Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer by Yong-Cheng Liu, Jun Shen

“…PubMed, EMBASE, OVID, Web of Science, Scopus, and Cochrane Library were systematically searched for relevant studies published up to August 25, 2024. Two independent researchers screened the literature according to predefined inclusion and exclusion criteria and extracted relevant data. …”
Get full text

Patterns of failure and prognosis in nasopharyngeal carcinoma according to Epstein-Barr virus DNA status by Lin-Feng Guo, Guan-Zhong Lu, Zhen-Zhen Lu, Yi-Feng Yu, San-Gang Wu

“…Multivariate analysis showed that liver metastasis (P = 0.012) and EBV-DNA levels ≥ 3,525 copies/mL at progression (P = 0.009) independently correlated with poorer overall survival. …”
Get full text

Effectiveness of an E-Nose Based on Metal Oxide Semiconductor Sensors for Coffee Quality Assessment by Yhan S. Mutz, Samara Mafra Maroum, Leticia L. G. Tessaro, Natália de Oliveira Souza, Mikaela Martins de Bem, Loyane Silvestre Alves, Luisa Pereira Figueiredo, Denes K. A. do Rosario, Patricia C. Bernardes, Cleiton Antônio Nunes

“…Moreover, a supervised classification employing soft independent modeling of class analogies (SIMCA), partial least squares discriminant analysis (PLS-DA), and least squares support vector machine (LS-SVM) led to great results with accuracy above 90% for every task. …”
Get full text

Pharmacological and non-pharmacological interventions in patients undergoing nasal surgeries for prevention of emergence agitation: a systematic review and network meta-analysis by Gustavo R.M. Wegner, Bruno F.M. Wegner, Henrik G. Oliveira, Luis A. Costa, Luigi W. Spagnol, Valentine W. Spagnol, Gilberto T.F. de Oliveira Filho

“…Electronic searches, including PubMed, Scopus, Embase, Cochrane Library, and Web of Science, without language or date restrictions, were conducted. Two independent reviewers selected studies, and data extraction was performed using standardized tables. …”
Get full text

Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects – a hurdle for vaccination? by Jonah Clegg, Jonah Clegg, Malgorzata E. Mnich, Malgorzata E. Mnich, Alberto Carignano, Giovanni Cova, Simona Tavarini, Chiara Sammicheli, Bruna Clemente, Megan Smith, Megan Smith, Emilio Siena, Monia Bardelli, Michela Brazzoli, Fabio Bagnoli, Rachel M. McLoughlin, Elisabetta Soldaini

“…Using an activation induced marker assay to sort for S. aureus-specific CD4+ T cells in an effector function-independent manner, single cell transcriptomic analysis was conducted. …”
Get full text

Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk by Fahad M. Aldakheel, Hadeel Alnajran, Shatha A. Alduraywish, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed

“…Multivariate regression analysis confirmed the SVM score as an independent predictor of recurrence (HR = 0.45; 95% CI 0.28–0.69, P < 0.001). …”
Get full text

The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) by Øyvind Helgeland, Jens K. Hertel, Anders Molven, Helge Ræder, Carl G. P. Platou, Kristian Midthjell, Kristian Hveem, Ottar Nygård, Pål R. Njølstad, Stefan Johansson

“…Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI, rs2065501  (P=0.03) and rs3217986  (P=0.04). …”
Get full text

Reconstructive trends and complications following parotidectomy: incidence and predictors in 11,057 cases by Cory Donovan Bovenzi, Peter Ciolek, Meghan Crippen, Joseph M. Curry, Howard Krein, Ryan Heffelfinger

“…Free flap reconstruction, COPD, bleeding disorders, smoking, and presence of malignant tumor were the strongest independent predictors of surgical site infection. Readmission and reoperation were uncommon at an incidence of 2.1% each. …”
Get full text

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…In animal studies, our BRCA-engineered hypomorphs and several independent PDX models with clinically relevant BRCA mutations were acutely more vulnerable to this drug combination. …”
Get full text

Sensitive windows for within- and trans-generational plasticity of anti-predator defences by Tariel-Adam, Juliette, Luquet, Émilien, Plénet, Sandrine

“…This suggests that transgenerational plasticity, although linked to within-generational plasticity by the embryonic sensitive window, may also be induced via a specific channel, independent of within-generational plasticity induction and expression. …”
Get full text

Utility of Circadian Variability Patterns in Differentiating Origins of Premature Ventricular Complexes by Mu Chen, Qunshan Wang, Jian Sun, Peng-Pai Zhang, Wei Li, Rui Zhang, Bin-Feng Mo, Tai-Zhong Chen, Juyi Wan, Dong-Zhu Xu, Kazutaka Aonuma, Yi-Gang Li

“…PVC circadian patterns were classified as fast-heart rate- (HR-) dependent (F-PVC), slow-HR-dependent (S-PVC), or HR-independent (I-PVC). PVC origins were determined intraprocedurally. …”
Get full text

Episodic Cancer Pain: Patient Reporting, Prevalence, and Clinicodemographic Associations at Initial Cancer Pain Clinic Assessment by Paulo Reis-Pina, Anand Acharya, Antonio Barbosa, Peter G. Lawlor

