Prevalence of autoimmune thyroid disease in patients with psoriasis: a meta-analysis by Peng Zhang, Ruifang Wu, Xiaochao Zhang, Suhan Zhang, Siying Li, Yuwen Su

“…This meta-analysis aims to determine the association between psoriasis and AITD.Design A meta-analysis of observational studies.Data sources PubMed, EMBASE, Scopus and the Cochrane Library were searched up to 1 November 2021.Eligibility criteria for selecting studies We included non-randomised studies, each with over 50 cases in every group, focusing on the rate of comorbidity between psoriasis and AITD.Data extraction and synthesis Two independent reviewers screened the articles and extracted data. …”
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Africa between East and West: Searching for its own path. Book review of ‘La Russie face aux occidentaux en Afrique centrale: Pour un arrimage des Africains aux enjeux de puissance... by A. V. Nefedov

“…The author argues that despite seemingly friendly rhetoric, all global actors regard Central Africa as yet another arena of interstate rivalry, and suggests that the African countries should develop an independent foreign policy strategy, including, among other things, a force component. …”
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Integrated analysis of M2 macrophage-related gene prognostic model and single-cell sequence to predict immunotherapy response in lung adenocarcinoma by Meifang Li, Zhiping Wang, Bin Huang, Yanyun Lai, Meng Zhang, Cheng Lin

“…Moreover, the signature was an independent prognostic factor for LUAD and a potential biomarker for patients receiving immunotherapy. …”
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Investigating the correlation of hip circumference to cardiovascular disease and type‐2 diabetes using Mendelian randomization by Hongtao Liu, Zhaoyu Li, Su Yan, Shaopeng Ming

“…Results Results indicated a positive causal relationship between HC and CVD (IVW: P = 1.84e‐07, OR: 1.37, 95% CI: 1.22–1.54) as well as type 2 diabetes mellitus (IVW: P = 0.04, OR: 1.62, 95% CI: 1.02–2.56), independent of BMI. However, HC after BMI adjustment showed no significant causal relationship with CVD (IVW: P = 0.05, OR: 1.09, 95% CI: 1.00–1.19) and exhibited a negative association with type 2 diabetes mellitus (IVW: P = 0.00, OR: 0.76, 95% CI: 0.66–0.88), suggesting a protective effect against type 2 diabetes mellitus. …”
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m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder by Shuang Zhu, Peng Wang, Jian Hu

“…The non-parametric Wilcoxon rank-sum test was used to analyze non-normally distributed data, and one-way ANOVA was used to compare three or more groups. Independent replication was ensured in the studies, with each experiment repeated at least three times and statistical significance was set at P < 0.05.…”
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Initial use of supplementary oxygen for trauma patients: a systematic review by Trine Grodum Eskesen, Josefine Stokholm Baekgaard, Jacob Steinmetz, Lars S Rasmussen

“…Objective This systematic review aimed to identify and describe the evidence for supplementary oxygen for spontaneously breathing trauma patients, and for high (0.60–0.90) versus low (0.30–0.50) inspiratory oxygen fraction (FiO2) for intubated trauma patients in the initial phase of treatment.Methods Several databases were systematically searched in September 2017 for studies fulfilling the following criteria: trauma patients (Population); supplementary oxygen/high FiO2 (Intervention) versus no supplementary oxygen/low FiO2 (Control) for spontaneously breathing or intubated trauma patients, respectively, in the initial phase of treatment; mortality, complications, days on mechanical ventilation and/or length of stay (LOS) in hospital/intensive care unit (ICU) (Outcomes); prospective interventional trials (Study design). Two independent reviewers screened and identified studies and extracted data from included studies.Results 6142 citations were screened with an inter-rater reliability (Cohen’s kappa) of 0.88. …”
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Identification of GPD1L as a Potential Prognosis Biomarker and Associated with Immune Infiltrates in Lung Adenocarcinoma by Zhengyang Fan, Song Wu, Hongyang Sang, Qianping Li, Shaofei Cheng, Hongling Zhu

