnostic groups, motor and non-motor symptoms. …”
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The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 years by Zhengming Wang, Rui Wang, Haiya Ge, Yong Gu, Sicheng Xian, Laijun Yan, Guoqing Du, Zhibi Shen, Shuaijie Lv, Hongsheng Zhan, Zhengyan Li

“…Consequently, age, bone mass stage, 25-hydroxyvitamin D (25-(OH)D), and BMD were included as independent variables in the logistic regression model. …”
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