Single-cell landscape of dynamic changes in CD8+ T cells, CD4+ T cells and exhausted T cells in hepatocellular carcinoma by Rongqiang Liu, Jing Ye, Jianguo Wang, Wangbin Ma, Zhendong Qiu, Jia Yu, Weixing Wang

“…The results of the three independent datasets suggested that the model had strong prognostic value. …”
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Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions by Chary López-Pedrera, Carlos Pérez-Sánchez, Manuel Ramos-Casals, Monica Santos-Gonzalez, Antonio Rodriguez-Ariza, Ma José Cuadrado

“…Epigenetics, the control of gene packaging and expression independent of alterations in the DNA sequence, is providing new directions linking genetics and environmental factors. …”
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Determination of Curcuma longa L. (Turmeric) Leaf Extraction Conditions Using Response Surface Methodology to Optimize Extraction Yield and Antioxidant Content by Sera Kim, Seok-Chun Ko, Yoon-Sook Kim, Sang-Keun Ha, Ho-Young Park, Yongkon Park, Sang-Hoon Lee

“…Central composite design was applied to confirm the effect of independent variables such as temperature (X1) and time (X2) to the yield (Y1). …”
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Modification of Lipid Profile in Commercial Cow Milk Samples before and after Their Expiration Date: Evaluation of Storage Crucial Parameters and Possible Environmentally Friendly... by Eduardo Sommella, Manuela Giovanna Basilicata, Gian Carlo Tenore, Michele Manfra, Raffaella Mastrocinque, Carmine Ostacolo, Andrea Vitale, Marcello Chieppa, Pietro Campiglia, Giacomo Pepe

“…It was shown that lipolysis in milk is a process independent of time but dependent on the values of pH and total titratable acidity, while crucial parameters for the lipid oxidation are temperature and time of exposure to atmospheric oxygen. …”
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Genomic Characterization of <i>Laodelphax striatellus</i> Permutotetra-like Virus and Self-Cleavage Function of Viral Capsid Protein by Jun Piao, Jiarui Zhang, Lujie Zhang, Jingai Piao, Haitao Wang, Yilin Xie, Shuo Li

“…Detection of purified CP in vitro showed that the cleavage could occur independent of any protease, confirming that CP has self-cleavage characteristics.…”
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Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease by Misun Hwang, Dana L. Tudorascu, Karen Nunley, Helmet Karim, Howard J. Aizenstein, Trevor J. Orchard, Caterina Rosano

“…Higher activation in inferior frontal gyrus, primary sensorimotor cortex, thalamus, and cuneus was related to longer response times; in contrast, higher activation in the superior parietal lobe was associated with shorter response times. Associations were independent of small vessel disease in the brain or other organs. …”
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The learning curve for hood‐sparing robotic‐assisted radical prostatectomy: A single‐surgeon experience by Keith R. S. Simpson, Jamie Krishnan, Linda Taylor, Alan McNeill, Daniel W. Good

“…The surgeon was an ‘in‐training’ fellowship trained surgeon in their first 2 years of independent practice. There were three cohorts identified from electronic and scanned paper operation notes. …”
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Modified screening and management strategies for chronic rhinosinusitis in hematologic patients receiving hematopoietic stem cell transplantation by Yen-Hui Lee, Chih-Feng Lin, Te-Huei Yeh, Huai-Hsuan Huang, Yi-Tsen Lin

“…The multivariable logistic analysis indicated that endoscopic sinus surgery (ESS) was an independent factor for better control of CRS. However, survival was not associated with rhinosinusitis-related factors, but only with hematologic-related factors, including allogenic HSCT, reduced-intensity conditioning, and remission. …”
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Risk factors for non-benefit of implantable cardioverter defibrillator therapy by Fabienne Kreimer, Marie Lewenhardt, Ibrahim El-Battrawy, Arash Haghikia, Michael Gotzmann

“…During a mean follow-up of 4.2 ± 3.0 years, no-benefit of ICD implantation was observed in 84 patients (20%). Independent risk factors for no-benefit were age ≥ 68 years (HR 4.599, p < 0.001), anemia (HR 2.549, p < 0.001), peripheral artery disease (HR 2.066, p = 0.007), and chronic obstructive pulmonary disease (HR 1.939, p = 0.014). …”
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Increased nuclear expression of DNA damage inducible transcript 4 can serve as a potential prognostic biomarker in patients with gliomas: a study based on data mining and experimen... by Alireza Sadeghipour, Fahimeh Fattahi, Zahra Madjd, Fatemeh Tajik, Farnoosh Sedaghati, Leili Saeednejad Zanjani

