Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

“…The Cox regression model (COX) results demonstrated that SPHK1 was an independent prognostic factor affecting the survival of patients with glioma. …”
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Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner by Jiani He, Changming Dong, Xiandong Song, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man

“…Overexpressed PLAGL2 is identified as a possible independent predictor in BC and bioinformatics predicted the potential binding sites between PLAGL2 and METTL7B promoter region. …”
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DR Loss-Free Dithering-Based Digital Background Linearity Calibration for SAR-Assisted Multi-Stage ADCs With Digital Input-Interference Cancellation by Lizhen Zhang, Bo Gao, Kun-Woo Park, Kent Edrian Lozada, Raymond Mabilangan, Hyeongjin Kim, Jianhui Wu, Seung-Tak Ryu

“…We also describe a capacitor-scanning dither method to accomplish simultaneous and independent identification of multiple bit weights. …”
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Effectiveness of Ai Chi as Aquatic Intervention for Balance Impairments in Community-dwelling Older Adults in India: A Randomised Controlled Study by Purnima Singh, Pratap Chandra Sarma

“…Balance was assessed using the Berg Balance Scale (BBS), Timed Up and Go Test (TUGT), and Dynamic Gait Index (DGI) before (P1), after four weeks (P2), and after eight weeks of intervention (P3). An Independent t-test was used for between-group analyses, and a Dependent t-test was used for within-group analysis. …”
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Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination by Colette B. Rogers, Wendy Leung, Ryan M. Baxley, Rachel E. Kram, Liangjun Wang, Joseph P. Buytendorp, Khoi Le, David A. Largaespada, Eric A. Hendrickson, Anja-Katrin Bielinsky

“…To investigate this, we examined three independent <i>RAD18</i>-null human cell lines. Our analyses found that loss of RAD18 in HCT116, but neither hTERT RPE-1 nor DLD1 cell lines, resulted in elevated sister chromatid exchange, gene conversion, and gene targeting, i.e., HCT116 mutants were hyper-recombinogenic (hyper-rec). …”
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Efficacy and safety of immune checkpoint inhibitors in elderly patients with advanced non-small cell lung cancer: a systematic review and meta-analysisResearch in context by Jiacheng Yao, Sihan Li, Lu Bai, Jun Chen, Chengbo Ren, Tingting Liu, Jingping Qiu, Jun Dang

“…The association between ICIs and improved OS was independent of patient characteristics (race and histological type) or treatment-related factors (ICI drug type, treatment mode, and treatment line). …”
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Coagulation Parameters in Elderly Patients with Severe Pneumonia: Correlation with Disease Severity and Prognosis by Zhang Q, Liu Y, Tong C, Zhang L, Li R, Guo W, Li J

“…Multivariate logistic regression analysis showed that elevated PT (odds ratio [OR] = 1.218, 95% confidence interval [CI]: 1.076– 1.379, p = 0.002) and D-dimer (OR = 1.109, 95% CI: 1.032– 1.192, p = 0.005) were independent risk factors for 28-day mortality. The combined model using PT and D-dimer showed the highest predictive value for 28-day mortality (area under the curve = 0.801, 95% CI: 0.739– 0.863, p < 0.001), with a sensitivity of 0.759 and specificity of 0.758.Conclusion: Coagulation dysfunction is common in elderly patients with severe pneumonia. …”
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The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT by Yuanqiu Li, Ziman Xiong, Yufan Wang, Yuchen Jiang, Yaqi Shen, Xuemei Hu, Daoyu Hu, Zhen Li

“…D-dimer level was an independent risk factor for severe intestinal involvement (OR = 1.104, p = .016). …”
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Risk factors associated with the failure of local methotrexate combined with minimally invasive surgery for late cesarean scar pregnancy by Xiao-Tong Cheng, Yan-Song Liu, Dan-Yang Song, Xiao-Cui Nie, Yu-Shi Xiang, Ju-Min Niu

“…Subsequent binary logistic regression analysis revealed the following independent risk factors linked to the failure of the initial combined treatment: baseline serum β-hCG levels exceeding 94,000 IU/L [odds ratio (OR) 3.060, 95% confidence interval (CI) 1.387–6.749, P = 0.006], type III CSP (OR 3.574, 95% CI 1.147–11.135, P = 0.028), a time interval greater than seven days between MTX and surgery (OR 3.847, 95% CI 1.725–8.581, P = 0.001), and the presence of a fetal heartbeat before surgery (OR 4.405, 95% CI 1.014–19.128, P = 0.048). …”
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Analysis of the predictive value of the prostate-specific antigen-to-neutrophil ratio for the diagnosis of prostate cancer by Yuxuan Chen, Haisheng Yan, Yaoqin Xu, Kexin Chen, Runqin Yang, Jiali Yang, Ruian Zhu, Rui Lin, Jiang Wang, Jie Liu, Pingsheng Gao, Lei Pang, Lexin Wang

“…Results When PSA levels are in the range of 4–10 ng/ml, an elevated PNR is an independent risk factor for prostate cancer. In this range, the diagnostic value of f/t PSA and PSAD for prostate cancer is limited. …”
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Big Earth data processing using machine learning for integrated mapping of the dead sea fault, Jordan by Polina Lemenkova

