Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review by Yan Wang, Yan Wang, Wenmin Yang, Wenmin Yang, Yuan Yang, Yuan Yang, Xingning Liu, Xingning Liu, Lanfen Peng, Lanfen Peng, Qi Huang, Qi Huang, Qi Huang, Kongli Fan, Kongli Fan, Rui Hu, Rui Hu, Jinyu Yi, Jinyu Yi, Xin Zhong, Xin Zhong, Jing Li, Jialing Sun, Xiaozhou Zhou, Xiaozhou Zhou

“…Detailed parameters were as follows: ALT [SMD = −1.16, 95% CI (−1.84, −0.47)], AST [SMD = −1.56, 95% CI (−2.18, −0.95)], GGT [SMD = −1.48, 95% CI (−2.09, −0.87)], TBIL [SMD = −1.14, 95% CI (−2.16, −0.13)], TG [SMD = −1.29, 95% CI (−1.93, −0.66)], TC [SMD = −1.11, 95% CI (−1.61, −0.61)], PT [SMD = −0.01, 95% CI (−0.29, 0.26)], PC-III [SMD = −1.94, 95% CI (−3.04, −0.84)], and Effective Rate [OR = 3.60, 95% CI (2.28, 5.70)]. …”
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Clonal hematopoiesis of indeterminate potential is a risk factor of gastric cancer: A Prospective Cohort in UK Biobank study by Zhihui Xi, Huolun Feng, Kunling Chen, Xin Guo, Dandan Zhu, Jiabin Zheng, Yong Li

“…Design: This cohort study used data from the UK Biobank collected from baseline (2006–2010) to the end of follow-up in March 2024. Setting: Data on age, sex, race, alcohol consumption, smoking status and type 2 diabetes were collected at baseline interview. …”
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Risk assessment and photo-disinfection of antibiotic residues and antibiotic-resistant bacteria in water sources from Ede, Nigeria by Gloria O. Taylor, Aemere Ogunlaja, Olumide D. Olukanni, Oluwatosin M. Awopetu, Frances Okodua, Daniel O. Godson, Afolarin Otusile, Daniella Ekpe, Esther Deguenon, Kevin M. Sintondji, Victorien Dougnon, Olumuyiwa O. Ogunlaja, Chidinma G. Olorunnisola, Martins O. Omorogie, Moses O. Alfred, Emmanuel I. Unuabonah

“…The mean log10 bacteria count (cfu/mL) followed the trend abattoir (5.68) > river (5.67) > hand-dug well (5.53) > sachet (5.03) > bottled (4.83). …”
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Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson’s disease? by Maaike Goris, Pieter Ginis, Clint Hansen, Christian Schlenstedt, Christian Schlenstedt, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Nicholas D’Cruz, Wim Vandenberghe, Wim Vandenberghe, Walter Maetzler, Alice Nieuwboer, Moran Gilat

“…Further development of the FOG-index is warranted, and long-term follow-up studies are needed to assess the predictive value of the 360 turning task for classifying FOG conversion.…”
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Food choice motivations and perceptions of healthy eating: a cross-sectional study among consumers in the UAE by Leila Cheikh Ismail, Tareq M. Osaili, Reyad Shaker Obaid, Mona Hashim, Marya Ahmed, Fatma Al-Fayadh, Aisha Farah, Hanin Sad, Humood Alghanem, Maysm N. Mohamad, Sheima T. Saleh, Rameez Al Daour, Emad Masuadi, Lily Stojanovska, Habiba I. Ali, Ayesha S. Al Dhaheri

“…Health motivation (mean = 3.43, SD ± 0.78) exhibited the highest influence on the participants’ food choices, followed by emotional motivations (mean = 3.26, SD ± 0.68). …”
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Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus by Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim

“…Physicochemical assessments using UV–visible, circular dichroism, and nuclear magnetic resonance spectroscopy confirmed that the G4-motif present in the mraZ promoter formed an intramolecular parallel G4 structure, interacting with NMM. In vivo reporter followed by coupled in vitro transcription/translation (IVT) assays confirmed the role of mraZ G4 as a target interacting NMM to impose extreme antibacterial activity against both the gram-positive and -negative bacteria. …”
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Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma by Hengchang Liu, Jialiang Liu, Xu Guan, Zhixun Zhao, Pu Cheng, Haipeng Chen, Zheng Jiang, Xishan Wang

