Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases by S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

“…The method showed a high correlation of theoretical predictions with measured values during repeated experimental testing by independent groups of researchers. This model served as a base for other ICG web services, SNP_TATA_Z-tester and SNP_TATA_Comparator, which make a statistical assessment of the SNP-induced change in the affinity of TBP binding to the human gene promoter and help predict changes in expression that may be associated with a genetic predisposition to diseases or phenotypic features of the organism. …”
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An efficient decoupled 3-D axial anisotropic resistivity inversion for magnetotelluric data with OpenMP parallelization by Wisart Thongyoy, Weerachai Siripunvaraporn, Puwis Amatayakul, Tawat Rung-Arunwan, Kiyoshi Baba

“…This novel technique splits the full axial inversion into two independent modes: $${\rho }_{xx}$$ ρ xx - and $${\rho }_{yy}$$ ρ yy -modes. …”
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Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center by Olivier Hugli, Jean-Yves Meuwly, Noémie Boillat-Blanco, Pierre-Nicolas Carron, Siméon Schaad, Thomas Brahier, Mary-Anne Hartley, Jean-Baptiste Cordonnier, Luca Bosso, Tanguy Espejo, Olivier Pantet

“…This study evaluates the diagnostic performance of lung ultrasound (LUS), an affordable, consumable-free point-of-care tool, for COVID-19 screening.Design, setting and participants This prospective observational cohort included adults presenting with cough and/or dyspnoea at a SARS-CoV-2 screening centre of Lausanne University Hospital between 31 March and 8 May 2020.Interventions Investigators recorded standardised LUS images and videos in 10 lung zones per patient. Two blinded independent experts reviewed LUS recording and classified abnormal findings according to prespecified criteria to investigate their predictive value to diagnose SARS-CoV-2 infection according to PCR on nasopharyngeal swabs (COVID-19 positive vs COVID-19 negative).Primary and secondary outcome measures We finally combined LUS and clinical findings to derive a multivariate logistic regression diagnostic score.Results Of 134 included patients, 23% (n=30/134) were COVID-19 positive and 77% (n=103/134) were COVID-19 negative; 85%, (n=114/134) cases were previously healthy healthcare workers presenting within 2–5 days of symptom onset (IQR). …”
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Usefulness of Discarded Vitreous Samples from Routine Vitrectomy by Natàlia Vilà, Pablo Zoroquiain, Vasco Bravo-Filho, Emilia Antecka, Helena Dietrich, John C. Chen, I. John Galic, Michael A. Kapusta, Miguel N. Burnier

“…In the multivariate analysis, three variables emerged as independent significant predictors of diabetes in vitrectomy samples: hemorrhage, endothelial-lined vessels, and age (P<0.001, P<0.001, and P=0.019, resp.). …”
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Carbapenem resistance in the Dominican Republic: clinical characteristics, genotypic profiles, and risk factors by Ricardo Ernesto Hernández-Landa, Rita Rojas-Fermín, Anel Guzman-Marte, Katherine Peralta Agramonte, Missel María Jiménez Cedano, Surelly Alexandra Mora-Peralta, Patricia Sanrregré-Oven, Alfredo J. Mena Lora

“…Statistical analysis included univariate and multivariate logistic regression to identify independent risk factors for CRE. Results: CRE cases showed higher prevalence of Enterobacter (36.5%) and Klebsiella (38.5%), while Escherichia predominated in CSE (65.5%). …”
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Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients by Yushi Nagaki, MD, PhD, Satoru Motoyama, MD, PhD, Yusuke Sato, MD, PhD, Akiyuki Wakita, MD, PhD, Hiromu Fujita, MD, PhD, Kohei Kemuriyama, MD, Ryohei Sasamori, MD, Shu Nozaki, MD, Kyoko Nomura, MD, PhD, Yoshihiro Minamiya, MD, PhD