“…GPD1L expression and clinical stages were found to be independent prognostic indicators for overall survival and disease-free survival in LUAD patients, according to multivariate analyses. …”
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Defining the high-risk category of patients with cutaneous melanoma: a practical tool based on prognostic modeling by Oleksandr Dudin, Oleksandr Dudin, Ozar Mintser, Vitalii Gurianov, Nazarii Kobyliak, Nazarii Kobyliak, Denys Kozakov, Sofiia Livshun, Oksana Sulaieva, Oksana Sulaieva

“…The impact of sex, age at diagnosis, anatomical site, histological characteristics (the histological type, pathological stage, ulceration; the depth of invasion, mitotic rate, lymphovascular invasion, neurotropism, association with a nevus, tumor-infiltrating lymphocyte density, tumor regression and BRAF codon 600 mutation status) on CM recurrence was evaluated.ResultsFive independent variables, including nodal status, a high mitotic rate, Breslow thickness, lymphovascular invasion, perineural invasion and regression features were identified as the most significant. …”
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Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study by Yunyi Yan, Nozomi Kondo, Kentaro Oniki, Hiroshi Watanabe, Tadashi Imafuku, Yuki Sakamoto, Takuro Shigaki, Akari Maruyama, Hitomi Nakazawa, Tetsuya Kaneko, Ayami Morita, Akira Yoshida, Hitoshi Maeda, Toru Maruyama, Hideaki Jinnouchi, Junji Saruwatari

“…Visit-to-visit variability of HbA1c was an independent risk factor of microalbuminuria in association with oxidative stress among type 2 diabetes mellitus patients. …”
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Predictive value of epicardial fat thickness for left ventricular reverse remodeling after radiofrequency ablation in atrial fibrillation patients with left ventricular hypertrophy by Ke Hu, Wenhui Wang, Junping Zhen, Chunsong Kang

“…[Results] A total of 28 patients who did not achieve reverse remodeling were included in the control group, and 22 patients who achieved reverse remodeling were included in the reverse remodeling group.There were significant differences in age, atrial fibrillation classification, duration of atrial fibrillation, left atrial diameter (LAD), left ventricular end-diastolic diameter, left ventricular end-diastolic diameter index (LVEDI), neutrophil to lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hsCRP), platelet distribution width(PDW), red cell distribution width, fibrinogen to albumin ratio (FAR) and EFT between the two groups (P<0.05).Multivariate logistic regression analysis showed that EFT, LAD, LVEDI, NLR, hsCRP, PDW and FAR were independent factors for left ventricular reverse remodeling(P<0.05).The cut-off value of EFT for predicting postoperative left ventricular reverse remodeling was 0.848, sensitivity was 95.5%, specificity was 89.3%, and AUC was 0.937 (95% CI: 0.868-0.983). …”
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Defining polypharmacy in the elderly: a systematic review protocol by Seyede Salehe Mortazavi, Mohsen Shati, Seyed Kazem Malakouti, Abasali Keshtkar, Mohsen Bazargan, Shervin Assari

“…, and Which definitions are more comprehensive and applicable? 2 independent reviewers will conduct the primary screening of the articles and data extraction, and eligible sources will be selected after discussing non-conformities. …”
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Risk Balancing of Cold Ischemic Time against Night Shift Surgery Possibly Reduces Rates of Reoperation and Perioperative Graft Loss by Nikos Emmanouilidis, Julius Boeckler, Bastian P. Ringe, Alexander Kaltenborn, Frank Lehner, Hans Friedrich Koch, Jürgen Klempnauer, Harald Schrem

“…Surgery between 3 AM and 6 AM is an independent risk factor for reoperation and graft loss, whereas prolonged CIT is only relevant for DGF. …”
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Genome-Wide Association Study of Metabolic Syndrome in Koreans by Seok Won Jeong, Myungguen Chung, Soo-Jung Park, Seong Beom Cho, Kyung-Won Hong

“…Although they should be replicated in other independent populations, 6 eQTLs and 2 nsSNP loci were located in the molecular pathways of LPL, APOA5, and CHRM2, which were the significant or suggestive loci in the METS GWAS. …”
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Effect of frailty on the short-term functional outcome of elderly patients with traumatic brain injury by Yujing Gu, Huiqin Cui, Yang Gu, Xiaojiang Liu

