The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity by Cuong J. Tran, Zahra Zubair-Nizami, Ingeborg M. Langohr, Matthew D. Welch

“…R. parkeri invades host cells, escapes from vacuoles into the cytosol, and undergoes two independent modes of actin-based motility mediated by effectors RickA or Sca2. …”
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Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…TNF internalization is mediated through M6PR, and it is correlated well with cell surface expression of cation-independent M6PR (CI-MPR) in immune cells. A significant amount of CI-MPR remains on the cell surface, while internalized TNF is degraded in lysosomes. …”
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Public Benefit and Public Interest – Two Sides of the Same Coin? by Tina Sever

“…This approach was chosen as much of the relevant legislation for this research is independent of EU influences. Nonetheless, being an EU member state, Slovenia’s legal framework shares some commonalities with other European systems. …”
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A model based cost-utility analysis of Embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 d... by Melanie J Davies, Alan Brennan, Danielle H Bodicoat, Daniel John Pollard, Anju Keetharuth, Michelle Hadjiconstantinou, Agnieszka Glab, Joesph P Mensa, Alison Northern

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Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer by Xiaojie Chu, Seungmin Shin, Du-San Baek, Liyong Zhang, Alex Conard, Megan Shi, Ye-Jin Kim, Cynthia Adams, Maggie Hines, Xianglei Liu, Chuan Chen, Zehua Sun, Dontcho V. Jelev, John W. Mellors, Dimiter S. Dimitrov, Wei Li

“…Prostate stem cell antigen (PSCA) is expressed in all stages of prostate cancer, including in advanced androgen-independent tumors and bone metastasis. PSCA may associate with prostate carcinogenesis and lineage plasticity in prostate cancer. …”
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Fighting Alzheimer’s with Movement: The Role of Physical Activity in Disease Management by Agnieszka Kosińska, Magdalena Balwierz, Karolina Kalinowska, Urszula Świrk, Jan Karczmarz, Joanna Orzechowska, Marika Gutowska, Michał Orzechowski, Aleksandra Paprocka, Paulina Fijałek

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Center-Related Variation in Hospitalization Cost for Patients Undergoing Percutaneous Left Atrial Appendage Occlusion by Shivaraj Patil, MD, Chaitanya Rojulpote, MD, Abhijit Bhattaru, BS, Avica Atri, MD, Krishna Vamsi Rojulpote, BS, Ola Khraisha, MD, Viha Atri, MD, William Frick, MD, Tarek Nafee, MD, Kishore Harjai, MD, Sumeet Mainigi, MD, Chien-Jung Lin, PhD, MD

“…Centers with low procedural volume, occurrence of procedural complications, congestive heart failure, and length of stay were independent predictors of a high-cost hospitalization. …”
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Research priorities for autosomal dominant polycystic kidney disease: a UK priority setting partnership by Tess Harris, Albert Ong, Paul J D Winyard, Richard N Sandford, Maryrose Tarpey, Hannah R Bridges, Wendy D Brown, Natasha L O’Brien, Ann C Daly, Bharat K Jindal, Gillian S Mundy, Albert J Power, John Sayer, Roslyn J Simms, Patricia D Wilson

“…We used adapted JLA methodology. Initially, an independent information specialist collated uncertainties in ADPKD care from recent consensus conference proceedings and additional literature. …”
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Jack Surgery: Reconstructing Collapsed Femoral Head in Association Research Circulation Osseous Stage III Osteonecrosis: A Series of 13 Cases by Ying Zhong, Yichen Gong, Shuaijie Lv, Wenxi Du, Xun Liu, Jianhua Zhang, Peijian Tong

“…Severe collapse of the femoral head ( > 2 mm) or receiving total hip arthroplasty (THA) was defined as failure of hip preservation therapy. An Independent sample t‐test was used to compare the data, and the chi‐square test was used for categorical data. …”
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Cellular heterogeneity and cytokine signatures in acute myeloid leukemia: A novel prognostic model by Jinxia Cao, Bin Hu, Tianqi Li, Dan Fang, ling Jiang, Jun Wang