“…Additionally, nuclear DDIT4 expression was identified as an independent prognostic factor for DSS. Conclusion Our findings suggest that nuclear DDIT4 expression may serve as a potential prognostic biomarker and therapeutic target in glioma patients. …”
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Body Mass Index Is Associated with Hypercholesterolemia following Thyroid Hormone Withdrawal in Thyroidectomized Patients by Dong Yeob Shin, Kwang Joon Kim, Yongin Cho, Kyeong Hye Park, Sena Hwang, Woong Youn Chung, Eun Jig Lee

“…In multiple logistic analysis, BMI was an independent determining factor of post-THW total cholesterol level (P=0.012).…”
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Smoking as a causative factor in chronic kidney disease: a two-sample Mendelian randomization study by Yue Yang, Zheng Zhang, Hai-tao Lu, Qian-qian Xu, Li Zhuo, Wen-ge Li

“…External validation was conducted using independent datasets. The results revealed positive associations between CKD and smoking initiation (Pivw = 1.8 × 10−2, OR = 1.192), earlier age at initiation (Pivw = 2.3 × 10−3, OR = 1.481), cigarettes smoked per day (Pivw = 8.8 × 10−3, OR = 1.216), and lifetime smoking (Pivw = 2.3 × 10−7, OR = 2.445). …”
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Subjectivity Formation of a Technical University Master’s Student: A New Challenge for Engineering Education by L. K. Geykhman, V. S. Kabanov

“…Based on a review of foreign and domestic approaches to understanding subjectivity and the conditions for its development, it is concluded that all researchers distinguish similar aspects and manifestations in subjectivity: motivational (intrinsic motivation), emotional-valuable (proactive and responsible attitude to life), regulatory (the ability to set goals and follow them through to the end), cognitive (desire and ability to apply knowledge) and practical (skills, experience of independent activity). It has been established that foreign studies more often consider subjectivity as a resource, which improves the quality of education, while Russian studies consider it as a goal and a result of education. …”
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Relationship between nerve ultrasonography image and electrophysiology in diabetic polyneuropathy by Pei‐Chen Hsieh, Long‐Sun Ro, Chun‐Che Chu, Ming‐Feng Liao, Hong‐Shiu Chang, Hung‐Chou Kuo

“…Multivariate step‐wise regression analysis revealed that the number of abnormal nerves was a positive independent variable for UPSS (β coefficient = 0.4205; P < 0.0001). …”
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Post-Implant Global Longitudinal Strain as a Predictor of Pacing-Induced Cardiomyopathy in Patients with Preserved Ejection Fraction Undergoing Pacemaker Placement by Sung Soo Kim, Hyung Wook Park, Hyung Ki Jeong

“…Reduced post-implant GLS was an independent predictor of PICM (hazard ratios (HR) 1.715, 95% CI 1.174–2.504; p = 0.005). …”
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Time in Russian and Japanese Lingo-cultures by N. E. Gorelova

“…These relations - are relations between two independent, different systems of traditions, meanings and world-views. …”
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The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review by Olga Theou, Liza Stathokostas, Kaitlyn P. Roland, Jennifer M. Jakobi, Christopher Patterson, Anthony A. Vandervoort, Gareth R. Jones

“…Eight electronic databases were searched for randomized controlled trials that identified their participants as “frail” either in the title, abstract, and/or text and included exercise as an independent component of the intervention. Three of the 47 included studies utilized a validated definition of frailty to categorize participants. …”
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How is cognitive behavioural therapy for insomnia delivered to adults with comorbid persistent musculoskeletal pain and disordered sleep? A scoping review. by Abigail Browne, Roisin Cahalan, Kieran O' Sullivan

“…The methodological quality of each study was evaluated by two independent reviewers using the PEDro tool. The reporting of CBT-I interventions was evaluated using the Template for Intervention Description and Replication (TIDieR) checklist.…”
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Need and utilization of primary health care among long-term unemployed Finns by Jan Klavus, Leena Forma, Jussi Partanen, Pekka Rissanen

“…Further, while the costs of utilization were independent of employment status, long-term unemployment had a distinct reducing effect on the number of medical visits. …”
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Methods of economic efficiency assessment of the operation stage of the aviation engines life cycle by Tatyana Rogulenko, Oleg Smolyakov

“…It has been noticed, that the engine can act on the market as an independent product, having a market price. But, at the same time, it is necessary to take into account that the aircraft engine is a subsystem of the aircraft, therefore, it follows to carry out its technical and economic assessment, taking into account, if possible, the characteristics of the aircraft and the characteristics of its operation, which is a difficult task and this is a necessary procedure in case of economic evaluation. …”
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