Clinical Outcomes and Donor-specific Antibody Rebound 5 y After Kidney Transplant Enabled by Imlifidase Desensitization by Ian S. Jaffe, BS, Anna Runström, MSc, Vasishta S. Tatapudi, MD, Elaina P. Weldon, MSN, ACNP-BC, Cecilia L. Deterville, MS, Rebecca A. Dieter, PharmD, Robert A. Montgomery, MD, DPhil, Bonnie E. Lonze, MD, PhD, Massimo Mangiola, PhD

“…One of these 7 had suboptimal graft function secondary to donor-derived disease but remained dialysis independent. Three participants had antibody-mediated rejection (AMR), which occurred in the first 30 d in all cases and was successfully treated. …”
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Solid Waste Management Practice and Its Associated Factors among Households in Gessa Town, Dawuro Zone, Southwest Ethiopia by Matiwos Maldaye, Desta Haftu, Sewunet Sako, Zenebe Jebero, Fikre Moga, Ayichew Alemu

“…All collected data were entered into epi data version 4.6 and then exported to STATA version 14.0 for further analysis. Each independent variable with a p value <0.25 in the bivariable logistic regression was included in the multivariable logistic regression model. …”
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Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study by Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

“…To identify the factors associated with mortality, clinical, laboratory and imaging data were analyzed with independent-sample t tests, Mann-Whitney U tests, Fisher exact probability tests and receiver operating characteristic curve analyses. …”
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A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance by Alexander Mazein, Marcio Luis Acencio, Irina Balaur, Adrien Rougny, Danielle Welter, Anna Niarakis, Anna Niarakis, Diana Ramirez Ardila, Ugur Dogrusoz, Piotr Gawron, Venkata Satagopam, Venkata Satagopam, Wei Gu, Wei Gu, Andreas Kremer, Reinhard Schneider, Reinhard Schneider, Marek Ostaszewski, Marek Ostaszewski

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Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination by Anurag Maheshwari, Kris Janssens, Jeroen Bogie, Chris Van Den Haute, Tom Struys, Ivo Lambrichts, Veerle Baekelandt, Piet Stinissen, Jerome J. A. Hendriks, Helena Slaets, Niels Hellings

“…In this study, the cuprizone-induced demyelination mouse model was used to elucidate effects of IL-11 on de- and remyelination, independent of the immune response. Prophylactic-lentiviral- (LV-) mediated overexpression of IL-11 in mouse brain significantly limited acute demyelination, which was accompanied with the preservation of CC1+ mature oligodendrocytes (OLs) and a decrease in microglial activation (Mac-2+). …”
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Gene–Environment Interaction: Small Deletions (DELs) and Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) and Potential Implications for Therapy by Farzana Jasmine, Armando Almazan, Yuliia Khamkevych, Maria Argos, Mohammad Shahriar, Tariqul Islam, Christopher R. Shea, Habibul Ahsan, Muhammad G. Kibriya

“…Comparing the (a) NMSC tissue (<i>n</i> = 32) and corresponding blood samples from each patient, and (b) an independent set of non-lesional, healthy skin (<i>n</i> = 16) and paired blood, we identified NMSC-associated DELs. …”
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Adjustment of condensing temperature of the vapor-compression heat pump based on a reciprocating long-stroke compressor stage at fixed temperatures of receiving coolant by V. L. Yusha, A. Yu. Gromov, P. V. Ushakov

“…The energy components are the indicated power of the compressor, the heating capacity of the consumer, the additional heating capacity supplied to the working fluid of the heat pump before the compression process, as well as the additional heating capacity supplied to the working fluid of the heat pump or removed from it during the compression process. As independent control parameters, the following are considered: the ratio of the mass flow rates of the working fluid of the heat pump and the receiving coolant; overheating of the working fluid of the heat pump at suction and compression polytropic index. …”
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Investigating the Activity Status of Inflammatory Bowel Disease and its Related Factors: A Study Protocol by Mehrnaz Asgharnezhad, Ehsan Amini-Salehi, Niloofar Faraji, Soheil Hassanipour, Saman Maroufizadeh, Adele Isanazar, Marjan Mahdavi-Roshan, Zahra Hedayatzadeh, Farahnaz Joukar, Fariborz Mansour Ghanaei

“…Regression models will be employed to control for potential confounders and assess the independent effects of each variable. Conclusion: The findings from this study are expected to provide valuable insights into the activity status of IBD and its related factors in Guilan Province, Iran. …”
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Agreement Between Provider-Completed and Patient-Completed Preoperative Frailty Screening Using the Clinical Risk Analysis Index: Cross-Sectional Questionnaire Study by Mehraneh Khalighi, Amy C Thomas, Karl J Brown, Katherine C Ritchey

“…In total, 41% (20/49) of participants completed and returned an independent postvisit RAI-C assessment before surgery and within 180 days of their initial evaluation. …”
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Synovial biomarkers in the diagnosis of post-traumatic osteoarthritis following anterior cruciate ligament and meniscus injuries: protocol for a systematic review by Helena Donato, Fernando Fonseca, João Pedro Oliveira, João Castro Mendes, José Casanova, Alexandrina Ferreira Mendes