“…In a multivariate analysis, tumor immunogenicity was a significant independent predictor of DSS. Of 68 patients without a pathological complete response (non-pCR) in their primary tumor, 51 (75%) had hot tumors after NACRT. …”
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Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study by Xiaoqin Wang, Zhaozhao Hui, Jiaru Sun, Paul D Terry, Xiaohan Ren, Shuangyan Lei, Caihua Wang, Mingxu Wang

“…Objective To explore the interaction effect between overweight/obesity and alcohol consumption on hypertension risk.Design A longitudinal study of the independent and combined effects of hypertension risk factors.Setting Twelve provinces in China, including Beijing Liaoning, Heilongjiang, Shanghai, Jiangsu, Shandong, Henan, Hubei, Hunan, Guangxi, Guizhou and Chongqing.Participants Longitudinal data of China Health and Nutrition Survey, collected between 2011 and 2015, were used in this study. …”
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ASA Class Is a Stronger Predictor of Early Revision Risk Following Primary Total Knee Arthroplasty than BMI by Christopher J. Wall, MBBS, BMedSc, FRACS, FAOrthA, Richard N. de Steiger, MBBS, PhD, DipBiomech, FRACS, FAOrthA, Christopher J. Vertullo, MBBS, PhD, FRACS, FAOrthA, Dylan Harries, BSc(Hons), MBiostat, PhD, Srinivas Kondalsamy-Chennakesavan, MBBS, MPH, FRSPH

“…Our aim was to determine whether a patient’s American Society of Anesthesiologists (ASA) class predicts their risks of early all-cause revision and revision for periprosthetic joint infection (PJI) following primary TKA, independent of their BMI. Methods:. Data from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) were obtained regarding all patients who underwent primary TKA for osteoarthritis in Australia from January 1, 2015, to December 31, 2022. …”
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Association between Circulating B-Type Natriuretic Peptide and Diabetic Peripheral Neuropathy: A Cross-Sectional Study of a Chinese Type 2 Diabetic Population by Pijun Yan, Qin Wan, Zhihong Zhang, Yong Xu, Ying Miao, Pan Chen, Chenlin Gao

“…Moreover, circulating levels of BNP was an independent decisive factor for the presence of DPN after multivariate adjustment (odds ratio, 1.044; 95% confidence interval, 1.006-1.084; P=0.024). …”
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Prognostic Factors for COVID-19 Hospitalized Patients with Preexisting Type 2 Diabetes by Yuanyuan Fu, Ling Hu, Hong-Wei Ren, Yi Zuo, Shaoqiu Chen, Qiu-Shi Zhang, Chen Shao, Yao Ma, Lin Wu, Jun-Jie Hao, Chuan-Zhen Wang, Zhanwei Wang, Richard Yanagihara, Youping Deng

“…Older age (HR = 1.076, 95% CI = 1.014–1.143, p=0.016), elevated glucose level (HR = 1.153, 95% CI = 1.038–1.28, p=0.0079), increased serum amyloid A (SAA) (HR = 1.007, 95% CI = 1.001–1.014, p=0.022), diabetes treatment with only oral diabetes medication (HR = 0.152, 95%CI = 0.032–0.73, p=0.0036), and oral medication plus insulin (HR = 0.095, 95%CI = 0.019–0.462, p=0.019) were independent prognostic factors. A nomogram based on these prognostic factors was built for early prediction of 7-day, 14-day, and 21-day survival of diabetes patients. …”
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Fast and Slow Roasting of Alcohol- and Honey-infused Coffee Blends: A Comparative Study of PAH and N-PAH Emissions by Hsin-Chieh Kung, Chung-Hsien Hung, Kun-Hui Lin, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chien

“…These results narrow the research gap on toxic emissions during coffee roasting and would be of particular interest in independent coffee shops where roasting is done in-house.…”
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Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…In order to identify potential genes related to poorly/well-controlled patients with T2D, our strategy of investigation included a primary screen by microarray (Human Genome U133) in a small group of individuals followed by an independent validation in a greater group using RT-qPCR. …”
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Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection by Jinjing Chai, Sujie Zhang, Chong Ma, Qimin Mei, Tao Liu, Jihai Liu, Yecheng Liu, Huadong Zhu