“…The technical methodology includes the following three independent tools: 1) Generic Mapping Tools (GMT); 2) Selected libraries of R programming language; 3) QGIS. …”
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Effects of mti-2 Transgenic Potato Plants on the Aphid Myzus persicae (Sternorrhyncha: Aphididae) by Julien Saguez, Anas Cherqui, Salima Lehraiki, Charles Vincent, Antony Beaujean, Lise Jouanin, Jean-Claude Laberche, Philippe Giordanengo

“…We transformed potato internodes with the mustard trypsin inhibitor mti-2 gene. Among the 35 independent transgenic potato lines obtained via Agrobacterium tumefasciens transformation, four (DM6, DM7, DM11, and DM19) were selected for their high level of MTI-2 (at least to 30% of trypsin activity inhibition). …”
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Access to Health Care and Use of Health Care Services Among Males in Africa: Protocol for a Scoping Review by Nkoleleng Johannah Mashilo, Kelechi Elizabeth Oladimeji, Siphamandla Gumede, Samanta Tresha Lalla-Edward

“…Two reviewers will independently screen full texts and chart the data; a third reviewer will be engaged in the event of disagreement between the 2 independent reviewers. …”
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Cardiovascular risk and mortality in men receiving testosterone replacement therapy for Klinefelter syndrome in Denmark: a retrospective cohort studyResearch in context by Simon Chang, Lars Pedersen, Anne Skakkebæk, Agnethe Berglund, Claus H. Gravholt

“…Moller Foundation, Fonden af 17-12-1981, Danish Diabetes and Endocrine Academy, Novo Nordisk Foundation, the Independent Research Fund Denmark, Sygesikringen danmark.…”
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Availability in ECMO Reduces the Failure to Rescue in Patients With Pulmonary Embolism After Major Surgery: A Nationwide Analysis of 2.4 Million Cases by Johannes Diers, MD, Nikolas Baumann, MD, Philip Baum, MD, Konstantin L. Uttinger, MD, Johanna C. Wagner, MD, Peter Kranke, MD, Patrick Meybohm, MD, Christoph-Thomas Germer, MD, Armin Wiegering, MD

“…This improved outcome is independent of the use of ECMO in these patients.…”
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Traumatic dental injuries in the first year of life and related risk factors in three regions of Brazil: a multicenter birth cohort study by Carlos Alberto Feldens, Bruno Antonio Sehn Konzen, Elisa Maria Rosa de Barros Coelho, Alessandra Castro Alves, Eliane Gerson Feldens, Márcia Regina Vítolo, Paulo Floriani Kramer

“…Poisson regression models were used to estimate associations between the independent variables and TDI, with the calculation of crude and adjusted relative risk (RR) and respective 95% confidence intervals (CI). …”
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Structural Disruption of Cilia and Increased Cytoplasmic Tubulin in Biliary Atresia—An Exploratory Study Focusing on Early Postoperative Prognosis Following Portoenterostomy by Patrícia Quelhas, Rui Oliveira, Carlos Kieling, Sandra Vieira, Jorge dos Santos

“…The detrimental effect of HIF-1alpha pathway activation over early native liver survival was confirmed, although independently from PC or cytoplasmic tubulin features.…”
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Hereditary angioedema diagnosis evaluation score (HADES): A new clinical scoring system for predicting hereditary angioedema with C1 inhibitor deficiency by Ricardo Zwiener, MD, Rafael Zamora, MD, Carlos María Galmarini, MD, PhD, Laura Brion, PhD, Laura Arias, MD, Andrea Pino, MD, Paula Rozenfeld, PhD

“…Eight clinical variables were identified as independent predictors of HAE: age at onset ≤20 years, recurrent limb edema, abdominal pain, vomiting, trauma as a trigger, absence of wheals, family history of angioedema, and recurrent edema lasting ≥24 hours. …”
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Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014–16 Ebola outbreak in Bo District, Sierra Leone by Grazia Caleo, Kamalini Lokuge, Katina Kardamanidis, Jane Greig, Jaroslava Belava, Emer Kilbride, Alhaji Sayui Turay, Gbessay Saffa, Ronald Kremer, Francesco Grandesso, Kostas Danis, Armand Sprecher, Gian Luca Di Tanna, Holly Baker, Helen A. Weiss

“…Methods We analysed the outputs of two independent population-based surveys conducted at the end of the 2014–2016 EVD outbreak in Bo District, Sierra Leone, in urban and rural areas. …”
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Lack of Male-Female Differences in Disposition and Esterase Hydrolysis of Ramipril to Ramiprilat in Healthy Volunteers after a Single Oral Dose by Tom B. Vree, Erik Dammers, Ivan Ulc, Stefan Horkovics-Kovats, Miroslav Ryska, IJsbrand Merkx

“…In both male and female groups, a subject-dependent yield of active metabolite ramiprilat was demonstrated, which was independent of the formulation.There is a large variation in the ramiprilat t1/2β (50�60% CV). …”
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