“…[Results] Among the 127 elderly patients with traumatic brain injury, 48 cases had frailty.A total of 34 patients died during hospitalization, and 63 patients had poor neurological outcome at 3 months follow-up.Compared with the non-frailty group, the frailty group was older, had a higher mortality rate during hospitalization, and had a higher proportion of poor neurological prognosis at 3 months after onset (P<0.05).Multivariate logistics regression analysis shows that age >75 years old, higher Glasgow coma score and clinical frailty score ≥5 were independent risk factors for poor neurological prognosis in elderly patients with traumatic brain injury at 3 months onset.The results of the ROC curve indicated that the area under the curve of the Glasgow coma score predicting poor neurological prognosis in elderly patients with traumatic brain injury at 3 months after onset was 0.643 (95%CI:0.532-0.727), which was increased to 0.874 (95%CI:0.782-0.931) when indicators of patient age, Glasgow coma score and clinical frailty score were applied. …”
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CT-based scoring system for diagnosing eosinophilic solid and cystic renal cell carcinoma versus clear cell renal cell carcinoma by Sunya Fu, Dawei Chen, Yuqin Zhang, Yuguo Wei, Yuning Pan

“…Multifactorial logistic regression identified three independent factors: intra-tumour necrosis (3 points), degree of corticomedullary phase (CMP) enhancement (3 points), and pseudocapsule (2 points). …”
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IL18 Polymorphism and Periodontitis Susceptibility, Regardless of IL12B, MMP9, and Smoking Habits by Patrícia Yumeko Tsuneto, Victor Hugo de Souza, Josiane Bazzo de Alencar, Joana Maira Valentini Zacarias, Cléverson O. Silva, Jeane Eliete Laguila Visentainer, Ana Maria Sell

“…Men had greater risk than women for developing the disease when IL18 polymorphism was considered and the susceptibility was independent of the smoking status.…”
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Responses of Loess Ground with Different Slopes and Vegetation Covers to Rainfall Infiltration by ZHANG Lina, LI Ping, HU Xiangyang, ZHONG Jianping, YANG Kai, ZHAO Zhiyan, LI Tonglu

“…Laboratory model tests revealed that the vertical infiltration depth in slope was independent of slope gradient. In contrast, the infiltration thickness normal to the slope surface decreased with increasing slope gradient. …”
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Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin by Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Atsushi Nakamura, Toshiaki Kashiwadate, Naoki Kawagishi, Noriaki Ohuchi

“…HbA1c was again an independent predictor for NODAT. Receiver-operating characteristic analysis revealed a cut-off value of 5.2% with an optimal sensitivity of 64% and specificity of 78% for predicting NODAT. …”
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Exploring the relationship between physical activity and Inhibitory Function in College Students with depressive symptoms through EEG by Zhao Jinlei, Si Yanran, Ding Feng, Jia Shuqi, Liu Cong, Wen Haiyan

“…Data were analyzed using independent samples t-tests, χ2 tests, Pearson correlation analysis, and structural equation modeling. …”
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Deltacoronavirus HKU11, HKU13, PDCoV (HKU15) and HKU17 spike pseudoviruses enter avian DF-1 cells via clathrin-mediated endocytosis in a Rab5-, Rab7- and pH-dependent manner by Qi-Zhang Liang, Chun-Miao Ji, Bin Wang, Wei Chen, Feng Cong, Yu Huang, Yao-Wei Huang

“…Pseudovirus entry was suppressed by means of pharmacological inhibitors, dominant-negative mutants, and siRNAs targeting various cellular proteins and signalling molecules, suggesting that PDCoV and avian DCoV pseudovirus entry into DF-1 cells depends on clathrin, dynamin-2, cathepsins and a low-pH environment but is independent of caveolae and macropinocytosis. Furthermore, we found that DCoV pseudovirus entry was linked to Rab5- and Rab7-dependent pathways. …”
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