Dietary protein intake and PM2.5 on ovarian cancer survival: A prospective cohort study by He-Li Xu, Yi-Fan Wei, Qi Bao, Ya-Li Wang, Xiao-Ying Li, Dong-Hui Huang, Fang-Hua Liu, Yi-Zi Li, Yue-Yang Zhao, Xin-Xin Zhao, Qian Xiao, Song Gao, Ren-Jie Chen, Ling Ouyang, Xia Meng, Xue Qin, Ting-Ting Gong, Qi-Jun Wu

“…Results: During a median follow-up of 37.60 months, 123 deaths were documented. …”
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Effectiveness of Electronic Quality Improvement Activities to Reduce Cardiovascular Disease Risk in People With Chronic Kidney Disease in General Practice: Cluster Randomized Trial... by Jo-Anne Manski-Nankervis, Barbara Hunter, Natalie Lumsden, Adrian Laughlin, Rita McMorrow, Douglas Boyle, Patty Chondros, Shilpanjali Jesudason, Jan Radford, Megan Prictor, Jon Emery, Paul Amores, An Tran-Duy, Craig Nelson

“…Of the 470 intervention patients and 425 control patients that received a recommendation for statins, 61 (13%) and 38 (9%) were prescribed statins at follow-up (Diff 4.3%, 95% CI 0 to 8.6%; odds ratio 1.55, 95% CI 1.02 to 2.35; P=.04). …”
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Presentations on How to Finance Iran's Higher Education Based on the Global Study Model by Ehsan Ehteshamnejad, Mehdi Pakzad Bonab, Mehdi Ramezani

“…As a knowledge enterprise, the university follows the activities of production, distribution, transformation and promotion of knowledge. …”
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Internet-Based Dementia Prevention Intervention (DementiaRisk): Protocol for a Randomized Controlled Trial and Knowledge Translation by Anthony J Levinson, Stephanie Ayers, Sandra Clark, Rebekah Woodburn, Maureen Dobbins, Dante Duarte, Roland Grad, Nick Kates, Sharon Marr, Doug Oliver, Alexandra Papaioannou, Karen Saperson, Henry Siu, Gillian Strudwick, Richard Sztramko, Sarah Neil-Sztramko

“…MethodsUsing a sequential explanatory mixed methods design, this study conducts a quantitative analysis followed by a qualitative inquiry to evaluate outcomes and feasibility. …”
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Development and validation of the pain management competency scale for nurses and a nationwide survey of Chinese nurses by Yixue Wu, Xiang Pan, Lihui Gu, Yingge Tong, Siyi Chen, Ke Ni, Hangyan Du, Meng Yang, Jianyi Wang, Yi Chen, Yeling Wei, Lingling Luo, Wenqian Cheng

“…Methods An item pool and a draft scale were developed through literature reviews, semi-structured interviews, and expert panel discussions. This was followed by refinement of the scale via Delphi expert consultations and a pilot test. …”
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Effectiveness of Inactivated Coronavirus Disease 2019 Vaccine Against Omicron BA.2.2 Infection in Beijing, China, 2022: A Cohabitation Retrospective Cohort Study by Shuaibing Dong, Ying Sun, Zhaomin Feng, Yi Tian, Lei Jia, Xiaoli Wang, Quanyi Wang, Daitao Zhang, Peng Yang

“…Based on data from a previous cohabitation retrospective cohort of COVID-19 outbreak in Beijing, China, 2022, the cohabitating contacts of individuals with BA.2.2 infection were followed up. Using a log-binomial regression model in which the unvaccinated group as the control group, the risk ratios of different doses of inactivated vaccine in terms of preventing SARS-CoV-2 infection, symptoms of COVID-19, and pneumonia were calculated, and the protective effect of the vaccine was estimated. …”
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A CO₂–Δ¹⁴CO₂ inversion setup for estimating European fossil CO₂ emissions by C. Gómez-Ortiz, G. Monteil, G. Monteil, S. Basu, S. Basu, M. Scholze

“…Although the posterior biosphere fluxes in these regions follow the seasonal patterns of the true fluxes, a significant bias remains, making it impossible to close the total <span class="inline-formula">CO₂</span> budget. …”
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Application of artificial neural networks for predictive model of municipal solid waste collection in tourist cities by T. Kridakorn Na Ayutthaya, N. Jakrawatana, D. Rinchumphu, V. Owatsakul