“…Multivariable analyses demonstrated significant (p<0.05) associations (odds ratios: 95% CIs) for 6 variables with S-BTcP: head and neck pain location (2.53; 1.20–5.37), NPC (2.39; 1.34–4.26), BPI average pain (1.64; 1.36–1.99), abdominal pain (0.324; 0.120–0.873), S-IcP (0.207; 0.116–0.369), and PMI-negative status (0.443; 0.213–0.918). Similar independent associations (p<0.05) occurred for S-IcP with NPC, BPI average pain, and PMI-negative status, in addition to radiotherapy, S-BTcP, soft tissue pain, and sleep interference. …”
Get full text

Correlation analysis of Hashimoto’s thyroiditis with papillary thyroid carcinoma occurrence and its central lymph node metastasis: a single center experience by Kang Sun, Kang Sun, Xiaoming Wang, Dexuan Chen, Chaoqun Ma

“…Through univariate and multivariate logistic regression, we proved that tumor position, Capsule + Extrathyroidal extension (ETE), multifocal tumors, and the total number of CLN dissected were independent risk factors for CLNM. Multiple linear regression analysis told us that invasion (β= 0.093, p=0.048) had a positively predictive impact on CLN positive rate.ConclusionFemale PTC patients are more prone to concurrent HT, which elevates the levels of TSH, TPOAb, and TgAb. …”
Get full text

Cost-effective whole-cell biosynthesis of ursodeoxycholic acid using engineered Escherichia coli with a multienzyme cascade by Xue Zhang, Xue Zhang, Jiagang Xin, Mengyu Liu, Mengyu Liu, Yue Zhang, Yue Zhang, Haoni Luan, Haoni Luan, Wei Feng, Wei Feng, Fei Wang, Fei Wang, Wei Xu, Wei Xu, Peng Song, Peng Song

“…This strain coexpressed four enzymes under the control of three independent T7 promoters: lactate dehydrogenase (LDH) derived from Lactobacillus delbrueckii, glucose dehydrogenase (GDH) derived from Priestia megaterium, 7α-HSDH derived from E. coli, and 7β-HSDH derived from Ruminococcus torques, enabling the whole-cell catalytic synthesis of UDCA from CDCA. …”
Get full text

Using partially shared radiomics features to simultaneously identify isocitrate dehydrogenase mutation status and epilepsy in glioma patients from MRI images by Yida Wang, Ankang Gao, Hongxi Yang, Jie Bai, Guohua Zhao, Huiting Zhang, Yang Song, Chenglong Wang, Yong Zhang, Jingliang Cheng, Guang Yang

“…Our study aimed to exploit this correlation to improve the performance of both of the IDH mutation status identification and epilepsy diagnosis models in patients with glioma II-IV. 399 patients were retrospectively enrolled and divided into a training (n = 279) and an independent test (n = 120) cohort. Multi-center dataset (n = 228) from The Cancer Imaging Archive (TCIA) was used for external test for identification of IDH mutation status. …”
Get full text

Efficacy analysis of drug-eluting beads transcatheter arterial chemoembolization combining systemic chemotherapy and immune checkpoint inhibitors in unresectable intrahepatic chola... by Liu Song, Wang Qingdong, Yin Shunhang, Li Long, Zhao Guangsheng, Yu Guangji, Wang Dong

“…The Cox proportional hazards model analysis revealed that, Child grade and treatment modality were independent predictors of PFS and OS in patients. The adverse effects during treatment were similar in the two groups, with no statistical difference. …”
Get full text

Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators by Lin Liu, Yan-Bo Zhao, Zhuo-Ting Cheng, Ya-Hui Li, Yang Liu

“…Eight inflammatory indicators were identified as independent risk factors for prognosis in critically ill patients with T2DM. …”
Get full text

In-Hospital and Long-Term Prognosis after Myocardial Infarction in Patients with Prior Coronary Artery Bypass Surgery; 19-Year Experience by Predrag M. Mitrovic, Branislav Stefanovic, Zorana Vasiljevic, Mina Radovanovic, Nebojsa Radovanovic, Gordana Krljanac, Ana Novakovic, Miodrag Ostojic

“…Previous angina, diabetes, and age, independently, as well as use of digitalis and diuretics together with angina, and male gender, older patients, and diabetes together, influenced a worse survival rate in these patients.…”
Get full text

Determinants of Success in Revision Cochlear Implant Surgeries: A Comprehensive Evaluation of Patient, Surgical, and Radiological Factors by Sarah Alshehri, Thikra Khalid Hamdi Alasmari

“…Statistical analyses, including multivariate logistic regression, were conducted to identify independent predictors of surgical success. <b>Results:</b> A total of 188 patients were included, with a mean age of 45.67 years. …”
Get full text

The Search of miRNA Related to Invasive Growth of Nonfunctioning Gonadotropic Pituitary Tumors by Joanna Boresowicz, Paulina Kober, Natalia Rusetska, Maria Maksymowicz, Agnieszka Paziewska, Michalina Dąbrowska, Natalia Zeber-Lubecka, Jacek Kunicki, Wiesław Bonicki, Jerzy Ostrowski, Janusz A. Siedlecki, Mateusz Bujko

“…The expression of selected miRNAs was assessed in the independent cohort of 80 patients with qRT-PCR. Results. …”
Get full text