“…This model was rigorously validated across several independent AML patient cohorts, showcasing its robust prognostic capability to stratify patients into distinct risk categories. …”
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The management and clinical outcome of paracetamol poisoning in South African adults: A single-centre retrospective review by C Kotze, J Swanepoel, E C Kruger, E Decloedt

“…Larger multicentre studies are needed to identify independent predictors of paracetamol-induced hepatoxicity and mortality in Africa. …”
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Pairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design by Jason J Sico, Laura J Myers, Dawn M Bravata, Ying Zhang, Anthony J Perkins, Edward J Miech, Joanne Daggy

“…Logistic regression models discriminate cases from controls and provided inferential relationships between outcomes and independent variables.…”
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Adjustment of the Framingham index by abdominal aortic calcification scores enables a more accurate prediction of long-term cardiac events in general population aged 40 years and a... by Xiao-Jun Liu, Li Wang, Li-sha Zhang, Li-Fei Cao, Zhao-Fei Wan, Jia-Hong Xue, Yan-Ru He, Xin-Hong Wang, Xiao-Fang Bai

“…Both FRS and AAC score were independent predictors of cardiac death (hazard ratio 1.216; 95%CI 1.135 to 1.302; p < 0.00001; 1.159; 95%CI 1.109 to 1.211; p < 0.00001; respectively). …”
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Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants by Jun Zhang, Qiye Zhan, Zhihao Deng, Ling Lin, Zhaolan Feng, Huabin He, Deju Zhang, Huilei Zhao, Xiang Gu, Xiaoping Yin, Peng Yu, Xiao Liu

“…Conclusion TyG index showed association with cardiovascular events, mortality, and all-cause mortality independent of diabetic status, with low to moderate certainty. …”
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Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China. by Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin

“…Main limitations in the current study included potential undiagnosed cases and lack of an independent population for replication.<h4>Conclusions</h4>In this study, we observed that a panel of novel sphingolipids with unique structures were positively associated with incident T2D, largely mediated through β-cell dysfunction, in Chinese individuals.…”
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Biomarkers for Predicting Left Atrial or Left Atrial Appendage Thrombus in Anticoagulated Patients with Nonvalvular Atrial Fibrillation by Xue Zhou, Zuolan Wang, Shuang Dou, Kangyin Chen, Enzhao Liu, Tong Liu, Guangping Li, Jingjin Che

“…Multivariate logistic regression and receiver operating characteristic curve (ROC) analyses were performed to explore the independent risk factors of LA/LAA thrombus and indicate the best cutoff point. …”
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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…Here, we demonstrate the feasibility, utility, and challenges associated with the use of culture-independent molecular techniques for accurate pleural infection diagnosis in a real-world clinical setting. …”
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Exploring practical experience with different treatments in NSCLC patients with MET-deregulated: a retrospective analysis from the real world by Mengmeng Li, Jiuyan Huang, Ruyue Xing, Xinyang Du, Chunhua Wei, Huijuan Wang

“…For secondary MET amplifications post-EGFR-TKI resistance, dual-target therapy surpasses Crizotinib monotherapy, independent of MET copy number.…”
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Free Fatty Acids in CSF and Neurological Clinical Scores: Prognostic Value for Stroke Severity in ICU by Sayed Gaber, Sherine Ibrahim ElGazzar, Mahmoud Qenawi, Nora Ismail Mohamed Abbas

“…FFA in CSF may serve as an independent prognostic biomarker for assessing the prognosis of acute ischemic stroke and the clinical outcome. …”
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Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…Multivariate analysis confirmed the prognostic value of this classification independent of traditional clinical factors. Moreover, m6A-TEX crosstalk influenced responses to immune checkpoint blockade therapies. …”
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