“…High Charlson Comorbidity Index (CCI), high neutrophil-to-lymphocyte-ratio (NLR), haematological disease, and disseminated infection were identified as independent predictors of unfavourable outcomes. The area under the curve (AUC) values for NLR and neutrophil-to-monocyte-plus-lymphocyte-ratio (NMLR) were 0.751 and 0.763 with optimal cut-off values of 9.50 and 3.83, respectively, for prediction of mortality in patients with NTM disease.…”
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Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission by Ryohei Mineo, Shiro Fukuda, Shigehito Suzuki, Yoshito Ito, Sachiko Tamba, Takuya Sugiyama, Yuya Fujishima, Hitoshi Nishizawa, Iichiro Shimomura, Koji Yamamoto, Yuji Matsuzawa

“…Obesity and visceral fat accumulation have been reported to be independent risk factors for severe COVID-19. Several reports have focused on the levels of adipocytokines/adipokines, including adiponectin (APN), which is exclusively secreted from adipocytes, although the importance of these factors in acute disease conditions remains unclear. …”
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Relative Fat Mass and Physical Indices as Predictors of Gallstone Formation: Insights From Machine Learning and Logistic Regression by Deng L, Wang S, Wan D, Zhang Q, Shen W, Liu X, Zhang Y

“…The models were validated internally through k-fold cross-validation and externally using independent datasets. Furthermore, we substantiated the link between relative fat mass (RFM) and gallstone formation by employing four logistic regression models, conducting subgroup analyses, and applying restricted cubic spline (RCS) curves.Results: The logistic regression algorithm demonstrated superior predictive capability for all risk factors associated with gallstone occurrence compared to other machine learning models. …”
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Hubungan Pola Makan dengan Status Gizi Anak Usia 3-5 tahun di Wilayah Kerja Puskesmas Nanggalo Padang 2014 by Gustiva Sari, Gustina Lubis, Edison .

“…This research used cross-sectional study, the diet as the independent variable and nutritional status as the dependent variable. …”
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Nonfimbrial Adhesin Mutants Reveal Divergent Escherichia coli O157:H7 Adherence Mechanisms on Human and Cattle Epithelial Cells by Matthew R. Moreau, Indira T. Kudva, Robab Katani, Rebecca Cote, Lingling Li, Terrance M. Arthur, Vivek Kapur

“…The unique bovine RAJ cell adherence model revealed that O157:H7 employs a LEE-independent mechanism of attachment to one of the RAJ cell types, the squamous epithelial (RSE) cells. …”
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Level of physical activity of students from the police force academy in Bratislava by Gabriel Bujdos, Štefan Adamčák, Michal Marko, Anna Kozaňáková

“…The results of the questionnaire were later compared based on the participants gender and analysed using homogeneity test of two independent samples, two-sample t-test with equality and inequality of variances and the chi-square test at the level of significance p < 0.01 or p < 0.05. …”
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Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary I... by An-Cheng Hou, Jian-Tong Hou, Wei-Ning Zhou, Yan-Jin Wei, Zhi-Hong Ou, Cun-Fei Liu

“…Conclusions: GGT is positively associated with in-hospital HF and is an independent risk factor for in-hospital HF in STEMI patients.…”
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Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heterorecept... by Dasiel O. Borroto-Escuela, Karolina Wydra, Julia Pintsuk, Manuel Narvaez, Fidel Corrales, Magdalena Zaniewska, Luigi F. Agnati, Rafael Franco, Sergio Tanganelli, Luca Ferraro, Malgorzata Filip, Kjell Fuxe

“…Anticocaine actions of A2AR agonists can also be produced at A2AR homocomplexes in these antireward neurons, actions in which are independent of D2R signaling. At the A2AR-D2R heterocomplex, they are dependent on the strength of the antagonistic allosteric A2AR-D2R interaction and the number of A2AR-D2R and A2AR-D2R-sigma1R heterocomplexes present in the ventral striatopallidal GABA neurons. …”
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