“…An in vivo mouse model and formalin‐fixed paraffin‐embedded samples from locally advanced rectal cancer (LARC) patients before and after radiotherapy were analyzed, followed by prognostic evaluation. Results Bioinformatics revealed that TTN mutations increase radiation sensitivity in LARC by slowing cell proliferation, promoting apoptosis, and reducing DDR. …”
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Inpatient dialectical behavior therapy combined with trauma-focused therapy for PTSD and borderline personality disorder symptoms: study design of the naturalistic trauma therapy s... by Annemieke C. Kamstra, Annemieke C. Kamstra, Sybolt O. de Vries, Maarten F. Brilman, Petty Vasilev, Manna A. Alma, Antoinette D. I. van Asselt, Antoinette D. I. van Asselt, Mia De Wolf, Robert A. Schoevers, Frederike Jörg

“…Measurements take place before the waiting list period, at pre- and posttreatment and at six- and twelve-months follow-up. Clients fill in a daily DBT-PTSD diary, which gives insight into individual symptom trajectories.ResultsStatistical analyses include two-sided paired samples t-tests, linear mixed model analyses and cost-effectiveness analyses. …”
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Effectiveness and tolerability of rimegepant in the acute treatment of migraine: a real-world, prospective, multicentric study (GAINER study) by Luigi Francesco Iannone, Gloria Vaghi, Gabriele Sebastianelli, Francesco Casillo, Antonio Russo, Marcello Silvestro, Francesca Pistoia, Giorgio Dalla Volta, Matteo Cortinovis, Alberto Chiarugi, Danilo Antonio Montisano, Maria Pia Prudenzano, Sabina Cevoli, Edoardo Mampreso, Gianluca Avino, Marina Romozzi, Mariarosaria Valente, Carla Fasano, Stefania Battistini, Antonio Granato, Elisa Maria Piella, Innocenzo Rainero, Raffaele Ornello, Roberto De Icco, On behalf of the Italian Headache Registry (RICe) Study Group

“…Using an ad hoc diary, participants prospectively collected migraine attack features at baseline and every 30 min after rimegepant administration, up to 2 h post dose. A 24 h follow up was also collected. Results We enrolled 103 participants with migraine (74.8% female, mean age 44.4 [42.0 – 46.7] years, 24.3% with chronic migraine of whom 44.0% presented a concomitant diagnosis of medication overuse headache). …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…The full-length 16S rRNA gene of the microbiota in each sample was sequenced using the PacBio single-molecule real-time sequencing platform, followed by clustering the sequences into operational taxonomic units (OTUs). …”
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An investigation on demands of clinical teaching among nursing undergraduates at school (在校本科护生临床教学需求调查分析) by GAN Lu (甘露), XIE Wei (谢薇), SHUAI Xuemei (帅雪梅), XUE Ting (徐婷), NI Dangcheng (倪当承), RAO Liu (饶柳), YUAN Zheng (袁铮), JIN Liping (金莉萍), TANG Jia (唐佳), LI Wei (李伟)

“…Results The top-ranked demand for clinical teaching was the combination of theoretic knowledge and clinical practice (91. 93%), followed by the diversified teaching methods including video-assisted and real case teaching (85. 71%) and developing students' interest in clinical work(81. 99%). …”
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Target trial emulation to evaluate the effect of immune-related adverse events on outcomes in metastatic urothelial cancer by Renate Pichler, Josef Fritz, Sarah Maier, Melanie R. Hassler, Johanna Krauter, David D`Andrea, Ekaterina Laukhtina, Kilian Gust, Keiichiro Mori, Karl H. Tully, Dora Niedersuess-Beke, Lea Korber, Jasmin Alija Spiegelberg, Thomas Bauernhofer, José D. Subiela, Roman Mayr, Andreas Kronbichler, Marco Moschini, Jeremy Teoh, Benjamin Pradere, Shahrokh F. Shariat, Hanno Ulmer, Laura S. Mertens, European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group