“…The approved protocol for extracting microplastics, which incorporates biological digestion, density separation, and microplastic identification, was strictly followed, although some adaptations were made as the process unfolded. …”
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Mechanism of Inhibition of Inflammation in Osteoarthritis by Tougu Xiaotong Capsule via Regulating Ras-Raf-MEK1/2-ERK1/2 Signaling Pathway by Munan LIN, Xiang SHAO, Limei XU, Xin ZHANG, Zaishi ZHU, Yidan HAN, Xinwei DUAN, Jianmei CHEN, song GAO, Xihai LI

“…Isolated chondrocytes of passage two were divided into blank group, model group(treatment with 10 ng/mL of LPS for 8 h), inhibitor group(treatment with 10 ng/mL of U0126 for 30 min followed by 10 ng/mL of LPS for additional 8 h)and TXC group(treatment with 10 ng/mL of LPS plus 300 μg/mL of TXC for 8 h).Western blot was carried out to detect the expression of Ras, Raf, p-ERK1/2, MEK1/2, MMP-3 and MMP-13.qPCR was used to detect the mRNAs expression of MEK1/2, ERK1/2, MMP-3 and MMP-13, as well as the expression of miR-27b, miR-34a and miR-146a.Results:1)The cytoplasm of isolated cells(P2)from the cartilage of knee joint of 4-week-old SD male rats was stained brown by typeⅡcollagen immunohistochemical staining as compared with the negative control cells, which indicated that the extracted cells were chondrocytes.2)The expression of Ras, Raf, MEK1/2, MMP-3, MMP-13 in the model group was significantly higher than that in the blank group, respectively(<italic>P</italic>&lt;0.01, <italic>P</italic>&lt;0.05), but the expression of p-ERK1/2 had no significant difference(<italic>P</italic>&gt;0.05);the expression of Ras, Raf, p-ERK1/2, MEK1/2, MMP-3, MMP-13 in both the inhibitor group and the TXC group was lower than that in the model group, respectively(<italic>P</italic>&lt;0.01, <italic>P</italic>&lt;0.05), but the expression of MEK1/2 in the TXC group had no significant difference compared to that in the model group(<italic>P</italic>&gt;0.05).3)The mRNA expression of MEK1/2, ERK1/2, MMP-3 and MMP-13 in the model group was significantly higher than that in the blank group, respectively(<italic>P</italic>&lt;0.01);their expression in both the inhibitor group and the TXC group was lower than that in the model group, respectively(<italic>P</italic>&lt;0.01, <italic>P</italic>&lt;0.05).4)The expression of miR-27b in the model group was significantly lower than that in the blank group(<italic>P</italic>&lt;0.01), but its expre-ssion in both the inhibitor group and the TXC group was higher than that in the model group(<italic>P</italic>&lt;0.01);the expression of both miR-34a and miR-146a in the model group was significantly higher than that in the blank group, respectively(<italic>P</italic>&lt;0.01, <italic>P</italic>&lt;0.05);however, their expression in both the inhibitor group and the TXC group was lower than that in the model group, respectively(<italic>P</italic>&lt;0.01, <italic>P</italic>&lt;0.05).Conclusion:Tougu Xiaotong capsule regulates the expression of key factors in Ras-Raf-MEK1/2-ERK1/2 signaling pathway and miR-27b, miR-34a and miR-146a to regulate the inflammatory of chondrocytes, thereby inhibiting osteoarthritis inflammation and protecting articular cartilage.…”
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BIJAKAWEB: Platform Berbasis Web Untuk Deteksi Hate Speech Pada Komentar Berita Bahasa Indonesia by Moh. Firdaus, Permata Nur Miftahur Rizki

“…The research process began by scraping over 15,000 comment data from news portals using Python libraries, followed by manually labeling the comments into two categories: "Hate" and "Non-Hate." …”
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Long-Term Safety of Ixekizumab Treatment in Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: a Post Hoc Analysis of Cerebro-Cardiovascular Events by Mark Lebwohl, Atul Deodhar, Sergio Schwartzman, Carlo Salvarani, Meghan Feely McDonald, Natalia Bello, Elsie L. Grace, Elsa Inman, Andris Kronbergs, Marcus Ngantcha, Proton Rahman, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Andrew Blauvelt

“…The most common types of MACE reported were non-fatal myocardial infarction (IR/100 PY: PsO = 0.3; PsA = 0.3; axSpA = 0.3), followed by non-fatal stroke (IR/100 PY: PsO = 0.1; PsA = 0.2; axSpA = 0.0), and cardiovascular death (IR/100 PY: PsO = 0.1; PsA = 0.1; axSpA = 0.0). …”
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Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients by Xiaowen Guo, Yang Qiao, Sijie Yin, Fengqin Luo, Lingmei Yi, Jiajia Chen, Man Lu