“…We will include randomised clinical trials, non-randomised prospective or retrospective clinical studies, case controls, cohort studies and case series, ranging from database inception to 30 June 2024 and published in English. Two independent reviewers will screen and evaluate the retrieved studies to determine their eligibility. …”
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Cerebral Malaria in Adults: A Retrospective Descriptive Analysis of 80 Cases in a Tertiary Hospital in The Gambia, 2020–2023 by Sheikh Omar Bittaye, Abubacarr Jagne, Lamin E. S. Jaiteh, Alfred Amambua‐Ngwa, Abdul Karim Sesay, Williams Estrada Ramirez, Asmell Ramos, Emmanuel Effa, Ousman Nyan, Ramou Njie

“…In multivariate analysis, CM patients with acute kidney injury at presentation was an independent predictor of mortality in this study. Conclusion CM seems to affect the adolescent age group more than the older adults in The Gambia. …”
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Clinical impact of the prognostic nutritional index and skeletal muscle index for the incompletion of adjuvant chemotherapy for pancreatic cancer by Hiromitsu Maehira, Haruki Mori, Nobuhito Nitta, Takeru Maekawa, Yusuke Nishina, Hajime Ishikawa, Katsushi Takebayashi, Sachiko Kaida, Toru Miyake, Masaji Tani

“…Multivariate analysis showed that decreasing rate of PNI (p = 0.016), decreasing rate of SMI (p = 0.013), and old age (p = 0.049) were independent risk factors for incompletion of S-1 adjuvant chemotherapy. …”
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Ramadan during pregnancy and the role of dietary intake for neonatal health in Kaduna, Northwestern Nigeria: a cross-sectional study by Musa Abubakar Kana, Bilkisu Usman, Amina Mohammed-Durosinlorun, Jennifer Ahmed, Hassana Habiba Abubakar, Yakub Abdulmalik, Fabienne Pradella

“…Women who fasted had infants with lower birth weights than non-fasting participants (-90.38 g, 95% CI: -173.64 g to -6.12 g). No independent associations were detected between reduced sleep and food intake, and birth weight. …”
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Why and how should we simulate platform trials? Learnings from EU-PEARL by Elias Laurin Meyer, Tobias Mielke, Marta Bofill Roig, Michaela Maria Freitag, Peter Jacko, Pavla Krotka, Peter Mesenbrink, Tom Parke, Sonja Zehetmayer, Dario Zocholl, Franz König

“…The separate use of two of these software packages to implement the same platform design by independent teams obtained the same results. Conclusion We provide a framework, as well as open-source software for the design and simulation of platform trials. …”
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The Bony Density of the Pedicle Plays a More Significant Role in the Screw Anchorage Ability Than Other Regions of the Screw Trajectory by Zan Chen, Yue Chen, Jiajun Zhou, Yanwei He, Jingchi Li

“…Data from patients with and without screw loosening were compared, and regression analyses were conducted to identify independent risk factors. Additionally, the area under the curve (AUC) values were computed to assess the predictive performance of different parameters. …”
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Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating by Vamshi Damagatla, Nadia G Boetti, Laura Di Sieno, Diego Pugliese, Ilaria Bargigia, Davide Janner, Alberto Dalla Mora, Antonio Pifferi

“…We tested the absorption linearity—retrieving the water spectrum in the 700–950 nm range with $\gt$ 85% accuracy over two decades of absorption change—and verified the hypothesis of a scattering-independent absorption retrieval. Further, we were able to detect spectral changes at a distance of 1 cm from an inclusion embedded in a biological tissue. …”
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Elevated Plasma Level of 8-Hydroxy-2′-deoxyguanosine Is Associated with Primary Open-Angle Glaucoma by Altaf A. Kondkar, Taif A. Azad, Tahira Sultan, Essam A. Osman, Faisal A. Almobarak, Saleh A. Al-Obeidan

“…In logistic regression analysis, 8-OHdG showed a significant effect on POAG outcome (p=0.016) independent of age, sex, smoking, and systemic diseases. …”
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Factors Determining Rehabilitation Needs After Intradural Spinal Tumor Surgery: A Prospective Study by Stanisław Krajewski, Jacek Furtak, Monika Zawadka-Kunikowska, Michał Kachelski, Jakub Soboń, Marek Harat

“…In multivariable analysis, MMS (odds ratio (OR) 8.7; 95% confidence interval (CI): 2.37–32.44) and STR (OR 13.00; 95%CI: 1.56–107.87) remained independent predictors of rehabilitation need (area under curve, 92%). …”
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MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway by Pei Huang, Guangli Yang, Pingping Zhang, Yin Zhu, Yaning Guan, Jian Sun, Qian Li, Yang An, Xiaoqi Shi, Juanjuan Zhao, Chaohong Liu, Zhixu He, Yan Chen, Zuochen Du

“…Furthermore, MAPK4 KO mice exhibit impaired T cell-independent humoral immune responses. Mechanistically, MAPK4 inhibits the activation of the PI3K signaling pathway in B cells by activating the IRF4-SHIP1 pathway. …”
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Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers by Anca Negovan, Mihaela Iancu, Valeriu Moldovan, Septimiu Voidazan, Simona Bataga, Monica Pantea, Kinga Sarkany, Cristina Tatar, Simona Mocan, Claudia Banescu

“…Concomitant use of NSAIDs or anticoagulants, comorbidities (cerebrovascular disease), and male gender are the most important independent risk factors for ulcer on endoscopy in low-dose aspirin consumers, in a population with a high prevalence of H. pylori infection.…”
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