“…Results Among 335 patients (median age: 69 yrs), 69.6% received ICI in the second line or further lines. During a median follow-up of 21.1 months, 122 (36.4%) patients developed irAEs of any grade (grade ≥ 3: 14.9%). …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…The problems found in the current healthcare model were grouped into ten main areas: (1) the healthcare model for RDs; (2) coordination with primary healthcare providers and other tertiary and secondary hospitals; (3) access to and coordination with non-medical services; (4) the role of case manager in the XUEC; (5) genetic diagnosis; (6) undiagnosed patients; (7) treatments; (8) referring process, continuous follow-up, and transition from pediatric to adult centers; (9) research and education for professionals; and (10) associations of PLWRD and their families (patients’ advocacy). …”
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Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover tr... by Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

“…Each sequence received four-weeks of either half-dose quadruple antihypertensives or standard-dose dual antihypertensives, followed by a two-week washout and crossover for four-weeks. …”
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Adaptive responses of large-seeded lentils across diverse Indian climates by Ashok Kumar Parihar, Kali Krishna Hazra, Amrit Lamichaney, Debjyoti Sen Gupta, Jitendra Kumar, Anil Kumar Singh, Sankar Prasad Das, Muniyandi Samuel Jeberson, Parvez Ahmad Sofi, Ajaz Ahmad Lone, Jai Dev, Ashok Kumar, Ravindra Kumar Panwar, Sarvjeet Singh, Harsh Kumar Dikshit, Murlidhar Aski, Bimal Singh Jamwal, Ved Prakash, Sumer Singh Punia, Khajan Singh, Sunil Kumar Nair, Mangala Parikh, Smita Tiwari, Ashok Kumar Saxena, Sudhakar Prasad Mishra, Kamaluddin, Hitesh Kumar, Umesh Kumar, Deepak Singh, Sanjeev Gupta, Shailesh Tripathi, Girish Prasad Dixit

“…Environment factors were the dominant contributor to the yield variability (58 %), followed by GEI (28 %), with minimal genotypic effect (8 %). …”
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Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy by Emilie Dubois‐Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y.M. Michel, Chantal Dessy, Luc Bertrand, Jean‐Luc Balligand

“…Conclusions Cardiac‐specific moderate expression of β3‐AR inhibits the hypertrophic response in part through AMPK activation followed by inhibition of protein synthesis and preservation of autophagy. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…Eligible individuals were diagnosed with HIV, ≥40 years of age, naïve to antiretroviral therapy (ART), had no dementia at the index date and were followed for ≥1 year during 2002–2016. Our main outcome was incident dementia. …”
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Confocal Microscopy for Detection of Intracellular Bacteria in Urine Samples of patients Suspected with Urinary Tract Infection: A Cross-sectional Observational Study by Bhagyashri Patil-Takbhate, Nilam Memane, Srikanth Tripathy, Nageswari Gandham, Shahzad Mirza

“…Urine samples showing intracellular gram-negative bacteria by Gram staining were further processed for fluorescence confocal microscopy followed by conventional culture and virulence detection by multiplex Polymerase Chain Reaction (PCR). …”
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Long-term Impact of Carotid Endarterectomy on Choroidal and Choriocapillaris Perfusion: The INFLATE Study by Alessandro Berni, MD, Yi Zhang, PhD, Sandy Zhou Wenting, MD, Natalie Noam, MD, David Rabinovitch, BSc, Basheer Sheick Yousif, MD, Gissel Herrera, MD, Mengxi Shen, MD, PhD, Robert O’Brien, PhD, Giovanni Gregori, PhD, Ruikang K. Wang, PhD, Philip J. Rosenfeld, MD, PhD, Omer Trivizki, MD

“…Methods: Swept-source OCT angiography scans were performed on both eyes at baseline (before CEA), within 1 week post-CEA (short-term follow-up [FU]), and ≥30 days post-CEA (long-term FU). …”
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Personality and help-seeking for psychological distress: a systematic review and meta-analysis by Anna Szücs, Anna Szücs, Anna Szücs, Rachel Hui Xin Lam, Wymann Shao Wen Tang, Lifan Zhou, Monica Lazarus, Andrea B. Maier, Andrea B. Maier, Andrea B. Maier, Jose M. Valderas, Jose M. Valderas, Jose M. Valderas

“…However, findings regarding associations of personality traits with help-seeking have been inconsistent.MethodsThis systematic review and meta-analysis focused on English-language research studies on the association of personality (encompassing personality disorders, Five Factor –Big Five– dimensions, and other measures of personality) with depression, anxiety, or unspecified psychological distress in adults aged 18 years and older. Procedures followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. …”
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