“…The pharmacokinetic (PK) parameters for ciprofol are listed as follows: Maximum Plasma Concentration (Cmax) 6.02 ± 2.13 μg/ml; Time to Maximum Concentration (Tmax) 0.18 ± 0.62 min; Apparent Volume of Distribution (Vz) 3.96 ± 0.84 L/kg; Total Clearance (CL) 0.83 ± 0.14 L/h/kg; Half-life (t½) 3.47 ± 1.85 h; Area Under the Curve (AUC) 5000 ± 900 L/h/kg; Terminal Elimination Rate Constant (λz) 0.23 ± 0.07 1/h. …”
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Analysis of the Spatial Pattern of Military River Defense on the Ming Great Wall: A Case Study of the Shanxi Section of the Yellow River by Tianlian WANG, Zhe LI

“…ResultsResearch results are summarized as follows. 1) In terms of the composition of element systems, the military river defense space focuses on strengthening the construction of the border wall system, military settlement, and beacon transmission system within each subsystem of the Ming Great Wall defense system. …”
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…By the fifth week, adenine followed by an HP diet induced rapid weight loss and high mortality rates in the mouse group, precluding further model development. …”
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Clinical Observation of Auricular Acupressure Combined with Transcranial Direct Current Stimulation for Nicotine Dependence by KUANG Hongjun, FU Shanshan, HUANG Qian, YANG Layuan, YUAN Yangyang, YUAN Nan, LIU Minquan, TANG Jian, FANG Chuang, ZHONG Feng

“…Compared with before treatment, the daily smoking frequency of each group decreased after 4 weeks of treatment (<italic>P</italic>&lt;0.05); the daily smoking frequency of the combination group was (8.50±3.60), which was better than that of the tDCS group (11.16±4.29) and the auricular acupressure group (12.83±3.39) (<italic>P</italic>&lt;0.05); at 4 weeks of follow-up period, the daily smoking frequency in the combination group was (10.38±4.56), which was better than that in the tDCS group (13.76±5.87) and the auricular acupressure group (15.65±6.25) (<italic>P</italic>&lt;0.05). …”
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Protein kinase inhibitors as targeted therapy for glioblastoma: a meta-analysis of randomized controlled clinical trials by José Pinto-Fraga, Celia García-Chico, Simone Lista, Pedro Miguel Lacal, Giuseppe Carpenzano, Maurizio Salvati, Alejandro Santos-Lozano, Grazia Graziani, Claudia Ceci

“…The standard treatment for newly diagnosed GBM includes surgical resection, when feasible, followed by radiotherapy and temozolomide-based chemotherapy. …”
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Effect of intradermal acupuncture combined with auricular acupoint pressing in the treatment of recurrent oral ulcers (皮内针联合耳穴压豆治疗复发性口腔溃疡的效果观察)... by ZHU Yuhua (朱玉华), ZHU Feng (朱凤), LI Doudou (李逗逗), SUN Guifeng (孙贵凤)

“…Patients in the control group were treated with watermelon frost cream spray, and patients in the observation group were treated with intradermal acupuncture acupuncture combined with auricular acupoint pressure. They were followed up for 6 months, and recovery from oral ulcers, reoccurrence of oral ulcers and adverse reactions were observed. …”
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Experimental study on freeze-thaw damage characteristics and mechanical properties of fractured rock mass of surface mine slope in cold region by Sen TIAN, Ying ZHAO, Hu SI, Chun ZHU, Quangui LI

“…According to the final fracture morphology of rock samples and the Gaussian mixture model-based classification of microcracks, the tensile fracture was the predominant microfracture mode of rock samples (up to 54.2%), followed by the mixed mode (up to 42.3%). With the increase of freeze-thaw cycles (20–30 times), the proportion of mixed-mode microcracks increased and that of shear cracks decreased. …”
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Prevalence of common diarrheagenic enterobacteriaceae in Iran (2000–2023): a systematic review and meta-analysis by Mozhgan Derakhshan-Sefidi, Fereshteh Eidy, Somayyeh Nadi-Ravandi, Sareh Bagheri-Josheghani, Maryam Mirfakhraei

“…Subgroup analysis revealed Shigella spp. had the highest prevalence at 18.0% (95% CI: 0.13–0.24; I²=99%), followed by diarrheagenic Escherichia coli at 11.0% (95% CI: 0.09–0.15; I²=97%), Salmonella spp. at 9.0% (95% CI: 0.05–0.17; I²=99%), and Yersinia spp. at 2.0% (95% CI: 0.00-0.10; I²=94%). …”
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Significance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review by Muhammad Taqi, Haseeb ul Rasool, Mobeen Zaka Haider, Munjed Al Muderis

“…Early diagnosis, and follow-up for recurrence is often difficult due to a lack of biogenetic markers. …”
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